利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

16 条记录 (耗时 0.042 秒)

    Treatment of dry eye restoring 15-lipoxygenase activity to ocular surface cells
    6.
    发明申请
    Treatment of dry eye restoring 15-lipoxygenase activity to ocular surface cells 审中-公开
    干眼症治疗眼部表面细胞的15-脂肪氧合酶活性

    公开(公告)号：US20060217325A1

    公开(公告)日：2006-09-28

    申请号：US10539093

    申请日：2003-10-17

    申请人： John Yanni ,  Daniel Gamache ,  Steven Miller

    发明人： John Yanni ,  Daniel Gamache ,  Steven Miller

    IPC分类号： A61K48/00

    CPC分类号： A61K48/005 ,  A61K38/44 ,  A61K48/00 ,  A61K48/0075 ,  C12Y113/11031

    摘要： The present invention provides compositions comprising the 15-lipoxygenase-1 (15-LO-1) or 15-lipoxyngenase-2 (15-LO-2) gene such that 15-LO-1 or 15-LO-2 protein expression is replaced or replenished in the ocular surface epithelium of post-menopausal women suffering from dry eye. Thus, methods for treatment of dry eye in postmenopausal women are further provided.

    摘要翻译： 本发明提供包含15-脂肪氧合酶-1（15-LO-1）或15-脂肪氧合酶-2（15-LO-2）基因的组合物，使得15-LO-1或15-LO-2蛋白质表达被替换 或补充在患有干眼症的绝经后妇女的眼表上皮中。 因此，进一步提供了在绝经后妇女中治疗干眼症的方法。

    Use of oculosurface selective glucocorticoid in the treatment of dry eye
    7.
    发明申请
    Use of oculosurface selective glucocorticoid in the treatment of dry eye 审中-公开
    使用ocuoseurface选择性糖皮质激素治疗干眼症

    公开(公告)号：US20060058277A1

    公开(公告)日：2006-03-16

    申请号：US11250262

    申请日：2005-10-14

    申请人： John Yanni ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

    发明人： John Yanni ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

    IPC分类号： A61K31/573

    CPC分类号： A61K31/575 ,  A61K9/0048 ,  A61K31/57 ,  A61K31/573 ,  A61K47/12 ,  A61K47/18 ,  A61K47/186 ,  A61K47/26 ,  A61K47/32

    摘要： Topical ophthalmic compositions and methods for treating dry eye are described. The compositions and methods of the invention are based on the finding that the oculosurface selective properties of the glucocorticoid rimexolone make this anti-inflammatory agent particularly well-suited for treating dry eye. As a result of the limited ability of rimexolone to penetrate the cornea, a high portion of the drug remains on the surface of the eye, which is the primary locus of the inflammatory conditions associated with dry eye. This enables a very low concentration of drug to be utilized, which in turn reduces the potential for elevations of intraocular pressure and cataract formation.

    摘要翻译： 描述了用于治疗干眼症的局部眼用组合物和方法。 本发明的组合物和方法基于这样的发现，即糖皮质激素瑞ol酮的眼部表面选择性使该抗炎剂特别适合于治疗干眼症。 由于赖ol酮渗透角膜的能力有限，药物的大部分残留在眼睛的表面上，这是与干眼症相关的炎性病症的主要位点。 这使得能够使用非常低浓度的药物，这又降低了眼压升高和白内障形成的可能性。

    USE OF OCULOSURFACE SELECTIVE GLUCOCORTICOID IN THE TREATMENT OF DRY EYE
    9.
    发明申请
    USE OF OCULOSURFACE SELECTIVE GLUCOCORTICOID IN THE TREATMENT OF DRY EYE 审中-公开
    用于治疗干眼症中的表面选择性胆固醇的用途

    公开(公告)号：US20080096852A1

    公开(公告)日：2008-04-24

    申请号：US11925178

    申请日：2007-10-26

    申请人： John YANNI ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

    发明人： John YANNI ,  Daniel Gamache ,  Steven Miller ,  Ernesto Castillo

    IPC分类号： A61K31/575 ,  A61P27/02

    CPC分类号： A61K31/575 ,  A61K9/0048 ,  A61K31/57 ,  A61K31/573 ,  A61K47/12 ,  A61K47/18 ,  A61K47/186 ,  A61K47/26 ,  A61K47/32

    摘要： Topical ophthalmic compositions and methods for treating dry eye are described. The compositions and methods of the invention are based on the finding that the oculosurface selective properties of the glucocorticoid rimexolone make this anti-inflammatory agent particularly well-suited for treating dry eye. As a result of the limited ability of rimexolone to penetrate the cornea, a high portion of the drug remains on the surface of the eye, which is the primary locus of the inflammatory conditions associated with dry eye. This enables a very low concentration of drug to be utilized, which in turn reduces the potential for elevations of intraocular pressure and cataract formation.

    摘要翻译： 描述了用于治疗干眼症的局部眼用组合物和方法。 本发明的组合物和方法基于这样的发现，即糖皮质激素瑞ol酮的眼部表面选择性使该抗炎剂特别适合于治疗干眼症。 由于赖ol酮渗透角膜的能力有限，药物的大部分残留在眼睛的表面上，这是与干眼症相关的炎性病症的主要位点。 这使得能够使用非常低浓度的药物，这又降低了眼压升高和白内障形成的可能性。