PH-DEPENDENT CONTROLLED RELEASE PHARMACEUTICAL OPIOID COMPOSITION WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL
    3.
    发明申请
    PH-DEPENDENT CONTROLLED RELEASE PHARMACEUTICAL OPIOID COMPOSITION WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL 有权
    PH依赖性控释药物抗药性组合物对乙醇的影响

    公开(公告)号:US20110217383A1

    公开(公告)日:2011-09-08

    申请号:US13062591

    申请日:2008-09-24

    CPC分类号: A61K9/5078

    摘要: The invention relates to a pH-dependent controlled release pharmaceutical composition, comprising a core, and an opioid, wherein the core is coated at least by one coating layer, controlling the release of the pharmaceutical composition, wherein the coating layer comprises a polymer mixture of i) 40 95% by weight, based on dry weight of the polymer mixture, of at least one water insoluble essentially neutral vinyl polymer, and ii) 5 60% by weight, based on dry weight of the polymer mixture, of at least one anionic polymer or copolymer, which is insoluble in a buffered medium below pH 4.0 and soluble at least in the range from pH 7.0 to pH 8.0, characterized in that the coating layer further comprises 110 to 250 % by weight of a non-porous inert lubricant, 1 to 35 % by weight of a neutral cellulosic compound and 1 to 25 % by weight of an emulsifier, each calculated on dry weight of the polymer mixture.

    摘要翻译: 本发明涉及一种pH依赖性控释药物组合物,其包含核心和阿片样物质,其中所述核心至少涂覆一层涂层,以控制药物组合物的释放,其中所述涂层包含: i)40 95重量%,基于聚合物混合物的干重,至少一种水不溶性基本上中性的乙烯基聚合物,和ii)基于聚合物混合物的干重计,60重量%的至少一种 阴离子聚合物或共聚物,其不溶于低于pH 4.0的缓冲介质,并且至少可溶于pH 7.0至pH 8.0,其特征在于,所述涂层还包含110至250重量%的无孔惰性润滑剂 ,1至35重量%的中性纤维素化合物和1至25重量%的乳化剂,其各自以聚合物混合物的干重计算。

    Motor oil with high dispersivity and good wear protection characteristics
    4.
    发明授权
    Motor oil with high dispersivity and good wear protection characteristics 失效
    机油具有高分散性和良好的防磨损特性

    公开(公告)号:US06475964B1

    公开(公告)日:2002-11-05

    申请号:US08510272

    申请日:1995-08-02

    IPC分类号: C10M16100

    摘要: Motor oils and transmission oils of the usual commercial SAE single- and multiple viscosity classes, which oils contain polymeric additives and which have high dispersivity and good wear protection characteristics, said oils containing the following additives: (i) at least one heavy-duty (HD) additive, which contains phosphorus compounds; and (ii) as dispersive polymeric components PC, cooligomers copolymers, or combinations thereof comprised of: (a) units of C6-24 alkyl (meth)acrylates, (b) units of at least one functionalized alkyl (meth)acrylate, (c) units of one or more C1-5-alkyl (meth)acrylate monomers, and (d) units of 1-alkenes, with the following provisions: (1) the units of formulas I and II together comprise 100 wt. %, (2) the content of polymer components) PC in the additive-containing mineral oils is in the range 0.5-50 wt. %, and (3) the content of phosphorus in the additive-containing mineral oils is less than or equal to 0.08 wt. %.

    摘要翻译: 含有以下添加剂的油的通常商业SAE单一和多重粘度等级的机油和传动油,其中油含有聚合物添加剂并具有高分散性和良好的耐磨损保护特性,所述油包含以下添加剂:(i)至少一种重载 HD)添加剂,含有磷化合物; 和(ii)作为分散聚合物组分PC,冷却体共聚物或其组合,其包含:(a)(甲基)丙烯酸C 6-24烷基酯单元,(b)至少一个官能化的(甲基)丙烯酸烷基酯单元,(c )单元,和(d)1-烯烃单元,其具有以下规定:(1)式I和II的单元一起包含100重量%的(甲基)丙烯酸C 1〜 %,(2)含添加剂的矿物油中的聚合物组分的含量PC在0.5-50wt。 %,和(3)含添加剂矿物油中的磷含量小于或等于0.08重量%。 %。

    PH-DEPENDENT CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION FOR NON-OPIOIDS WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL
    6.
    发明申请
    PH-DEPENDENT CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION FOR NON-OPIOIDS WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL 审中-公开
    对依赖于乙醇的影响的非依赖性药物的PH依赖性控制释放药物组合物

    公开(公告)号:US20110229562A1

    公开(公告)日:2011-09-22

    申请号:US13120112

    申请日:2008-09-24

    CPC分类号: A61K9/5078

    摘要: The invention relates to a pH-dependent controlled release pharmaceutical composition, comprising at least one pharmaceutical active ingredient, with the exception of opioids, wherein the core is coated at least by one coating layer, controlling the release of the pharmaceutical composition, wherein the coating layer comprises a polymer mixture of i) 40-95% by weight, based on dry weight of the polymer mixture, of at least one water insoluble essentially neutral vinyl polymer or copolymer, and ii) 5-60% by weight, based on dry weight of the polymer mixture, of at least one anionic polymer or copolymer, which is insoluble in a buffered medium below pH 4.0 and soluble at least in the range from pH 7.0 to pH 8.0, characterized in that the coating layer further comprises 110 to 250% by weight of a non-porous inert lubricant, 1 to 35% by weight of at least one neutral cellulosic compound and 1 to 25% by weight of at least one emulsifier, each calculated on dry weight of the polymer mixture.

    摘要翻译: 本发明涉及pH依赖性控释药物组合物,其包含除阿片样物质以外的至少一种药物活性成分,其中核心至少涂覆一层涂层,以控制药物组合物的释放,其中涂层 至少一种不溶于水的基本上中性的乙烯基聚合物或共聚物,和ii)5-60重量%,基于干燥的聚合物混合物,i)40-95重量%,基于聚合物混合物的干重, 聚合物混合物的重量,至少一种阴离子聚合物或共聚物,其不溶于低于pH 4.0的缓冲介质中并且可溶于至少在7.0至8.0的范围内,其特征在于所述涂层还包含110至250 重量%的无孔惰性润滑剂,1至35重量%的至少一种中性纤维素化合物和1至25重量%的至少一种乳化剂,其各自以聚合物混合物的干重计算。

    Method for forming polythiophosphazene macromolecules
    7.
    发明授权
    Method for forming polythiophosphazene macromolecules 失效
    形成聚硫磷腈大分子的方法

    公开(公告)号:US5101003A

    公开(公告)日:1992-03-31

    申请号:US474411

    申请日:1990-02-02

    IPC分类号: C08G79/02

    CPC分类号: C08G79/02

    摘要: The synthesis of the first examples of a new class of inorganic macromolecules, the polythiophosphazenes, is reported. When heated at 90.degree. C., the cyclothiophosphazene N.sub.3 P.sub.2 SCl.sub.5 undergoes ring-opening polymerization to yield the high polymeric polythiophosphazene [N.sub.3 P.sub.2 SCl.sub.5 ].sub.n. The latter functions as a reactive macromolecular intermediate and undergoes halogen replacement with sodium phenoxide and sodium o-phenylphenoxide to afford the polymers [N.sub.3 P.sub.2 S(OPh).sub.5 ].sub.n and [N.sub.3 P.sub.2 S(OC.sub.6 H.sub.4 Ph--o).sub.3.25 Cl.sub.1.75 ].sub.n, respectively.

    摘要翻译: 报道了一类新的无机大分子,即聚硫代磷腈的合成。 当在90℃下加热时,环硫基磷腈N 3 P 2 SCl 5进行开环聚合,得到高分子聚硫代磷腈[N 3 P 2 SCl 5] n。 后者用作反应性大分子中间体,并用苯酚钠和邻苯基苯酚钠进行卤素置换,分别得到聚合物[N 3 P 2 S(OPh)5] n和[N 3 P 2 S(OC 6 H 4 Ph-o)3.25 Cl1.75] n。

    Fluid analyzer utilizing a laser beam
    8.
    发明授权
    Fluid analyzer utilizing a laser beam 失效
    使用激光束的流体分析仪

    公开(公告)号:US4365157A

    公开(公告)日:1982-12-21

    申请号:US271376

    申请日:1981-06-08

    IPC分类号: G01N21/71 B01D59/44

    CPC分类号: G01N21/718

    摘要: A method for studying a fluid by forming a stream of the fluid, exciting the stream by causing a laser beam to impinge thereon to produce secondary particles or quanta, and subjecting the resulting secondary particles or quanta to an analysis operation in an analyzer.

    摘要翻译: 一种用于通过形成流体流来研究流体的方法,通过使激光束在其上冲击以产生二次粒子或量子来激发流,以及使得到的二次粒子或量子在分析器中进行分析操作。

    CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL EMPLOYING A COATING COMPRISING NEUTRAL VINYL POLYMERS AND EXCIPIENTS
    9.
    发明申请
    CONTROLLED RELEASE PHARMACEUTICAL COMPOSITION WITH RESISTANCE AGAINST THE INFLUENCE OF ETHANOL EMPLOYING A COATING COMPRISING NEUTRAL VINYL POLYMERS AND EXCIPIENTS 有权
    控制释放的药物组合物具有抵抗乙酸乙酯对包含中性乙烯基聚合物和其特性的涂料的影响

    公开(公告)号:US20120045506A1

    公开(公告)日:2012-02-23

    申请号:US13256694

    申请日:2009-03-18

    CPC分类号: A61K9/5078

    摘要: The invention relates to a controlled release pharmaceutical composition, comprising a core, comprising a pharmaceutical active ingredient, whereby the core is coated by an ethanol resistance conferring coating layer which has the effect of conferring the release profile of the pharmaceutical active ingredient to be resistant against the influence of ethanol, whereby the ethanol resistance conferring coating layer comprises at least 70% by weight of a mixture of a polymeric portion a) and an excipients portion b), with the polymeric portion a) is consisting of a water insoluble essentially neutral vinyl polymer or vinyl copolymer and the excipients portion b) is consisting of the excipients b1) 100 to 250% by weight of a non-porous inert lubricant, b2) 1 to 35% by weight of a cellulosic compound, b3) 0.1 to 25% by weight of an emulsifier and additionally or alternatively to b3), b4) 0.1 to 30% by weight of a plasticizer whereby the excipients of the excipients portion b) are each calculated on the dry weight of the polymer portion a).

    摘要翻译: 本发明涉及一种控释药物组合物,其包含核心,其包含药物活性成分,由此核心由赋予乙醇抗性的涂层涂覆,其具有赋予药物活性成分的释放特性以抵抗 乙醇的影响,其中赋予涂料的乙醇抗性包含至少70重量%的聚合物部分a)和赋形剂部分b)的混合物,聚合物部分a)由不溶于水的基本上为中性的乙烯基 聚合物或乙烯基共聚物和赋形剂部分b)由赋形剂b1)100-250重量%的无孔惰性润滑剂组成,b2)1至35重量%的纤维素化合物,b3)0.1至25重量% 的b),b4)0.1〜30重量%的增塑剂,其中赋形剂部分b)的赋形剂各自计算 以聚合物部分a)的干重计。