Apparatus and method for personalized hormonal diagnostics and therapy

    公开(公告)号:US20230015833A1

    公开(公告)日:2023-01-19

    申请号:US17857096

    申请日:2022-07-04

    摘要: A method and system for measuring hormone levels in human samples. Either actual levels can be measured, or hormone related parameters can be measured with computation extrapolating the parameters to the actual hormone level. A patient hormone level can be compared against a population database based on age, gender and other factors to determine a score for a particular hormone. A dosage of the hormone being given a patient can be automatically adjusted based on the score with optional approval of the adjustment made by a health professional. This is particularly useful in hormone replacement therapy and in-vitro fertilization.

    Multiple testing apparatus and method
    2.
    发明申请
    Multiple testing apparatus and method 审中-公开
    多种检测仪器及方法

    公开(公告)号:US20100173423A1

    公开(公告)日:2010-07-08

    申请号:US12319306

    申请日:2009-01-06

    IPC分类号: G01N33/48

    CPC分类号: G01N33/54386 G01N33/558

    摘要: A multiple test strip assembly comprising a non-bibulous support, a sample application site comprising a defined area of said non-bibulous support delimited by a liquid impervious barrier, and at least two test strips placed on said support, each having a bibulous sample receiving pad, wherein the sample receiving pad of each of said at least two test strips is in contact with said sample application site.

    摘要翻译: 包括非吸水性支撑物的多个测试条组件,包括由液体不可渗透屏障限定的所述非吸水支撑物的限定区域的样品施加位置和放置在所述支撑件上的至少两个测试条,每个测试条具有吸收样品接收 垫,其中所述至少两个测试条中的每一个的样品接收垫与所述样品施加部位接触。

    Dry format sialidase assay
    3.
    发明申请
    Dry format sialidase assay 有权
    干式唾液酸酶测定

    公开(公告)号:US20080038766A1

    公开(公告)日:2008-02-14

    申请号:US11502192

    申请日:2006-08-10

    IPC分类号: C12Q1/34 C12M3/00

    摘要: A solid-phase test device and method for the detection of sialidase activity in a fluid sample. The test device comprises a solid support provided with pre-deposited dry form of a sialidase detecting composition comprising a sialidase substrate and a color-developing reagent, wherein the sialidase substrate when exposed to sialidase yields an intermediate compound which reacts with the color-developing reagent to form a detectable color change.

    摘要翻译: 一种用于检测流体样品中唾液酸酶活性的固相试验装置和方法。 测试装置包括提供有预沉积干燥形式的包含唾液酸酶底物和显色剂的唾液酸酶检测组合物的固体支持物,其中当唾液酸酶底物暴露于唾液酸酶时产生与显色剂反应的中间体化合物 以形成可检测的颜色变化。

    Device for the determination of blood clotting by capacitance or resistance
    4.
    发明授权
    Device for the determination of blood clotting by capacitance or resistance 有权
    用于通过电容或电阻测定血液凝固的装置

    公开(公告)号:US07021122B1

    公开(公告)日:2006-04-04

    申请号:US09646348

    申请日:1999-03-18

    IPC分类号: G01N11/00

    摘要: A sensor device (10) and a method for measuring a viscosity of a sample of a liquid. The sensor features a chamber (12) for receiving the sample of the liquid, two electrodes (18) disposed either on the surfaces of the chamber, but possibly isolated from contacting the sample, or electrodes located externally to the chamber, and a capacitance measuring circuit (25). The sensor is used by connecting to a measurer for determining a capacitance on the electrodes, such that the capacitance directly reflects a volume occupied by the sample of the liquid. Preferably, the liquid is blood and the capacitance is used to determine the clotting time of the blood. Also preferably, a cover for the chamber is provided with at least one aperture, which more preferably is a mesh. Alternatively, an electrical property such as the amplitude of current passed through the sample is used to determine clotting time. Also preferably, the time period required for the maximum capacitance to be reached could be measured. Alternatively, the capacitance could be measured after a fixed time period (34) had elapsed. Also alternatively, the time period required for the maximum current to be reached could be measured, or the amount of current could be measured after a fixed time period had elapsed. In preferred embodiments of the present invention, a kit for measuring the clotting time of blood is provided. In other preferred embodiments of the present invention, methods are provided for using the kit and device of the present invention.

    摘要翻译: 传感器装置(10)和用于测量液体样品的粘度的方法。 传感器具有用于接收液体样品的腔室(12),设置在腔室表面上但可能与接触样品或位于腔室外部的电极隔离的两个电极(18)和电容测量 电路(25)。 传感器通过连接到用于确定电极上的电容的测量器来使用,使得电容直接反映由液体样品占据的体积。 优选地,液体是血液,并且电容用于确定血液的凝血时间。 还优选地,用于腔室的盖设置有至少一个孔,更优选地是网。 或者,使用诸如通过样品的电流的振幅的电特性来确定凝固时间。 还优选地,可以测量达到最大电容所需的时间。 或者,可以在经过固定时间段(34)之后测量电容。 或者,可以测量达到最大电流所需的时间段,或者在固定时间段过去之后可以测量电流量。 在本发明的优选实施方案中,提供了用于测量血液凝血时间的试剂盒。 在本发明的其它优选实施方案中,提供了使用本发明的试剂盒和装置的方法。

    Solid phase test device for sialidase assay
    6.
    发明授权
    Solid phase test device for sialidase assay 有权
    唾液酸酶测定固相试验装置

    公开(公告)号:US07591978B2

    公开(公告)日:2009-09-22

    申请号:US11502192

    申请日:2006-08-10

    IPC分类号: G01N21/00

    摘要: A solid-phase test device and a method for the detection of sialidase activity in a fluid sample. The test device includes a solid support provided with a pre-deposited dry form of a sialidase detecting composition. The sialidase detecting composition includes a sialidase substrate and a color-developing reagent. When the sialidase substrate is exposed to sialidase it yields an intermediate compound which reacts with the color-developing reagent to form a detectable color change.

    摘要翻译: 固相试验装置和用于检测流体样品中唾液酸酶活性的方法。 测试装置包括具有预沉积干燥形式的唾液酸酶检测组合物的固体支持物。 唾液酸酶检测组合物包括唾液酸酶底物和显色剂。 当唾液酸酶底物暴露于唾液酸酶时,产生与显色剂反应形成可检测颜色变化的中间体化合物。

    Novel device, system and method for fluorescence detection
    7.
    发明申请
    Novel device, system and method for fluorescence detection 审中-公开
    用于荧光检测的新型装置,系统和方法

    公开(公告)号:US20050109951A1

    公开(公告)日:2005-05-26

    申请号:US10500186

    申请日:2002-12-26

    摘要: A device, system and method for portable fluorescence detection. The portable device of the present invention features a low power light, in which a wavelength range is defined as at least one wavelength of light. The light source is preferably highly energy efficient, such that a majority of the electrical power which is consumed is then converted into transmitted light. The emitted light from the excited fluorophore is then preferably detected with any low cost and low power photodetector. Although optionally a highly sensitive optical detector may be used, preferably fluorescence is detected with any light sensing device, such as a regular photodiode or a CCD (charge-coupled device) sensor for example.

    摘要翻译: 用于便携式荧光检测的装置,系统和方法。 本发明的便携式装置具有低功率光,其中波长范围被定义为至少一个波长的光。 光源优选地是高能量的,使得消耗的大部分电功率然后被转换成透射光。 然后优选用任何低成本和低功率光电检测器检测来自激发的荧光团的发射光。 尽管可选地使用高灵敏度的光学检测器,但是优选地,例如使用诸如常规光电二极管或CCD(电荷耦合器件)传感器的任何光感测装置来检测荧光。

    VOLUMETRIC SAMPLING PIPETTE
    9.
    发明申请
    VOLUMETRIC SAMPLING PIPETTE 审中-公开
    体积采样管

    公开(公告)号:US20110129396A1

    公开(公告)日:2011-06-02

    申请号:US12790828

    申请日:2010-05-30

    申请人: Falk Fish

    发明人: Falk Fish

    IPC分类号: B01L3/02

    摘要: A volumetric micropipette for sampling and dispensing a precise quantity of liquid comprising an elongated hollow tubular body configured to draw liquid by capillary action: a reservoir connected proximate the upper end of the tubular body and a deformable hollow bulb connected to the reservoir and having an opening in a wall thereof to allow liquid to be drawn into the tubular body by capillary action. The reservoir is laterally offset with respect to the tubular body and has at least a portion thereof below the upper end of the tubular body.

    摘要翻译: 一种用于取样和分配精确量的液体的体积微量移液器,其包括细长的中空管状体,其构造成通过毛细管作用来拉伸液体:靠近管状体的上端连接的储存器和连接到储存器的可变形的中空球, 在其壁中以允许液体通过毛细管作用被吸入管状体。 储存器相对于管状体侧向偏移,并且其至少一部分在管状体的上端下方。

    Method and kit for the transdermal determination of analyte concentration in blood
    10.
    发明授权
    Method and kit for the transdermal determination of analyte concentration in blood 失效
    用于透皮测定血液中分析物浓度的方法和试剂盒

    公开(公告)号:US07004901B2

    公开(公告)日:2006-02-28

    申请号:US10381704

    申请日:2001-09-06

    申请人: Falk Fish

    发明人: Falk Fish

    IPC分类号: A61B5/00 G01N33/66

    CPC分类号: G01N33/66 Y10T436/144444

    摘要: A method is provided for determining the level of an analyte in the blood of an individual by measuring the level of the analyte in an interstitial fluid or in any other non blood fluid which does not contain red blood cells and adjusting the measurement value by the concentration of at least one reference analyte.

    摘要翻译: 提供了一种用于通过测量间质液中的分析物的水平或不含红细胞的任何其它非血液中的分析物的水平并通过浓度调节测量值来确定个体血液中分析物的水平的方法 的至少一种参考分析物。