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公开(公告)号：US08993734B2
公开(公告)日：2015-03-31
申请号：US12789365
申请日：2010-05-27
申请人： Leopold Bruckschwaiger , Sonja Svatos , Julia Nürnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenburger , Azra Pljevljakovic
发明人： Leopold Bruckschwaiger , Sonja Svatos , Julia Nürnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenburger , Azra Pljevljakovic
IPC分类号： A23J1/00 , C07K1/00 , C07K14/16 , C07K16/00 , C07K17/00 , C07K1/36 , A61K9/00 , A61K9/08 , A61K35/16 , A61K47/18 , C07K1/30 , C07K16/06 , A61K38/17 , C07K1/14 , C07K1/34 , C07K1/18
CPC分类号： C07K1/36 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K47/183 , C07K1/14 , C07K1/18 , C07K1/30 , C07K1/34 , C07K16/065
摘要： The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
摘要翻译： 本发明提供了用于制造IVIG产品的改进方法。 这些方法提供各种优点，例如在净化期间减少IgG的损失并提高最终产品的质量。 在其它方面，本发明提供适用于静脉内，皮下和/或肌内给药的水性和药物组合物。 在其它实施方案中，本发明提供了治疗疾病或病症的方法，包括施用本文提供的IgG组合物。
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2.发明申请REMOVAL OF SERINE PROTEASES BY TREATMENT WITH FINELY DIVIDED SILICON DIOXIDE 有权用精细二氧化硅二氧化硅处理去除丝氨酸蛋白公开(公告)号：US20110293594A1
公开(公告)日：2011-12-01
申请号：US13117028
申请日：2011-05-26
申请人： Wolfgang Teschner , Hans-Peter Schwarz , Ruth Madlener , Sonja Svatos , Azra Pljevljakovic , Alfred Weber
发明人： Wolfgang Teschner , Hans-Peter Schwarz , Ruth Madlener , Sonja Svatos , Azra Pljevljakovic , Alfred Weber
IPC分类号： A61K38/46 , C07K1/36 , A61K38/17 , A61P7/00 , C12N9/18 , A61K38/57 , A61K38/38 , C07K14/47 , C07K1/14 , C07K14/76
CPC分类号： C07K16/065 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K39/39525 , A61K47/183 , B01D15/12 , B01D15/362 , B01D15/363 , B01D15/424 , C07K1/30 , C07K1/36
摘要： The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.
摘要翻译： 本发明提供了用于降低血浆来源的蛋白质组合物的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的新方法。 还提供了制备具有降低的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的血浆衍生蛋白质组合物的方法。 在其它方面中，本发明提供具有降低的丝氨酸蛋白酶和/或丝氨酸蛋白酶酶原含量的血浆衍生蛋白质的水性和冻干组合物。 还有其它方面包括用于治疗，控制和/或预防疾病的方法，所述疾病包括施用具有降低的丝氨酸蛋白酶或丝氨酸蛋白酶酶原含量的血浆衍生的蛋白质组合物。
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公开(公告)号：US08772462B2
公开(公告)日：2014-07-08
申请号：US13117028
申请日：2011-05-26
申请人： Wolfgang Teschner , Hans-Peter Schwarz , Ruth Madlener , Sonja Svatos , Azra Pljevljakovic , Alfred Weber
发明人： Wolfgang Teschner , Hans-Peter Schwarz , Ruth Madlener , Sonja Svatos , Azra Pljevljakovic , Alfred Weber
CPC分类号： C07K16/065 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K39/39525 , A61K47/183 , B01D15/12 , B01D15/362 , B01D15/363 , B01D15/424 , C07K1/30 , C07K1/36
摘要： The present invention provides novel methods for reducing the serine protease and/or serine protease zymogen content of a plasma-derived protein composition. Also provided are methods for manufacturing plasma-derived protein compositions having reduced serine protease and\or serine protease zymogen content. Among yet other aspects, the present invention provides aqueous and lyophilized compositions of plasma-derived proteins having reduced serine protease and/or serine protease zymogen content. Yet other aspects include methods for treating, managing, and/or preventing a disease comprising the administration of a plasma-derived protein composition having a reduced serine protease or serine protease zymogen content.
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4.发明授权Process for producing a plasma protein-containing medicament with reduced concentration of citrate and metals 有权用于生产具有降低的柠檬酸盐和金属浓度的含血浆蛋白的药物的方法公开(公告)号：US08709492B2
公开(公告)日：2014-04-29
申请号：US11151295
申请日：2005-06-14
申请人： Wolfgang Teschner , Yendra Linnau , Sonja Svatos , Herwig Igel
发明人： Wolfgang Teschner , Yendra Linnau , Sonja Svatos , Herwig Igel
IPC分类号： A61K35/16
CPC分类号： A61K35/16 , A61K38/1709 , C07K14/76 , C07K16/06
摘要： There is disclosed a method of preparing a plasma-protein-containing medicament from citrated plasma or from a citrate-containing plasma fraction, the medicament being substantially free from undesired metals, which method comprises the following steps: exchanging the citrate and optionally citrate-bound metals in a plasma-protein-containing solution for a water-soluble mono- or dicarboxylate or for an organic mono- or dicarboxylic acid under non-precipitating conditions, recovering the plasma protein or the plasma proteins, and finishing the medicament.
摘要翻译： 公开了一种从柠檬酸盐血浆或含柠檬酸盐血浆级分制备含血浆蛋白的药物的方法，该药物基本上不含不期望的金属，该方法包括以下步骤：将柠檬酸盐和任选的柠檬酸盐结合 用于水溶性单羧酸盐或二羧酸盐的含血浆蛋白的溶液中的金属或非沉淀条件下的有机单羧酸或二羧酸的金属，回收血浆蛋白或血浆蛋白，以及整理药物。
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公开(公告)号：US08796430B2
公开(公告)日：2014-08-05
申请号：US13085056
申请日：2011-04-12
申请人： Leopold Bruckschwaiger , Sonja Svatos , Julia Nürnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenburger , Azra Pljevljakovic
发明人： Leopold Bruckschwaiger , Sonja Svatos , Julia Nürnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenburger , Azra Pljevljakovic
IPC分类号： A23J1/00 , C07K1/00 , C07K14/16 , C07K16/00 , C07K17/00 , C07K1/14 , C07K1/30 , C07K1/34 , C07K1/18
摘要： The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
摘要翻译： 本发明提供了用于制造IVIG产品的改进方法。 这些方法提供各种优点，例如在净化期间减少IgG的损失并提高最终产品的质量。 在其它方面，本发明提供适用于静脉内，皮下和/或肌内给药的水性和药物组合物。 在其它实施方案中，本发明提供了治疗疾病或病症的方法，包括施用本文提供的IgG组合物。
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公开(公告)号：US20110293638A1
公开(公告)日：2011-12-01
申请号：US12789365
申请日：2010-05-27
申请人： Leopold Bruckschwaiger , Sonja Svatos , Julia N+e,uml u+ee rnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenberger , Azra Pljevljakovic
发明人： Leopold Bruckschwaiger , Sonja Svatos , Julia N+e,uml u+ee rnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenberger , Azra Pljevljakovic
IPC分类号： A61K39/395 , A61P37/00 , A61P31/00
CPC分类号： C07K1/36 , A61K9/0019 , A61K9/08 , A61K35/16 , A61K38/1709 , A61K47/183 , C07K1/14 , C07K1/18 , C07K1/30 , C07K1/34 , C07K16/065
摘要： The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
摘要翻译： 本发明提供了用于制造IVIG产品的改进方法。 这些方法提供各种优点，例如在净化期间减少IgG的损失并提高最终产品的质量。 在其它方面，本发明提供适用于静脉内，皮下和/或肌内给药的水性和药物组合物。 在其它实施方案中，本发明提供了治疗疾病或病症的方法，包括施用本文提供的IgG组合物。
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7.发明申请Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof 有权透明质酸酶和免疫球蛋白的稳定共配方及其使用方法公开(公告)号：US20110066111A1
公开(公告)日：2011-03-17
申请号：US12807991
申请日：2010-09-16
申请人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
发明人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
CPC分类号： A61K39/00 , A61K9/0021 , A61K39/39591 , A61K47/42 , A61K2039/505 , C07K16/00 , C07K16/06 , C07K2317/21 , C12N9/2474 , C12Y302/01035 , Y02A50/464
摘要： Provided herein are stable co-formulations of immunoglobulin and hyaluronidase that are stable to storage in liquid form at room temperature for at least 6 months and at standard refrigerator temperatures for 1-2 years. Such co-formulations can be used in methods of treating IG-treatable diseases or conditions by subcutaneous administration.
摘要翻译： 本文提供了免疫球蛋白和透明质酸酶的稳定共配方，其在室温下以液体形式储存至少6个月，并在标准冰箱温度下保存1-2年。 这种共同制剂可用于通过皮下给药治疗IG治疗性疾病或病症的方法。
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8.发明授权Stable co-formulation of hyaluronidase and immunoglobulin, and methods of use thereof 有权透明质酸酶和免疫球蛋白的稳定共配方及其使用方法公开(公告)号：US09084743B2
公开(公告)日：2015-07-21
申请号：US12807991
申请日：2010-09-16
申请人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
发明人： Wolfgang Teschner , Sonja Svatos , Leopold Bruckschwaiger , Alfred Weber , Hans-Peter Schwarz , Laura Lei
CPC分类号： A61K39/00 , A61K9/0021 , A61K39/39591 , A61K47/42 , A61K2039/505 , C07K16/00 , C07K16/06 , C07K2317/21 , C12N9/2474 , C12Y302/01035 , Y02A50/464
摘要： Provided herein are stable co-formulations of immunoglobulin and hyaluronidase that are stable to storage in liquid form at room temperature for at least 6 months and at standard refrigerator temperatures for 1-2 years. Such co-formulations can be used in methods of treating IG-treatable diseases or conditions by subcutaneous administration.
摘要翻译： 本文提供了免疫球蛋白和透明质酸酶的稳定共配方，其在室温下以液体形式储存至少6个月，并在标准冰箱温度下保存1-2年。 这种共同制剂可用于通过皮下给药治疗IG治疗性疾病或病症的方法。
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公开(公告)号：US20110293598A1
公开(公告)日：2011-12-01
申请号：US13085056
申请日：2011-04-12
申请人： Leopold Bruckschwaiger , Sonja Svatos , Julia Nürnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenburger , Azra Pljevljakovic
发明人： Leopold Bruckschwaiger , Sonja Svatos , Julia Nürnberger , Wolfgang Teschner , Harald Arno Butterweck , Hans-Peter Schwarz , Thomas Gundinger , Bernhard Koelbl , Reinhard Grausenburger , Azra Pljevljakovic
IPC分类号： A61K39/395 , A61P31/00 , A61P37/00 , C07K16/00 , A61P37/04
摘要： The present invention provides improved methods for the manufacturing of IVIG products. These methods offer various advantages such as reduced loss of IgG during purification and improved quality of final products. In other aspects, the present invention provides aqueous and pharmaceutical compositions suitable for intravenous, subcutaneous, and/or intramuscular administration. In yet other embodiments, the present invention provides methods of treating a disease or condition comprising administration of an IgG composition provided herein.
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公开(公告)号：US20050249815A1
公开(公告)日：2005-11-10
申请号：US11151295
申请日：2005-06-14
申请人： Wolfgang Teschner , Yendra Linnau , Sonja Svatos , Herwig Igel
发明人： Wolfgang Teschner , Yendra Linnau , Sonja Svatos , Herwig Igel
CPC分类号： A61K35/16 , A61K38/1709 , C07K14/76 , C07K16/06
摘要： There is disclosed a method of preparing a plasma-protein-containing medicament from citrated plasma or from a citrate-containing plasma fraction, the medicament being substantially free from undesired metals, which method comprises the following steps: exchanging the citrate and optionally citrate-bound metals in a plasma-protein-containing solution for a water-soluble mono- or dicarboxylate or for an organic mono- or dicarboxylic acid under non-precipitating conditions, recovering the plasma protein or the plasma proteins, and finishing the medicament.
摘要翻译： 公开了一种从柠檬酸盐血浆或含柠檬酸盐血浆级分制备含血浆蛋白的药物的方法，该药物基本上不含不期望的金属，该方法包括以下步骤：将柠檬酸盐和任选的柠檬酸盐结合 用于水溶性单羧酸盐或二羧酸盐的含血浆蛋白的溶液中的金属或非沉淀条件下的有机单羧酸或二羧酸的金属，回收血浆蛋白或血浆蛋白，以及整理药物。
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