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    Locally targeted anti-fibrotic agents and methods of use
    1.
    发明授权
    Locally targeted anti-fibrotic agents and methods of use 有权
    局部靶向的抗纤维化剂及使用方法

    公开(公告)号：US08404268B2

    公开(公告)日：2013-03-26

    申请号：US12911967

    申请日：2010-10-26

    申请人： Elaine Lee ,  John Scott Surfus

    发明人： Elaine Lee ,  John Scott Surfus

    IPC分类号： A61F2/02

    CPC分类号： A61K9/0009 ,  A61K9/0024 ,  A61K47/34 ,  A61M37/0092

    摘要： Effective devices and methods using an antifibrotic agent are provided for treating fibrosis or treating normal fibrous tissue. The devices and methods comprise an antifibrotic agent to degrade shrink, relax or stretch at least a portion of the fibrotic tissue. In some embodiments, the methods and devices are configured to immediately release an effective amount of the antifibrotic agent within 24 hours. In some embodiments, when the device comes in contact directly or indirectly with an activator, the antifibrotic agent will be immediately released from the depot. In some embodiments, the depot provides sustained release of the antifibrotic agent over a period of up to one year to treat fibrous tissue.

    摘要翻译： 提供使用抗纤维化剂的有效装置和方法用于治疗纤维化或治疗正常的纤维组织。 所述装置和方法包括抗纤维化剂以降解收缩，松弛或拉伸纤维组织的至少一部分。 在一些实施方案中，方法和装置被配置为在24小时内立即释放有效量的抗纤维化剂。 在一些实施方案中，当装置直接或间接与活化剂接触时，抗纤维化剂将立即从贮库释放。 在一些实施方案中，贮存库在长达一年的时间内提供抗纤维化剂的持续释放以治疗纤维组织。

    LOW LEVEL LASER THERAPY FOR LOW BACK PAIN
    2.
    发明申请
    LOW LEVEL LASER THERAPY FOR LOW BACK PAIN 审中-公开
    低水平激光治疗低背痛

    公开(公告)号：US20120158099A1

    公开(公告)日：2012-06-21

    申请号：US12972931

    申请日：2010-12-20

    申请人： Elaine Lee

    发明人： Elaine Lee

    IPC分类号： A61N5/06

    CPC分类号： A61N5/0601 ,  A61N2005/0612

    摘要： The invention provides an energy source emitting, such as a low level laser light, catheter having a throughbore, an energy emitting surface disposed near the distal end of the catheter that is connected, directly or indirectly, to the energy source, which allows for the application of therapeutic energy to treat internal areas of a patient that have been accessed by way of a catheter.

    摘要翻译： 本发明提供了一种能量源，例如低级激光，具有通孔的导管，设置在导管的远端附近的能量发射表面，该能量发射表面直接或间接连接到能量源，该能量源允许 施加治疗能量来治疗已经通过导管进入的患者的内部区域。

    DEVICES CONTAINING A CHEMONUCLEOLYSIS AGENT AND METHODS FOR TREATING AN INTERVERTEBRAL DISC OR SPINAL ARACHNOIDITIS
    3.
    发明申请
    DEVICES CONTAINING A CHEMONUCLEOLYSIS AGENT AND METHODS FOR TREATING AN INTERVERTEBRAL DISC OR SPINAL ARACHNOIDITIS 有权
    含有化学溶解剂的装置及治疗椎间盘突出症或脊髓损伤的方法

    公开(公告)号：US20120101578A1

    公开(公告)日：2012-04-26

    申请号：US12911981

    申请日：2010-10-26

    申请人： Elaine Lee

    发明人： Elaine Lee

    IPC分类号： A61F2/44

    CPC分类号： A61F2/441 ,  A61B17/3415 ,  A61F2/4455 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2002/444 ,  A61F2002/4445 ,  A61K38/00

    摘要： Effective devices and methods using a chemonucleolysis agent are provided for treating an intervertebral disc or treating spinal arachnoiditis. The devices and methods comprise a chemonucleolysis agent to degrade or to shrink at least a portion of the intervertebral disc. In some embodiments, the methods and devices are configured to immediately release an effective amount of the chemonucleolysis agent within 24 hours and provide sustained release of the chemonucleolysis agent over a period of up to one year to treat the intervertebral disc. In some embodiments, the chemonucleolysis agent in the device is administered in or near the intrathecal space and/or thecal sac to treat spinal arachnoiditis.

    摘要翻译： 提供使用化学解毒剂的有效装置和方法用于治疗椎间盘或治疗脊髓蛛网膜炎。 所述装置和方法包括降解或收缩至少一部分椎间盘的化学核解分解剂。 在一些实施方案中，所述方法和装置被配置为在24小时内立即释放有效量的化学解毒剂，并在长达一年的时间内提供化学解毒剂的持续释放以治疗椎间盘。 在一些实施方案中，装置中的化学解毒剂在鞘内空间和/或囊囊内或附近施用以治疗脊髓蛛网膜炎。

    CARPAL TUNNEL DRAINAGE
    4.
    发明申请
    CARPAL TUNNEL DRAINAGE 审中-公开
    CARPAL TUNNEL排水

    公开(公告)号：US20120029411A1

    公开(公告)日：2012-02-02

    申请号：US12845668

    申请日：2010-07-28

    申请人： Elaine Lee

    发明人： Elaine Lee

    IPC分类号： A61M5/00

    CPC分类号： A61B17/320036 ,  A61B2218/007 ,  A61F2/08 ,  A61M1/0058 ,  A61M27/00 ,  A61M31/00 ,  A61M2210/083

    摘要： A procedure for treating carpal tunnel syndrome can involve aspirating one or more of the flexor tendons running through the carpal tunnel to reduce swelling, and hence reduce the cross-sectional area of those flexor tendons. As a result, the median nerve also running through the carpal tunnel is less constricted, and the CTS symptoms associated with such constriction can be relieved. Such relief can be enhanced by delivery of one or more therapeutic substances to the area to provide additional or supplemental symptom treatment.

    摘要翻译： 用于治疗腕管综合征的方法可以包括抽出一个或多个穿过腕管的屈肌腱以减少肿胀，从而减少屈肌腱的横截面积。 结果，穿过腕管的正中神经受到的收缩也较少，与此相关的CTS症状可以缓解。 通过将一种或多种治疗物质递送到该区域以提供额外的或补充的症状治疗可以增强这种缓解。

    Device and method for treatment of a vascular defect
    6.
    发明授权
    Device and method for treatment of a vascular defect 失效
    用于治疗血管缺陷的装置和方法

    公开(公告)号：US08075585B2

    公开(公告)日：2011-12-13

    申请号：US10231391

    申请日：2002-08-29

    申请人： Elaine Lee ,  Robert Abrams

    发明人： Elaine Lee ,  Robert Abrams

    IPC分类号： A61M29/00

    CPC分类号： A61B17/12022 ,  A61B17/12113 ,  A61B17/12131 ,  A61B17/12172 ,  A61B17/1219 ,  A61B2017/1205

    摘要： A device for the occlusion of a vascular defect includes a first sheet and a second sheet which may be formed from a material which is the same as or different from the first sheet. At least one sheet functions as a securement member, and at least one sheet functions as an occluding member. The first sheet may be replaced by an alternative securement structure. At least one sheet may be coated with a biocompatible material for promoting integration with the vasculature and/or healing of the vascular defect.

    摘要翻译： 用于阻塞血管缺损的装置包括可由与第一片相同或不同的材料形成的第一片和第二片。 至少一个片材用作固定构件，并且至少一个片材用作闭塞构件。 第一片可以由替代的固定结构代替。 可以用生物相容性材料涂覆至少一个片材，以促进与血管缺损的脉管系统和/或愈合的整合。

    Internal restraint for delivery of self-expanding stents
    7.
    发明申请
    Internal restraint for delivery of self-expanding stents 有权
    自我扩张支架的内部限制

    公开(公告)号：US20050143773A1

    公开(公告)日：2005-06-30

    申请号：US11028808

    申请日：2005-01-03

    申请人： Robert Abrams ,  Elaine Lee

    发明人： Robert Abrams ,  Elaine Lee

    IPC分类号： A61L29/00 ,  A61F2/06 ,  A61F2/82 ,  A61F2/84 ,  G06Q10/00 ,  A61M29/00

    CPC分类号： G06Q10/00 ,  A61F2/95 ,  A61F2002/9511 ,  G06F19/00 ,  G06Q50/22 ,  G06Q50/24

    摘要： A medical device delivery system comprises a catheter having a catheter shaft with a proximal region and a distal region. The catheter shaft has a pull wire lumen therein. An expandable medical device is disposed about medical device receiving region of the catheter shaft. The expandable medical device has a reduced configuration and an expanded configuration. The system further comprises a retractable retaining wire, at least a portion of which is coiled about the expandable medical device and retains the expandable medical device in the reduced configuration. One end of the retractable retaining wire terminates in a pull-wire. The pull-wire extends into the pull-wire lumen to the proximal region of the catheter shaft.

    摘要翻译： 医疗装置输送系统包括具有导管轴的导管，其具有近端区域和远端区域。 导管轴在其中具有拉丝腔。 可扩张医疗装置设置在导管轴的医疗装置接收区域周围。 可扩展医疗设备具有减小的配置和扩展配置。 该系统进一步包括可缩回保持线，其至少一部分围绕可扩张医疗装置卷绕并将可扩张医疗装置保持在减小的构型。 可伸缩保持线的一端终止于拉线。 拉线延伸到拉线管腔到导管轴的近端区域。

    Activatable devices containing a chemonucleolysis agent
    9.
    发明授权
    Activatable devices containing a chemonucleolysis agent 有权
    含有化学解毒剂的活化装置

    公开(公告)号：US09414930B2

    公开(公告)日：2016-08-16

    申请号：US12911988

    申请日：2010-10-26

    申请人： Elaine Lee

    发明人： Elaine Lee

    IPC分类号： A61F2/44 ,  A61K38/00 ,  A61B17/34 ,  A61F2/30

    CPC分类号： A61F2/441 ,  A61B17/3415 ,  A61F2/4455 ,  A61F2002/30062 ,  A61F2002/30677 ,  A61F2002/444 ,  A61F2002/4445 ,  A61K38/00

    摘要： Effective devices and methods using a chemonucleolysis agent are provided for treating an intervertebral disc or treating spinal arachnoiditis. The devices and methods comprise a chemonucleolysis agent to degrade or to shrink at least a portion of the intervertebral disc. In some embodiments, the methods and devices are configured to immediately release an effective amount of the chemonucleolysis agent within 24 hours when the device comes in contact directly or indirectly with an activator and provide sustained release of the chemonucleolysis agent over a period of up to one year to treat the intervertebral disc. In some embodiments, the chemonucleolysis agent in the device is administered in or near the intrathecal space and/or thecal sac to treat spinal arachnoiditis.

    摘要翻译： 提供使用化学解毒剂的有效装置和方法用于治疗椎间盘或治疗脊髓蛛网膜炎。 所述装置和方法包括降解或收缩至少一部分椎间盘的化学核解分解剂。 在一些实施方案中，所述方法和装置被配置为当所述装置直接或间接与活化剂接触时在24小时内立即释放有效量的化学解毒剂，并在多至一个时间段内提供化学解毒剂的持续释放 一年治疗椎间盘。 在一些实施方案中，装置中的化学解毒剂在鞘内空间和/或囊囊内或附近施用以治疗脊髓蛛网膜炎。