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公开(公告)号：US20210403760A1
公开(公告)日：2021-12-30
申请号：US16624918
申请日：2018-06-21
发明人： Lauri Hauru , Alistair King , Ilkka Kilpeläinen , Antti Korpela , Hannes Orelma
IPC分类号： C09J5/06
摘要： According to an example aspect of the present invention, there is provided a method of joining objects of hydrophilic polymeric biomaterials. In the method, an ionic liquid is applied onto the surfaces of the objects; the surfaces are pressed together; and the ionic liquid is removed. The method produces a product that can consist to 100% of biomaterial, with no synthetic polymer or chemicals remaining in the product.
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公开(公告)号：US11052245B2
公开(公告)日：2021-07-06
申请号：US15748657
申请日：2016-07-02
申请人： Helsingin Yliopisto
摘要： The present invention relates to a device exploiting magneto-hydrodynamics (MHD) for localized delivery of material into a target or extraction of material from a target. The device includes a frame (101) comprising a space (102) for conductive fluid and the material, at least one pair of electrodes (103A, 103B) facing each other, a source of electric current (105), a magnet (105), and an opening (106). The electric current and the magnetic field are synchronized so that the material can be moved from the volume between the electrodes through the opening towards the target or from the target through the opening towards the volume. According to the invention the volume is ≤2000 mm3, in proviso that mean distance between tips of the electrodes is ≤20 mm.
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公开(公告)号：US20210181391A1
公开(公告)日：2021-06-17
申请号：US16761813
申请日：2018-11-06
摘要： A field-enhancing device includes at least one metal layer or a metal grating consisting of metal stripes or a dielectric grating. Usually the device is constructed on some substrate. The adhesive layer is advantageous when the next layer is metallic but is not needed with dielectric layers. The next layers to be constructed form a mirror structure that can also be omitted for simple field-enhancing device constructs. The mirror structure can be either a metal mirror structure or a distributed Bragg reflector structure (DBR). The next layer is the thin metal layer. This layer can be covered with a 1-D metal grating consisting of metal stripes or with a dielectric grating having similar geometry. The structure can also be fabricated without metals when dielectric grating is used as the field-enhancing part. Finally, a protective layer can be added on top of the structure.
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公开(公告)号：US20210127720A1
公开(公告)日：2021-05-06
申请号：US16672658
申请日：2019-11-04
申请人： Helsingin yliopisto
发明人： Fabio VALOPPI , Ari SALMI , Edward HAEGGSTRÖM
摘要： Disclosed is a method for producing oleogels by sonicating a mixture including an oleogelator component and an oil component with ultrasound including superpositioned ultrasound waves while cooling the mixture from a temperature wherein the mixture is in molten state to a temperature wherein the oleogelator component of the mixture is at least partially in solid state. The method produces oleogels of improved stability.
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公开(公告)号：US20190023862A1
公开(公告)日：2019-01-24
申请号：US15757380
申请日：2016-09-05
申请人： Helsingin yliopisto
摘要： Method of dewatering nanocellulose and other water soluble of hydrophilic polymers. The method comprises providing an aqueous suspension formed by nanocellulose in water, said nanocellulose having free hydroxyl groups; mixing the aqueous suspension with an ionic liquid or eutectic solvent which is capable of hydrogen bonding to at least a part of the free hydroxyl groups to form a modified suspension; and evaporating off water from the modified suspension in order to dewater the nanocellulose. With the ionic liquid procedure, solvent exchange with repeated centrifugation steps can be avoided, and solvent consumption and costs reduced, and processing sped up. The nanocellulose stabilized in the water-free environment then allows for access to efficient and thorough water-free chemical modification procedures resulting in highly fibrillated products.
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公开(公告)号：US20160002659A1
公开(公告)日：2016-01-07
申请号：US14410941
申请日：2012-11-29
申请人： HELSINGIN YLIOPISTO
发明人： Anne VATÈN , Jan DETTMER , Shunsuke MIYASHIMA , Shri Ram YADAV , Ana CAMPILHO , Vincent BULONE , Raffael LICHTENBERGER , Satu LEHESRANTA , Ari Pekka MÄHÖNEN , Annelie CARLSBECKER , Yrjö HELARIUTTA , Kaori FURUTA
CPC分类号： C12N9/1051 , A61K9/0075 , C12N15/8246 , C12N15/8261 , C12N15/8271 , C12Y204/01034
摘要： The present invention relates to a polypeptide, or a fragment thereof, capable of enhancing callose biosynthesis and/or accumulation, wherein at least one of the conserved amino acid residues selected from the group consisting of residue corresponding to R84 of SEQ ID NO: 1, residue corresponding to R1926 or SEQ ID NO: 1 and residue corresponding to P189 of SEQ ID NO: 1, of the polypeptide or a fragment thereof, is modified by a mutation selected from the group consisting of substitution and deletion.
摘要翻译： 本发明涉及能够增强胼cal质生物合成和/或积累的多肽或其片段，其中至少一个保守氨基酸残基选自对应于SEQ ID NO：1的R84的残基， 对应于R1926或SEQ ID NO：1的残基和对应于SEQ ID NO：1的多肽或其片段的P189的残基通过选自取代和缺失的突变修饰。
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公开(公告)号：US11331527B2
公开(公告)日：2022-05-17
申请号：US15775403
申请日：2015-11-12
申请人： Helsingin yliopisto
发明人： Ullastiina Hakala , Risto Hakala
IPC分类号： A62D3/34 , A62D3/32 , A62D3/35 , A62D3/38 , A62D101/02 , A62D101/04
摘要： There are disclosed processes for destructing a toxic chemical including the steps of mixing the toxic chemical with a liquid phase formed by an aqueous mixture of water and an ionic liquid or molten salt which is miscible with water, the ionic liquid or molten salt comprising a tertiary amine group or quaternary ammonium group; and contacting the toxic chemical in the liquid phase with the ionic liquid or molten salt so as to decompose the toxic chemical.
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公开(公告)号：US20210403658A1
公开(公告)日：2021-12-30
申请号：US17289289
申请日：2019-10-29
申请人： Helsingin Yliopisto
发明人： Mari Lehtonen , Kirsi Mikkonen , Maija Tenkanen
摘要： The present invention relates to a composition and method for active packaging of fresh plant products, in particular fresh plant based food products. The invention also relates to means for storage of fresh plant products and to a method for continuous production and controlled release of volatile oxidation products of lipids in packages or in the vicinity of fresh plant based goods.
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公开(公告)号：US20210382071A1
公开(公告)日：2021-12-09
申请号：US17284129
申请日：2019-10-09
申请人： HELSINGIN YLIOPISTO
发明人： Anu WARTIOVAARA , Jana BUZKOVA
摘要： The present invention relates to the fields of life sciences and medicine. Specifically, the invention relates to a method for determining a mitochondrial disorder of a subject or predicting a prognosis of a subject having a mitochondrial disorder, wherein the method comprises determining specific biomarkers from a sample of a subject. Also, the present invention relates to a method of selecting a treatment for a subject having a mitochondrial disorder or following up a treatment of a subject having a mitochondrial disorder, wherein the method comprises determining specific biomarkers from a sample of a subject. Still, the present invention relates to a kit comprising tools for determining said specific biomarkers from a sample of a subject and to use of the kit or specific biomarkers of the present invention for determining a mitochondrial disorder of a subject, predicting a prognosis of a subject having a mitochondrial disorder, selecting a treatment for a subject having a mitochondrial disorder or following up a treatment of a subject having a mitochondrial disorder.
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10.发明申请公开(公告)号：US20200071372A1
公开(公告)日：2020-03-05
申请号：US16610532
申请日：2018-05-04
申请人： Helsingin yliopisto
发明人： Mart Saarma , Mikko Airavaara , Merja Voutilainen , Li Ying Yu , Maria Lindahl
IPC分类号： C07K14/475 , A61P25/28
摘要： The present invention provides a C-terminal CDNF fragment sequence or a sequence which has at least 90% homology to said sequence. The C-terminal CDNF fragment protects ER stressed neurons, motoneurons and dopaminergic neurons and the fragment is capable of penetrating neuronal cell membrane as well as the blood-brain-barrier. The present invention further provides said fragment and pharmaceutical compositions comprising said fragment for use in treatments of degenerative diseases and disorders including central nervous system diseases, diabetes and retinal disorders. The present invention is also providing a C-terminal MANF fragment sequence or a sequence which has at least 90% homology to the said sequence and pharmaceutical compositions comprising said MANF fragment for use in the treatment of degenerative diseases and disorders including central nervous system diseases, diabetes and retinal disorders.
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