公开(公告)号：US20230256073A1

公开(公告)日：2023-08-17

申请号：US17888916

申请日：2022-08-16

申请人： EPITOPIX, LLC

发明人： Charles Nelson Carver, III ,  Daryll A. Emery

IPC分类号： A61K39/114 ,  C07K14/195 ,  A61P31/04 ,  A61K39/39 ,  G01N33/569

CPC分类号： A61K39/114 ,  C07K14/195 ,  A61P31/04 ,  A61K39/39 ,  G01N33/56911 ,  C12N2500/24

摘要： The present invention provides isolated polypeptides isolatable from a Fusobacterium spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

公开(公告)号：US20190070281A1

公开(公告)日：2019-03-07

申请号：US15741574

申请日：2016-07-08

申请人： EPITOPIX, LLC

发明人： Douglas T. BURKHARDT ,  Daryll EMERY ,  Darren STRAUB

IPC分类号： A61K39/108 ,  A61K39/40 ,  A61P31/04

摘要： Provided herein are isolated proteins isolatable from a Klebsiella spp. Also provided are compositions that include one or more of the proteins, and methods for making and methods for using the proteins.

公开(公告)号：US09981026B2

公开(公告)日：2018-05-29

申请号：US15370797

申请日：2016-12-06

申请人： EPITOPIX, LLC

发明人： Daryll A. Emery ,  Darren E. Straub ,  Laura Wonderling

IPC分类号： A61K39/108 ,  A61K39/00 ,  C07K14/255 ,  C07K14/205 ,  A61K39/02 ,  C07K14/245

CPC分类号： A61K39/0258 ,  A61K39/0275 ,  A61K39/105 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/552 ,  C07K14/205 ,  C07K14/245 ,  C07K14/255 ,  Y10S530/825

摘要： The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.

公开(公告)号：US20180064799A1

公开(公告)日：2018-03-08

申请号：US15617541

申请日：2017-06-08

申请人： EPITOPIX LLC

发明人： Patricia E. Tam ,  Michael Nathan Harris ,  Timothy James Tripp ,  Sandra Lobo

IPC分类号： A61K39/07 ,  C07K14/32

CPC分类号： A61K39/07 ,  A61K2039/55561 ,  A61K2039/55566 ,  A61K2039/57 ,  A61K2039/70 ,  C07K14/32

摘要： The present invention provides isolated polypeptides isolatable from a Bacillus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

公开(公告)号：US09623076B2

公开(公告)日：2017-04-18

申请号：US15043740

申请日：2016-02-15

申请人： EPITOPIX, LLC

发明人： Daryll A. Emery ,  Darren E. Straub ,  Lisa L. Herron-Olson ,  Laura Wonderling

IPC分类号： A61K39/00 ,  A61K38/16 ,  C07K14/31 ,  G01N33/569 ,  A61K39/085 ,  C07K16/12 ,  C07K7/06 ,  C07K7/08 ,  A61K38/00

CPC分类号： A61K39/085 ,  A61K38/00 ,  A61K38/164 ,  A61K39/00 ,  A61K2039/505 ,  A61K2039/575 ,  C07K7/06 ,  C07K7/08 ,  C07K14/31 ,  C07K16/1271 ,  C07K16/1275 ,  C07K16/1285 ,  C07K16/1289 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  G01N33/56938 ,  Y10S530/825

摘要： The present invention provides isolated polypeptides isolatable from a Staphylococcus spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

公开(公告)号：US20160228527A1

公开(公告)日：2016-08-11

申请号：US15140767

申请日：2016-04-28

申请人： EPITOPIX, LLC

发明人： Daryll A. Emery ,  Darren E. Straub ,  Laura Wonderling

IPC分类号： A61K39/02

CPC分类号： A61K39/0291 ,  A61K39/00 ,  A61K39/025 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K14/24 ,  C07K16/1228 ,  A61K2300/00

摘要： The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

公开(公告)号：US20160008450A1

公开(公告)日：2016-01-14

申请号：US14798726

申请日：2015-07-14

申请人： EPITOPIX, LLC

发明人： Daryll A. Emery ,  Darren E. Straub ,  Laura Wonderling

IPC分类号： A61K39/112

CPC分类号： A61K39/0258 ,  A61K39/0275 ,  A61K39/105 ,  A61K2039/54 ,  A61K2039/542 ,  A61K2039/545 ,  A61K2039/55 ,  A61K2039/552 ,  C07K14/205 ,  C07K14/245 ,  C07K14/255 ,  Y10S530/825

摘要： The present invention provides compositions including polypeptides having the characteristics of polypeptides expressed by a reference microbe such E. coli or Salmonella. Examples of Salmonella strains that can be used include, for instance, S. enterica serovar Newport, S. enterica serovar Enteritidis, S. enterica serovar Typhimurium, and S. enterica serovar Dublin. Also provided are compositions including polypeptides having a particular molecular weight and a mass fingerprint that includes polypeptide fragments having a particular set of masses, or polypeptides having an amino acid sequence with at least about 95% identity with an amino acid sequence, wherein the polypeptide has seroreactive activity. The present invention also provides methods of making and methods of using such compositions.

摘要翻译： 本发明提供了包含具有由参考微生物如大肠杆菌或沙门氏菌表达的多肽特征的多肽的组合物。 可以使用的沙门氏菌属菌株的实例包括例如肠杆菌血清型Newport，肠杆菌肠炎沙门氏菌，肠炎沙门氏菌血清型鼠伤寒沙门氏菌和肠溶肠炎血清型都柏林。 还提供了包括具有特定分子量的多肽和包括具有特定质量组的多肽片段的质量指纹的组合物，或具有与氨基酸序列具有至少约95％同一性的氨基酸序列的多肽，其中所述多肽具有 血清活性。 本发明还提供了制备方法和使用这些组合物的方法。

公开(公告)号：US20140170164A1

公开(公告)日：2014-06-19

申请号：US14048640

申请日：2013-10-08

申请人： EPITOPIX, LLC

发明人： Daryll A. Emery ,  Darren E. Straub ,  Laura Wonderling

IPC分类号： C07K14/24 ,  C07K16/12

CPC分类号： A61K39/0291 ,  A61K39/00 ,  A61K39/025 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K14/24 ,  C07K16/1228 ,  A61K2300/00

摘要： The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

公开(公告)号：US20140161838A1

公开(公告)日：2014-06-12

申请号：US14048649

申请日：2013-10-08

申请人： EPITOPIX, LLC.

发明人： Daryll A. Emery ,  Darren E. Straub ,  Laura Wonderling

IPC分类号： A61K39/02

CPC分类号： A61K39/0291 ,  A61K39/00 ,  A61K39/025 ,  A61K2039/54 ,  A61K2039/55 ,  A61K2039/552 ,  A61K2039/55505 ,  A61K2039/55566 ,  A61K2039/575 ,  C07K14/24 ,  C07K16/1228 ,  A61K2300/00

摘要： The present invention provides isolated polypeptides isolatable from a Yersinia spp. Also provided by the present invention are compositions that include one or more of the polypeptides, and methods for making and methods for using the polypeptides.

摘要翻译： 本发明提供可从耶尔森氏菌属分离的分离的多肽。 本发明还提供了包含一种或多种多肽的组合物，以及制备方法和使用该多肽的方法。

公开(公告)号：US20130217048A1

公开(公告)日：2013-08-22

申请号：US13848634

申请日：2013-03-21

申请人： Epitopix LLC

发明人： Daryll A. Emery ,  Darren E. Straub ,  Donavan E. Zammert ,  Gayla K. Kallevig

IPC分类号： G01N33/53

CPC分类号： A61K39/0275 ,  A61K31/739 ,  A61K39/085 ,  A61K39/39 ,  A61K2039/552 ,  A61K2039/55572 ,  C07K14/24 ,  G01N33/53 ,  Y02A50/482 ,  Y10S424/823 ,  Y10S424/824 ,  Y10S424/825 ,  Y10S424/826 ,  Y10S424/827 ,  Y10S424/828 ,  Y10S424/829

摘要： The present invention provides compositions including siderophore receptor polypeptides and porins from gram negative microbes, and preferably, lipopolysaccharide at a concentration of no greater than about 10.0 endotoxin units per milliliter. The present invention also provides methods of making and methods of using such compositions.

摘要翻译： 本发明提供了包含来自革兰氏阴性微生物的铁载体受体多肽和孔蛋白的组合物，优选浓度不超过约10.0内毒素单位/毫升的脂多糖。 本发明还提供了制备方法和使用这些组合物的方法。