-
1.发明申请公开(公告)号：US20110212105A1
公开(公告)日：2011-09-01
申请号：US12298808
申请日：2007-04-26
申请人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
发明人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martín Dunn , Mónica Sarría Núñez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sánchez Puente , Vladimir Armando Besada Pérez , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramón Padrón Palomares , Luis Javier González López
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
-
2.发明申请CHIMERICAL PEPTIDIC MOLECULES WITH ANTIVIRAL PROPERTIES AGAINST THE VIRUSES OF THE FLAVIVIRIDAE FAMILY 有权具有抗FLAVIVIRIDIDE家族病毒抗性特性的二肽分子公开(公告)号：US20100273702A1
公开(公告)日：2010-10-28
申请号：US12513085
申请日：2007-10-30
申请人： Glay Chinea Santiago , Vivian Juerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Srria Nüñez , Alexis Musacchio Lasa , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico
发明人： Glay Chinea Santiago , Vivian Juerta Galindo , Alejandro Miguel Martin Dunn , Noralvis Fleitas Salazar , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Mónica Srria Nüñez , Alexis Musacchio Lasa , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Ania Cabrales Rico
CPC分类号： A61K47/48315 , A61K38/00 , A61K47/645 , C07K14/005 , C07K2319/04 , C07K2319/10 , C12N2770/24022 , C12N2770/24122 , C12N2770/24222 , Y02A50/385 , Y02A50/387 , Y02A50/389 , Y02A50/393 , Y02A50/395
摘要： The present invention is relative to chimerical peptides, whose primary structure holds at least one segment which inhibits the activation of the NS3 protease of a virus from the Flaviviridae family, they also contain a cell penetrating segment and they are capable of inhibiting or attenuate the viral infection. This invention is also relative to pharmaceutical compounds which contain these chimerical peptides for the prevention and/or treatment of the infection caused by a virus of the Flaviviridae family.
摘要翻译： 本发明是相对于嵌合肽，其主要结构保持至少一个片段，其抑制来自黄病毒科的病毒的NS3蛋白酶的活化，它们还含有细胞穿透片段，并且它们能够抑制或减弱病毒 感染。 本发明还涉及含有这些嵌合肽用于预防和/或治疗由黄病毒科病毒引起的感染的药物化合物。
-
公开(公告)号：US08420311B2
公开(公告)日：2013-04-16
申请号：US12298808
申请日：2007-04-26
申请人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
发明人： Vivian Huerta Galindo , Glay Chinea Santiago , Noralvis Fleitas Salazar , Alejandro Miguel Martin Dunn , Monica Sarria Nunez , Osmany Guirola Cruz , Patricia Gabriela Toledo Mayora , Aniel Sanchez Puente , Vladimir Armando Besada Perez , Osvaldo Reyes Acosta , Hilda Elisa Garay Perez , Ania Cabrales Rico , Alexis Musacchio Lasa , Gabriel Ramon Padron Palomares , Luis Javier Gonzalez Lopez
CPC分类号： C07K14/005 , A61K38/00 , A61K39/00 , C07K14/70596 , C07K14/8107 , C12N2770/24122 , Y02A50/386 , Y02A50/388 , Y02A50/39 , Y02A50/394 , Y02A50/396
摘要： The present invention is related to a method for blocking the infection of cells by dengue virus, based on interfering the direct interaction of the viral envelope protein with a cellular receptor or its indirect interaction with said cellular receptor through a carrier protein, as well as related uses; wherein said cellular receptor is the alpha-2 macroglobulin receptor, also known as the low density receptor-related protein or as CD91, and said carrier protein is human alpha-2 macroglobulin.
摘要翻译： 本发明涉及一种基于干扰病毒包膜蛋白与细胞受体的直接相互作用或其通过载体蛋白与所述细胞受体的间接相互作用而阻断登革热病毒感染细胞的方法，以及相关的 用途; 其中所述细胞受体是α-2巨球蛋白受体，也称为低密度受体相关蛋白或CD91，所述载体蛋白是人α-2巨球蛋白。
-
公开(公告)号：US09375459B2
公开(公告)日：2016-06-28
申请号：US14005855
申请日：2012-03-21
申请人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Diaz , Hilda Elisa Garay Pérez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
发明人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Diaz , Hilda Elisa Garay Pérez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
IPC分类号： A61K38/12 , A61K31/4025 , A61K45/06 , C07K7/64 , C07K7/06 , C07K7/08 , A61K47/48 , A61K38/00 , A61K9/00 , A61K9/127 , A61K9/50
CPC分类号： A61K38/12 , A61K9/0019 , A61K9/127 , A61K9/5031 , A61K31/4025 , A61K38/00 , A61K45/06 , A61K47/60 , C07K7/06 , C07K7/08 , C07K7/64
摘要： The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems.
摘要翻译： 本发明包括具有抗肿瘤和抗血管生成特性的环肽，以及它们相应的药学上合适的盐以及含有它的药物组合物。 这些环肽用于制备用于人和/或兽医治疗剂的药物，另外用于诊断。 这些化合物可用于检测，监测和/或控制一系列细胞增殖相关疾病，例如肿瘤疾病和不期望的血管生成。 此外，它们可以作为控制释放系统的一部分进行纳入，并且在纳米生物技术领域更加精确地使用，无论是由于其自组装能力还是作为其他系统的一部分。
-
5.发明申请Peptidic Growth Hormone Secretagogues Analog Compounds and Preparations Thereof 有权肽生长激素促分泌素类似物及其制备方法公开(公告)号：US20100055118A1
公开(公告)日：2010-03-04
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia Del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
-
6.发明授权公开(公告)号：US08367620B2
公开(公告)日：2013-02-05
申请号：US12281085
申请日：2007-02-28
申请人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
发明人： Rolando Eduardo Rodriguez Fernandez , Ania De La Nuez Veulens , Mario Pablo Estrada Garcia , Rebeca Martinez Rodriguez , Glay Chinea Santiago , Osvaldo Reyes Acosta , Julio Raul Fernandez Masso , Diana Garcia del Barco Herrera , Jorge Amador Berlanga Acosta , Alexis Musacchio Lasa
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过在硅分子模拟中获得的肽化学化合物，其具有使得它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养补充剂或人或动物使用的其它制剂中的用途。
-
公开(公告)号：US08283324B2
公开(公告)日：2012-10-09
申请号：US12278990
申请日：2007-02-23
申请人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
发明人： Maribel Guerra Vallespi , Isis del Carmen Torréns Madrazo , Osvaldo Reyes Acosta , Hilda Elisa Garay Pérez , Gerardo Enrique Guillén Nieto , Boris Ernesto Acevedo Castro , Raimundo Ubieta Gómez
CPC分类号： C07K14/43509 , A61K38/00
摘要： The present invention is related to the development of peptides derived from the sequence HYRIKPTFRRLKWKYKGKFW (SEQ ID NO.: 13), showing amino acid substitutions, these peptides unable to bind to the lipopolysaccharides and bearing anti-tumoral and immunomodulatory capacities. These peptides alone or in combination are useful to treat cancer, and also in synergy with conventional therapies.
摘要翻译： 本发明涉及来自序列HYRIKPTFRRLKWKYKGKFW（SEQ ID NO：13）的肽的开发，显示氨基酸取代，这些肽不能结合脂多糖并具有抗肿瘤和免疫调节能力。 单独或组合的这些肽可用于治疗癌症，并且与常规疗法协同作用。
-
8.发明授权Peptides for the treatment of cancer associated with the human papilloma virus (HPV) and other epithelial tumors 有权用于治疗与人乳头状瘤病毒（HPV）和其他上皮肿瘤相关的癌症的肽公开(公告)号：US07374767B2
公开(公告)日：2008-05-20
申请号：US10499458
申请日：2002-12-04
申请人： Silvio Ernesto Perea Rodriguez , Osvaldo Reyes Acosta , Nelson Francisco Santiago Vispo , Yaquelin Puchades Izaguirre , Ricardo Silva Rodriguez , Alejandro Moro Soria , Alicia Santos Savio , Luis Javier González López , Belkis González Barrios
发明人： Silvio Ernesto Perea Rodriguez , Osvaldo Reyes Acosta , Nelson Francisco Santiago Vispo , Yaquelin Puchades Izaguirre , Ricardo Silva Rodriguez , Alejandro Moro Soria , Alicia Santos Savio , Luis Javier González López , Belkis González Barrios
IPC分类号： A61K39/12
CPC分类号： C07K14/005 , A61K38/00 , A61K48/00 , C07K7/06 , C07K2319/10 , C12N7/00 , C12N2710/20022 , C12N2710/20032
摘要： This invention is related to the Molecular Pharmacology field and especially to the development of peptides useful for treating epithelial tumors and mainly those associated to oncogenic types of HPVs. The main objective of this invention is to identify peptides whose structure permits to block the Casein Kinase II (CKII) phosphorylation domain by direct interaction with such a site. In the present invention it is shown eleven cyclic peptides with different aminoacid sequences which inhibit the CKII phosphorylation in vitro, exhibit cytotoxicity on HPV-16 transformed cells (CaSki) and also increase the sensitivity of these cells to the cytostatic effect of interferon (IFN). Furthermore, the invention relates to the use of these peptides conjugated or fused to other peptides and chemical compounds which penetrates into cells as well as with the use of both peptide and chemical mimetic molecules.
摘要翻译： 本发明涉及分子药理学领域，特别涉及可用于治疗上皮肿瘤和主要与致癌型HPV相关的肽的发展。 本发明的主要目的是鉴定其结构允许通过与这种位点的直接相互作用阻断酪蛋白激酶II（CKII）磷酸化结构域的肽。 在本发明中，显示了11种具有不同氨基酸序列的环肽，其在体外抑制CKII磷酸化，对HPV-16转化细胞（CaSki）表现出细胞毒性，并且还增加了这些细胞对干扰素（IFN）的细胞抑制作用的敏感性， 。 此外，本发明涉及这些肽与其它肽和化合物共轭或融合的用途，这些肽和化合物可以渗入细胞以及使用肽和化学模拟分子。
-
公开(公告)号：US20090136511A1
公开(公告)日：2009-05-28
申请号：US11662844
申请日：2005-09-16
申请人： Alicia Santos Savio , Ania Cabrales Rico , Osvaldo Reyes Acosta , Haydee Geronimo Perez , Celia Aurora Arrieta Aguero , Silvio Ernesto Perea Rodriguez
发明人： Alicia Santos Savio , Ania Cabrales Rico , Osvaldo Reyes Acosta , Haydee Geronimo Perez , Celia Aurora Arrieta Aguero , Silvio Ernesto Perea Rodriguez
IPC分类号： A61K38/08 , C07K7/06 , A61K39/00 , A61K39/395 , A61P19/02 , A61P17/06 , C07K16/00 , C07H21/00
CPC分类号： C07K14/5443 , A61K38/00 , A61K39/00 , C07K16/244
摘要： Current invention is related to the molecular pharmacology branch particularly to a peptide belonging to the Interleukin-15 sequence (IL-15) which is able to inhibit IL-15 biological activity, analogues or mimetic of such peptides. In the current invention it is shown that the peptide inhibits both IL-15-induced T cells proliferation upon binding to the IL15 receptor α subunit (IL15Rα) and TNFα-mediated apoptosis.Besides, this invention is related to the use of this peptide in the treatment of several pathologies where aberrant IL-15 or IL-15Rα expression is associated to the disease progression.
摘要翻译： 本发明涉及分子药理学分支，特别是涉及能够抑制IL-15生物活性，类似物或模拟这些肽的白细胞介素-15序列（IL-15）的肽。 在本发明中，显示该肽在结合IL15受体α亚基（IL15Rα）和TNFα介导的细胞凋亡时抑制IL-15诱导的T细胞增殖。 此外，本发明涉及该肽用于治疗其中异常IL-15或IL-15Rα表达与疾病进展相关的若干病理学的用途。
-
公开(公告)号：US20140112976A1
公开(公告)日：2014-04-24
申请号：US14005855
申请日：2012-03-21
申请人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Díaz , Hilda Elisa Garay Perez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
发明人： María del Carmen Abrahantes Pérez , Glay Chinea Santiago , Eduardo Martínez Díaz , Hilda Elisa Garay Perez , Osvaldo Reyes Acosta , Ernesto Lopez Mola , Cruz Matilde Lopez Abad , Sonia Gonzalez Blanco
IPC分类号： A61K38/12 , A61K31/4025 , A61K45/06 , C07K7/64
CPC分类号： A61K38/12 , A61K9/0019 , A61K9/127 , A61K9/5031 , A61K31/4025 , A61K38/00 , A61K45/06 , A61K47/60 , C07K7/06 , C07K7/08 , C07K7/64
摘要： The present invention comprises cyclic peptides bearing antitumor and antiangiogenic properties, as well as their corresponding pharmaceutically-suitable salts and also pharmaceutical compositions containing it. These cyclic peptides are used to prepare medicines for human and/or veterinary therapeutics, and additionally in diagnosis. These compounds can be used to detect, monitor and/or control a range of cellular proliferation-related disorders, such as oncological diseases and undesired angiogenesis. Moreover, they can be included as part of controlled release systems, and used more precisely in the field of nanobiotechnology, either because of their self-assembly capacity or as part of other systems.
摘要翻译： 本发明包括具有抗肿瘤和抗血管生成特性的环肽，以及它们相应的药学上合适的盐以及含有它的药物组合物。 这些环肽用于制备用于人和/或兽医治疗剂的药物，另外用于诊断。 这些化合物可用于检测，监测和/或控制一系列细胞增殖相关疾病，例如肿瘤疾病和不期望的血管生成。 此外，它们可以作为控制释放系统的一部分进行纳入，并且在纳米生物技术领域更加精确地使用，无论是由于其自组装能力还是作为其他系统的一部分。
-
-
-
-
-
-
-
-
-
搜索结果
28 条记录 (耗时 0.072 秒)
