-
公开(公告)号：US20100041642A1
公开(公告)日：2010-02-18
申请号：US12541922
申请日：2009-08-15
IPC分类号： A61K31/496 , C07D409/14 , C07D413/14 , A61K31/5377 , A61K31/551 , A61P43/00
CPC分类号： C07D417/14 , C07D401/12 , C07D405/14 , C07D409/06 , C07D409/12 , C07D409/14 , C07D413/14 , C07D495/04
摘要： Urea containing compounds that inhibit MAP kinases, pharmaceutical compositions including such compounds and methods for using these compounds to treat inflammatory diseases and cancer are described herein.
摘要翻译： 本文描述了抑制MAP激酶的含尿素化合物，包含这些化合物的药物组合物和使用这些化合物治疗炎性疾病和癌症的方法。
-
公开(公告)号：US06353020B1
公开(公告)日：2002-03-05
申请号：US09615462
申请日：2000-07-13
IPC分类号： A01N4308
CPC分类号： A01N37/46 , A01N37/18 , A01N43/08 , A01N43/76 , A01N53/00 , A01N47/48 , A01N47/46 , A01N37/40 , A01N37/34 , A01N37/20 , A01N2300/00
摘要： The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from an acylalanine type fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.
摘要翻译： 本发明涉及杀真菌组合物及其作为控制植物病原真菌的方法的用途，其包括将选择的杀真菌活性N-丙酰基苯甲酰胺化合物和选自酰基丙氨酸型杀真菌剂的第二种杀真菌活性化合物施用于植物种子，植物叶子或 植物生长培养基。 组合物和使用方法比单独使用相同的化合物提供更高的杀真菌活性。
-
公开(公告)号：US6075047A
公开(公告)日：2000-06-13
申请号：US433676
申请日：1999-11-04
IPC分类号： A01N37/18 , A01N37/20 , A01N37/40 , A01N47/12 , A01N47/46 , A01N47/48 , A01N59/20 , A01N59/26 , A01N47/10
摘要： The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of an inhibitor of respiration at cytochrome complex III, ziram, fluazinam, zarilamide, chlorothalonil, propamocarb, folpet, fosetyl-aluminum or a fungitoxic metabolite thereof, a triphenyltin type fungicide and a copper containing fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.
摘要翻译： 本发明涉及杀真菌组合物及其作为控制植物病原真菌的方法的用途，其包括施用选择的杀真菌活性N-丙酮基苯甲酰胺化合物和选自以下的第二杀真菌活性化合物：在细胞色素复合物III中的呼吸抑制剂， 紫杉醇，氟啶胺，唑胺，百菌清，丙酸假单胞菌，叶磷酯，卵磷脂 - 铝或其杀真菌代谢物，三苯基锡型杀真菌剂和含铜杀真菌剂种植种子，种植叶片或植物生长培养基。 组合物和使用方法比单独使用相同的化合物提供更高的杀真菌活性。
-
公开(公告)号：US6057356A
公开(公告)日：2000-05-02
申请号：US433974
申请日：1999-11-04
IPC分类号： A01N37/18 , A01N37/20 , A01N37/40 , A01N47/12 , A01N47/46 , A01N47/48 , A01N59/20 , A01N59/26 , A01N43/38
摘要： The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound selected from the group consisting of an inhibitor of respiration at cytochrome complex III, ziram, fluazinam, zarilamide, chlorothalonil, propamocarb, folpet, fosetyl-aluminum or a fungitoxic metabolite thereof, a triphenyltin type fungicide and a copper containing fungicide to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.
-
公开(公告)号：US5874466A
公开(公告)日：1999-02-23
申请号：US873131
申请日：1997-06-10
申请人： Enrique Luis Michelotti , Heather Lynnette Rayle , Randall Wayne Stephens , William Joseph Zabrodski
发明人： Enrique Luis Michelotti , Heather Lynnette Rayle , Randall Wayne Stephens , William Joseph Zabrodski
IPC分类号： B01J31/02 , C07B61/00 , C07C51/62 , C07C205/57 , C07C205/58 , C07C205/59 , C07C231/02 , C07C231/04 , C07C233/76 , C07C235/44 , C07C237/30 , C07C249/08 , C07C251/48 , A61K31/21 , C07C255/00 , C07C533/00
CPC分类号： C07C51/62 , C07C201/12 , C07C221/00 , C07C227/10 , C07C231/02 , C07C249/08
摘要： Novel routes for the preparation of acetonylbenzamides are provided by the reaction of an amine and acyl chloride. Novel routes to various intermediates used in the manufacture of acetonylbenzamides are also disclosed.
-
公开(公告)号：US07741479B2
公开(公告)日：2010-06-22
申请号：US11295638
申请日：2005-12-07
申请人： Enrique Luis Michelotti , Eric Bruce Springman , Duyan Nguyen , Rupa S. Shetty , Younghee Lee , Kristofer Kent Moffett , Jennifer Lee Ludington , Ted Tsutomis Fujimoto , Zenon D. Konteatis , Bin Liu , Frank Hollinger , Bruce D. Dorsey
发明人： Enrique Luis Michelotti , Eric Bruce Springman , Duyan Nguyen , Rupa S. Shetty , Younghee Lee , Kristofer Kent Moffett , Jennifer Lee Ludington , Ted Tsutomis Fujimoto , Zenon D. Konteatis , Bin Liu , Frank Hollinger , Bruce D. Dorsey
IPC分类号： C07D273/06
CPC分类号： C07D333/38 , C07D231/40 , C07D243/08 , C07D277/48 , C07D277/56 , C07D295/192 , C07D333/36 , C07D403/06 , C07D405/06 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/12 , C07D413/14 , C07D417/06 , C07D417/14 , C07D495/04
摘要： The present invention is directed to a compound having the formula wherein R1, R2, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases such as MAP kinases, in particular p38 kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease. The present invention is also directed to a method of treating or preventing a protein kinase-mediated condition.
摘要翻译： 本发明涉及具有下式的化合物：其中R1，R2，G和Q如本文所定义。 本发明的化合物可用作蛋白激酶如MAP激酶，特别是p38激酶的抑制剂。 本发明还涉及包含根据上式的化合物的组合物。 本文所述的化合物和组合物可用于治疗和预防炎性疾病或疾病。 本发明还涉及治疗或预防蛋白激酶介导的病症的方法。
-
公开(公告)号：US20090192307A1
公开(公告)日：2009-07-30
申请号：US11295433
申请日：2005-12-07
IPC分类号： C07D417/14 , C07D409/14
CPC分类号： C07D409/12 , C07D409/14 , C07D417/12 , C07D417/14
摘要： The present invention is directed to a compound having the formula wherein R1, R2, R3, R4, G, and Q are defined herein. The compounds of the present invention are useful as inhibitors of protein kinases. The present invention is also directed to compositions comprising a compound according to the above formula. The present invention is also directed to compounds that stabilize the open conformation of a protein kinase, a crystallized protein kinase in the open conformation, and uses thereof. The compounds and compositions described herein are useful for treating and preventing an inflammatory condition or disease.
摘要翻译： 本发明涉及具有下式的化合物：其中R1，R2，R3，R4，G和Q如本文所定义。 本发明的化合物可用作蛋白激酶的抑制剂。 本发明还涉及包含根据上式的化合物的组合物。 本发明还涉及稳定蛋白激酶，开放构象中的结晶蛋白激酶的开放构象的化合物及其用途。 本文所述的化合物和组合物可用于治疗和预防炎性疾病或疾病。
-
公开(公告)号：US6140362A
公开(公告)日：2000-10-31
申请号：US939516
申请日：1997-09-29
IPC分类号： C07D333/38 , A61K31/16 , A61K31/165 , A61K31/166 , A61K31/26 , A61K31/27 , A61K31/277 , A61K31/34 , A61K31/341 , A61K31/38 , A61K31/381 , A61K31/42 , A61K31/423 , A61K31/425 , A61K31/426 , A61K31/428 , A61K31/44 , A61K31/4402 , A61K31/4418 , A61K31/455 , A61P35/00 , A61P43/00 , C07C233/31 , C07C237/30 , C07C251/48 , C07D213/81 , C07D263/56 , C07D275/02 , C07D277/20 , C07D277/32 , C07D277/38 , C07D307/58 , A61K31/21 , A61K31/15 , A61K31/275
CPC分类号： A61K31/455 , A61K31/16 , A61K31/166 , A61K31/27 , A61K31/277 , A61K31/341 , A61K31/381 , A61K31/423 , A61K31/428 , A61K31/44
摘要： A method for inhibiting mammalian cell growth is disclosed. The method uses compounds known as N-acetonylarylamides. The compounds have been shown to inhibit cell mitosis and to inhibit microtubule assembly. The method may be used to treat diseases associated with rapid cell growth, particularly cancer. The compounds used in the method of the present invention may be used in combination with other therapies and may be administered by known techniques for drug administration.
摘要翻译： 公开了抑制哺乳动物细胞生长的方法。 该方法使用称为N-丙酰基芳基酰胺的化合物。 化合物已显示出抑制细胞有丝分裂并抑制微管组装。 该方法可用于治疗与快速细胞生长相关的疾病，特别是癌症。 用于本发明方法的化合物可以与其它治疗组合使用，并且可以通过用于药物给药的已知技术施用。
-
公开(公告)号：US6057365A
公开(公告)日：2000-05-02
申请号：US218204
申请日：1998-12-22
CPC分类号： A01N47/12
摘要： The present invention relates to fungicidal compositions and their use as a method for controlling phytopathogenic fungi comprising the application of a selected fungicidally active N-acetonylbenzamide compound and a second fungicidally active compound which is [2-methyl-1-[1-(4-methylphenyl)-ethylaminocarbonyl]-propyl]-carbamic acid, isopropyl ester to plant seed, to plant foliage or to a plant growth medium. The compositions and method of use provide higher fungicidal activity than separate use of the same compounds.
摘要翻译： 本发明涉及杀真菌组合物及其作为控制植物病原真菌的方法的用途，其包括施用选择的杀真菌活性N-丙酮基苯甲酰胺化合物和第二杀真菌活性化合物，其为[2-甲基-1- [1-（4- 甲基苯基） - 乙基氨基羰基] - 丙基] - 氨基甲酸异丙酯，种植种子，植物叶子或植物生长培养基。 组合物和使用方法比单独使用相同的化合物提供更高的杀真菌活性。
-
公开(公告)号：US5891918A
公开(公告)日：1999-04-06
申请号：US877946
申请日：1997-06-18
IPC分类号： C07C233/76 , A01N37/20 , A01N37/44 , A01N37/50 , C07C251/48 , A01N37/18
摘要： A method for controlling phytopathogenic fungi is disclosed. The method uses a fungicidal composition which has been found to be effective against strains of fungi which are resistant to benzimidazole fungicides. When combined with one or more of benzimidazole, thiophanate, or dicarboximide fungicides, and applied to a mixed population of sensitive and resistant fungi, the fungicidal compound of the present invention is more effective against the mixed population of fungi than either of the fungicidal compounds alone.
摘要翻译： 公开了一种控制植物病原真菌的方法。 该方法使用已被发现对抗苯扎莫尔杀真菌剂的真菌菌株有效的杀真菌组合物。 当与一种或多种苯并咪唑，硫菌灵或二甲酰亚胺杀真菌剂组合并施用于敏感和抗性真菌的混合群体时，本发明的杀真菌化合物对于混合真菌群体比单独的杀真菌化合物更有效 。
-
-
-
-
-
-
-
-
-
搜索结果
34 条记录 (耗时 0.015 秒)
