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公开(公告)号：US07283868B2
公开(公告)日：2007-10-16
申请号：US10204719
申请日：2001-04-05
申请人： Harvey W. Ko , Dexter G. Smith
发明人： Harvey W. Ko , Dexter G. Smith
IPC分类号： A61B5/05
CPC分类号： A61B5/0522 , A61B5/05 , A61B5/053 , A61B5/0536 , A61B5/4381
摘要： An electromagnetic bioimpedance measurement apparatus uses an alternating magnetic field to induce electrical eddy currents in biological tissue. The eddy currents produce secondary magnetic fields that have the effect of changing the mutual inductance between the tissue and the coil that applied to the initial magnetic field. The amplitude of the resultant voltage, as measured by the same coil or a different receiver coil, is proportional to the conductivity of the tissue. A simple, marginally stable oscillator circuit is used to generate the current into the coil. Nearfield holographic signal processing is then used for holographic image formation. Bioimpedance is used to distinguish between normal tissue and cancerous tissue, especially cancerous prostate tissue. An invasive embodiment includes driven needle electrodes that are inserted into the body segment to be tested. Noninvasive embodiments include single or multiple coils arranged on a probe shaft.
摘要翻译： 电磁生物阻抗测量装置使用交变磁场来诱导生物组织中的电涡流。 涡流产生二次磁场，其具有改变应用于初始磁场的组织和线圈之间的互感的作用。 由相同线圈或不同的接收器线圈测量的合成电压的幅度与组织的电导率成比例。 使用简单的，稍微稳定的振荡器电路来产生线圈中的电流。 然后将近场全息信号处理用于全息图像形成。 生物阻抗用于区分正常组织和癌组织，特别是癌前列腺组织。 侵入性实施例包括被插入被检体内段的驱动针电极。 非侵入性实施例包括布置在探针轴上的单个或多个线圈。
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公开(公告)号：US20220015669A1
公开(公告)日：2022-01-20
申请号：US17305787
申请日：2021-07-14
申请人： Harvey W. Ko
发明人： Harvey W. Ko
摘要： A noninvasive glucose monitoring device includes a drive-and-sense coil and an electronic oscillator with multiple circuits electrically connected to the coil. The drive-and-sense coil may be embedded in either a finger clip or a finger push button. The device measures bioimpedance with a magnetic field coil outside a user's finger. The coil measures blood and glucose electrical conductivity without penetrating the finger. No blood extraction is required. A noninvasive method of measuring glucose in-vivo includes placing the drive-and-sense coil next to a subject's finger and inducing magnetic fields in blood in the subject's finger. A change in mutual impedance between the drive-and-sense coil and the blood is measured at predetermined frequencies and glucose content is calculated from the change in mutual impedance according to a predetermined correlation for each frequency.
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公开(公告)号：US07830515B2
公开(公告)日：2010-11-09
申请号：US12141298
申请日：2008-06-18
申请人： George M. Murray , Cheryl S. Schein , David R. Kohler , Jennifer L. Sample , Jennifer A. Nix , Protagoras N. Cutchis , Adam K. Arabian , Harvey W. Ko , Micah A. Carlson , Michael P. McLoughlin
发明人： George M. Murray , Cheryl S. Schein , David R. Kohler , Jennifer L. Sample , Jennifer A. Nix , Protagoras N. Cutchis , Adam K. Arabian , Harvey W. Ko , Micah A. Carlson , Michael P. McLoughlin
IPC分类号： G01N21/25
CPC分类号： G01N21/645 , G01N21/64 , G01N21/6408 , G01N21/6486 , G01N2021/6413 , G01N2021/6421
摘要： A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.
摘要翻译： 提供了一种用于评估生物气溶胶样品的方法和装置，其包括检测频率和/或时间分辨率因子，其允许区分由生物气溶胶发射的多个信号，以从非生物来源的材料中选择性地检测生物气溶胶样品中包含的生物材料 并且可能与致病性生物气溶胶相关。
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公开(公告)号：US06765527B2
公开(公告)日：2004-07-20
申请号：US10048769
申请日：2002-01-31
IPC分类号： G01S1304
CPC分类号： G01S7/411 , G01N22/00 , G01S7/41 , G01S13/347 , G01S17/87
摘要： A harmonic radar nonlinear junction detector system for detecting concealed weapons, electronics, and other man-made objects utilizing state-of-the art wireless technology, circuit fabrication, signal synthesis, and computer processing techniques to detect and characterize man-made objects possessing nonlinear junctions. The system transmits a pair of low power waveforms and a receiver within the system is coherently tuned to harmonics of the transmitted frequencies of the waveforms to detect man-made metal objects and electronics that contain non-linear junctions. The receiver is also capable of receiving inter-modulation products reflected from the man-made objects that are a result of using two incident signals. The system uses two signal sources generating user-definable waveforms of variable frequencies in order to provide enhanced discrimination and target identification abilities via the processing of returned inter-modulation products.
摘要翻译： 一种谐波雷达非线性结检测器系统，用于利用最先进的无线技术，电路制造，信号合成和计算机处理技术来检测隐藏的武器，电子和其他人造物体，以检测和表征具有非线性的人造物体 路口 系统传输一对低功率波形，并且系统内的接收器被相干地调谐到波形的发射频率的谐波，以检测包含非线性结的人造金属物体和电子器件。 接收机还能够接收由人造物体反射的作为使用两个入射信号的结果的互调产物。 该系统使用两个信号源产生可变频率的用户可定义波形，以便通过返回的互调产物的处理来提供增强的识别和目标识别能力。
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5.发明授权Imaging objects in a dissipative medium by nearfield electromagnetic holography 失效通过近场电磁全息术在耗散介质中成像物体
公开(公告)号：US6084412A
公开(公告)日：2000-07-04
申请号：US824644
申请日：1997-03-24
申请人： Yanping Guo , Harvey W. Ko , Carl V. Nelson , David M. White
发明人： Yanping Guo , Harvey W. Ko , Carl V. Nelson , David M. White
摘要： A unique time-domain electromagnetic system and data processing technique which, using low frequency electromagnetic fields, can localize, in three-dimensions, the position of buried metallic objects is disclosed. The measurement system uses time-domain electromagnetic techniques on a scanning frame similar to a X-Y plotter. The system collects magnetic data over a large area above the buried object. The spatial information of the field detected on the ground is then processed with an unique `nearfield holographic` data processing method to reconstruct the field image of the buried object.
摘要翻译： 公开了一种使用低频电磁场的独特的时域电磁系统和数据处理技术，可以三维定位埋藏金属物体的位置。 测量系统在类似于X-Y绘图仪的扫描框架上使用时域电磁技术。 该系统在掩埋物体上方的大面积上收集磁性数据。 然后用独特的“近场全息”数据处理方法处理在地面上检测到的场的空间信息，以重建掩埋物体的场图像。
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6.发明授权Electromagnetic non-invasive measurement and monitoring system for osteoporosis 失效用于骨质疏松症的电磁无创测量和监测系统
公开(公告)号：US4850372A
公开(公告)日：1989-07-25
申请号：US89193
申请日：1987-08-25
申请人： Harvey W. Ko , Joseph P. Skura
发明人： Harvey W. Ko , Joseph P. Skura
CPC分类号： A61B5/053 , A61B5/4504
摘要： A method for noninvasively sensing bone mass loss associated with osteoporosis is disclosed. The method uses an electromagnetic field to measure impedance (or conductivity) changes in the bone. A decrease in conductivity is indicative of osteoporosis.
摘要翻译： 公开了一种用于非侵入性地感测与骨质疏松症相关的骨质量损失的方法。 该方法使用电磁场来测量骨骼中的阻抗（或电导率）变化。 电导率的降低表明骨质疏松症。
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7.发明授权Non-invasive electromagnetic technique for monitoring time-trends of physiological changes at a particular location in the brain 失效用于监测大脑特定位置的生理变化的时间趋势的非侵入式电磁技术
公开(公告)号：US4819648A
公开(公告)日：1989-04-11
申请号：US92268
申请日：1987-09-01
申请人： Harvey W. Ko
发明人： Harvey W. Ko
CPC分类号： A61B5/053 , A61B5/4064
摘要： An apparatus and method for non-invasively sensing physiological changes in the brain is disclosed. The apparatus and method uses an electromagnetic field to measure localized impedance changes in brain matter and fluid. The apparatus and method has particular application in providing time-trend measurements of the process of brain edema associated with head trauma.
摘要翻译： 公开了一种用于非侵入式感测大脑生理变化的装置和方法。 该装置和方法使用电磁场来测量脑物质和流体中的局部阻抗变化。 该装置和方法在提供与头部创伤相关的脑水肿过程的时间趋势测量中具有特别的应用。
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公开(公告)号：US11298055B2
公开(公告)日：2022-04-12
申请号：US17305787
申请日：2021-07-14
申请人： Harvey W. Ko
发明人： Harvey W. Ko
摘要： A noninvasive glucose monitoring device includes a drive-and-sense coil and an electronic oscillator with multiple circuits electrically connected to the coil. The drive-and-sense coil may be embedded in either a finger clip or a finger push button. The device measures bioimpedance with a magnetic field coil outside a user's finger. The coil measures blood and glucose electrical conductivity without penetrating the finger. No blood extraction is required. A noninvasive method of measuring glucose in-vivo includes placing the drive-and-sense coil next to a subject's finger and inducing magnetic fields in blood in the subject's finger. A change in mutual impedance between the drive-and-sense coil and the blood is measured at predetermined frequencies and glucose content is calculated from the change in mutual impedance according to a predetermined correlation for each frequency.
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9.发明授权公开(公告)号：US09370309B2
公开(公告)日：2016-06-21
申请号：US13885746
申请日：2011-11-18
CPC分类号： A61B5/04008 , A61B5/04009 , A61B5/6814 , A61B5/721 , A61B2562/0219
摘要： A magnetoencephalogram (MEG) system is provided for use with a head. The MEG system includes a shell, and three three-axis gradiometers and a computing portion. Each three-axis gradiometer detects a magnetic field vector from a magnetic dipole in the head and generates a respective detected signal based on the respective magnetic field vector. Each three-axis gradiometer is disposed at a respective position of the shell. The computing portion determines a location of the magnetic dipole based on the first detected signal, the second detected signal and the third detected signal.
摘要翻译： 提供脑磁图（MEG）系统用于头部。 MEG系统包括壳体和三个三轴梯度计和计算部分。 每个三轴梯度计检测来自头部中的磁偶极子的磁场矢量，并且基于相应的磁场矢量产生相应的检测信号。 每个三轴梯度计设置在壳体的相应位置。 计算部分基于第一检测信号，第二检测信号和第三检测信号来确定磁偶极子的位置。
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10.发明申请公开(公告)号：US20140005518A1
公开(公告)日：2014-01-02
申请号：US13885746
申请日：2011-11-18
IPC分类号： A61B5/04
CPC分类号： A61B5/04008 , A61B5/04009 , A61B5/6814 , A61B5/721 , A61B2562/0219
摘要： A magnetoencephalogram (MEG) system is provided for use with a head. The MEG system includes a shell, and three three-axis gradiometers and a computing portion. Each three-axis gradiometer detects a magnetic field vector from a magnetic dipole in the head and generates a respective detected signal based on the respective magnetic field vector. Each three-axis gradiometer is disposed at a respective position of the shell. The computing portion determines a location of the magnetic dipole based on the first detected signal, the second detected signal and the third detected signal.
摘要翻译： 提供脑磁图（MEG）系统用于头部。 MEG系统包括壳体和三个三轴梯度计和计算部分。 每个三轴梯度计检测来自头部中的磁偶极子的磁场矢量，并且基于相应的磁场矢量产生相应的检测信号。 每个三轴梯度计设置在壳体的相应位置。 计算部分基于第一检测信号，第二检测信号和第三检测信号来确定磁偶极子的位置。
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