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    METHODS AND KITS FOR DIAGNOSING AND/OR PROGNOSING OSTEOARTHRITIS
    1.
    发明申请
    METHODS AND KITS FOR DIAGNOSING AND/OR PROGNOSING OSTEOARTHRITIS 审中-公开
    用于诊断和/或预防OSTEOARTHRITIS的方法和工具

    公开(公告)号：US20140329252A1

    公开(公告)日：2014-11-06

    申请号：US14351398

    申请日：2012-10-15

    申请人： HOPITAL SAINTE-JUSTINE

    发明人： Alain Moreau

    IPC分类号： G01N33/573 ,  G01N33/569

    CPC分类号： G01N33/6893 ,  G01N33/5005 ,  G01N33/56966 ,  G01N33/573 ,  G01N2333/47 ,  G01N2333/9015 ,  G01N2440/36 ,  G01N2800/105 ,  G01N2800/50

    摘要： A method of determining whether a subject is at risk of developing osteoarthritis (OA), said method comprising: determining the cellular localization of a Prohibitin-1 (PHB1) polypeptide and/or Small Ubiquitin-like Modifier (SUMO) polypeptide and/or UBC9, in a cell sample from said subject; and determining whether said subject is at risk of developing OA based on the cellular localization of a PHB1 polypeptide and/or SUMO and/or UBC9 polypeptide, is described.

    摘要翻译： 一种确定受试者是否处于发展为骨关节炎（OA）的风险的方法，所述方法包括：确定Prohibitin-1（PHB1）多肽和/或小泛素样修饰（SUMO）多肽和/或UBC9的细胞定位 在来自所述受试者的细胞样品中; 并且基于PHB1多肽和/或SUMO和/或UBC9多肽的细胞定位来确定所述受试者是否处于发展OA的风险。

    METHOD OF DIAGNOSING ADOLESCENT IDIOPATHIC SCOLIOSIS
    2.
    发明申请
    METHOD OF DIAGNOSING ADOLESCENT IDIOPATHIC SCOLIOSIS 审中-公开
    诊断青光眼发病的方法

    公开(公告)号：US20140113313A1

    公开(公告)日：2014-04-24

    申请号：US14143811

    申请日：2013-12-30

    申请人： HOPITAL SAINTE-JUSTINE

    发明人： ALAIN MOREAU

    IPC分类号： G01N33/569

    CPC分类号： G01N33/566 ,  C12Q1/02 ,  C12Q1/527 ,  G01N33/56966 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/726 ,  G01N2800/10

    摘要： A method for diagnosing an increased risk for developing adolescent idiopathic scoliosis (AIS) in a human subject, comprising detecting the presence or absence of at least one impairment in melatonin-signaling pathway in a cell sample of the subject in the presence and in the absence of a known melatonin-signaling pathway agonist, wherein the cell sample is selected from the group consisting of blood cell sample, osteoblast cell sample, osteoclast cell sample and myoblast cell sample, and wherein the presence of the at least one impairment in the melatonin-signaling pathway indicates that the subject possesses an increased risk for developing AIS.

    摘要翻译： 一种用于诊断在人类受试者中发展青少年特发性脊柱侧凸（AIS）的风险增加的方法，包括在存在和不存在的情况下检测受试者的细胞样品中褪黑激素信号通路中至少一种损伤的存在或不存在 的已知褪黑激素信号通路激动剂，其中所述细胞样品选自血细胞样品，成骨细胞样品，破骨细胞样品和成肌细胞样品，并且其中所述褪黑激素信号通路激动剂中存在至少一种损伤， 信号通路表明该受试者具有增加发展AIS的风险。

    Method of classifying human subjects having adolescent idiopathic scoliosis (AIS) and method for screening for a compound useful in the treatment of AIS and related syndromes causing spinal deformities
    3.
    发明授权
    Method of classifying human subjects having adolescent idiopathic scoliosis (AIS) and method for screening for a compound useful in the treatment of AIS and related syndromes causing spinal deformities 有权
    对具有青少年特发性脊柱侧凸（AIS）的人类受试者进行分类的方法以及用于筛选用于治疗AIS和引起脊柱畸形的相关综合征的化合物的方法

    公开(公告)号：US08652791B2

    公开(公告)日：2014-02-18

    申请号：US13726416

    申请日：2012-12-24

    申请人： Hopital Sainte-Justine

    发明人： Alain Moreau

    IPC分类号： G01N33/567 ,  C12Q1/02

    CPC分类号： G01N33/566 ,  C12Q1/02 ,  C12Q1/527 ,  G01N33/56966 ,  G01N33/6893 ,  G01N33/74 ,  G01N2333/726 ,  G01N2800/10

    摘要： A method of classifying a human subject having adolescent idiopathic scoliosis (AIS) comprising: providing a cell sample isolated from the subject; detecting an impairment in melatonin-signaling pathway in the sample in the presence and in the absence of a known melatonin-signaling pathway agonist, whereby the results of the detecting step enables the classification of the subject having AIS in one AIS subgroup; and a method of screening for a compound useful in the treatment of a disease characterized by a dysfunctional melatonin-signaling pathway, said method comprising the steps of contacting a candidate compound with at least one cell expressing at least one melatonin-signaling pathway impairment, wherein the candidate compound is selected if said melatonin-signaling pathway impairment is reduced in the presence of the candidate compound as compared to that in the absence thereof.

    摘要翻译： 一种对具有青少年特发性脊柱侧凸（AIS）的人类受试者进行分类的方法，包括：提供从受试者分离的细胞样品; 在存在和不存在已知的褪黑激素信号通路激动剂的情况下检测样品中褪黑激素信号通路的损伤，由此检测步骤的结果使得能够在一个AIS亚组中对具有AIS的受试者进行分类; 以及筛选用于治疗以功能失调的褪黑激素信号传导途径为特征的疾病的化合物的方法，所述方法包括使候选化合物与至少一种表达至少一种褪黑激素信号传导途径损伤的细胞接触的步骤，其中 如果所述褪黑素信号传导途径损伤在候选化合物存在下降低而与不存在候选化合物相比，则选择候选化合物。