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    Smart drug delivery system
    3.
    发明授权
    Smart drug delivery system 失效
    智能药物输送系统

    公开(公告)号：US07238361B2

    公开(公告)日：2007-07-03

    申请号：US11327605

    申请日：2006-01-06

    申请人： Roger S. Cubicciotti

    发明人： Roger S. Cubicciotti

    IPC分类号： A61K9/00

    CPC分类号： B82Y5/00 ,  A61K47/51 ,  A61K47/555 ,  A61K47/6891 ,  Y10S424/829 ,  Y10S436/829

    摘要： The present invention provides prodrug and multi-prodrug complexes comprising drugs specifically bound to synthetic receptors in such a manner that active drug becomes available only in the presence of a targeted pathophysiologic receptor. Methods for preparation and use of these prodrug complexes in drug delivery systems are also provided.

    摘要翻译： 本发明提供了包含特异性结合于合成受体的药物的前药和多前体药物复合物，使得活性药物仅在靶向的病理生理受体的存在下才可用。 还提供了在药物递送系统中制备和使用这些前药复合物的方法。

    Equine strangles vaccine and the method of preparing and using the same
    9.
    发明授权
    Equine strangles vaccine and the method of preparing and using the same 失效
    马扼杀疫苗及其制备和使用方法

    公开(公告)号：US4788059A

    公开(公告)日：1988-11-29

    申请号：US754909

    申请日：1985-07-15

    申请人： Myron G. Usdin

    发明人： Myron G. Usdin

    IPC分类号： A61K39/00 ,  C12N1/20 ,  C12N15/00 ,  A61K37/00

    CPC分类号： A61K39/092 ,  Y10S424/829 ,  Y10S435/885

    摘要： A vaccine for immunizing equines against strangles and a method of using the vaccine. The vaccine is made by isolating the causative organism Streptococcus equi (S. equi) from an abscess on a horse showing typical symptoms of strangles, and confirming the identity of the organism through standard biochemical techniques. The isolated S. equi is passed through a suitable growth medium (Todd-Hewitt broth) and two parts per million acriflavine hydrochloride is added. The acriflavine level is increased over a period of approximately eleven weeks to a concentration of about sixteen parts per million to yield an avirulent S. equi while retaining its antigenicity. The method of administering the vaccine consists of inoculating the horse intranasally with the attenuated S. equi.

    摘要翻译： 一种用于免疫针对窒息的马的疫苗和使用该疫苗的方法。 该疫苗是通过从马脓脓中分离出致病生物体马链球菌（S. equi），显示典型的扼杀症状，并通过标准生物化学技术证实该生物体的身份。 将分离的S. equi通过合适的生长培养基（Todd-Hewitt肉汤），加入每百万份Acriflavine盐酸盐的两份。 阿伐他汀水平在大约十一个星期的时间内增加到约百万分之十六分之一的浓度，以产生无毒的马氏足球，同时保持其抗原性。 施用疫苗的方法包括用减毒的S. equi鼻内接种马。