-
公开(公告)号：US20130196413A1
公开(公告)日：2013-08-01
申请号：US13849051
申请日：2013-03-22
申请人： Ellen Chi , Michael Hunter , Ronald Swanson
发明人： Ellen Chi , Michael Hunter , Ronald Swanson
IPC分类号： C12N9/50
CPC分类号： C12N9/506 , C07K14/005 , C12N2770/34022
摘要： The present invention relates to potato virus NIa protease variants or fragments thereof, polynucleotides encoding them, and methods of making and using the foregoing.
摘要翻译： 本发明涉及马铃薯病毒NIa蛋白酶变体或其片段，编码它们的多核苷酸，以及制备和使用上述物质的方法。
-
公开(公告)号：US20130189250A1
公开(公告)日：2013-07-25
申请号：US13803887
申请日：2013-03-14
申请人： Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
发明人： Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
IPC分类号： C07K16/46
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
摘要翻译： 本发明涉及能够预防组织因子（凝血因子F3）信号传导但不干扰因子VII结合或FX与组织因子结合并且不延长凝血时间的抗体的人源化形式。 本发明的抗体可用于治疗相关细胞表达组织因子和组织因子信号传导的病症，例如肿瘤进展。
-
公开(公告)号：US08334125B2
公开(公告)日：2012-12-18
申请号：US13169853
申请日：2011-06-27
申请人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay Short , David Weiner , Mark Madden , Darcy Madden, legal representative , Mark Burk , Dan Robertson
发明人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay Short , David Weiner , Mark Madden , Mark Burk , Dan Robertson
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12Q1/00 , C12Q1/68 , A61K38/00 , C07H21/04 , C07H21/02
CPC分类号： C12P7/42 , C12N9/78 , C12N15/00 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/815 , C12P7/40 , C12P13/004 , C12P13/04 , C12P21/00 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
-
公开(公告)号：US20120237528A1
公开(公告)日：2012-09-20
申请号：US13398881
申请日：2012-02-17
申请人： Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
发明人： Juan Carlos Almagro , Glenn Mark Anderson , Ellen Chi , Christian Martinez , Gopalan Raghunathan , Ronald Swanson , Alexey Teplyakov , Kam-Fai Tse , Sheng-Jiun Wu , Hong Mimi Zhou
IPC分类号： A61K39/395 , C12N1/21 , C12N1/19 , C12N15/63 , C07K16/18 , C07H21/04 , A61P35/00 , A61P35/02 , A61P35/04 , A61P27/02 , A61P27/06 , A61P7/00 , A61P19/02 , A61P17/06 , A61P17/02 , A61P9/00 , A61P21/00 , A61P1/00 , A61P9/10 , C12N5/10
CPC分类号： C07K16/40 , A61K2039/505 , C07K16/28 , C07K16/36 , C07K16/464 , C07K2317/24 , C07K2317/34 , C07K2317/41 , C07K2317/524 , C07K2317/55 , C07K2317/565 , C07K2317/72 , C07K2317/732 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The invention relates to a humanized form of an antibody capable of preventing tissue factor (coagulation factor F3) signaling but which does not interfere with Factor VII binding or FX binding to tissue factor and does not prolong coagulation time. The antibody of the invention is useful in treating conditions, such as tumor progression, in which the associated cells express tissue factor and tissue factor signaling occurs.
摘要翻译： 本发明涉及能够预防组织因子（凝血因子F3）信号传导但不干扰因子VII结合或FX与组织因子结合并且不延长凝血时间的抗体的人源化形式。 本发明的抗体可用于治疗相关细胞表达组织因子和组织因子信号传导的病症，例如肿瘤进展。
-
公开(公告)号：US07993901B2
公开(公告)日：2011-08-09
申请号：US12629818
申请日：2009-12-02
申请人： Grace Desantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay Short , David Weiner , Mark Madden , Marcy Madden, legal representative , Mark Burk , Dan Robertson
发明人： Grace Desantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay Short , David Weiner , Mark Madden , Mark Burk , Dan Robertson
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12Q1/00 , C12Q1/68 , A61K38/00 , C07H21/04 , C07H21/02
CPC分类号： C12P7/42 , C12N9/78 , C12N15/00 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/815 , C12P7/40 , C12P13/004 , C12P13/04 , C12P21/00 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
-
公开(公告)号：US20100086986A1
公开(公告)日：2010-04-08
申请号：US12629818
申请日：2009-12-02
申请人： Grace DESANTIS , Jennifer Ann CHAPLIN , Ellen CHI , Aileen MILAN , Jay M. SHORT , David WEINER , Mark MADDEN , Darcy MADDEN , Mark J. BURK , Dan E. ROBERTSON
发明人： Grace DESANTIS , Jennifer Ann CHAPLIN , Ellen CHI , Aileen MILAN , Jay M. SHORT , David WEINER , Mark MADDEN , Darcy MADDEN , Mark J. BURK , Dan E. ROBERTSON
CPC分类号： C12P7/42 , C12N9/78 , C12N15/00 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/815 , C12P7/40 , C12P13/004 , C12P13/04 , C12P21/00 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
-
公开(公告)号：US07651849B2
公开(公告)日：2010-01-26
申请号：US12397204
申请日：2009-03-03
申请人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay M. Short , David Paul Weiner , Mark Madden , Darcy Madden, legal representative , Mark J. Burk , Dan E. Robertson
发明人： Grace DeSantis , Ellen Chi , Jennifer Ann Chaplin , Aileen Milan , Jay M. Short , David Paul Weiner , Mark Madden , Mark J. Burk , Dan E. Robertson
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12Q1/00 , A61K38/00 , C07H21/04 , C12Q1/68 , C07H21/02
CPC分类号： C12P7/42 , C12N9/78 , C12N15/00 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/815 , C12P7/40 , C12P13/004 , C12P13/04 , C12P21/00 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
-
公开(公告)号：US07521216B2
公开(公告)日：2009-04-21
申请号：US10146772
申请日：2002-05-15
申请人： Grace DeSantis , Jennifer Ann Chaplin , Ellen Chi , Aileen Milan , Jay M. Short , David Weiner , Darcy Madden, legal representative , Mark J. Burk , Dan E. Robertson
发明人： Mark Madden
IPC分类号： C12N9/78 , C12N15/00 , C12N1/20 , C12P21/04 , C12Q1/00 , A61K38/00 , C07H21/04 , C12Q1/68 , C07H21/02
CPC分类号： C12P7/42 , C12N9/78 , C12N15/00 , C12N15/70 , C12N15/74 , C12N15/81 , C12N15/815 , C12P7/40 , C12P13/004 , C12P13/04 , C12P21/00 , C12P41/006
摘要： The invention relates to nitrilases and to nucleic acids encoding the nitrilases. In addition methods of designing new nitrilases and method of use thereof are also provided. The nitrilases have increased activity and stability at increased pH and temperature.
摘要翻译： 本发明涉及腈水解酶和编码腈水解酶的核酸。 另外还提供了设计新腈水解酶的方法及其使用方法。 在增加的pH和温度下，腈水解酶具有增加的活性和稳定性。
-
9.发明授权Polynucleotides encoding engineered plant cysteine proteases and their uses 有权编码工程化植物半胱氨酸蛋白酶的多核苷酸及其用途公开(公告)号：US08759067B2
公开(公告)日：2014-06-24
申请号：US13849051
申请日：2013-03-22
申请人： Ellen Chi , Michael Hunter , Ronald Swanson
发明人： Ellen Chi , Michael Hunter , Ronald Swanson
CPC分类号： C12N9/506 , C07K14/005 , C12N2770/34022
摘要： The present invention relates to potato virus NIa protease variants or fragments thereof, polynucleotides encoding them, and methods of making and using the foregoing.
摘要翻译： 本发明涉及马铃薯病毒NIa蛋白酶变体或其片段，编码它们的多核苷酸，以及制备和使用上述物质的方法。
-
公开(公告)号：US20110318808A1
公开(公告)日：2011-12-29
申请号：US13086627
申请日：2011-04-14
申请人： Ellen Chi , Michael Hunter , Ronald Swanson
发明人： Ellen Chi , Michael Hunter , Ronald Swanson
IPC分类号： C12N9/50 , C12N15/57 , C12N1/00 , C12N5/10 , C12N1/13 , C12N1/15 , C12N1/19 , C12N9/96 , C12N1/21
CPC分类号： C12N9/506 , C07K14/005 , C12N2770/34022
摘要： The present invention relates to potato virus NIa protease variants or fragments thereof, polynucleotides encoding them, and methods of making and using the foregoing.
摘要翻译： 本发明涉及马铃薯病毒NIa蛋白酶变体或其片段，编码它们的多核苷酸，以及制备和使用上述物质的方法。
-
-
-
-
-
-
-
-
-
搜索结果
23 条记录 (耗时 0.052 秒)
