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    Influenza virus binding, sialylated oligosaccharide substance and use thereof
    2.
    发明授权
    Influenza virus binding, sialylated oligosaccharide substance and use thereof 失效
    流感病毒结合，唾液酸化寡糖物质及其用途

    公开(公告)号：US07902170B2

    公开(公告)日：2011-03-08

    申请号：US10311713

    申请日：2001-06-20

    申请人： Halina Miller-Podraza ,  Karl-Anders Karlsson

    发明人： Halina Miller-Podraza ,  Karl-Anders Karlsson

    IPC分类号： A61K31/715 ,  A61K31/739 ,  C07H5/04

    CPC分类号： C07H3/06 ,  A61K31/715 ,  A61K31/739

    摘要： The present invention is directed to human influenza virus binding substance containing at least one oligosaccharide chain, which comprises a terminal NeuNAcα6 linked to: (a) a linear or branched polylactosamine type structure consisting of at least three lactosamine residues, a linear sequence optionally containing one or two α3-linked fucose residues in a non-sialylated lactosamine, a branched structure optionally carrying one or more additional NeuNAcα-residues at a terminal position in a branch, and/or (b) a linear or branched structure with two lactosamine and one lactose residue, a linear structure in addition containing one or two α3-linked fucose residues in a non-sialylated lactosamine or lactose, a branched structure optionally carrying one additional NeuNAcα-residue in a terminal position of the branch, or an analog or derivative of said oligosaccharide chain for use in binding of human influenza virus.

    摘要翻译： 本发明涉及含有至少一个寡糖链的人流感病毒结合物质，其包含与以下连接的末端NeuNAcα6连接的末端NeuNAcα6：（a）由至少三个乳糖胺残基组成的直链或支链多聚乳糖胺型结构，任选地含有一个 或非唾液酸化乳糖胺中的两个α3连接的岩藻糖残基，任选地在支链末端携带一个或多个另外的NeuNAcα残基的支链结构和/或（b）具有两个乳糖胺和一个 乳糖残基，在非唾液酸化乳糖胺或乳糖中另外含有一个或两个α3连接的岩藻糖残基的线性结构，任选地在该分支的末端位置携带一个额外的NeuNAcα-残基的支链结构，或其衍生物 所述寡糖链用于人流感病毒的结合。