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公开(公告)号：US20170342102A1
公开(公告)日：2017-11-30
申请号：US15531313
申请日：2015-11-27
申请人： Gabriel Martinez BOTELLA , Boyd L. HARRISON , Albert Jean ROBICHAUD , Francesco G. SALITURO , Richard Thomas BERESIS , Sage Therapeutics, Inc.
发明人： Gabriel Martinez Botella , Boyd L. Harrison , Albert J. Robichaud , Francesco G. Salituro , Richard T. Beresis
摘要： Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.
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公开(公告)号：US08686143B2
公开(公告)日：2014-04-01
申请号：US13280670
申请日：2011-10-25
申请人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
发明人： Marion W. Wannamaker , Francesco Salituro , Albert Pierce , Alex Aronov , Gabriel Martinez-Botella , Jian Wang , Luc Farmer , Mark Ledeboer , Tiansheng Wang , Randy Bethiel , Brian Ledford , Emilie Porter Huck
IPC分类号： C07D401/04 , C07D401/14 , C07D403/04 , C07D403/14 , A61K31/506 , A61P35/00
CPC分类号： C07D401/14 , C07D213/74 , C07D239/42 , C07D401/04 , C07D403/04 , C07D403/12 , C07D403/14 , C07D405/04 , C07D417/04 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US07767816B2
公开(公告)日：2010-08-03
申请号：US11654375
申请日：2007-01-17
申请人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
发明人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion Wannamaker , Tiansheng Wang
IPC分类号： C07D471/02
CPC分类号： A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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4.发明授权Pyrrole inhibitors of ERK protein kinase, synthesis thereof and intermediates thereto 有权ERK蛋白激酶的吡咯抑制剂，其合成及其中间体公开(公告)号：US07354939B2
公开(公告)日：2008-04-08
申请号：US11128870
申请日：2005-05-13
IPC分类号： A61K31/4439 , C07D401/04
CPC分类号： C07F9/65583 , C07D401/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20060160807A1
公开(公告)日：2006-07-20
申请号：US11312618
申请日：2005-12-20
申请人： Alexander Aronov , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Judith Straub , Qing Tang
发明人： Alexander Aronov , Michael Hale , Francois Maltais , Gabriel Martinez-Botella , Judith Straub , Qing Tang
IPC分类号： A61K31/53 , A61K31/506 , C07D413/02 , C07D403/02
CPC分类号： C07D403/04
摘要： Described herein are compounds that are useful as ERK2 inhibitors. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
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公开(公告)号：US20060142572A1
公开(公告)日：2006-06-29
申请号：US11302295
申请日：2005-12-13
申请人： Gabriel Martinez-Botella , Alex Aronov , Michael Hale , Francois Maltais , Judith Straub , Qing Tang
发明人： Gabriel Martinez-Botella , Alex Aronov , Michael Hale , Francois Maltais , Judith Straub , Qing Tang
IPC分类号： C07D405/02 , C07D403/02
CPC分类号： C07D239/48
摘要： Described herein are compounds that are useful as protein kinase inhibitors of formula I: or a pharmaceutically acceptable salt thereof, wherein Ring A, Z1, Z2, U, Q, R1, R2, and L are as defined herein. These compounds, and pharmaceutically acceptable compositions thereof, are useful for treating or lessening the severity of a variety of disorders, including proliferative disorders such as cancer.
摘要翻译： 本文描述了可用作式I的蛋白激酶抑制剂的化合物或其药学上可接受的盐，其中环A，Z 1，Z 2，U，Q， R 1，R 2和L如本文所定义。 这些化合物及其药学上可接受的组合物可用于治疗或减轻各种病症（包括增殖性疾病如癌症）的严重性。
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公开(公告)号：US20060058318A1
公开(公告)日：2006-03-16
申请号：US11129114
申请日：2005-05-13
IPC分类号： A61K31/506 , C07D403/04
CPC分类号： C07D403/04
摘要： The present invention relates to compounds useful of inhibitors of protein kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用于蛋白激酶抑制剂的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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公开(公告)号：US20180179247A1
公开(公告)日：2018-06-28
申请号：US15314565
申请日：2015-05-29
申请人： Gabriel Martinez Botella , Boyd L. Harrison , Albert Jean Robichaud , Francesco G. Salituro , Richard Thomas Beresis , SAGE THERAPEUTICS, INC.
发明人： Gabriel Martinez Botella , Boyd L. Harrison , Albert Jean Robichaud , Francesco G. Salituro , Richard Thomas Beresis
摘要： Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.
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公开(公告)号：US08741912B2
公开(公告)日：2014-06-03
申请号：US11732845
申请日：2007-04-05
申请人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
发明人： Mark Ledeboer , David Messersmith , Francois Maltais , Huai Gao , Tiansheng Wang , Jingrong Cao , John Duffy , Gabriel Martinez-Botella , Cornelia Forster , Marion Wannamaker , Francesco Salituro , Albert Pierce , Luc Farmer , Valerie Marone
IPC分类号： C07D487/04 , A61K31/519 , A61P35/00 , A61P29/00 , A61P37/06 , A61P25/16 , A61P25/28
CPC分类号： C07D487/04
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders. The compounds are generally represented by structural formula I or pharmaceutically acceptable salts thereof:
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。 化合物通常由结构式I或其药学上可接受的盐表示：
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公开(公告)号：US08450489B2
公开(公告)日：2013-05-28
申请号：US13409702
申请日：2012-03-01
申请人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion W. Wannamaker , Tiansheng Wang
发明人： Luc Farmer , Gabriel Martinez-Botella , Albert Pierce , Francesco Salituro , Jian Wang , Marion W. Wannamaker , Tiansheng Wang
IPC分类号： C07D471/02
CPC分类号： A61K31/506 , A61K31/517 , A61K31/53 , A61K31/5377 , A61K45/06 , C07D471/04 , C07D495/10 , C07D519/00 , C12N9/12 , C12Y207/10002
摘要： The present invention relates to compounds useful as inhibitors of protein kinases, particularly of JAK family kinases. The invention also provides pharmaceutically acceptable compositions comprising said compounds and methods of using the compositions in the treatment of various disease, conditions, or disorders.
摘要翻译： 本发明涉及可用作蛋白激酶抑制剂，特别是JAK家族激酶的化合物。 本发明还提供包含所述化合物的药学上可接受的组合物和使用该组合物治疗各种疾病，病症或病症的方法。
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