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公开(公告)号:US20080254502A1
公开(公告)日:2008-10-16
申请号:US12141298
申请日:2008-06-18
申请人: George M. Murray , Cheryl S. Schein , David R. Kohler , Jennifer L. Sample , Jennifer A. Nix , Protagoras N. Cutchis , Adam K. Arabian , Harvey W. Ko , Micah A. Carlson , Michael P. McLoughlin
发明人: George M. Murray , Cheryl S. Schein , David R. Kohler , Jennifer L. Sample , Jennifer A. Nix , Protagoras N. Cutchis , Adam K. Arabian , Harvey W. Ko , Micah A. Carlson , Michael P. McLoughlin
CPC分类号: G01N21/645 , G01N21/64 , G01N21/6408 , G01N21/6486 , G01N2021/6413 , G01N2021/6421
摘要: A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.
摘要翻译: 提供了一种用于评估生物气溶胶样品的方法和装置,其包括检测频率和/或时间分辨率因子,其允许区分由生物气溶胶发射的多个信号,以从非生物来源的材料中选择性地检测生物气溶胶样品中包含的生物材料 并且可能与致病性生物气溶胶相关。
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公开(公告)号:US07830515B2
公开(公告)日:2010-11-09
申请号:US12141298
申请日:2008-06-18
申请人: George M. Murray , Cheryl S. Schein , David R. Kohler , Jennifer L. Sample , Jennifer A. Nix , Protagoras N. Cutchis , Adam K. Arabian , Harvey W. Ko , Micah A. Carlson , Michael P. McLoughlin
发明人: George M. Murray , Cheryl S. Schein , David R. Kohler , Jennifer L. Sample , Jennifer A. Nix , Protagoras N. Cutchis , Adam K. Arabian , Harvey W. Ko , Micah A. Carlson , Michael P. McLoughlin
IPC分类号: G01N21/25
CPC分类号: G01N21/645 , G01N21/64 , G01N21/6408 , G01N21/6486 , G01N2021/6413 , G01N2021/6421
摘要: A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.
摘要翻译: 提供了一种用于评估生物气溶胶样品的方法和装置,其包括检测频率和/或时间分辨率因子,其允许区分由生物气溶胶发射的多个信号,以从非生物来源的材料中选择性地检测生物气溶胶样品中包含的生物材料 并且可能与致病性生物气溶胶相关。
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公开(公告)号:US20110049390A1
公开(公告)日:2011-03-03
申请号:US12939265
申请日:2010-11-04
申请人: George M. Murray , Cheryl S. Schein , David R. Kohler , Jennifer L. Sample , Jennifer A. Nix , Protagoras N. Cutchis , Adam K. Arabian , Harvey W. Ko , Micah A. Carlson , Michael P. McLoughlin
发明人: George M. Murray , Cheryl S. Schein , David R. Kohler , Jennifer L. Sample , Jennifer A. Nix , Protagoras N. Cutchis , Adam K. Arabian , Harvey W. Ko , Micah A. Carlson , Michael P. McLoughlin
CPC分类号: G01N21/645 , G01N21/64 , G01N21/6408 , G01N21/6486 , G01N2021/6413 , G01N2021/6421
摘要: A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.
摘要翻译: 提供了一种用于评估生物气溶胶样品的方法和装置,其包括检测频率和/或时间分辨率因子,其允许区分由生物气溶胶发射的多个信号,以从非生物来源的材料中选择性地检测生物气溶胶样品中包含的生物材料 并且可能与致病性生物气溶胶相关。
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公开(公告)号:US07494769B2
公开(公告)日:2009-02-24
申请号:US10503168
申请日:2003-04-16
申请人: George M. Murray , Cheryl S. Schein , David R. Kohler , Jennifer L. Sample , Jennifer A. Nix , Protagoras N. Cutchis , Adam K. Arabian , Harvey W. Ko , Micah A. Carlson , Michael P. McLoughlin
发明人: George M. Murray , Cheryl S. Schein , David R. Kohler , Jennifer L. Sample , Jennifer A. Nix , Protagoras N. Cutchis , Adam K. Arabian , Harvey W. Ko , Micah A. Carlson , Michael P. McLoughlin
IPC分类号: C12Q1/70
CPC分类号: G01N21/645 , G01N21/64 , G01N21/6408 , G01N21/6486 , G01N2021/6413 , G01N2021/6421
摘要: A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.
摘要翻译: 提供了一种用于评估生物气溶胶样品的方法和装置,其包括检测频率和/或时间分辨率因子,其允许区分由生物气溶胶发射的多个信号,以从非生物来源的材料中选择性地检测生物气溶胶样品中包含的生物材料 并且可能与致病性生物气溶胶相关。
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公开(公告)号:US06261848B1
公开(公告)日:2001-07-17
申请号:US09074644
申请日:1998-05-08
申请人: Charles W. Anderson , C. Brent Bargeron , Richard C. Benson , Micah A. Carlson , Allan B. Fraser , John D. Groopman , Harvey W. Ko , David R. Kohler , Terry E. Phillips , Paul T. Strickland
发明人: Charles W. Anderson , C. Brent Bargeron , Richard C. Benson , Micah A. Carlson , Allan B. Fraser , John D. Groopman , Harvey W. Ko , David R. Kohler , Terry E. Phillips , Paul T. Strickland
IPC分类号: G01N33543
CPC分类号: G01N1/40 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L2200/04 , B01L2200/10 , B01L2300/0867 , B01L2400/0481 , G01N1/405 , G01N21/6428 , G01N21/645 , G01N30/02 , G01N33/54373 , G01N33/582 , G01N2001/022 , G01N2201/0221 , B01D15/3804
摘要: A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined. The rinsing and elution fluids, and/or the affinity column can be placed in a module for easy insertion and removal from the sensor when depleted or when the sensor is to be used against a different analyte.
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公开(公告)号:US06969605B2
公开(公告)日:2005-11-29
申请号:US09906243
申请日:2001-07-16
申请人: Charles W. Anderson , C. Brent Bargeron , Richard C. Benson , Micah A. Carlson , Allan B. Fraser , John D. Groopman , Harvey W. Ko , David R. Kohler , Terry E. Phillips , Paul T. Strickland
发明人: Charles W. Anderson , C. Brent Bargeron , Richard C. Benson , Micah A. Carlson , Allan B. Fraser , John D. Groopman , Harvey W. Ko , David R. Kohler , Terry E. Phillips , Paul T. Strickland
IPC分类号: B01L3/00 , G01N1/02 , G01N1/40 , G01N21/64 , G01N21/76 , G01N21/78 , G01N30/02 , G01N33/543 , G01N33/58 , C12M3/00
CPC分类号: G01N1/40 , B01L3/5027 , B01L3/502715 , B01L3/502753 , B01L2200/04 , B01L2200/10 , B01L2300/0867 , B01L2400/0481 , G01N1/405 , G01N21/6428 , G01N21/645 , G01N30/02 , G01N33/54373 , G01N33/582 , G01N2001/022 , G01N2201/0221 , B01D15/3804
摘要: A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined. The rinsing and elution fluids, and/or the affinity column can be placed in a module for easy insertion and removal from the sensor when depleted or when the sensor is to be used against a different analyte.
摘要翻译: 用于检测和量化多种分析物的手持式,独立的,自动的,低功率和快速的传感器平台。 可能含有未知量的分析物的样品溶液通过亲和柱,其包含分析物结合的抗体,从而提取分析物。 然后漂洗亲和柱以除去可能发荧光的任何其他化学物质。 然后用已知体积的洗脱液洗脱漂洗的亲和柱,使得分析物从抗体中释放并溶解在流体(洗脱剂)中。 然后将洗脱液置于荧光计的石英比色杯中。 悬浮在洗脱液中的分析物以与激发它的光源不同的波段发出荧光。 测量荧光的量并测定分析物的水平。 冲洗和洗脱流体和/或亲和柱可以放置在模块中,以便在耗尽时或当传感器用于抵抗不同分析物时容易地从传感器中插入和移除。
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