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1.发明申请Novel compounds as inhibitors of hepatitis C virus NS3 serine protease 失效新型化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20050288233A1
公开(公告)日：2005-12-29
申请号：US11065509
申请日：2005-02-24
申请人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
发明人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
IPC分类号： A61K38/00 , A61K38/04 , C07D209/52 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/04 , C07K5/06 , C07K5/065 , C07K5/08
CPC分类号： C07D209/52 , A61K38/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/06034 , C07K5/06078
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的疾病的方法。
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2.发明申请公开(公告)号：US20080004287A1
公开(公告)日：2008-01-03
申请号：US11769030
申请日：2007-06-27
申请人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
发明人： Yao Ma , Brian Lahue , Gerald Shipps , Yaolin Wang , Stephane Bogen , Matthew Voss , Latha Nair , Yuan Tian , Ronald Doll , Zhuyan Guo , Corey Strickland , Rumin Zhang , Mark McCoy , Weidong Pan , Elise Siegel , Craig Gibeau
IPC分类号： A61K31/497 , A61P43/00 , C07D401/14
CPC分类号： C07D409/14 , C07D401/06 , C07D401/14
摘要： In its many embodiments, the present invention discloses novel compounds, as inhibitors of HDM2 protein, methods for preparing such compounds, pharmaceutical compositions including one or more such compounds, methods of treatment, prevention, inhibition, of one or more diseases associated with the HDM2 protein or P53 using such compounds or pharmaceutical compositions.
摘要翻译： 在其许多实施方案中，本发明公开了作为HDM2蛋白的抑制剂的新化合物，制备这些化合物的方法，包含一种或多种这样的化合物的药物组合物，治疗，预防，抑制与HDM2相关的一种或多种疾病的方法 蛋白质或P53使用这些化合物或药物组合物。
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公开(公告)号：US20070142301A1
公开(公告)日：2007-06-21
申请号：US11645181
申请日：2006-12-21
申请人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan
发明人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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4.发明申请公开(公告)号：US20070032433A1
公开(公告)日：2007-02-08
申请号：US10052386
申请日：2002-01-18
申请人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair
发明人： Anil Saksena , Viyyoor Girijavallabhan , Raymond Lovey , Edwin Jao , Frank Bennett , Jinping Mc Cormick , Haiyan Wang , Russell Pike , Stephane Bogen , Tin-Yau Chan , Yi-Tsung Liu , Zhaoning Zhu , F. Njoroge , Ashok Arasappan , Tejal Parekh , Ashit Ganguly , Kevin Chen , Srikanth Venkatraman , Henry Vaccaro , Patrick Pinto , Bama Santhanam , Scott Kemp , Odile Levy , Marguerita Lim-wilby , Susan Tamura , Wanli Wu , Siska Hendrata , Yuhua Huang , Jesse Wong , Latha Nair
CPC分类号： C07K5/0804 , A61K38/00 , C07K5/0202 , C07K5/0812 , C07K5/0827 , C07K7/02
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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5.发明授权2′-cyano substituted nucleoside derivatives and methods of use thereof useful for the treatment of viral diseases 有权2'-氰基取代的核苷衍生物及其用于治疗病毒性疾病的方法公开(公告)号：US09150603B2
公开(公告)日：2015-10-06
申请号：US14111688
申请日：2012-04-11
申请人： Vinay Girijavallabhan , F. George Njoroge , Stephane Bogen , Angela Kerekes , Frank Bennett , Ying Huang , Latha Nair , Dmitri Pissarnitski , Vishal Verma , Qun Dang , Ian Davies , David B. Olsen , Andrew Stamford , Joseph P. Vacca
发明人： Vinay Girijavallabhan , F. George Njoroge , Stephane Bogen , Angela Kerekes , Frank Bennett , Ying Huang , Latha Nair , Dmitri Pissarnitski , Vishal Verma , Qun Dang , Ian Davies , David B. Olsen , Andrew Stamford , Joseph P. Vacca
IPC分类号： C07H19/06 , C07H19/20 , C07H19/10 , C07H19/12 , C07H19/16 , C07H19/04 , C07H19/207 , C07H19/11 , C07H19/213 , A61K31/7056 , A61K31/7068 , A61K31/7076 , A61K45/06
CPC分类号： C07H19/16 , A61K31/7056 , A61K31/7068 , A61K31/7076 , A61K45/06 , C07H19/06 , C07H19/10 , C07H19/11 , C07H19/20 , C07H19/207 , C07H19/213 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/395
摘要： The present invention relates to 2′-Cyano Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Cyano Substituted Nucleoside Derivative, and methods of using the 2′-Cyano Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的2'-氰基取代的核苷衍生物及其药学上可接受的盐，其中B，X，R 1，R 2和R 3如本文所定义。 本发明还涉及包含至少一种2'-氰基取代的核苷衍生物的组合物，以及使用2'-氰基取代的核苷衍生物治疗或预防患者HCV感染的方法。
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6.发明授权2′-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases 有权2'-叠氮基取代的核苷衍生物及其用于治疗病毒性疾病的方法公开(公告)号：US09156872B2
公开(公告)日：2015-10-13
申请号：US14111685
申请日：2012-04-11
申请人： Vinay Girijavallabhan , F. George Njoroge , Stephane Bogen , Frank Bennett , Vishal Verma , Ashok Arasappan , Kevin Chen , Ying Huang , Angela Kerekes , Latha Nair , Dmitri Pissarnitski , Qun Dang , Ian Davies , David B. Olsen , Andrew Stamford , Joseph P. Vacca
发明人： Vinay Girijavallabhan , F. George Njoroge , Stephane Bogen , Frank Bennett , Vishal Verma , Ashok Arasappan , Kevin Chen , Ying Huang , Angela Kerekes , Latha Nair , Dmitri Pissarnitski , Qun Dang , Ian Davies , David B. Olsen , Andrew Stamford , Joseph P. Vacca
IPC分类号： C07H19/06 , C07H19/10 , C07H19/12 , C07H19/16 , C07H19/04 , C07H19/20 , C07H19/207 , C07H19/11 , C07H19/213 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06
CPC分类号： C07H19/06 , A61K31/7056 , A61K31/706 , A61K31/7064 , A61K31/7068 , A61K31/7072 , A61K31/708 , A61K45/06 , A61P31/14 , C07H19/10 , C07H19/11 , C07H19/12 , C07H19/16 , C07H19/20 , C07H19/207 , C07H19/213
摘要： The present invention relates to 2′-Azido Substituted Nucleoside Derivatives of Formula (I): and pharmaceutically acceptable salts thereof, wherein B, X, R1, R2 and R3 are as defined herein. The present invention also relates to compositions comprising at least one 2′-Azido Substituted Nucleoside Derivative, and methods of using the 2′-Azido Substituted Nucleoside Derivatives for treating or preventing HCV infection in a patient.
摘要翻译： 本发明涉及式（I）的2'-叠氮基取代的核苷衍生物及其药学上可接受的盐，其中B，X，R 1，R 2和R 3如本文所定义。 本发明还涉及包含至少一种2'-叠氮基取代的核苷衍生物的组合物，以及使用2'-叠氮基取代的核苷衍生物治疗或预防患者HCV感染的方法。
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7.发明申请Novel ketoamides with cyclic P4's as inhibitors of NS3 serine protease of hepatitis C virus 失效具有循环P4的新型酮酰胺作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20070093430A1
公开(公告)日：2007-04-26
申请号：US11602174
申请日：2006-11-20
申请人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
发明人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
IPC分类号： A61K38/04 , C07K5/06 , C07D417/02
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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8.发明申请Novel compounds as inhibitors of hepatitis C virus NS3 serine protease 失效新型化合物作为丙型肝炎病毒NS3丝氨酸蛋白酶的抑制剂公开(公告)号：US20070049536A1
公开(公告)日：2007-03-01
申请号：US11542228
申请日：2006-10-03
申请人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
发明人： Srikanth Venkatraman , F. Njoroge , Melissa Blackman , Wanli Wu , Latha Nair , Ashok Arasappan , Stephane Bogen , Kevin Chen , Mousumi Sannigrahi , Frank Bennett , Viyyoor Girijavallabhan
CPC分类号： C07D209/52 , A61K38/00 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , C07K5/06034 , C07K5/06078
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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公开(公告)号：US20050267043A1
公开(公告)日：2005-12-01
申请号：US11065572
申请日：2005-02-24
申请人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan
发明人： Stephane Bogen , Weidong Pan , Sumei Ruan , Kevin Chen , Ashok Arasappan , Srikanth Venkatraman , Latha Nair , Mousumi Sannigrahi , Frank Bennett , Anil Saksena , F. Njoroge , Viyyoor Girijavallabhan
IPC分类号： A61K31/401 , A61K31/403 , A61K31/4035 , A61K31/407 , A61K31/422 , A61K31/427 , A61K31/4439 , A61K31/496 , A61K31/497 , A61K38/00 , A61K38/04 , C07D207/10 , C07D209/02 , C07D209/52 , C07D209/70 , C07D295/16 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/02 , C07D413/12 , C07D417/02 , C07D417/12 , C07D491/04 , C07D495/10 , C07K5/02 , C07K5/04 , C07K5/08 , C07K5/083 , C07K5/087 , C07D43/02
CPC分类号： C07D209/52 , A61K38/00 , C07D209/02 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07K5/0205 , C07K5/0808 , C07K5/0812 , C07K5/0827
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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10.发明申请Novel ketoamides with cyclic P4'S as inhibitors of NS3 protease of hepatitis C virus 有权具有环状P4'S的新型酮酰胺作为丙型肝炎病毒NS3蛋白酶的抑制剂公开(公告)号：US20050222047A1
公开(公告)日：2005-10-06
申请号：US11065647
申请日：2005-02-24
申请人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
发明人： Kevin Chen , F. Njoroge , Mousumi Sannigrahi , Latha Nair , Weiying Yang , Bancha Vibulbhan , Srikanth Venkatraman , Ashok Arasappan , Stephane Bogen , Frank Bennett , Viyyoor Girijavallabhan
IPC分类号： A61K31/40 , A61K38/00 , A61K38/04 , C07D209/52 , C07D401/12 , C07D417/02 , C07D417/12 , C07D513/04 , C07K5/02 , C07K5/04 , C07K5/08 , C12Q1/70 , C07D43/02 , C07D49/02
CPC分类号： C07K5/0202 , A61K31/40 , A61K38/00 , C07K5/0205 , C12Q1/707
摘要： The present invention discloses novel compounds which have HCV protease inhibitory activity as well as methods for preparing such compounds. In another embodiment, the invention discloses pharmaceutical compositions comprising such compounds as well as methods of using them to treat disorders associated with the HCV protease.
摘要翻译： 本发明公开了具有HCV蛋白酶抑制活性的新型化合物及其制备方法。 在另一个实施方案中，本发明公开了包含这些化合物的药物组合物以及使用它们来治疗与HCV蛋白酶相关的病症的方法。
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