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公开(公告)号：US20120263760A1
公开(公告)日：2012-10-18
申请号：US13266115
申请日：2010-04-23
申请人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H. William Bosch
发明人： Aaron Dodd , Felix Meiser , Marck Norret , Adrian Russell , H. William Bosch
IPC分类号： A61K31/421 , A61P25/04 , B32B5/16 , A61K9/00
CPC分类号： C07D263/20 , A61K9/14 , A61K9/145 , A61K9/146 , A61K9/1617 , A61K9/1623 , A61K9/1641 , A61K9/1694 , A61K31/421 , Y10T428/2978
摘要： The present invention relates to methods for producing particles of metaxalone using dry milling processes as well as compositions comprising metaxalone, medicaments produced using metaxalone in particulate form and/or compositions, and to methods of treatment of an animal, including man, using a therapeutically effective amount of metaxalone administered by way of said medicaments.
摘要翻译： 本发明涉及使用干研磨方法生产美他沙酮颗粒的方法以及包含美他沙酮，以颗粒形式和/或组合物使用美他沙酮制备的药物的组合物，以及使用治疗有效的方法治疗动物，包括人的方法 通过所述药物施用的美他沙酮的量。
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公开(公告)号：US10022303B2
公开(公告)日：2018-07-17
申请号：US13781115
申请日：2013-02-28
IPC分类号： A61K9/00 , A61K31/00 , A61J3/02 , A61K31/137 , A61K31/46
摘要： Methods for making inhalable composite particles comprising a pharmaceutically-active agent, the method comprising: a) providing composite particles comprising a millable grinding matrix and a solid pharmaceutically-active agent, wherein the pharmaceutically-active agent has an median particle size on a volume average basis between 50 nm and 3 μm; and b) milling the composite particles in a mill without milling bodies for a time period sufficient to produce inhalable composite particles having a mass median aerodynamic diameter between 1 μm and 20 μm are described.
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公开(公告)号：US20100329976A1
公开(公告)日：2010-12-30
申请号：US12870749
申请日：2010-08-27
申请人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
IPC分类号： A61K31/565 , A61K9/00 , A61K9/20 , A61K9/48 , A61K38/16 , A61K31/7052 , A61K49/00 , A61K36/00 , A61K36/886 , A61K36/82 , A61K36/55 , A61K35/60 , A61K35/00 , A61K39/00 , A61P9/00 , A61P35/00
CPC分类号： A61K31/00 , A61K9/145 , A61K9/146 , A61K9/148 , A61K31/565
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
摘要翻译： 描述包含至少一种难溶性血管发生抑制剂和至少一种表面稳定剂的纳米颗粒组合物。 纳米颗粒组合物具有小于约2000nm的平均粒度。 本发明还描述了制备和使用这些组合物的方法。
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公开(公告)号：US20100322852A1
公开(公告)日：2010-12-23
申请号：US12870722
申请日：2010-08-27
申请人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
IPC分类号： A61K31/565 , A61K9/00 , A61K38/16 , A61K31/7052 , A61K49/00 , A61K36/00 , A61K36/886 , A61K36/82 , A61K36/55 , A61K35/60 , A61K35/00 , A61K39/00 , A61P9/00 , A61P35/00
CPC分类号： A61K31/00 , A61K9/145 , A61K9/146 , A61K9/148 , A61K31/565
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
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公开(公告)号：US07521068B2
公开(公告)日：2009-04-21
申请号：US09190138
申请日：1998-11-12
IPC分类号： A61K8/00 , A61K9/14 , A61K9/16 , A61K31/12 , A61K31/04 , A61K31/28 , A61K31/33 , A61K31/56 , A61K31/70 , A61K38/00 , A61K38/02
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , A61K9/146 , A61K9/1694 , A61K9/19 , Y10S514/826 , Y10S514/851 , Y10S514/872
摘要： There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
摘要翻译： 本发明公开了纳米颗粒气雾剂配方的水性分散体，干燥粉末纳米颗粒气溶胶配制剂，基于推进剂的气溶胶制剂，在气溶胶递送装置中使用制剂的方法，以及制备这些制剂的方法。 含水分散体或干粉配方的纳米颗粒包含在其表面上具有表面改性剂的不溶性药物颗粒。
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公开(公告)号：US20080220075A1
公开(公告)日：2008-09-11
申请号：US12076247
申请日：2008-03-14
申请人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine Merisko-Liversidge , H. William Bosch , Greta G. Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
CPC分类号： A61K31/565 , A61K9/145 , A61K9/146 , A61K31/00
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
摘要翻译： 描述包含至少一种难溶性血管发生抑制剂和至少一种表面稳定剂的纳米颗粒组合物。 纳米颗粒组合物具有小于约2000nm的平均粒度。 本发明还描述了制备和使用这些组合物的方法。
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公开(公告)号：US20080050461A1
公开(公告)日：2008-02-28
申请号：US11928250
申请日：2007-10-30
申请人： Elaine Merisko-Liversidge , H. William Bosch , Greta Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
发明人： Elaine Merisko-Liversidge , H. William Bosch , Greta Cary , John Pruitt , Tuula Ryde , Rajeev Jain , Amy Walters
IPC分类号： A61K31/565 , A61K36/00 , A61K38/02 , A61K9/14
CPC分类号： A61K31/00 , A61K9/145 , A61K9/146 , A61K9/148 , A61K31/565
摘要： Nanoparticulate compositions comprising at least one poorly soluble angiogenesis inhibitor and at least one surface stabilizer are described. The nanoparticulate compositions have an average particle size of less than about 2000 nm. The invention also describes methods of making and using such compositions.
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8.发明申请公开(公告)号：US20120183476A1
公开(公告)日：2012-07-19
申请号：US13348351
申请日：2012-01-11
申请人： Ray W. WOOD , Lan DeCastro , H. William Bosch
发明人： Ray W. WOOD , Lan DeCastro , H. William Bosch
CPC分类号： A61K9/0078 , A61K9/145 , A61K9/146 , A61K49/00 , A61K49/049 , B82Y5/00
摘要： There is disclosed an aerosol comprising droplets of an aqueous dispersion of nanoparticles, said nanoparticles comprising insoluble therapeutic or diagnostic agent particles having a surface modifier on the surface thereof. There is also disclosed a method for making the aerosol and methods for treatment and diagnosis using the aerosol.
摘要翻译： 公开了一种包含纳米颗粒的水分散体的液滴的气溶胶，所述纳米颗粒包含在其表面上具有表面改性剂的不溶性治疗剂或诊断剂颗粒。 还公开了一种制造气溶胶的方法以及使用该气溶胶的治疗和诊断方法。
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9.发明授权公开(公告)号：US08124057B2
公开(公告)日：2012-02-28
申请号：US12320431
申请日：2009-01-26
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/008 , A61K9/146 , A61K9/1694 , A61K9/19 , Y10S514/826 , Y10S514/851 , Y10S514/872
摘要： There invention discloses aqueous dispersions of nanoparticulate aerosol formulations, dry powder nanoparticulate aerosol formulation, propellant-based aerosol formulations, methods of using the formulations in aerosol delivery devices, and methods of making such formulations. The nanoparticles of the aqueous dispersions or dry powder formulations comprise insoluble drug particles having a surface modifier on the surface thereof.
摘要翻译： 本发明公开了纳米颗粒气雾剂配方的水性分散体，干燥粉末纳米颗粒气溶胶配制剂，基于推进剂的气溶胶制剂，在气溶胶递送装置中使用制剂的方法，以及制备这些制剂的方法。 含水分散体或干粉配方的纳米颗粒包含在其表面上具有表面改性剂的不溶性药物颗粒。
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10.发明申请STERILIZATION OF DISPERSIONS OF NANOPARTICULATE ACTIVE AGENTS WITH GAMMA RADIATION 有权纳米粒子活性剂与伽马辐射的分散剂灭菌公开(公告)号：US20100255102A1
公开(公告)日：2010-10-07
申请号：US10851661
申请日：2004-05-24
申请人： H. William Bosch , Janine Keller
发明人： H. William Bosch , Janine Keller
IPC分类号： A61K9/14 , A61K31/192 , A61K31/58 , A61P29/00 , A61P31/00 , A61P25/04 , A61P25/24 , A61P35/00 , A61P37/06 , A61P25/20 , A61P11/00 , A61L2/08
CPC分类号： A61L2/0035 , A61K9/146 , A61L2202/21
摘要： The present invention relates to methods for sterilization of dispersions of one or more nanoparticulate active agents via gamma irradiation.
摘要翻译： 本发明涉及通过γ照射灭菌一种或多种纳米颗粒活性剂的分散体的方法。
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