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1.发明授权Antibodies against human respiratory syncytial virus (RSV) and methods of use 有权针对人呼吸道合胞病毒（RSV）的抗体及其使用方法公开(公告)号：US08568719B2
公开(公告)日：2013-10-29
申请号：US12806498
申请日：2010-08-13
IPC分类号： A61K39/395
CPC分类号： C07K16/1027 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus (RSV). Also provided are methods for of prevention, treatment and diagnosis of viral infection and/or the treatment of one more symptoms of RSV-mediated disease. Methods of generating antibodies that immunospecifically bind RSV F protein also are provided.
摘要翻译： 本文提供了免疫特异性结合呼吸道合胞病毒（RSV）的融合（F）蛋白的抗体或其抗原结合片段。 还提供了用于预防，治疗和诊断病毒感染和/或治疗另一种RSV介导的疾病症状的方法。 还提供产生免疫特异性结合RSV F蛋白的抗体的方法。
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2.发明申请公开(公告)号：US20080182778A1
公开(公告)日：2008-07-31
申请号：US11886057
申请日：2006-03-10
CPC分类号： G01N33/6872 , G01N33/5023 , G01N33/5041 , G01N2333/70567 , G01N2333/726
摘要： The present invention relates to a method of screening for a compound that regulate SUMOylation of the nuclear receptor proteins comprising contacting the compound of interest to the nuclear receptor protein, and detecting SUMOylation of the nuclear receptor protein, thereby screening for a compound that regulates SUMOylation.
摘要翻译： 本发明涉及一种筛选调节核受体蛋白的SUMO化的化合物的方法，包括将感兴趣的化合物与核受体蛋白质接触，并检测核受体蛋白的SUMO化，从而筛选调节SUMO化的化合物。
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3.发明授权公开(公告)号：US08241863B2
公开(公告)日：2012-08-14
申请号：US11886057
申请日：2006-03-10
IPC分类号： G01N33/53
CPC分类号： G01N33/6872 , G01N33/5023 , G01N33/5041 , G01N2333/70567 , G01N2333/726
摘要： The present invention relates to a method of screening for a compound that regulate SUMOylation of the nuclear receptor proteins comprising contacting the compound of interest to the nuclear receptor protein, and detecting SUMOylation of the nuclear receptor protein, thereby screening for a compound that regulates SUMOylation.
摘要翻译： 本发明涉及一种筛选调节核受体蛋白质的SUMO化的化合物的方法，包括将感兴趣的化合物与核受体蛋白质接触并检测核受体蛋白质的SUMO化，从而筛选调节SUMO化的化合物。
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公开(公告)号：US20210347868A1
公开(公告)日：2021-11-11
申请号：US17283229
申请日：2019-10-17
申请人： Gabriel PASCUAL , Adrian APETRI , Xinji LI
发明人： Gabriel PASCUAL , Adrian APETRI , Xinji LI
IPC分类号： C07K16/18 , A61K47/68 , G01N33/577 , G01N33/68
摘要： Anti-alpha-synuclein antibodies and antigen-binding fragments thereof are described. Also described are nucleic acids encoding the antibodies, compositions comprising the antibodies, and methods of producing the antibodies and using the antibodies for treating or preventing diseases characterized by Lewy bodies or alpha-synuclein aggregation.
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5.发明申请Antibodies against human respiratory syncytial virus (RSV) and methods of use 有权针对人呼吸道合胞病毒（RSV）的抗体及其使用方法公开(公告)号：US20110076268A1
公开(公告)日：2011-03-31
申请号：US12806498
申请日：2010-08-13
IPC分类号： A61K39/42 , C07K16/10 , A61K39/00 , C07H21/00 , A61P11/00 , A61P31/14 , C12N15/63 , C12N5/10 , C12P21/06
CPC分类号： C07K16/1027 , C07K2317/21 , C07K2317/55 , C07K2317/76
摘要： Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus (RSV). Also provided are methods for of prevention, treatment and diagnosis of viral infection and/or the treatment of one more symptoms of RSV-mediated disease. Methods of generating antibodies that immunospecifically bind RSV F protein also are provided.
摘要翻译： 本文提供了免疫特异性结合呼吸道合胞病毒（RSV）的融合（F）蛋白的抗体或其抗原结合片段。 还提供了用于预防，治疗和诊断病毒感染和/或治疗另一种RSV介导的疾病症状的方法。 还提供产生免疫特异性结合RSV F蛋白的抗体的方法。
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6.发明授权Anti-human respiratory syncytial virus (RSV) antibodies and methods of use 有权抗人呼吸道合胞病毒（RSV）抗体及其使用方法公开(公告)号：US09139642B2
公开(公告)日：2015-09-22
申请号：US13809397
申请日：2011-07-08
IPC分类号： A61K39/12 , A61K39/155 , C12N7/00 , C07K16/10 , A61K31/7056 , A61K39/42 , C07K16/46 , G01N33/569 , A61K39/00
CPC分类号： C07K16/1027 , A61K31/7056 , A61K39/42 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/10 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N7/00 , C12N2760/18534 , C12N2760/18571 , G01N33/56983 , G01N2333/135
摘要： Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus (RSV). Also provided are methods for of prevention, treatment and diagnosis of viral infection and/or the treatment of one more symptoms of RSV-mediated disease. Methods of generating antibodies that immunospecifically bind RSV F protein also are provided.
摘要翻译： 本文提供了免疫特异性结合呼吸道合胞病毒（RSV）的融合（F）蛋白的抗体或其抗原结合片段。 还提供了用于预防，治疗和诊断病毒感染和/或治疗另一种RSV介导的疾病症状的方法。 还提供产生免疫特异性结合RSV F蛋白的抗体的方法。
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7.发明申请公开(公告)号：US20130177573A1
公开(公告)日：2013-07-11
申请号：US13809397
申请日：2011-07-08
IPC分类号： C07K16/10
CPC分类号： C07K16/1027 , A61K31/7056 , A61K39/42 , A61K45/06 , A61K2039/505 , A61K2039/507 , A61K2300/00 , C07K16/10 , C07K16/468 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/55 , C07K2317/565 , C07K2317/76 , C07K2317/92 , C12N7/00 , C12N2760/18534 , C12N2760/18571 , G01N33/56983 , G01N2333/135
摘要： Provided herein are antibodies or antigen-binding fragments thereof that immunospecifically bind to the fusion (F) protein of Respiratory Syncytial Virus (RSV). Also provided are methods for of prevention, treatment and diagnosis of viral infection and/or the treatment of one more symptoms of RSV-mediated disease. Methods of generating antibodies that immunospecifically bind RSV F protein also are provided.
摘要翻译： 本文提供了免疫特异性结合呼吸道合胞病毒（RSV）的融合（F）蛋白的抗体或其抗原结合片段。 还提供了用于预防，治疗和诊断病毒感染和/或治疗另一种RSV介导的疾病症状的方法。 还提供产生免疫特异性结合RSV F蛋白的抗体的方法。
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