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公开(公告)号：US08221366B2
公开(公告)日：2012-07-17
申请号：US12202809
申请日：2008-09-02
IPC分类号： A61M1/00
CPC分类号： A61M1/0049 , A61M1/005 , A61M2202/0464 , Y10T137/3109
摘要： A system and method are disclosed for automatically limiting the drainage of a bodily fluid such as cerebrospinal fluid (CSF) from a patient into a collection chamber. The collection chamber includes a vent having an hydrophobic filter for the passage of air to facilitate the movement of CSF yet to maintain a closed system. The system includes a buoyant float hingedly connected with the top of the collection chamber in one embodiment. When fluid rises in the collection chamber to a predetermined volume, buoyant force raises the float and causes a seal plug mounted on top of the float to seal one of an inflow port or a vent port. The float is limited to pivoting movement in one plane and to a certain angle within that plane. The system and method avoid overdrainage of CSF from the patient and overfilling of the collection chamber.
摘要翻译： 公开了一种系统和方法，用于自动限制诸如脑脊液（CSF）的体液从患者排入收集室。 收集室包括具有用于空气通过的疏水过滤器以促进CSF运动以维持封闭系统的排气口。 在一个实施例中，系统包括与收集室的顶部铰接连接的浮力浮子。 当流体在收集室中升高至预定的体积时，浮力提升浮子并使安装在浮子顶部上的密封塞密封流入端口或通风口中的一个。 浮子被限制在一个平面中的枢转运动并且在该平面内的一定角度。 该系统和方法避免CSF患者过度排出血液并过度填充收集室。
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公开(公告)号：US07238520B2
公开(公告)日：2007-07-03
申请号：US10727037
申请日：2003-12-04
申请人： Drew Chapman Brown , Carrie Lynn Holmes , Eric Scott Clasen , Richard Karl Pallo , Michael Joseph Rello , Lisa Miller , Tiffany Howland
发明人： Drew Chapman Brown , Carrie Lynn Holmes , Eric Scott Clasen , Richard Karl Pallo , Michael Joseph Rello , Lisa Miller , Tiffany Howland
CPC分类号： B01L3/5029 , B01L7/52 , B01L2200/026 , B01L2200/082 , B01L2200/16 , B01L2300/042 , B01L2300/0672 , B01L2400/0478 , B01L2400/0683 , G01N2001/028
摘要： A simplified Polymerase Chain Reaction (PCR) sample preparation apparatus and method of using a PCR sample preparation for both liquid and dry samples. A portable apparatus comprising a handle removably attached to a wand assembly. The handle includes a cover and a swab with an absorbent material. The wand assembly includes a buffer container for a buffer that is ruptured by a spike when the holder is inserted into the wand assembly. The apparatus may include a waste container removably attached to a tube comprising a plunger, a safety clip to prevent the plunger from depressing, and a port for introduction of a liquid sample. A filter on the waste container collects a specimen of the liquid sample for preparation as described above.
摘要翻译： 简单的聚合酶链式反应（PCR）样品制备装置和使用PCR样品制备用于液体和干样品的方法。 一种便携式设备，包括可移除地附接到杆组件的手柄。 手柄包括具有吸收材料的盖和棉签。 该棒棒组件包括用于缓冲器的缓冲容器，该缓冲容器在保持器插入到棒组件中时被尖钉破裂。 该装置可以包括可拆卸地附接到包括柱塞的管的废物容器，用于防止柱塞压下的安全夹，以及用于引入液体样品的端口。 如上所述，废物容器上的过滤器收集用于制备的液体样品的样品。
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公开(公告)号：US08603057B2
公开(公告)日：2013-12-10
申请号：US13550405
申请日：2012-07-16
IPC分类号： A61M1/00
CPC分类号： A61M1/0049 , A61M1/005 , A61M2202/0464 , Y10T137/3109
摘要： A system and method are disclosed for automatically limiting the drainage of a bodily fluid such as cerebrospinal fluid (CSF) from a patient into a collection chamber. The collection chamber includes a vent having an hydrophobic filter for the passage of air to facilitate the movement of CSF yet to maintain a closed system. The system includes a buoyant float hingedly connected with the top of the collection chamber in one embodiment. When fluid rises in the collection chamber to a predetermined volume, buoyant force raises the float and causes a seal plug mounted on top of the float to seal one of an inflow port or a vent port. The float is limited to pivoting movement in one plane and to a certain angle within that plane. The system and method avoid overdrainage of CSF from the patient and overfilling of the collection chamber.
摘要翻译： 公开了一种系统和方法，用于自动限制诸如脑脊液（CSF）的体液从患者排入收集室。 收集室包括具有用于空气通过的疏水过滤器以促进CSF运动以维持封闭系统的排气口。 在一个实施例中，系统包括与收集室的顶部铰接连接的浮力浮子。 当流体在收集室中升高至预定的体积时，浮力提升浮子并使安装在浮子顶部上的密封塞密封流入端口或通风口中的一个。 浮子被限制在一个平面中的枢转运动并且在该平面内的一定角度。 该系统和方法避免CSF患者过度排出血液并过度填充收集室。
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公开(公告)号：US20120283676A1
公开(公告)日：2012-11-08
申请号：US13550405
申请日：2012-07-16
IPC分类号： A61M1/00
CPC分类号： A61M1/0049 , A61M1/005 , A61M2202/0464 , Y10T137/3109
摘要： A system and method are disclosed for automatically limiting the drainage of a bodily fluid such as cerebrospinal fluid (CSF) from a patient into a collection chamber. The collection chamber includes a vent having an hydrophobic filter for the passage of air to facilitate the movement of CSF yet to maintain a closed system. The system includes a buoyant float hingedly connected with the top of the collection chamber in one embodiment. When fluid rises in the collection chamber to a predetermined volume, buoyant force raises the float and causes a seal plug mounted on top of the float to seal one of an inflow port or a vent port. The float is limited to pivoting movement in one plane and to a certain angle within that plane. The system and method avoid overdrainage of CSF from the patient and overfilling of the collection chamber.
摘要翻译： 公开了一种系统和方法，用于自动限制诸如脑脊液（CSF）的体液从患者排入收集室。 收集室包括具有用于空气通过的疏水过滤器以促进CSF运动以维持封闭系统的排气口。 在一个实施例中，系统包括与收集室的顶部铰接连接的浮力浮子。 当流体在收集室中升高至预定的体积时，浮力提升浮子并使安装在浮子顶部上的密封塞密封流入端口或通风口中的一个。 浮子被限制在一个平面中的枢转运动并且在该平面内的一定角度。 该系统和方法避免CSF患者过度排出血液并过度填充收集室。
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公开(公告)号：US20080131949A1
公开(公告)日：2008-06-05
申请号：US11804598
申请日：2007-05-18
申请人： Laura T. Bortolin , Lalitha Parameswaran , James Harper , Johanna Bobrow , Mark A. Hollis , Drew Chapman Brown , Eric Scott Clasen , John Calvin Schmidt
发明人： Laura T. Bortolin , Lalitha Parameswaran , James Harper , Johanna Bobrow , Mark A. Hollis , Drew Chapman Brown , Eric Scott Clasen , John Calvin Schmidt
CPC分类号： B01L3/502 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/043 , B01L2300/044 , B01L2300/047 , B01L2300/048 , B01L2300/0609 , B01L2300/0672 , B01L2300/0681 , B01L2300/069 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , B01L2400/0644 , B01L2400/0683 , C07H21/04 , C12N15/1013
摘要： A method for preparing a nucleic acid component of a sample for amplification includes contacting the sample with a porous support that deactivates a nucleic acid amplification inhibitor component of the sample and directing a fluid through the porous support, whereby the nucleic acid component of the sample is directed through at least a portion of the porous support and is separated from the support, thereby preparing the nucleic acid component for amplification. The sample is separated from raw sample components through means that include a magnetic substrate. An apparatus suitable for conducting the method of the invention also is described.
摘要翻译： 用于制备用于扩增的样品的核酸组分的方法包括使样品与多孔载体接触，多孔载体使样品的核酸扩增抑制剂组分失活并引导流体通过多孔载体，由此样品的核酸组分为 引导通过多孔载体的至少一部分并与载体分离，由此制备用于扩增的核酸组分。 样品通过包括磁性底物的方式与原始样品组分分离。 还描述了适用于进行本发明的方法的装置。
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公开(公告)号：US08062846B2
公开(公告)日：2011-11-22
申请号：US11804598
申请日：2007-05-18
申请人： Laura T. Bortolin , Lalitha Parameswaran , James Harper , Johanna Bobrow , Mark A. Hollis , Drew Chapman Brown , Eric Scott Clasen , John Calvin Schmidt
发明人： Laura T. Bortolin , Lalitha Parameswaran , James Harper , Johanna Bobrow , Mark A. Hollis , Drew Chapman Brown , Eric Scott Clasen , John Calvin Schmidt
CPC分类号： B01L3/502 , B01L2200/10 , B01L2200/16 , B01L2300/042 , B01L2300/043 , B01L2300/044 , B01L2300/047 , B01L2300/048 , B01L2300/0609 , B01L2300/0672 , B01L2300/0681 , B01L2300/069 , B01L2300/0867 , B01L2300/1822 , B01L2300/1827 , B01L2400/043 , B01L2400/0644 , B01L2400/0683 , C07H21/04 , C12N15/1013
摘要： An apparatus for preparing a nucleic acid component of a sample for amplification includes a porous support having an agent that deactivates a nucleic acid amplification inhibitor component of the sample. The apparatus further includes a housing with an opening and defining an interior. The interior of the housing is in fluid communication with the porous support, and at least a portion of a fluid directed through the opening is directed through at least a portion of the porous support. The apparatus also includes a magnetic substrate for separating nucleic acid from a sample.
摘要翻译： 用于制备用于扩增的样品的核酸组分的装置包括具有使样品的核酸扩增抑制剂组分失活的试剂的多孔载体。 该装置还包括具有开口并限定内部的壳体。 壳体的内部与多孔支撑件流体连通，并且引导通过开口的流体的至少一部分被引导通过多孔支撑件的至少一部分。 该装置还包括用于从样品中分离核酸的磁性底物。
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公开(公告)号：US20090088710A1
公开(公告)日：2009-04-02
申请号：US12202809
申请日：2008-09-02
IPC分类号： A61M1/00
CPC分类号： A61M1/0049 , A61M1/005 , A61M2202/0464 , Y10T137/3109
摘要： A system and method are disclosed for automatically limiting the drainage of a bodily fluid such as cerebrospinal fluid (CSF) from a patient into a collection chamber. The collection chamber includes a vent having an hydrophobic filter for the passage of air to facilitate the movement of CSF yet to maintain a closed system. The system includes a buoyant float hingedly connected with the top of the collection chamber in one embodiment. When fluid rises in the collection chamber to a predetermined volume, buoyant force raises the float and causes a seal plug mounted on top of the float to seal one of an inflow port or a vent port. The float is limited to pivoting movement in one plane and to a certain angle within that plane. The system and method avoid overdrainage of CSF from the patient and overfilling of the collection chamber.
摘要翻译： 公开了一种系统和方法，用于自动限制诸如脑脊液（CSF）的体液从患者排入收集室。 收集室包括具有用于空气通过的疏水过滤器以促进CSF运动以维持封闭系统的排气口。 在一个实施例中，系统包括与收集室的顶部铰接连接的浮力浮子。 当流体在收集室中升高至预定的体积时，浮力提升浮子并使安装在浮子顶部上的密封塞密封流入端口或通风口中的一个。 浮子被限制在一个平面中的枢转运动并且在该平面内的一定角度。 该系统和方法避免CSF患者过度排出血液并过度填充收集室。
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