公开(公告)号：US6150138A

公开(公告)日：2000-11-21

申请号：US305086

申请日：1999-05-04

Applicant: Dirk Lindemann ,  Axel Rethwilm

Inventor： Dirk Lindemann ,  Axel Rethwilm

IPC: C07K14/15 ,  C12N15/867 ,  C12P21/04 ,  C07H21/04 ,  C12N5/00

CPC classification number: C07K14/005 ,  C12N15/86 ,  C07K2319/00 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/15022 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2740/17022 ,  C12N2810/40 ,  C12N2810/50 ,  C12N2810/6054

Abstract: The invention concerns constructs for the expression of a protein comprising at least a modified FV envelope protein, the protein so obtained as well as the complementation cell line permitting the production of pseudotyped viral particle. It also concerns pharmaceutical composition comprising said particles and a method for treating a disease.

公开(公告)号：US6111087A

公开(公告)日：2000-08-29

申请号：US42012

申请日：1998-03-13

Applicant: Axel Rethwilm ,  Dirk Lindemann ,  Arend Jan Winter

Inventor： Axel Rethwilm ,  Dirk Lindemann ,  Arend Jan Winter

IPC: C07K14/15 ,  C12N15/867 ,  C07H21/04 ,  A61K39/21 ,  C07K16/00 ,  C12P21/04

CPC classification number: C12N15/86 ,  C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/15022 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2740/17022 ,  C12N2810/40 ,  C12N2810/50 ,  C12N2810/6054

Abstract: The invention concerns constructs for the expression of a protein comprising at least a modified FV envelope protein, the protein so obtained as well as the complementation cell line permitting the production of pseudotyped viral particle. It also concerns pharmaceutical composition comprising said particles and a method for treating a disease.

Abstract translation: 本发明涉及用于表达包含至少修饰的FV包膜蛋白的蛋白质，如此获得的蛋白质以及允许产生假型病毒颗粒的互补细胞系的蛋白质的构建体。 它还涉及包含所述颗粒的药物组合物和治疗疾病的方法。

公开(公告)号：US06703226B1

公开(公告)日：2004-03-09

申请号：US09923317

申请日：2001-08-08

Applicant: Dirk Lindemann ,  Axel Rethwilm

Inventor： Dirk Lindemann ,  Axel Rethwilm

IPC: C12P2104

CPC classification number: C12N15/86 ,  C07K14/005 ,  C07K2319/00 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/17022 ,  C12N2810/40 ,  C12N2810/50 ,  C12N2810/6054

Abstract: The invention concerns constructs for the expression of a protein comprising at least a modified FV envelope protein, the protein so obtained as well as the complementation cell line permitting the production of pseudotyped viral particle. It also concerns pharmaceutical composition comprising said particles and a method for treating a disease.

Abstract translation: 本发明涉及用于表达包含至少修饰的FV包膜蛋白的蛋白质，如此获得的蛋白质以及允许产生假型病毒颗粒的互补细胞系的蛋白质的构建体。 它还涉及包含所述颗粒的药物组合物和治疗疾病的方法。

公开(公告)号：US06277601B1

公开(公告)日：2001-08-21

申请号：US09457324

申请日：1999-12-09

Applicant: Axel Rethwilm ,  Dirk Lindemann ,  Arend Jan Winter

Inventor： Axel Rethwilm ,  Dirk Lindemann ,  Arend Jan Winter

IPC: C12P2104

CPC classification number: C12N15/86 ,  A61K39/00 ,  C07K14/005 ,  C07K2319/00 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/15022 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2740/17022 ,  C12N2810/40 ,  C12N2810/50 ,  C12N2810/6054

Abstract: The invention concerns constructs for the expression of a protein comprising at least a modified FV envelope protein, the protein so obtained as well as the complementation cell line permitting the production of pseudotyped viral particle. It also concerns pharmaceutical composition comprising said particles and a method for treating a disease.

Abstract translation: 本发明涉及用于表达包含至少修饰的FV包膜蛋白的蛋白质，如此获得的蛋白质以及允许产生假型病毒颗粒的互补细胞系的蛋白质的构建体。 它还涉及包含所述颗粒的药物组合物和治疗疾病的方法。

公开(公告)号：US06274722B1

公开(公告)日：2001-08-14

申请号：US09617917

申请日：2000-07-17

Applicant: Dirk Lindemann ,  Axel Rethwilm

Inventor： Dirk Lindemann ,  Axel Rethwilm

IPC: C07H2104

CPC classification number: C07K14/005 ,  C07K2319/00 ,  C12N15/86 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/15022 ,  C12N2740/15043 ,  C12N2740/15045 ,  C12N2740/17022 ,  C12N2810/40 ,  C12N2810/50 ,  C12N2810/6054

Abstract: The invention concerns constructs for the expression of a protein comprising at least a modified FV envelope protein, the protein so obtained as well as the complementation cell line permitting the production of pseudotyped viral particle. It also concerns pharmaceutical composition comprising said particles and a method for treating a disease.

公开(公告)号：US08309071B2

公开(公告)日：2012-11-13

申请号：US12147947

申请日：2008-06-27

Applicant: Dirk Lindemann ,  Kristin Stirnnagel ,  Daniel Lueftenegger

Inventor： Dirk Lindemann ,  Kristin Stirnnagel ,  Daniel Lueftenegger

IPC: A61K48/00

CPC classification number: A61K31/7115 ,  A61K38/00 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/16043 ,  C12N2740/16045 ,  C12N2740/17022 ,  C12N2810/6054

Abstract: The present invention concerns the technical field of nucleic acids and expression-optimized nucleic acids. The present invention concerns especially nucleic acids comprising a mutated foamy viral envelope gene encoding a foamy viral envelope polypeptide, which comprises a leader peptide (LP), a surface unit (SU) and a transmembrane domain (TM). The present invention also relates to modified polypeptides encoded by these nucleic acids. Furthermore, the present invention regards a method for preparing pseudotyped vector particles as well as a method for treating a genetic disorder comprising administering a nucleic acid or a polypeptide encoded by that nucleic acid.

Abstract translation: 本发明涉及核酸和表达优化的核酸的技术领域。 本发明尤其涉及包含编码泡沫病毒包膜多肽的突变泡沫病毒包膜基因的核酸，其包含前导肽（LP），表面单元（SU）和跨膜结构域（TM）。 本发明还涉及由这些核酸编码的修饰的多肽。 此外，本发明涉及一种制备假型载体颗粒的方法以及用于治疗遗传病症的方法，包括施用由该核酸编码的核酸或多肽。

公开(公告)号：US20120141440A1

公开(公告)日：2012-06-07

申请号：US13259190

申请日：2010-03-26

Applicant: Axel Rethwilm ,  Dirk Lindemann ,  Helmut Hanenberg ,  Wade D. Clapp

Inventor： Axel Rethwilm ,  Dirk Lindemann ,  Helmut Hanenberg ,  Wade D. Clapp

IPC: A61K48/00 ,  C12N5/10 ,  A61P7/06 ,  C12N15/63

CPC classification number: C12N15/86 ,  C12N2740/17032 ,  C12N2799/021

Abstract: The disclosure of the present application provides foamyvirus vectors, as well as methods and kits involving the same. In at least one embodiment, a plurality of recombinant vectors comprises an expression sequence encoding at least one component of a foamyvirus particle, wherein at least one codon of the expression sequence is optimized for expression in homo sapiens.

Abstract translation: 本申请的公开内容提供泡沫病毒载体，以及涉及其的方法和试剂盒。 在至少一个实施方案中，多个重组载体包含编码泡沫病毒颗粒的至少一种组分的表达序列，其中表达序列的至少一个密码子被优化用于在智人中表达。

公开(公告)号：US20090325870A1

公开(公告)日：2009-12-31

申请号：US12147947

申请日：2008-06-27

Applicant: Dirk Lindemann ,  Kristin Stirnnagel ,  Daniel Lueftenegger

Inventor： Dirk Lindemann ,  Kristin Stirnnagel ,  Daniel Lueftenegger

IPC: A61K38/16 ,  C12N15/11 ,  C07K14/00 ,  C12N15/00 ,  C12P19/34 ,  A61K31/7088

CPC classification number: A61K31/7115 ,  A61K38/00 ,  C07K14/005 ,  C12N15/86 ,  C12N2740/13043 ,  C12N2740/13045 ,  C12N2740/16043 ,  C12N2740/16045 ,  C12N2740/17022 ,  C12N2810/6054

Abstract: The present invention concerns the technical field of nucleic acids and expression-optimized nucleic acids. The present invention concerns especially nucleic acids comprising a mutated foamy viral envelope gene encoding a foamy viral envelope polypeptide, which comprises a leader peptide (LP), a surface unit (SU) and a transmembrane domain (TM). The present invention also relates to modified polypeptides encoded by these nucleic acids. Furthermore, the present invention regards a method for preparing pseudotyped vector particles as well as a method for treating a genetic disorder comprising administering a nucleic acid or a polypeptide encoded by that nucleic acid.

Abstract translation: 本发明涉及核酸和表达优化的核酸的技术领域。 本发明尤其涉及包含编码泡沫病毒包膜多肽的突变泡沫病毒包膜基因的核酸，其包含前导肽（LP），表面单元（SU）和跨膜结构域（TM）。 本发明还涉及由这些核酸编码的修饰的多肽。 此外，本发明涉及一种制备假型载体颗粒的方法以及用于治疗遗传病症的方法，包括施用由该核酸编码的核酸或多肽。

公开(公告)号：US06861029B2

公开(公告)日：2005-03-01

申请号：US10176434

申请日：2002-06-20

Applicant: Werner Menk ,  Dirk Lindemann ,  Dirk Richarz

Inventor： Werner Menk ,  Dirk Lindemann ,  Dirk Richarz

IPC: C21C1/10 ,  C21D1/30 ,  C21D5/02 ,  C21D7/06 ,  C22C37/04 ,  C22C37/10

CPC classification number: C22C37/04 ,  C21C1/10 ,  C21D1/30 ,  C21D5/02 ,  C21D7/06 ,  C22C37/10

Abstract: A modified nodular cast iron alloy contains positive additions of boron and silicon in a content of greater than 2.4% by wt.

Abstract translation: 改性球墨铸铁合金含有大于2.4重量％的硼和硅的正添加。

公开(公告)号：US5929222A

公开(公告)日：1999-07-27

申请号：US816439

申请日：1997-03-14

Applicant: Dirk Lindemann ,  Axel Rethwilm

Inventor： Dirk Lindemann ,  Axel Rethwilm

IPC: C12N15/09 ,  A61K35/12 ,  A61K35/76 ,  A61K38/00 ,  A61K39/00 ,  A61K39/21 ,  A61K48/00 ,  C07K14/15 ,  C07K19/00 ,  C12N5/00 ,  C12N5/10 ,  C12N7/00 ,  C12N15/00 ,  C12P21/02 ,  C12P21/04 ,  C12R1/91 ,  C12R1/92 ,  C07H21/04

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K2319/00 ,  C12N2740/17022 ,  C12N2810/40

Abstract: The invention concerns constructs for the expression of a protein comprising at least a modified FV envelope protein, the protein so obtained as well as the complementation cell line permitting the production of pseudotyped viral particle. It also concerns pharmaceutical composition comprising said particles and a method for treating a disease.