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公开(公告)号：US20200023045A1
公开(公告)日：2020-01-23
申请号：US16486768
申请日：2018-02-20
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Munehisa SHIMAMURA , Tomohiro KAWANO , Hironori NAKAGAMI , Ryuichi MORISHITA , Hideki MOCHIZUKI , Akiko TENMA , Takako EHARA
Abstract: Provided is an immunogenic composition comprising an antigenic peptide capable of inducing production of a neutralizing antibody against S100A9 and a carrier protein. The immunogenic composition can be used as a highly safe antithrombotic vaccine having antithrombotic effect without a long-term bleeding risk and is useful for the prevention of a disease associated with thrombus formation in which platelet aggregation is involved, particularly for the prevention of recurrent ischemic stroke.
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公开(公告)号：US20250057928A1
公开(公告)日：2025-02-20
申请号：US18717944
申请日：2022-12-07
Applicant: OSAKA UNIVERSITY , FunPep Co., Ltd.
Inventor： Hironori NAKAGAMI , Hiroki HAYASHI , Ryuichi MORISHITA , Makoto SAKAGUCHI , Sotaro KAWABATA
Abstract: The present invention provides a vaccine composition containing a complex of a T cell receptor antigen peptide and a B cell receptor antigen peptide and capable of inducing the production of an antibody against IL-23, wherein the B cell receptor antigen peptide is represented by the following formula (I): X1-X2-X3-X4-X5-X6-X7-X8 (I) wherein X1 is S, A, G, T, K, or R, X2 is P, A, G, S, T, K, or R, X3 is S, A, G, T, K, or R, X4 is Q, A, G, T, or N, X5 is P, A, G, S, T, Q, or N, X6 is W, A, Y, or E, X7 is Q, A, G, T, or N, and X8 is R, A, G, or K.
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公开(公告)号：US20190105388A1
公开(公告)日：2019-04-11
申请号：US16087799
申请日：2017-03-24
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Hironori NAKAGAMI , Ryuichi MORISHITA , Akiko TENMA
IPC: A61K39/39 , A61P37/04 , A61K39/395 , A61K39/00
Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.
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公开(公告)号：US20210205446A1
公开(公告)日：2021-07-08
申请号：US17200552
申请日：2021-03-12
Applicant: OSAKA UNIVERSITY , FUNPEP CO., LTD.
Inventor： Hironori NAKAGAMI , Ryuichi MORISHITA , Akiko TENMA
IPC: A61K39/39 , A61K39/00 , A61P37/04 , A61K39/395
Abstract: The present invention provides a vaccine containing a complex of a peptide consisting of the amino acid sequence of SEQ ID NO: 1 and an epitope of a disease-causing biological protein such as DPP4, IL-17A, IgE, S100A9 or PCSK9, which vaccine uses a less antigenic carrier protein and is capable of inducing antibody production to serve as an effective vaccine.
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公开(公告)号：US20230330214A1
公开(公告)日：2023-10-19
申请号：US18028613
申请日：2021-09-30
Applicant: OSAKA UNIVERSITY , TAKARA BIO INC. , ANGES, INC.
Inventor： Hironori NAKAGAMI , Ryuichi MORISHITA , Hiroki HAYASHI , Yasunori AMAISHI , Sachiko OKAMOTO , Junichi MINENO , Hisato IKAI , Junko MICHIBATA , Takao KOMATSUNO
IPC: A61K39/215 , A61P37/04
CPC classification number: A61K39/215 , A61P37/04 , A61K2039/53
Abstract: Provided is DNA that: encodes a coronavirus (SARS CoV-2) spike protein or a fragment thereof; and has been optimized to partially or fully exhibit a codon included in a DNA sequence.
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Patent Agency Ranking
公开(公告)号：US20190106484A1
公开(公告)日：2019-04-11
申请号：US16168275
申请日：2018-10-23
Applicant: OSAKA UNIVERSITY
Inventor： Yoshiaki TANIYAMA , Ryuichi MORISHITA , Junya AZUMA , Fumihiro SANADA , Naruto KATSURAGI
Abstract: The present invention provides a drug for preventing or treating inflammation-associated diseases in which a periostin isoform having cell adhesion activity is involved, and also provides an inhibitor of a periostin isoform having cell adhesion activity.
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公开(公告)号：US20170275336A1
公开(公告)日：2017-09-28
申请号：US15514310
申请日：2015-09-25
Applicant: OSAKA UNIVERSITY
Inventor： Hironori NAKAGAMI , Ryuichi MORISHITA , Hiroshi KORIYAMA , Akiko TENMA
Abstract: An object of the present invention is to provide a novel peptide and a novel immunostimulant or hair grower containing the peptide as an active ingredient. The present invention provides a peptide of 23 or less amino acids comprising the amino acid sequence LHRLKRLRKRL (SEQ ID NO: 1), preferably the amino acid sequence LHRLKRLRKRLK (SEQ ID NO: 9), and also provides an immunostimulant containing the peptide, a vaccine adjuvant containing the peptide, a vaccine composition containing the peptide, and a hair grower containing the peptide.
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8.发明申请ANTIBODY TO PEPTIDE ENCODED BY Exon-21 OF PERIOSTIN, AND PHARMACEUTICAL COMPOSITION FOR PREVENTION OR TREATMENT OF INFLAMMATORY DISEASE CONTAINING SAID ANTIBODY 审中-公开由PERIOSTIN的外显子21编码的肽的抗体和用于预防或治疗含有抗体的炎症疾病的药物组合物公开(公告)号：US20160108109A1
公开(公告)日：2016-04-21
申请号：US14772122
申请日：2014-03-06
Applicant: OSAKA UNIVERSITY
Inventor： Yoshiaki TANIYAMA , Ryuichi MORISHITA , Junya AZUMA , Fumihiro SANADA , Naruto KATSURAGI
CPC classification number: C07K16/18 , A61K2039/505 , C07K14/47 , C07K2317/14 , C07K2317/34 , C07K2317/73 , C07K2317/76 , C12N5/12 , G01N33/68 , G01N2333/47
Abstract: The present invention provides a drug for preventing or treating inflammation-associated diseases in which a periostin isoform having cell adhesion activity is involved, and also provides an inhibitor of a periostin isoform having cell adhesion activity.
Abstract translation: 本发明提供了用于预防或治疗涉及具有细胞粘附活性的骨膜素异构体的炎症相关疾病的药物，并且还提供了具有细胞粘附活性的骨膜素同种型的抑制剂。
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公开(公告)号：US20170258895A1
公开(公告)日：2017-09-14
申请号：US15528502
申请日：2015-11-20
Applicant: ANGES MG, INC. , OSAKA UNIVERSITY , DS PHARMA ANIMAL HEALTH CO., LTD.
Inventor： Hironori NAKAGAMI , Ryuichi MORISHITA , Hiroshi KORIYAMA , Hideki TOMIOKA , Kenji NAOHARA
Abstract: The present invention provides a combination preparation for inducing a specific immune response to an antigenic peptide, which contains (I) the antigenic peptide, and (II) an expression vector encoding a chimeric hepatitis B virus core antigen polypeptide, into which the antigenic peptide has been inserted or added, wherein said antigenic peptide is inserted in a region of amino acid residues 74-87 or 130-138 of the hepatitis B virus core antigen polypeptide, or added to the N-terminal or C-terminal of the hepatitis B virus core antigen polypeptide, wherein the antigenic peptide of (I) and the expression vector of (II) are substantially simultaneously administered to a subject.
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公开(公告)号：US20160319013A1
公开(公告)日：2016-11-03
申请号：US15108415
申请日：2014-12-26
Applicant: OSAKA UNIVERSITY
Inventor： Hiroshi KORIYAMA , Hironori NAKAGAMI , Ryuichi MORISHITA
CPC classification number: C07K16/244 , A61K39/0005 , C07K2317/34 , C07K2317/76
Abstract: The present invention provides a vaccine against IL-17A, which uses, as an immunogen, a polypeptide containing the amino acid sequence shown in SEQ ID NO: 1, or an amino acid sequence derived from a non-human mammal, which corresponds to SEQ ID NO: 1, a prophylactic or therapeutic agent containing the vaccine for diseases involving IL-17A as an aggravation factor, and the like.
Abstract translation: 本发明提供一种针对IL-17A的疫苗，其使用包含SEQ ID NO：1所示的氨基酸序列的多肽或来自非人哺乳动物的氨基酸序列作为免疫原，其对应于SEQ ID NO： ID NO：1，含有涉及IL-17A的疾病疫苗作为加重因子的预防或治疗剂等。
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