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    MULTISIGNAL REAGENTS FOR LABELING ANALYTES
    5.
    发明申请
    MULTISIGNAL REAGENTS FOR LABELING ANALYTES 审中-公开

    公开(公告)号：US20190285621A1

    公开(公告)日：2019-09-19

    申请号：US16378904

    申请日：2019-04-09

    Applicant: Enzo Life Science, Inc.

    Inventor： Jack Coleman ,  Maciej Szczepanik ,  Richard Jin

    IPC: G01N33/543 ,  C12Q1/68 ,  G01N33/58

    Abstract: Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer. In this composition, the analyte is less than about 2000 MW; the polymer further comprises more than one signal or first member of a second binding pair; and the analyte is not a member of the first binding pair or the second binding pair. Also provided is an assay for an analyte. The assay comprises: combining a sample suspected of containing the analyte with the above-described composition and a binding agent that binds to the analyte; and detecting the signal or the first member of the second binding pair that is bound to the binding agent. In this assay, the amount of the signal or the first member of the second binding pair bound to the binding agent is inversely proportional to the analyte in the sample. Additionally provided is a multisignal labeling reagent comprising a first polymer covalently bound to (a) a reactive group or a first member of a first binding pair, and (b) more than one digoxigenin molecule.

    Vitamin D assays
    8.
    发明授权
    Vitamin D assays 有权
    维生素D测定

    公开(公告)号：US09476873B2

    公开(公告)日：2016-10-25

    申请号：US14772098

    申请日：2014-03-05

    Applicant: Enzo Life Science, Inc.

    Inventor： John F. Zielinski ,  Rory J. Olson ,  Michael C. Mullenix

    IPC: G01N33/53 ,  G01N33/82

    CPC classification number: G01N33/82 ,  G01N33/5308

    Abstract: The disclosure relates to methods for measuring levels of 25(OH)vitamin D (250HD) in a mammalian fluid sample. The disclosure further relates to kits for measuring levels of 25(OH)vitamin D (250HD) in a mammalian fluid, the procedure comprising the step of release of the vitamin D from the serum binding protein (DBP), capturing of the released analyte by a specific antibody and competitive assay of the captured vitamin D against a conjugate between the vitamin D and a tracer. The observed signal is inversely proportional to vitamin D concentration.

    Abstract translation: 本公开涉及用于测量哺乳动物流体样品中25（OH）维生素D（250HD）水平的方法。 本公开还涉及用于测量哺乳动物流体中25（OH）维生素D（250HD）水平的试剂盒，该方法包括从血清结合蛋白（DBP）释放维生素D的步骤，通过 捕获的维生素D针对维生素D和示踪剂之间的缀合物的特异性抗体和竞争性测定。 观察到的信号与维生素D浓度成反比。

    Multisignal reagents for labeling analytes
    9.
    发明授权
    Multisignal reagents for labeling analytes 有权

    公开(公告)号：US11162939B2

    公开(公告)日：2021-11-02

    申请号：US16812769

    申请日：2020-03-09

    Applicant: Enzo Life Science, Inc.

    Inventor： Jack Coleman ,  Maciej Szczepanik ,  Richard Jin

    IPC: G01N33/543 ,  G01N33/58 ,  C12Q1/68

    Abstract: Provided is a composition comprising an analyte bound covalently or through a first binding pair to a polymer. In this composition, the analyte is less than about 2000 MW; the polymer further comprises more than one signal or first member of a second binding pair; and the analyte is not a member of the first binding pair or the second binding pair. Also provided is an assay for an analyte. The assay comprises: combining a sample suspected of containing the analyte with the above-described composition and a binding agent that binds to the analyte; and detecting the signal or the first member of the second binding pair that is bound to the binding agent. In this assay, the amount of the signal or the first member of the second binding pair bound to the binding agent is inversely proportional to the analyte in the sample. Additionally provided is a multisignal labeling reagent comprising a first polymer covalently bound to (a) a reactive group or a first member of a first binding pair, and (b) more than one digoxigenin molecule.

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