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公开(公告)号：US20090074666A1
公开(公告)日：2009-03-19
申请号：US11918791
申请日：2006-04-20
申请人： Jonas Angstrom , Halina Miller-Podraza , Martina Pantzar , Karl-Anders Karlsson , Maria Blomqvist , Annamari Heiskanen , Ritva Niemela , Jari Helin , Jari Natunen , Tero Satomaa , Olli Aitio
发明人： Jonas Angstrom , Halina Miller-Podraza , Martina Pantzar , Karl-Anders Karlsson , Maria Blomqvist , Annamari Heiskanen , Ritva Niemela , Jari Helin , Jari Natunen , Tero Satomaa , Olli Aitio
IPC分类号： A61K39/145 , G01N33/566 , A61B10/00 , G06G7/58 , A61P31/16 , C12Q1/70 , C07K14/11
CPC分类号： C07K14/005 , A61K39/00 , A61K39/12 , A61K39/145 , C07H15/04 , C07H15/26 , C07K7/06 , C07K7/08 , C12N2760/16122 , C12N2760/16134 , G01N33/56983
摘要： The invention relates to the method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus. The invention also provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza.
摘要翻译： 本发明涉及用于评价化学实体（例如抗体）与源自流感病毒血凝素蛋白的二价唾液酸苷结合位点的肽表位结合的方法。 本发明还提供用于预防和/或治疗流感或用于开发这种针对流感的治疗或疫苗的肽表位。
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2.发明申请公开(公告)号：US20070243629A1
公开(公告)日：2007-10-18
申请号：US10576477
申请日：2004-10-20
申请人： Jonas Ångström , Halina Miller-Podraza , Martina Pantzar , Kart-Anders Karlsson , Maria Blomqvist , Annamari Helskanen , Ritva Niemela , Jari Helin , Jari Natunen
发明人： Jonas Ångström , Halina Miller-Podraza , Martina Pantzar , Kart-Anders Karlsson , Maria Blomqvist , Annamari Helskanen , Ritva Niemela , Jari Helin , Jari Natunen
CPC分类号： A61K31/7028
摘要： The present invention relates to long branched poly-N-acetyllactosamines and analogous spacer modified divalent sialosides binding to the large binding site of influenza hemagglutinin. The invention further relates to the method for evaluating the potential of a chemical entity to bind to a molecule or molecular complex comprising a large binding site of influenza hemagglutinin. The invention also provides ligands to influenza hemagglutinin for use in the prevention and/or treatment of influenza.
摘要翻译： 本发明涉及与流感血凝素的大结合位点结合的长支链聚-N-乙酰乳糖胺和类似的间隔子修饰的二价唾液酸苷。 本发明还涉及用于评估化学实体结合包含流感血凝素的大结合位点的分子或分子复合物的潜力的方法。 本发明还提供用于预防和/或治疗流感的流感血凝素的配体。
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公开(公告)号：US20050220819A1
公开(公告)日：2005-10-06
申请号：US10501786
申请日：2003-01-20
申请人： Halina Miller-Podraza , Susann Teneberg , Jonas Angstrom , Karl-Anders Karlsson , Jari Natunen , Jari Helin
发明人： Halina Miller-Podraza , Susann Teneberg , Jonas Angstrom , Karl-Anders Karlsson , Jari Natunen , Jari Helin
IPC分类号： A23L1/30 , A61K9/10 , A61K31/702 , A61K31/7028 , A61K31/715 , A61K31/726 , A61K39/00 , A61K47/48 , A61P1/04 , A61P1/16 , A61P1/18 , A61P7/06 , A61P9/00 , A61P17/00 , A61P31/04 , A61P35/00 , A61P37/00 , A61P37/02 , C07H3/02 , C07H5/06 , C08B37/00 , C12P19/26 , C12Q1/02 , C12R1/01 , C07K14/195 , A61K39/02
CPC分类号： A61K31/726 , A61K31/702 , A61K31/7028 , A61K31/715
摘要： The present application describes a binding epitope to Helicobacter pylori, namely substances comprising the oligosaccharide sequence -Gal(Nac)r2$g(b)4Glc(A)q2(Nac)r3-, and the use thereof in pharmaceutical and nutritional compositions for the treatment of conditions due to the presence of Helicobacter pylori in a subject, e.g. gastritis, gastric ulcers, gastric adenocarcinoma, liver disease, pancreatic disease, skin disease, heart disease, autoimmune diseases and sudden infant death syndrome. The invention is also directed to the use of the receptor for diagnostics of Helicobacter pylori, to a method of producing chondroitin oligosaccharides from chondroitin sulphates, and a method for production of amidated glucuronic acid comprising oligosaccharides and monosaccharides from glucuronic acid comprising polysaccharides.
摘要翻译： 本申请描述了幽门螺旋杆菌的结合表位，即包含寡糖序列的物质 - （G）（b）4Glc（A）Q2（Nac） 和其在药物和营养组合物中的用途，用于治疗由于幽门螺杆菌在受试者中的存在而引起的病症，例如 胃炎，胃溃疡，胃腺癌，肝病，胰腺疾病，皮肤病，心脏病，自身免疫性疾病和婴儿猝死综合征。 本发明还涉及用于诊断幽门螺杆菌的用途，用于从硫酸软骨素生产软骨素寡糖的方法，以及包含寡糖和包含多糖的葡糖醛酸的单糖的酰胺化葡糖醛酸的方法。
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公开(公告)号：US20100074920A1
公开(公告)日：2010-03-25
申请号：US12447018
申请日：2007-10-26
申请人： Jari Natunen , Jukka Hiltunen , Ritva Niemela , Jari Helin , Olli Aitio
发明人： Jari Natunen , Jukka Hiltunen , Ritva Niemela , Jari Helin , Olli Aitio
CPC分类号： A61K39/145 , A61K38/00 , A61K39/00 , A61K39/12 , A61K2039/64 , C07K5/0815 , C07K5/0821 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , G01N33/56983 , G01N2333/11 , Y10T436/143333
摘要： The invention relates to the method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus. The invention also provides peptide epitopes 5 for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza.
摘要翻译： 本发明涉及用于评价化学实体（例如抗体）与源自流感病毒血凝素蛋白的二价唾液酸苷结合位点的肽表位结合的方法。 本发明还提供了用于预防和/或治疗流感或用于开发这种针对流感的治疗或疫苗的肽表位。
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公开(公告)号：US20110191867A1
公开(公告)日：2011-08-04
申请号：US12739796
申请日：2008-10-24
申请人： Jari Natunen , Jukka Hiltunen , Ritva Niemela , Jari Helin , Olli Aitio
发明人： Jari Natunen , Jukka Hiltunen , Ritva Niemela , Jari Helin , Olli Aitio
CPC分类号： A61K39/145 , A61K38/00 , A61K39/00 , A61K39/12 , A61K2039/64 , C07K5/0815 , C07K5/0821 , C07K14/005 , C12N2760/16122 , C12N2760/16134 , G01N33/56983 , G01N2333/11 , Y10T436/143333
摘要： The invention provides peptide epitopes for use in the prevention and/or treatment of influenza or for the development of such treatment or vaccine against influenza. The invention also relates to a method for evaluating the potential of a chemical entity, such as an antibody, to bind to a peptide epitope derived from the divalent sialoside binding site of hemagglutinin protein of influenza virus, and to conjugates containing one or more such peptide epitopes. The peptide epitopes of the invention are cyclic peptides comprising a 7-mer peptide derived from H1, H3 or H5 hemagglutinin of influenza virus. The 7-mer peptide has a sequence corresponding to the loop sequence at positions 220-226 of X31-hemagglutinin.
摘要翻译： 本发明提供用于预防和/或治疗流感或用于开发这种针对流感的治疗或疫苗的肽表位。 本发明还涉及用于评价化学实体（例如抗体）与流感病毒血凝素蛋白的二价唾液酸苷结合位点衍生的肽表位结合的方法，以及含有一种或多种这样的肽的缀合物 表位。 本发明的肽表位是包含源自流感病毒的H1，H3或H5血凝素的7聚体肽的环肽。 7聚体肽具有与X31-血凝素的220-226位的环序列相对应的序列。
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公开(公告)号：US20090324617A1
公开(公告)日：2009-12-31
申请号：US12320297
申请日：2009-01-22
申请人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Anne Olonen , Noora Salovuori , Juhani Saarinen , Jari Helin
发明人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Anne Olonen , Noora Salovuori , Juhani Saarinen , Jari Helin
CPC分类号： G01N33/574 , A61K39/0011 , A61K2039/505 , C07K16/3076 , G01N33/57469 , G01N2400/00
摘要： The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer specific glycans as well as methods for the production of reagents binding to said glycans. The invention is also directed to the use of said glycans and reagents binding to them for the diagnostics of cancer and malignancies. Furthermore, the invention is directed to the use of said glycans and reagents binding to them for the treatment of cancer and malignancies. Moreover, the present invention comprises efficient methods to differentiate between malignant and benign tumors by analyzing glycan structures.
摘要翻译： 本发明描述了由某些癌细胞，肿瘤和其他恶性组织特异性表达的聚糖。 本发明描述了检测癌症特异性聚糖的方法以及生产结合所述聚糖的试剂的方法。 本发明还涉及所述聚糖和与其结合的试剂用于癌症和恶性肿瘤的诊断的用途。 此外，本发明涉及使用所述聚糖和与其结合的试剂来治疗癌症和恶性肿瘤。 此外，本发明包括通过分析聚糖结构来区分恶性和良性肿瘤的有效方法。
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公开(公告)号：US20090117106A1
公开(公告)日：2009-05-07
申请号：US11989031
申请日：2006-07-20
申请人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Anne Olonen , Juhani Saarinen , Noora Salovuori , Jari Helin
发明人： Tero Satomaa , Jari Natunen , Annamari Heiskanen , Anne Olonen , Juhani Saarinen , Noora Salovuori , Jari Helin
IPC分类号： A61K39/395 , C12Q1/02 , C12Q1/34 , G01N33/53 , A61K39/00
CPC分类号： C07K16/44 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C12Q1/34 , G01N33/574 , G01N33/57488 , G01N33/57492 , G01N2400/38 , Y10T436/143333
摘要： The present invention describes glycans, which are specifically expressed by certain cancer cells, tumours and other malignant tissues. The present invention describes methods to detect cancer specific glycans as well as methods for the production of reagents binding to said glycans. The invention is also directed to the use of said glycans and reagents binding to them for the diagnostics of cancer and malignancies. Furthermore, the invention is directed to the use of said glycans and reagents binding to them for the treatment of cancer and malignancies. Moreover, the present invention comprises efficient methods to differentiate between malignant and benign tumors by analyzing glycan structures.
摘要翻译： 本发明描述了由某些癌细胞，肿瘤和其他恶性组织特异性表达的聚糖。 本发明描述了检测癌症特异性聚糖的方法以及生产结合所述聚糖的试剂的方法。 本发明还涉及所述聚糖和与其结合的试剂用于癌症和恶性肿瘤的诊断的用途。 此外，本发明涉及使用所述聚糖和与其结合的试剂来治疗癌症和恶性肿瘤。 此外，本发明包括通过分析聚糖结构来区分恶性和良性肿瘤的有效方法。
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公开(公告)号：US20110274646A1
公开(公告)日：2011-11-10
申请号：US13102451
申请日：2011-05-06
申请人： Johanna Nystedt , Heidi Anderson , Tero Satomaa , Jari Natunen , Jari Helin , Juhani Saarinen
发明人： Johanna Nystedt , Heidi Anderson , Tero Satomaa , Jari Natunen , Jari Helin , Juhani Saarinen
IPC分类号： A61K31/737 , C08B37/08 , A61P7/00 , A61K38/19
CPC分类号： A61K31/728 , A61K31/737 , A61K38/193 , C08B37/0072 , A61K2300/00
摘要： The present invention relates to a combination of a hyaluronan oligomer and/or polymer and a factor capable of mobilizing stem cells. The present invention also relates to a method for altering the relative amounts of blood cells and/or the types of blood cells in a subject by administering the combination to the subject. Further, the present invention relates to a method for mobilizing stem cells to the bloodstream of a subject by administering the combination to the subject. Additionally, the present invention relates to a hyaluronan oligomer and/or polymer.
摘要翻译： 本发明涉及透明质酸低聚物和/或聚合物的组合以及能够动员干细胞的因子。 本发明还涉及通过对受试者施用组合来改变受试者的血细胞相对量和/或血细胞类型的方法。 此外，本发明涉及一种通过向受试者施用组合来将干细胞移动到受试者的血液中的方法。 另外，本发明涉及透明质酸低聚物和/或聚合物。
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9.发明授权Production of a saccharide composition comprising glucans and mannans by alkaline and acid hydrolysis of yeast cells 有权通过酵母细胞的碱和酸水解生产包含葡聚糖和甘露聚糖的糖组合物公开(公告)号：US09320291B2
公开(公告)日：2016-04-26
申请号：US13140765
申请日：2009-12-18
申请人： Juhani Saarinen , Ritva Niemela , Jari Helin , Jari Natunen , Jukka Hiltunen
发明人： Juhani Saarinen , Ritva Niemela , Jari Helin , Jari Natunen , Jukka Hiltunen
IPC分类号： A61K45/00 , A61K47/00 , A61K31/715 , A61K36/06 , A61K36/064 , A23L1/09 , A23K1/16 , A23L1/30 , A23L2/52 , C08B37/00 , C12P19/04
CPC分类号： C12P19/04 , A23K20/163 , A23L2/52 , A23L5/00 , A23L29/30 , A23L31/10 , A23L33/10 , A23L33/14 , C08B37/0003 , C08B37/0087
摘要： The present invention is directed to a method of production of an immunostimulatory composition having a saccharide fraction, the method including the steps of hydrolyzes of yeast cells and recovering the soluble fraction. The saccharide fraction having composition thus obtained may be incorporated as a food or beverage component or be used as a pharmaceutical for treatment of specific conditions.
摘要翻译： 本发明涉及生产具有糖部分的免疫刺激组合物的方法，该方法包括水解酵母细胞并回收可溶性级分的步骤。 具有如此得到的组合物的糖类成分可以作为食品或饮料成分加入，也可以用作特定条件的药物。
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10.发明申请PRODUCTION OF A SACCHARIDE COMPOSITION COMPRISING GLUCANS AND MANNANS BY ALKALINE AND ACID HYDROLYSIS OF YEAST CELLS 有权通过碱性和酸分解YEAST细胞生产包含葡萄球菌和曼尼沙星的组合物公开(公告)号：US20110250235A1
公开(公告)日：2011-10-13
申请号：US13140765
申请日：2009-12-18
申请人： Juhani Saarinen , Ritva Niemela , Jari Helin , Jari Natunen , Jukka Hiltunen
发明人： Juhani Saarinen , Ritva Niemela , Jari Helin , Jari Natunen , Jukka Hiltunen
IPC分类号： A61K31/715 , A61P37/04 , A61P31/04
CPC分类号： C12P19/04 , A23K20/163 , A23L2/52 , A23L5/00 , A23L29/30 , A23L31/10 , A23L33/10 , A23L33/14 , C08B37/0003 , C08B37/0087
摘要： The present invention is directed to a method of production of an immunostimulatory composition having a saccharide fraction, the method including the steps of hydrolyses of yeast cells and recovering the soluble fraction. The saccharide fraction having composition thus obtained may be incorporated as a food or beverage component or be used as a pharmaceutical for treatment of specific conditions.
摘要翻译： 本发明涉及生产具有糖部分的免疫刺激组合物的方法，该方法包括水解酵母细胞并回收可溶性级分的步骤。 具有如此得到的组合物的糖类成分可以作为食品或饮料成分加入，也可以用作特定条件的药物。
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