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16 条记录 (耗时 0.026 秒)

    Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof
    1.
    发明申请
    Piperazinylalkylpyrazole derivatives useful as selective T-type calcium channel blockers and preparation method thereof 失效
    可用作选择性T型钙通道阻滞剂的哌嗪基烷基吡唑衍生物及其制备方法

    公开(公告)号：US20070049604A1

    公开(公告)日：2007-03-01

    申请号：US11509769

    申请日：2006-08-25

    申请人： Ghilsoo Nam ,  Kyung Choi ,  Hun Koh ,  Ae Pae ,  Hyewhon Rhim ,  In-Sung Choi

    发明人： Ghilsoo Nam ,  Kyung Choi ,  Hun Koh ,  Ae Pae ,  Hyewhon Rhim ,  In-Sung Choi

    IPC分类号： A61K31/496 ,  C07D403/02

    CPC分类号： C07D231/12 ,  C07D405/04

    摘要： The present invention provides for novel piperazinylalkylpyrazole derivatives, the preparation method thereof and the selective T-type calcium channel blocking activity thereof. Particularly, it provides a piperazinylalkylpyrazole derivative as represented by the formula set forth below or its pharmaceutically acceptable salts, and its preparation method thereof. The compound of Formula 1 is a novel piperazinylalkylpyrazole derivative, which particulary has T-type Ca2+ channel blocking effect and thus can be useful as a therapeutic agent for nerve and muscle pain.

    摘要翻译： 本发明提供新的哌嗪基烷基吡唑衍生物，其制备方法和选择性T型钙通道阻断活性。 特别地，其提供如下式所示的哌嗪基烷基吡唑衍生物或其药学上可接受的盐及其制备方法。 式1的化合物是新型的哌嗪基烷基吡唑衍生物，特别是具有T型Ca 2+通道阻断效应，因此可用作神经和肌肉疼痛的治疗剂。

    3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and method of preparing the same
    8.
    发明授权
    3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and method of preparing the same 失效
    3,4-二氢喹唑啉衍生物作为T型钙通道阻滞剂及其制备方法

    公开(公告)号：US07271260B2

    公开(公告)日：2007-09-18

    申请号：US11018786

    申请日：2004-12-20

    申请人： Yong Sup Lee ,  Jae Yeol Lee ,  Hyewhon Rhim

    发明人： Yong Sup Lee ,  Jae Yeol Lee ,  Hyewhon Rhim

    IPC分类号： C07D239/84 ,  C07D239/74 ,  A61K31/517 ,  A61K31/5377

    CPC分类号： C07D239/74 ,  C07D239/84

    摘要： The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihydroquinazoline derivatives of the present invention can be effectively used for preventing and treating angina pectoris, high blood pressure, myocardial disease, pain and epilepsy by blocking the T-type calcium channel.

    摘要翻译： 本发明涉及作为T型钙通道阻断剂的3,4-二氢喹唑啉衍生物及其制备方法。 本发明还涉及包含该组合物的组合物。 包含本发明的3,4-二氢喹唑啉衍生物的组合物可以有效地用于通过阻断T型钙通道来预防和治疗心绞痛，高血压，心肌病，疼痛和癫痫。