公开(公告)号：US20070179366A1

公开(公告)日：2007-08-02

申请号：US11539949

申请日：2006-10-10

申请人： Eliahu Pewzner ,  Avraham Mayevsky

发明人： Eliahu Pewzner ,  Avraham Mayevsky

IPC分类号： A61B5/00

CPC分类号： A61B5/14546 ,  A61B5/0261 ,  A61B5/14553 ,  A61B2562/0242

摘要： Apparatus for determining the oxygenation state of at least one tissue element, comprising: a) illumination means for illuminating said tissue element with an illuminating radiation at a predetermined wavelength via at least one illumination location with respect to said tissue element, said illuminating radiation being at a wavelength within the NADH excitation spectrum or the Fp excitation spectrum; b) radiation receiving means and detection means for measuring the intensity of the corresponding NADH fluorescence or Fp fluorescence emitted by the tissue element at at least two predetermined wavelengths within the range of wavelengths comprised within the corresponding fluorescence emission spectrum.

摘要翻译： 用于确定至少一个组织元件的氧合状态的装置，包括：a）照射装置，用于通过相对于所述组织元件的至少一个照明位置以预定波长的照射辐射照射所述组织元件，所述照射辐射处于 NADH激发光谱内的波长或Fp激发光谱; b）辐射接收装置和检测装置，用于在包含在相应的荧光发射光谱内的波长范围内，以至少两个预定波长测量由组织元件发射的相应NADH荧光或Fp荧光的强度。

公开(公告)号：US08574490B2

公开(公告)日：2013-11-05

申请号：US12751365

申请日：2010-03-31

申请人： Eyal Haytman ,  Assaf Deutsch ,  Eliahu Pewzner

发明人： Eyal Haytman ,  Assaf Deutsch ,  Eliahu Pewzner

IPC分类号： A61L2/00 ,  A61F5/00 ,  A61M5/32 ,  A61N5/00

CPC分类号： A61L2/084 ,  A61L2202/23 ,  A61N5/0624

摘要： Methods and apparatus for preventing patient bloodstream infection by microorganisms during administration of various medications or fluids through IV lines. In particular, the invention reduces contamination of IV lines, connecters, stopcock valves, manifolds, ports, etc. by means of irradiation by violet and/or blue light. Each embodiment comprises a source of violet and/or blue light and an optical element optically coupled to that light source for shaping the radiation pattern of the light emitted by the light source. Preferably, a light-emitting diode or a laser diode that emits light in the desired wavelength can be used. The optical element, optically coupled to the light source, is embedded or installed in or attached to a component of an IV set, the emitted light being directed to a “point of entry” or any other stagnation point of an IV set.

摘要翻译： 在通过IV线施用各种药物或液体期间预防微生物患者血液感染的方法和装置。 特别地，本发明通过紫外线和/或蓝光的照射来减少IV线，连接器，旋塞阀，歧管，端口等的污染。 每个实施例包括紫色和/或蓝色光源和与该光源光耦合的光学元件，用于对由光源发射的光的辐射图进行整形。 优选地，可以使用发射所需波长的光的发光二极管或激光二极管。 与光源光学耦合的光学元件被嵌入或安装在IV组件的一个部件中或附着于IV组件的组件上，所发射的光被引导到IV组的“入口点”或任何其它停滞点。

公开(公告)号：US20100324391A1

公开(公告)日：2010-12-23

申请号：US12682610

申请日：2008-10-05

申请人： Genady Kostenich ,  Sol Kimel ,  Arie Orenstein ,  Reuben Achiron ,  Eliahu Pewzner

发明人： Genady Kostenich ,  Sol Kimel ,  Arie Orenstein ,  Reuben Achiron ,  Eliahu Pewzner

IPC分类号： A61B5/1459

CPC分类号： A61B5/0084 ,  A61B5/0071

摘要： Disclosed are methods and devices comprising an elongated probe for the in vivo detection of meconium in amniotic fluid held in an amniotic sac based on detecting the presence of Zinc-coproporphyrin I (ZnCP). ZnCP is excited at approximately 405 nm and emits characteristic fluorescence, centered at about 580 nm and less intensely at 630 nm.

摘要翻译： 公开了包括用于基于检测锌 - -卟啉I（ZnCP）的存在来保持在羊膜囊中的羊水体内检测胎粪的细长探针的方法和装置。 ZnCP在约405nm处被激发并发射出以580nm为中心的特征荧光，而在630nm处则强烈地发射。

公开(公告)号：US20110085936A1

公开(公告)日：2011-04-14

申请号：US12751365

申请日：2010-03-31

申请人： Eyal Haytman ,  Assaf Deutsch ,  Eliahu Pewzner

发明人： Eyal Haytman ,  Assaf Deutsch ,  Eliahu Pewzner

IPC分类号： A61L2/08 ,  G21G5/00

CPC分类号： A61L2/084 ,  A61L2202/23 ,  A61N5/0624

摘要： Methods and apparatus for preventing patient bloodstream infection by microorganisms during administration of various medications or fluids through IV lines. In particular, the invention reduces contamination of IV lines, connecters, stopcock valves, manifolds, ports, etc. by means of irradiation by violet and/or blue light. Each embodiment comprises a source of violet and/or blue light and an optical element optically coupled to that light source for shaping the radiation pattern of the light emitted by the light source. Preferably, a light-emitting diode or a laser diode that emits light in the desired wavelength can be used. The optical element, optically coupled to the light source, is embedded or installed in or attached to a component of an IV set, the emitted light being directed to a “point of entry” or any other stagnation point of an IV set.

摘要翻译： 在通过IV线施用各种药物或液体期间预防微生物患者血液感染的方法和装置。 特别地，本发明通过紫外线和/或蓝光的照射来减少IV线，连接器，旋塞阀，歧管，端口等的污染。 每个实施例包括紫色和/或蓝色光源和与该光源光耦合的光学元件，用于对由光源发射的光的辐射图进行整形。 优选地，可以使用发射所需波长的光的发光二极管或激光二极管。 与光源光学耦合的光学元件被嵌入或安装在IV组件的一个部件中或附着于IV组件的组件上，所发射的光被引导到IV组的“进入点”或任何其它停滞点。

公开(公告)号：US20050234315A1

公开(公告)日：2005-10-20

申请号：US10508232

申请日：2003-03-06

申请人： Avraham Mayevsky ,  Eliahu Pewzner ,  Assaf Deutsch ,  Tamar Manor

发明人： Avraham Mayevsky ,  Eliahu Pewzner ,  Assaf Deutsch ,  Tamar Manor

IPC分类号： A61B5/00

CPC分类号： A61B5/4519 ,  A61B5/0059 ,  A61B5/0084 ,  A61B5/14546 ,  A61B5/412

摘要： An apparatus, system and method are provided for diagnosing the degree of body metabolic emergency state. A non-vital organ with respect to the metabolic emergency state is first chosen. One or more tissue viability parameters including at least one of NADH and Flavoprotein (Fp) concentration are monitored in the non-vital organ, whereupon the degree of body metabolic emergency state may be determined based on the monitored tissue viability parameters.

摘要翻译： 提供了用于诊断身体代谢紧急状态的装置，系统和方法。 首先选择关于代谢紧急状态的非重要器官。 在非重要器官中监测包括NADH和黄素蛋白（Fp）浓度中的至少一种浓度的一种或多种组织生存力参数，从而可以基于所监测的组织存活力参数来确定身体代谢紧急状态的程度。

公开(公告)号：US20050043606A1

公开(公告)日：2005-02-24

申请号：US10490674

申请日：2001-09-25

申请人： Eliahu Pewzner ,  Avraham Mayevsky ,  Alexander Jaronkin ,  Igor Derzy

发明人： Eliahu Pewzner ,  Avraham Mayevsky ,  Alexander Jaronkin ,  Igor Derzy

IPC分类号： A61B5/00 ,  A61B5/026 ,  A61B5/05

CPC分类号： A61B5/14546 ,  A61B5/0261 ,  A61B5/1455 ,  A61B5/14551

摘要： Apparatus for monitoring a plurality of tissue viability parameters of a substantially identical tissue element, in which a single illumination laser source provides illumination radiation at a wavelength such as to enable monitoring of blood flow rate and NADH or flavoprotein concentration, together with blood volume and also blood oxygenation state. In preferred embodiments, an external cavity laser diode system is used to ensure that the laser operates in single mode or at else in two or three non-competing modes, each mode comprising a relatively narrow bandwidth. A laser stabilisation control system is provided to ensure long term operation of the laser source at the desired conditions.

摘要翻译： 用于监测基本上相同的组织元件的多个组织活力参数的装置，其中单个照明激光源提供波长的照射辐射，以便能够监测血液流速和NADH或黄素蛋白浓度以及血液体积，并且还 血氧饱和状态。 在优选实施例中，使用外腔激光二极管系统来确保激光器以单个模式操作，或者以两个或三个非竞争模式操作，每个模式包括相对窄的带宽。 提供激光稳定控制系统以确保激光源在期望条件下的长期操作。

公开(公告)号：US08768425B2

公开(公告)日：2014-07-01

申请号：US12682610

申请日：2008-10-05

申请人： Genady Kostenich ,  Sol Kimel ,  Arie Orenstein ,  Reuben Achiron ,  Eliahu Pewzner

发明人： Genady Kostenich ,  Sol Kimel ,  Arie Orenstein ,  Reuben Achiron ,  Eliahu Pewzner

IPC分类号： A61B5/1455

CPC分类号： A61B5/0084 ,  A61B5/0071

摘要： Disclosed are methods and devices comprising an elongated probe for the in vivo detection of meconium in amniotic fluid held in an amniotic sac based on detecting the presence of Zinc-coproporphyrin I (ZnCP). ZnCP is excited at approximately 405 nm and emits characteristic fluorescence, centered at about 580 nm and less intensely at 630 nm.

摘要翻译： 公开了包括用于基于检测锌 - -卟啉I（ZnCP）的存在来保持在羊膜囊中的羊水体内检测胎粪的细长探针的方法和装置。 ZnCP在约405nm处被激发并发射出以580nm为中心的特征荧光，而在630nm处则强烈地发射。

公开(公告)号：US07130672B2

公开(公告)日：2006-10-31

申请号：US10381383

申请日：2001-09-25

申请人： Eliahu Pewzner ,  Avraham Mayevsky

发明人： Eliahu Pewzner ,  Avraham Mayevsky

IPC分类号： A61B5/00 ,  A61B5/02

CPC分类号： A61B5/14546 ,  A61B5/0261 ,  A61B5/14553 ,  A61B2562/0242

摘要： Apparatus for monitoring a plurality of tissue viability parameters of a tissue layer element, in which two different illumination sources are used via a common illumination element in contact with the tissue. One illumination source is used for monitoring blood flow rate and optionally flavoprotein concentration, and collection fibers are provided to receive the appropriate radiation from the tissue. The other illuminating radiation is used for monitoring any one of and preferably all of NADH, blood volume and blood oxygenation state of the tissue element, and collection fibers are provided to receive the appropriate radiation from the tissue. In one embodiment, the wavelengths of the two illumination sources are similar, and common collection fibers for the two illuminating radiations are used. In another embodiment, the respective collection fibers are distanced from the illumination point at different distances correlated to the ratio of the first and second illuminating wavelengths.

摘要翻译： 用于监测组织层元件的多个组织活力参数的装置，其中两个不同的照明源经由与组织接触的公共照明元件使用。 一个照明源用于监测血液流速和任选的黄素蛋白浓度，并且提供收集纤维以从组织接收适当的辐射。 其他照射辐射用于监测组织元件的任何一种，优选全部NADH，血液体积和血氧饱和状态，并且提供收集纤维以从组织接收适当的辐射。 在一个实施例中，两个照明源的波长是相似的，并且使用用于两个照明辐射的公共收集光纤。 在另一个实施例中，相应的收集光纤在与第一和第二照明波长的比率相关的不同距离处离开照明点。

公开(公告)号：US20060161055A1

公开(公告)日：2006-07-20

申请号：US11311203

申请日：2005-12-19

申请人： Eliahu Pewzner ,  Assaf Deutsch ,  Yoram Blum ,  Avraham Mayevsky

发明人： Eliahu Pewzner ,  Assaf Deutsch ,  Yoram Blum ,  Avraham Mayevsky

IPC分类号： A61B5/00

CPC分类号： A61B5/0261 ,  A61B5/0059 ,  A61B5/0084 ,  A61B5/14546 ,  A61B5/1455 ,  A61B5/412 ,  A61B5/7214 ,  A61B2562/0242 ,  A61B2562/08

摘要： An optical probe, for acquiring measurements of material in a surface, the probe comprising: a probe body; at least one illuminating optical fiber that transmits light to a distal end thereof to illuminate a region of the surface and interact with the material; and at least one receiving optical fiber, positioned to receive light that has been transmitted by the illuminating fiber to the region and has interacted with the material, which received light is used for acquiring the measurements, the receiving fiber thereby being defined as associated with the illuminating fiber; wherein at least one of the fibers has a portion inside the probe body with a bend.

摘要翻译： 一种用于获取表面中的材料的测量的光学探针，所述探针包括：探针体; 至少一个照明光纤，其将光透射到其远端以照亮所述表面的区域并与所述材料相互作用; 并且至少一个接收光纤被定位成接收已经被照明光纤传输到该区域并且与接收光的材料相互作用的光已被用于获取测量值，因此接收光纤被定义为与 照明纤维; 其中所述纤维中的至少一个在所述探针体内具有弯曲部分。

公开(公告)号：US08980174B2

公开(公告)日：2015-03-17

申请号：US13513975

申请日：2012-05-11

申请人： Eyal Haytman ,  Assaf Deutsch ,  Eliahu Pewzner

发明人： Eyal Haytman ,  Assaf Deutsch ,  Eliahu Pewzner

IPC分类号： A61L2/08

CPC分类号： A61N5/0624 ,  A61N2005/0645 ,  A61N2005/0662 ,  A61N2005/0663

摘要： The device disclosed herein may be affixed over a transparent dressing overlying the catheter entry point, or may be used independent of such a dressing. The device may be affixed to the catheter insertion site using an adhesive or fastening band, or through other methods. Depending on context, the device may be used continuously or periodically, and may be affixed such that it is directly abutting a transparent dressing or directly adjacent to the skin surface, or it may be spaced a certain distance from the skin. If spaced from the skin, light may be directed from the light sources, either directly or indirectly through optical conduits. Preferably the light sources will be positioned such that light from the light sources overlaps at one or more areas on the skin, especially the catheter entry point.

摘要翻译： 本文公开的装置可以贴在覆盖导管入口点的透明敷料上，或者可以独立于这种敷料使用。 该装置可以使用粘合剂或紧固带或通过其它方法固定到导管插入部位。 根据上下文，可以连续或周期地使用该装置，并且可以将其固定，使得其直接邻接透明敷料或直接邻近皮肤表面，或者可以与皮肤间隔一定距离。 如果与皮肤间隔开，则可以从光源直接或间接地通过光导管引导光。 优选地，光源将被定位成使得来自光源的光在皮肤上的一个或多个区域，特别是导管入口点重叠。