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公开(公告)号：US20090074666A1
公开(公告)日：2009-03-19
申请号：US11918791
申请日：2006-04-20
申请人： Jonas Angstrom , Halina Miller-Podraza , Martina Pantzar , Karl-Anders Karlsson , Maria Blomqvist , Annamari Heiskanen , Ritva Niemela , Jari Helin , Jari Natunen , Tero Satomaa , Olli Aitio
发明人： Jonas Angstrom , Halina Miller-Podraza , Martina Pantzar , Karl-Anders Karlsson , Maria Blomqvist , Annamari Heiskanen , Ritva Niemela , Jari Helin , Jari Natunen , Tero Satomaa , Olli Aitio
IPC分类号： A61K39/145 , G01N33/566 , A61B10/00 , G06G7/58 , A61P31/16 , C12Q1/70 , C07K14/11
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/145 , C07H15/04 , C07H15/26 , C07K7/06 , C07K7/08 , C12N2760/16122 , C12N2760/16134 , G01N33/56983
摘要： The invention relates to the method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus. The invention also provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza.
摘要翻译： 本发明涉及用于评价化学实体（例如抗体）与源自流感病毒血凝素蛋白的二价唾液酸苷结合位点的肽表位结合的方法。 本发明还提供用于预防和/或治疗流感或用于开发这种针对流感的治疗或疫苗的肽表位。
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公开(公告)号：US20100047827A1
公开(公告)日：2010-02-25
申请号：US12522858
申请日：2008-01-18
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Ulla Impola , Olli Aitio , Leena Valmu , Suvi Natunen , Hanna Salo
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Ulla Impola , Olli Aitio , Leena Valmu , Suvi Natunen , Hanna Salo
CPC分类号： C07K16/28 , C07K16/2896 , C07K16/44 , G01N33/56966 , G01N2400/38
摘要： The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
摘要翻译： 本发明描述了干细胞聚糖结构的特异性结合剂的试剂和方法。 此外，本发明涉及筛选针对干细胞表面上的特定聚糖表位的另外的结合试剂。 聚糖结构的优选粘合剂包括蛋白质，例如酶，凝集素和抗体。
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3.发明申请NOVEL CARBOHYDRATE PROFILE COMPOSITIONS FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开新型碳水化合物人体细胞组成及其分析及其改良方法公开(公告)号：US20100145032A1
公开(公告)日：2010-06-10
申请号：US12523628
申请日：2008-01-18
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinin , Sari Tiitinen , Ulla Impola , Milla Mikkola , Hanna Salo , Olli Aitio , Leena Valmu , Suvi Natunen , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen , Minna Tiitanen , Tia Hirvonen
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinin , Sari Tiitinen , Ulla Impola , Milla Mikkola , Hanna Salo , Olli Aitio , Leena Valmu , Suvi Natunen , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen , Minna Tiitanen , Tia Hirvonen
IPC分类号： C12Q1/02 , C12N5/074 , C12P21/00 , C07K14/435
CPC分类号： G01N33/5308 , C12N5/0606 , C12N5/0647 , C12N2500/34 , G01N2400/38
摘要： The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
摘要翻译： 本发明描述了干细胞聚糖结构的特异性结合剂的试剂和方法。 此外，本发明涉及筛选针对干细胞表面上的特定聚糖表位的另外的结合试剂。 聚糖结构的优选粘合剂包括蛋白质，例如酶，凝集素和抗体。
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4.发明申请NOVEL CARBOHYDRATE FROM HUMAN CELLS AND METHODS FOR ANALYSIS AND MODIFICATION THEREOF 审中-公开来自人类细胞的新型碳水化合物及其分析和改性方法公开(公告)号：US20100028913A1
公开(公告)日：2010-02-04
申请号：US12523586
申请日：2008-01-18
申请人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen
发明人： Jarmo Laine , Tero Satomaa , Jari Natunen , Annamari Heiskanen , Maria Blomqvist , Anne Olonen , Juhani Saarinen , Sari Titinen , Ulla Impola , Olli Aitio , Leena Valmu , Heidi Anderson , Virve Pitkänen , Jukka Partanen , Taina Jaatinen
IPC分类号： G01N33/569 , G01N33/53 , G01N33/577
CPC分类号： G01N33/5308 , C12N5/0606 , C12N5/0647 , C12N2500/34 , G01N2400/38
摘要： The invention describes reagents and methods for specific binders to glycan structures of stem cells. Furthermore the invention is directed to screening of additional binding reagents against specific glycan epitopes on the surfaces of the stem cells. The preferred binders of the glycans structures includes proteins such as enzymes, lectins and antibodies.
摘要翻译： 本发明描述了干细胞聚糖结构的特异性结合剂的试剂和方法。 此外，本发明涉及筛选针对干细胞表面上的特定聚糖表位的另外的结合试剂。 聚糖结构的优选粘合剂包括蛋白质，例如酶，凝集素和抗体。
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公开(公告)号：US20100074920A1
公开(公告)日：2010-03-25
申请号：US12447018
申请日：2007-10-26
申请人： Jari Natunen , Jukka Hiltunen , Ritva Niemela , Jari Helin , Olli Aitio
发明人： Jari Natunen , Jukka Hiltunen , Ritva Niemela , Jari Helin , Olli Aitio
CPC分类号： A61K39/145 , A61K38/00 , A61K39/00 , A61K39/12 , A61K2039/64 , C07K5/0815 , C07K5/0821 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , G01N33/56983 , G01N2333/11 , Y10T436/143333
摘要： The invention relates to the method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus. The invention also provides peptide epitopes 5 for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza.
摘要翻译： 本发明涉及用于评价化学实体（例如抗体）与源自流感病毒血凝素蛋白的二价唾液酸苷结合位点的肽表位结合的方法。 本发明还提供了用于预防和/或治疗流感或用于开发这种针对流感的治疗或疫苗的肽表位。
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公开(公告)号：US20110191867A1
公开(公告)日：2011-08-04
申请号：US12739796
申请日：2008-10-24
申请人： Jari Natunen , Jukka Hiltunen , Ritva Niemela , Jari Helin , Olli Aitio
发明人： Jari Natunen , Jukka Hiltunen , Ritva Niemela , Jari Helin , Olli Aitio
CPC分类号： A61K39/145 , A61K38/00 , A61K39/00 , A61K39/12 , A61K2039/64 , C07K5/0815 , C07K5/0821 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , G01N33/56983 , G01N2333/11 , Y10T436/143333
摘要： The invention provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza. The invention also relates to a method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus, and to conjugates containing one or more such peptide epitopes. The peptide epitopes of the invention are cyclic peptides comprising a 7-mer peptide derived from H1, H3 or H5 hemagglutinin of influenza virus. The 7-mer peptide has a sequence corresponding to the loop sequence at positions 220-226 of X31-hemagglutinin.
摘要翻译： 本发明提供用于预防和/或治疗流感或用于开发这种针对流感的治疗或疫苗的肽表位。 本发明还涉及用于评价化学实体（例如抗体）与流感病毒血凝素蛋白的二价唾液酸苷结合位点衍生的肽表位结合的方法，以及含有一种或多种这样的肽的缀合物 表位。 本发明的肽表位是包含源自流感病毒的H1，H3或H5血凝素的7聚体肽的环肽。 7聚体肽具有与X31-血凝素的220-226位的环序列相对应的序列。
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