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1.发明授权Atrial overdrive pacing in non-atrial tracking mode while maintaining AV synchrony 失效心房超速起搏在非心房跟踪模式同时保持AV同步公开(公告)号：US07583996B2
公开(公告)日：2009-09-01
申请号：US11560099
申请日：2006-11-15
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3688
摘要： Heart stimulator that stimulates at least a heart's right atrium and ventricle in an atrium asynchronous stimulation mode with an overdrive stimulation rate. Interposes one resynchronization cycle after a sensed atrial event to regain AV synchrony during otherwise asynchronous stimulation mode. Allows for pacing mode that can pace the atrium with an overdrive stimulation rate in dual-chamber asynchronous mode while maintaining the AV synchrony and is called DDI(R)+. In DDI(R)+, pacemaker performs an atrial asynchronous (V synchronous) pacing mode such as DDI or DDI(R). The overdrive stimulation rate (OSR) is either a fixed rate (programmed by the external device) that is thought to be above the underlying intrinsic atrial rate, or is dynamically adjusted according to the measured atrial cycle length to be slightly above intrinsic atrial rate. The overdrive stimulation rate may be based on an intrinsic atrial rate or on hemodynamic need. DDI(R)+ timing may be ventricle-based.
摘要翻译： 心脏刺激器，可以刺激至少一个心脏异位刺激模式的心脏和心室，具有超速刺激速率。 在感应到的心房事件之后插入一个再同步循环，以在其他异步刺激模式下重新获得AV同步。 允许起搏模式，可以在双室异步模式下以过驱动刺激速率调节心房，同时保持AV同步，称为DDI（R）+。 在DDI（R）+中，起搏器执行心房异步（V同步）起搏模式，如DDI或DDI（R）。 超速刺激速率（OSR）是被认为高于潜在固有心房率的固定比率（由外部设备编程），或根据测量的心房周期长度动态调整为略高于固有心房率。 超速刺激速率可以基于固有心房率或血液动力学需要。 DDI（R）+时间可能是基于心室的。
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公开(公告)号：US20080114409A1
公开(公告)日：2008-05-15
申请号：US11560099
申请日：2006-11-15
IPC分类号： A61N1/368
CPC分类号： A61N1/3622 , A61N1/3624 , A61N1/3688
摘要： Heart stimulator that stimulates at least a heart's right atrium and ventricle in an atrium asynchronous stimulation mode with an overdrive stimulation rate. Interposes one resynchronization cycle after a sensed atrial event to regain AV synchrony during otherwise asynchronous stimulation mode. Allows for pacing mode that can pace the atrium with an overdrive stimulation rate in dual-chamber asynchronous mode while maintaining the AV synchrony and is called DDI(R)+. In DDI(R)+, pacemaker performs an atrial asynchronous (V synchronous) pacing mode such as DDI or DDI(R). The overdrive stimulation rate (OSR) is either a fixed rate (programmed by the external device) that is thought to be above the underlying intrinsic atrial rate, or is dynamically adjusted according to the measured atrial cycle length to be slightly above intrinsic atrial rate. The overdrive stimulation rate may be based on an intrinsic atrial rate or on hemodynamic need. DDI(R)+ timing may be ventricle-based.
摘要翻译： 心脏刺激器，可以刺激至少一个心脏异位刺激模式的心脏和心室，具有超速刺激速率。 在感应到的心房事件之后插入一个再同步循环，以在其他异步刺激模式下重新获得AV同步。 允许起搏模式，可以在双室异步模式下以过驱动刺激速率调节心房，同时保持AV同步，称为DDI（R）+。 在DDI（R）+中，起搏器执行心房异步（V同步）起搏模式，如DDI或DDI（R）。 超速刺激速率（OSR）是被认为高于潜在固有心房率的固定比率（由外部设备编程），或根据测量的心房周期长度动态调整为略高于固有心房率。 超速刺激速率可以基于固有心房率或血液动力学需要。 DDI（R）+时间可能是基于心室的。
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公开(公告)号：US08060198B2
公开(公告)日：2011-11-15
申请号：US11848824
申请日：2007-08-31
申请人： Jie Lian , Garth Garner , Hannes Kraetschmer , Dirk Müssig
发明人： Jie Lian , Garth Garner , Hannes Kraetschmer , Dirk Müssig
IPC分类号： A61N1/362 , A61B5/0456
CPC分类号： A61N1/3622 , A61N1/368
摘要： Method and apparatus that uses dual-chamber (RA-RV), three-chamber (BiA-RV, or RA-BiV), or four-chamber (BiA-BiV) implantable cardiac devices including pacemakers, defibrillators and cardioverters, which stimulate cardiac tissue electrically to control the patient's heart rhythm. The method and apparatus are further configured to create a far-field intra-atrial electrogram (AEGM) and a far-field intra-ventricular electrogram (VEGM) that are independently filtered, scaled, and then summed to form a composite far-field electrogram.
摘要翻译： 使用双室（RA-RV），三室（BiA-RV或RA-BiV）或四室（BiA-BiV）可植入心脏装置的方法和装置，包括起搏器，除颤器和心律转换器，其刺激心脏 组织电气以控制患者的心律。 所述方法和装置还被配置为创建远场心房电描记图（AEGM）和远场心室电描记图（VEGM），所述远场心室电描记图被独立地过滤，缩放，然后相加以形成复合远场电描记图 。
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公开(公告)号：US20070288063A1
公开(公告)日：2007-12-13
申请号：US11451138
申请日：2006-06-12
申请人： Christopher S. de Voir , Jie Lian , Richard A. Schomburg , Duane Patterson , Hannes Kraetschmer , Dirk Muessig
发明人： Christopher S. de Voir , Jie Lian , Richard A. Schomburg , Duane Patterson , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61N1/00
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： The invention relates to heart stimulators and implantable atrial pacemakers which utilize a rhythm based atrial capture threshold test wherein in a ventricle based DDI mode a predetermined number of ventricle started atrial and ventricular escape intervals are triggered with an overdrive rate about 20% higher than an intrinsic heart rate. The number of atrial sense events during atrial capture threshold test is counted. Too high of a number of atrial sense events indicates loss of capture due to too small of a pulse strength of the atrial stimulation pulses.
摘要翻译： 本发明涉及心脏刺激器和可植入心房起搏器，其利用基于心律的心房采集阈值测试，其中在基于心室的DDI模式中，预定数量的心室开始心房和心室逃逸间隔被触发，超速率比内在的 心率。 在心房采集阈值测试期间心房感觉事件的数量被计数。 许多心房感觉事件的太高表示由于心房刺激脉冲的脉冲强度太小而导致的捕获损失。
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公开(公告)号：US07761163B2
公开(公告)日：2010-07-20
申请号：US11451138
申请日：2006-06-12
申请人： Christopher S. de Voir , Jie Lian , Richard A. Schomburg , Duane Patterson , Hannes Kraetschmer , Dirk Muessig
发明人： Christopher S. de Voir , Jie Lian , Richard A. Schomburg , Duane Patterson , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61N1/362
CPC分类号： A61N1/3712 , A61N1/3622 , A61N1/3714
摘要： The invention relates to heart stimulators and implantable atrial pacemakers which utilize a rhythm based atrial capture threshold test wherein in a ventricle based DDI mode a predetermined number of ventricle started atrial and ventricular escape intervals are triggered with an overdrive rate about 20% higher than an intrinsic heart rate. The number of atrial sense events during atrial capture threshold test is counted. Too high of a number of atrial sense events indicates loss of capture due to too small of a pulse strength of the atrial stimulation pulses.
摘要翻译： 本发明涉及心脏刺激器和可植入心房起搏器，其利用基于心律的心房采集阈值测试，其中在基于心室的DDI模式中，预定数量的心室开始心房和心室逃逸间隔被触发，超速率比内在的 心率。 在心房采集阈值测试期间心房感觉事件的数量被计数。 许多心房感觉事件的太高表示由于心房刺激脉冲的脉冲强度太小而导致的捕获损失。
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公开(公告)号：US20080065161A1
公开(公告)日：2008-03-13
申请号：US11848824
申请日：2007-08-31
申请人： Jie Lian , Garth Garner , Hannes Kraetschmer , Dirk Mussig
发明人： Jie Lian , Garth Garner , Hannes Kraetschmer , Dirk Mussig
IPC分类号： A61N1/362
CPC分类号： A61N1/3622 , A61N1/368
摘要： Uses dual-chamber (RA-RV), three-chamber (BiA-RV, or RA-BiV), or four-chamber (BiA-BiV) implantable cardiac device including pacemakers, defibrillators and cardioverters, which stimulate cardiac tissue electrically to control the patient's heart rhythm to create a far-field intra-atrial electrogram (AEGM) and a far-field intra-ventricular electrogram (VEGM) that are independently filtered, scaled, and then summed to form a composite far-field electrogram.
摘要翻译： 使用双室（RA-RV），三室（BiA-RV或RA-BiV）或四室（BiA-BiV）植入式心脏装置，包括起搏器，除颤器和心律转换器，其电刺激心脏组织以控制 患者的心律以创建远场心房电图（AEGM）和远场心室电图（VEGM），其被独立过滤，缩放，然后相加以形成复合远场电描记图。
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公开(公告)号：US20090312649A1
公开(公告)日：2009-12-17
申请号：US12476164
申请日：2009-06-01
IPC分类号： A61B5/0205 , A61B5/085
CPC分类号： A61B5/0809 , A61B5/0538 , A61N1/36521 , A61N1/36585 , A61N1/36592
摘要： The invention refers to a monitoring device for monitoring and analyzing physiological signals. The monitoring device comprises a transthoracic impedance measurement unit and an evaluation unit connected to the transthoracic impedance measurement unit. The transthoracic impedance measurement unit is adapted to conduct a transthoracic impedance measurement and to generate a transthoracic impedance signal representing a measured transthoracic impedance at consecutive points in time. The evaluation unit being configured to process the transthoracic impedance signal received from the transthoracic impedance measurement unit and to thus generate a respiration signal and to generate therefrom an evaluation signal reflecting at least a diurnal pattern of the respiration rate.
摘要翻译： 本发明涉及用于监测和分析生理信号的监测装置。 监测装置包括经胸阻抗测量单元和连接到经胸阻抗测量单元的评估单元。 经胸阻抗测量单元适于进行经胸阻抗测量，并产生表示连续时间点测量的经胸阻抗的经胸阻抗信号。 评估单元被配置为处理从经胸阻抗测量单元接收的经胸阻抗信号，并因此产生呼吸信号，并从其产生反映呼吸速率的至少昼夜模式的评估信号。
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公开(公告)号：US08394029B2
公开(公告)日：2013-03-12
申请号：US12476164
申请日：2009-06-01
IPC分类号： A61B5/08
CPC分类号： A61B5/0809 , A61B5/0538 , A61N1/36521 , A61N1/36585 , A61N1/36592
摘要： The invention refers to a monitoring device for monitoring and analyzing physiological signals. The monitoring device comprises a transthoracic impedance measurement unit and an evaluation unit connected to the transthoracic impedance measurement unit. The transthoracic impedance measurement unit is adapted to conduct a transthoracic impedance measurement and to generate a transthoracic impedance signal representing a measured transthoracic impedance at consecutive points in time. The evaluation unit being configured to process the transthoracic impedance signal received from the transthoracic impedance measurement unit and to thus generate a respiration signal and to generate therefrom an evaluation signal reflecting at least a diurnal pattern of the respiration rate.
摘要翻译： 本发明涉及用于监测和分析生理信号的监测装置。 监测装置包括经胸阻抗测量单元和连接到经胸阻抗测量单元的评估单元。 经胸阻抗测量单元适于进行经胸阻抗测量，并产生表示连续时间点测量的经胸阻抗的经胸阻抗信号。 评估单元被配置为处理从经胸阻抗测量单元接收的经胸阻抗信号，并因此产生呼吸信号，并从其产生反映呼吸速率的至少昼夜模式的评估信号。
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公开(公告)号：US20130079839A1
公开(公告)日：2013-03-28
申请号：US13603418
申请日：2012-09-05
申请人： Jie Lian , Volker Lang , Hannes Kraetschmer , Dirk Muessig
发明人： Jie Lian , Volker Lang , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61N1/365
CPC分类号： A61N1/3627 , A61B5/0402 , A61N1/36521 , A61N1/3682 , A61N1/3684 , A61N1/3686
摘要： The present disclosure refers to a heart stimulator comprising a stimulation control unit, a stimulation unit, an impedance measurement unit and an impedance evaluation unit. The stimulation control unit is operatively connected to the stimulation unit to control timing of stimulation pulses by said stimulation unit. The impedance measurement unit is configured to determine an impedance signal reflecting intracardiac impedance. The impedance evaluation unit is operatively connected to the impedance measurement unit and to the stimulation control unit and is configured to evaluate the impedance signal so as to determine an isovolumic contraction time, an isovolumic relaxation time, an ejection time and a filling time from said impedance signal. The stimulation control unit is further configured to control timing of stimulation pulses depending on a performance index.
摘要翻译： 本公开涉及包括刺激控制单元，刺激单元，阻抗测量单元和阻抗评估单元的心脏刺激器。 刺激控制单元可操作地连接到刺激单元以控制所述刺激单元的刺激脉冲的定时。 阻抗测量单元被配置为确定反映心内阻抗的阻抗信号。 阻抗评估单元可操作地连接到阻抗测量单元和刺激控制单元，并被配置为评估阻抗信号，以便确定等容收缩时间，等容弛豫时间，喷射时间和来自所述阻抗的填充时间 信号。 刺激控制单元还被配置为根据性能指标来控制刺激脉冲的定时。
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公开(公告)号：US08175709B2
公开(公告)日：2012-05-08
申请号：US11668491
申请日：2007-01-30
申请人： Jie Lian , Hannes Kraetschmer , Dirk Muessig
发明人： Jie Lian , Hannes Kraetschmer , Dirk Muessig
IPC分类号： A61N1/362
CPC分类号： A61B5/04017 , A61B5/0402 , A61B5/04525 , A61B5/7232
摘要： A system for heart monitoring comprises an IEGM input for an intracardiac electrocardiogram (IEGM) that is connected to an active filtering stage that is adapted to transform an incoming IEGM into an output ECG signal. The active filtering stage is connected to a filter characterization stage that is adapted to process a recorded, patient specific IEGM template and a corresponding SECG template and to adapt the filter characteristics of said active filtering stage such that the filter characteristics best characterize the input-output relationship between the IEGM template and the corresponding SECG template. As a consequence, the active filtering stage is adapted to transform an incoming IEGM such that the output ECG signal closely resembles a morphology of a corresponding SECG.
摘要翻译： 用于心脏监测的系统包括用于心内心电图（IEGM）的IEGM输入，其连接到适用于将输入的IEGM变换为输出ECG信号的有源滤波级。 有源滤波级连接到滤波器表征阶段，其适于处理记录的，患者特异性IEGM模板和对应的SECG模板，并适应所述有源滤波级的滤波器特性，使得滤波器特性最好地表征输入 - 输出 IEGM模板与相应的SECG模板之间的关系。 因此，有源滤波阶段适于变换输入的IEGM，使得输出的ECG信号非常类似于对应的SECG的形态。
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