公开(公告)号：US06600320B2

公开(公告)日：2003-07-29

申请号：US09928632

申请日：2001-08-13

申请人： Yanping Guo ,  Harvey W. Ko ,  Carl V. Nelson ,  David M. White

发明人： Yanping Guo ,  Harvey W. Ko ,  Carl V. Nelson ,  David M. White

IPC分类号： G01V308

CPC分类号： G01V3/15 ,  G01V3/12

摘要： A unique time-domain electromagnetic system and data processing technique which, using low frequency electromagnetic fields, can localize, in three-dimensions, the position of buried metallic objects is disclosed. The measurement system uses time-domain electromagnetic techniques on a scanning frame similar to a X-Y plotter. The system collects magnetic data over a large area above the buried object. The spatial information of the field detected on the ground is then processed with an unique ‘nearfield holographic’ data processing method to reconstruct the field image of the buried object.

摘要翻译： 公开了一种使用低频电磁场的独特的时域电磁系统和数据处理技术，可以三维定位埋藏金属物体的位置。 测量系统在类似于X-Y绘图仪的扫描框架上使用时域电磁技术。 该系统在掩埋物体上方的大面积上收集磁性数据。 然后用独特的“近场全息”数据处理方法处理在地面上检测到的场的空间信息，以重建被埋物体的场图像。

公开(公告)号：US6084412A

公开(公告)日：2000-07-04

申请号：US824644

申请日：1997-03-24

申请人： Yanping Guo ,  Harvey W. Ko ,  Carl V. Nelson ,  David M. White

发明人： Yanping Guo ,  Harvey W. Ko ,  Carl V. Nelson ,  David M. White

IPC分类号： G01V3/11 ,  G01V3/12 ,  G01V3/15 ,  C01V3/11 ,  G01N27/72 ,  C01V3/36 ,  C01V3/38

CPC分类号： G01V3/15 ,  G01V3/12

摘要： A unique time-domain electromagnetic system and data processing technique which, using low frequency electromagnetic fields, can localize, in three-dimensions, the position of buried metallic objects is disclosed. The measurement system uses time-domain electromagnetic techniques on a scanning frame similar to a X-Y plotter. The system collects magnetic data over a large area above the buried object. The spatial information of the field detected on the ground is then processed with an unique `nearfield holographic` data processing method to reconstruct the field image of the buried object.

摘要翻译： 公开了一种使用低频电磁场的独特的时域电磁系统和数据处理技术，可以三维定位埋藏金属物体的位置。 测量系统在类似于X-Y绘图仪的扫描框架上使用时域电磁技术。 该系统在掩埋物体上方的大面积上收集磁性数据。 然后用独特的“近场全息”数据处理方法处理在地面上检测到的场的空间信息，以重建掩埋物体的场图像。

公开(公告)号：US06765527B2

公开(公告)日：2004-07-20

申请号：US10048769

申请日：2002-01-31

申请人： Daniel G. Jablonski ,  Harvey W. Ko ,  Douglas A. Oursler ,  Dexter G. Smith ,  David M. White

发明人： Daniel G. Jablonski ,  Harvey W. Ko ,  Douglas A. Oursler ,  Dexter G. Smith ,  David M. White

IPC分类号： G01S1304

CPC分类号： G01S7/411 ,  G01N22/00 ,  G01S7/41 ,  G01S13/347 ,  G01S17/87

摘要： A harmonic radar nonlinear junction detector system for detecting concealed weapons, electronics, and other man-made objects utilizing state-of-the art wireless technology, circuit fabrication, signal synthesis, and computer processing techniques to detect and characterize man-made objects possessing nonlinear junctions. The system transmits a pair of low power waveforms and a receiver within the system is coherently tuned to harmonics of the transmitted frequencies of the waveforms to detect man-made metal objects and electronics that contain non-linear junctions. The receiver is also capable of receiving inter-modulation products reflected from the man-made objects that are a result of using two incident signals. The system uses two signal sources generating user-definable waveforms of variable frequencies in order to provide enhanced discrimination and target identification abilities via the processing of returned inter-modulation products.

摘要翻译： 一种谐波雷达非线性结检测器系统，用于利用最先进的无线技术，电路制造，信号合成和计算机处理技术来检测隐藏的武器，电子和其他人造物体，以检测和表征具有非线性的人造物体 路口 系统传输一对低功率波形，并且系统内的接收器被相干地调谐到波形的发射频率的谐波，以检测包含非线性结的人造金属物体和电子器件。 接收机还能够接收由人造物体反射的作为使用两个入射信号的结果的互调产物。 该系统使用两个信号源产生可变频率的用户可定义波形，以便通过返回的互调产物的处理来提供增强的识别和目标识别能力。

公开(公告)号：US07283868B2

公开(公告)日：2007-10-16

申请号：US10204719

申请日：2001-04-05

申请人： Harvey W. Ko ,  Dexter G. Smith

发明人： Harvey W. Ko ,  Dexter G. Smith

IPC分类号： A61B5/05

CPC分类号： A61B5/0522 ,  A61B5/05 ,  A61B5/053 ,  A61B5/0536 ,  A61B5/4381

摘要： An electromagnetic bioimpedance measurement apparatus uses an alternating magnetic field to induce electrical eddy currents in biological tissue. The eddy currents produce secondary magnetic fields that have the effect of changing the mutual inductance between the tissue and the coil that applied to the initial magnetic field. The amplitude of the resultant voltage, as measured by the same coil or a different receiver coil, is proportional to the conductivity of the tissue. A simple, marginally stable oscillator circuit is used to generate the current into the coil. Nearfield holographic signal processing is then used for holographic image formation. Bioimpedance is used to distinguish between normal tissue and cancerous tissue, especially cancerous prostate tissue. An invasive embodiment includes driven needle electrodes that are inserted into the body segment to be tested. Noninvasive embodiments include single or multiple coils arranged on a probe shaft.

摘要翻译： 电磁生物阻抗测量装置使用交变磁场来诱导生物组织中的电涡流。 涡流产生二次磁场，其具有改变应用于初始磁场的组织和线圈之间的互感的作用。 由相同线圈或不同的接收器线圈测量的合成电压的幅度与组织的电导率成比例。 使用简单的，稍微稳定的振荡器电路来产生线圈中的电流。 然后将近场全息信号处理用于全息图像形成。 生物阻抗用于区分正常组织和癌组织，特别是癌前列腺组织。 侵入性实施例包括被插入被检体内段的驱动针电极。 非侵入性实施例包括布置在探针轴上的单个或多个线圈。

公开(公告)号：US11298055B2

公开(公告)日：2022-04-12

申请号：US17305787

申请日：2021-07-14

申请人： Harvey W. Ko

发明人： Harvey W. Ko

IPC分类号： A61B5/145 ,  A61B5/01 ,  A61B5/00

摘要： A noninvasive glucose monitoring device includes a drive-and-sense coil and an electronic oscillator with multiple circuits electrically connected to the coil. The drive-and-sense coil may be embedded in either a finger clip or a finger push button. The device measures bioimpedance with a magnetic field coil outside a user's finger. The coil measures blood and glucose electrical conductivity without penetrating the finger. No blood extraction is required. A noninvasive method of measuring glucose in-vivo includes placing the drive-and-sense coil next to a subject's finger and inducing magnetic fields in blood in the subject's finger. A change in mutual impedance between the drive-and-sense coil and the blood is measured at predetermined frequencies and glucose content is calculated from the change in mutual impedance according to a predetermined correlation for each frequency.

公开(公告)号：US09370309B2

公开(公告)日：2016-06-21

申请号：US13885746

申请日：2011-11-18

申请人： Harvey W. Ko ,  Ibolja Cernak ,  Michael P. McLoughlin

发明人： Harvey W. Ko ,  Ibolja Cernak ,  Michael P. McLoughlin

IPC分类号： A61B5/04 ,  A61B5/00

CPC分类号： A61B5/04008 ,  A61B5/04009 ,  A61B5/6814 ,  A61B5/721 ,  A61B2562/0219

摘要： A magnetoencephalogram (MEG) system is provided for use with a head. The MEG system includes a shell, and three three-axis gradiometers and a computing portion. Each three-axis gradiometer detects a magnetic field vector from a magnetic dipole in the head and generates a respective detected signal based on the respective magnetic field vector. Each three-axis gradiometer is disposed at a respective position of the shell. The computing portion determines a location of the magnetic dipole based on the first detected signal, the second detected signal and the third detected signal.

摘要翻译： 提供脑磁图（MEG）系统用于头部。 MEG系统包括壳体和三个三轴梯度计和计算部分。 每个三轴梯度计检测来自头部中的磁偶极子的磁场矢量，并且基于相应的磁场矢量产生相应的检测信号。 每个三轴梯度计设置在壳体的相应位置。 计算部分基于第一检测信号，第二检测信号和第三检测信号来确定磁偶极子的位置。

公开(公告)号：US20140005518A1

公开(公告)日：2014-01-02

申请号：US13885746

申请日：2011-11-18

申请人： Harvey W. Ko ,  Ibolja Cernak ,  Michael P. McLoughlin

发明人： Harvey W. Ko ,  Ibolja Cernak ,  Michael P. McLoughlin

IPC分类号： A61B5/04

CPC分类号： A61B5/04008 ,  A61B5/04009 ,  A61B5/6814 ,  A61B5/721 ,  A61B2562/0219

摘要： A magnetoencephalogram (MEG) system is provided for use with a head. The MEG system includes a shell, and three three-axis gradiometers and a computing portion. Each three-axis gradiometer detects a magnetic field vector from a magnetic dipole in the head and generates a respective detected signal based on the respective magnetic field vector. Each three-axis gradiometer is disposed at a respective position of the shell. The computing portion determines a location of the magnetic dipole based on the first detected signal, the second detected signal and the third detected signal.

摘要翻译： 提供脑磁图（MEG）系统用于头部。 MEG系统包括壳体和三个三轴梯度计和计算部分。 每个三轴梯度计检测来自头部中的磁偶极子的磁场矢量，并且基于相应的磁场矢量产生相应的检测信号。 每个三轴梯度计设置在壳体的相应位置。 计算部分基于第一检测信号，第二检测信号和第三检测信号来确定磁偶极子的位置。

公开(公告)号：US07126148B2

公开(公告)日：2006-10-24

申请号：US10621595

申请日：2003-07-17

申请人： George M. Murray ,  Harvey W. Ko ,  Glen Southard

发明人： George M. Murray ,  Harvey W. Ko ,  Glen Southard

IPC分类号： G01V5/10

CPC分类号： G01T3/06 ,  Y10S250/90

摘要： A system for detecting neutron radiation. A liquid cocktail mixture comprised of a neutron absorber and a scintillator is housed in a Teflon® tube having a mirror at one end of the tube and a windowed portal at the other end of the tube. Neutrons that penetrate the tube react with the neutron absorber producing ionization that excites a scintillator to produce photons. A photo-multiplier tube is coupled with the windowed portal for receiving photons and converting the photons to electrical signals. A processing device is coupled to the photo-multiplier output for receiving and analyzing the electrical signals so as to provide a measurement pertaining to the presence and relative strength of neutron radiation. The tube can be adapted to function as a portable survey instrument. Alternatively, the tube can be stretched to cover large apertured areas. In such implementations a wavelength shifter is employed to convert light emitted to another wavelength giving a multiplier effect necessary for long light guides.

摘要翻译： 一种用于检测中子辐射的系统。 由中子吸收剂和闪烁体组成的液体混合物混合物容纳在管的一端具有反射镜的Teflon管和管的另一端的窗口入口。 渗透管的中子与中子吸收剂反应产生电离，激发闪烁体产生光子。 光电倍增管与窗口门户耦合以接收光子并将光子转换成电信号。 处理装置耦合到光电倍增器输出端，用于接收和分析电信号，以提供与中子辐射的存在和相对强度有关的测量。 该管可适用于便携式测量仪器。 或者，管可以被拉伸以覆盖大的有孔区域。 在这种实现中，使用波长移位器将发射的光转换成另一波长，给出长光导所需的乘法器效应。

公开(公告)号：US06969605B2

公开(公告)日：2005-11-29

申请号：US09906243

申请日：2001-07-16

申请人： Charles W. Anderson ,  C. Brent Bargeron ,  Richard C. Benson ,  Micah A. Carlson ,  Allan B. Fraser ,  John D. Groopman ,  Harvey W. Ko ,  David R. Kohler ,  Terry E. Phillips ,  Paul T. Strickland

发明人： Charles W. Anderson ,  C. Brent Bargeron ,  Richard C. Benson ,  Micah A. Carlson ,  Allan B. Fraser ,  John D. Groopman ,  Harvey W. Ko ,  David R. Kohler ,  Terry E. Phillips ,  Paul T. Strickland

IPC分类号： B01L3/00 ,  G01N1/02 ,  G01N1/40 ,  G01N21/64 ,  G01N21/76 ,  G01N21/78 ,  G01N30/02 ,  G01N33/543 ,  G01N33/58 ,  C12M3/00

CPC分类号： G01N1/40 ,  B01L3/5027 ,  B01L3/502715 ,  B01L3/502753 ,  B01L2200/04 ,  B01L2200/10 ,  B01L2300/0867 ,  B01L2400/0481 ,  G01N1/405 ,  G01N21/6428 ,  G01N21/645 ,  G01N30/02 ,  G01N33/54373 ,  G01N33/582 ,  G01N2001/022 ,  G01N2201/0221 ,  B01D15/3804

摘要： A hand held, self-contained, automatic, low power and rapid sensor platform for detecting and quantifying a plurality of analytes. A sample solution potentially containing an unknown amount of an analyte is passed through an affinity column which contains antibodies to which the analyte binds thereby extracting the analyte. The affinity column is then rinsed to remove any other chemicals that may fluoresce. The rinsed affinity column is then eluted with a known volume of elution fluid causing the analyte to release from the antibody and dissolve in the fluid (eluant). The eluant is then placed in the quartz cuvette of a fluorometer. The analyte suspended in the eluant fluoresces at a waveband which is different than that of the light source that excites it. The amount of fluorescence is measured and the level of analyte determined. The rinsing and elution fluids, and/or the affinity column can be placed in a module for easy insertion and removal from the sensor when depleted or when the sensor is to be used against a different analyte.

摘要翻译： 用于检测和量化多种分析物的手持式，独立的，自动的，低功率和快速的传感器平台。 可能含有未知量的分析物的样品溶液通过亲和柱，其包含分析物结合的抗体，从而提取分析物。 然后漂洗亲和柱以除去可能发荧光的任何其他化学物质。 然后用已知体积的洗脱液洗脱漂洗的亲和柱，使得分析物从抗体中释放并溶解在流体（洗脱剂）中。 然后将洗脱液置于荧光计的石英比色杯中。 悬浮在洗脱液中的分析物以与激发它的光源不同的波段发出荧光。 测量荧光的量并测定分析物的水平。 冲洗和洗脱流体和/或亲和柱可以放置在模块中，以便在耗尽时或当传感器用于抵抗不同分析物时容易地从传感器中插入和移除。

公开(公告)号：US20080254502A1

公开(公告)日：2008-10-16

申请号：US12141298

申请日：2008-06-18

申请人： George M. Murray ,  Cheryl S. Schein ,  David R. Kohler ,  Jennifer L. Sample ,  Jennifer A. Nix ,  Protagoras N. Cutchis ,  Adam K. Arabian ,  Harvey W. Ko ,  Micah A. Carlson ,  Michael P. McLoughlin

发明人： George M. Murray ,  Cheryl S. Schein ,  David R. Kohler ,  Jennifer L. Sample ,  Jennifer A. Nix ,  Protagoras N. Cutchis ,  Adam K. Arabian ,  Harvey W. Ko ,  Micah A. Carlson ,  Michael P. McLoughlin

IPC分类号： C12Q1/04 ,  C12M1/00

CPC分类号： G01N21/645 ,  G01N21/64 ,  G01N21/6408 ,  G01N21/6486 ,  G01N2021/6413 ,  G01N2021/6421

摘要： A method and apparatus for evaluating a bioaerosol sample is provided which includes detecting frequency and/or time resolution factors that allow discriminate between a plurality of signals emitted by the bioaerosol to selectively detect biological materials contained in the bioaerosol sample from materials of non-biological origin and potentially associated with a pathogenic bioaerosol.

摘要翻译： 提供了一种用于评估生物气溶胶样品的方法和装置，其包括检测频率和/或时间分辨率因子，其允许区分由生物气溶胶发射的多个信号，以从非生物来源的材料中选择性地检测生物气溶胶样品中包含的生物材料 并且可能与致病性生物气溶胶相关。