公开(公告)号：US06861473B2

公开(公告)日：2005-03-01

申请号：US10376095

申请日：2003-02-28

申请人： Mitchell J. Poss ,  Henk Blom ,  Alex Odufu ,  Robert Smakman

发明人： Mitchell J. Poss ,  Henk Blom ,  Alex Odufu ,  Robert Smakman

IPC分类号： A61M1/16 ,  B01J20/26 ,  B01J39/20 ,  B01J41/14 ,  C08F8/06 ,  C08G63/91

CPC分类号： B01J20/265 ,  A61M1/1696 ,  B01J20/26 ,  B01J39/20 ,  B01J41/14 ,  C08F8/06 ,  C08F8/10 ,  C08F212/08

摘要： Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.

摘要翻译： 提供生产大分子组合物并使用其的方法。 该方法包括制备树脂材料; 在树脂材料上形成乙酰基; 并通过一步反应氧化乙酰基，包括使亚砜与酸与乙酰基反应形成酮醛基。 大分子组合物能够在透析治疗期间从生理溶液例如尿素中除去有效量的一种或多种成分。

公开(公告)号：US20090218290A1

公开(公告)日：2009-09-03

申请号：US12465000

申请日：2009-05-13

申请人： Mitchell J. Poss ,  Henk Blom ,  Alex Odufu ,  Robert Smakman

发明人： Mitchell J. Poss ,  Henk Blom ,  Alex Odufu ,  Robert Smakman

IPC分类号： B01J39/18 ,  B01D15/04

CPC分类号： B01J20/265 ,  A61M1/1696 ,  B01J20/26 ,  B01J39/20 ,  B01J41/14 ,  C08F8/06 ,  C08F8/10 ,  C08F212/08

摘要： Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.

公开(公告)号：US07544737B2

公开(公告)日：2009-06-09

申请号：US10987331

申请日：2004-11-12

申请人： Mitchell J. Poss ,  Henk Blom ,  Alex Odufu ,  Robert Smakman

发明人： Mitchell J. Poss ,  Henk Blom ,  Alex Odufu ,  Robert Smakman

IPC分类号： C08F220/12 ,  C08L29/00 ,  C08F16/34 ,  C08F16/36 ,  C08F12/02 ,  C08F112/02

CPC分类号： B01J20/265 ,  A61M1/1696 ,  B01J20/26 ,  B01J39/20 ,  B01J41/14 ,  C08F8/06 ,  C08F8/10 ,  C08F212/08

摘要： Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.

摘要翻译： 提供生产大分子组合物并使用其的方法。 该方法包括制备树脂材料; 在树脂材料上形成乙酰基; 并通过一步反应氧化乙酰基，包括使亚砜与酸与乙酰基反应形成酮醛基。 大分子组合物能够在透析治疗期间从生理溶液例如尿素中除去有效量的一种或多种成分。

公开(公告)号：US20050123703A1

公开(公告)日：2005-06-09

申请号：US11042651

申请日：2005-01-24

申请人： Michael Ling ,  William Hurst ,  Lecon Woo ,  Algirdas Bindokas ,  Patrick Ryan ,  Scott Edwards ,  Henk Blom ,  Atul Khare

发明人： Michael Ling ,  William Hurst ,  Lecon Woo ,  Algirdas Bindokas ,  Patrick Ryan ,  Scott Edwards ,  Henk Blom ,  Atul Khare

IPC分类号： F16L11/04 ,  A61J1/10 ,  A61J1/14 ,  A61L29/12 ,  A61L31/00 ,  B29C35/08 ,  B29C65/04 ,  B32B1/08 ,  B32B25/08 ,  B32B27/08 ,  B32B27/32 ,  C08L23/08 ,  C08L23/12 ,  C08L23/14 ,  C08L51/00 ,  C08L53/02 ,  C08L75/04 ,  C08L77/00 ,  C08L101/00

CPC分类号： C08L23/12 ,  A61L29/126 ,  B29C65/04 ,  B29C66/1122 ,  B29C66/53262 ,  B29C66/71 ,  B29C66/7234 ,  B29C2035/0861 ,  B32B1/08 ,  B32B27/08 ,  B32B27/32 ,  C08L23/0815 ,  C08L23/0869 ,  C08L23/142 ,  C08L51/00 ,  C08L53/02 ,  C08L75/04 ,  C08L77/00 ,  C08L101/00 ,  C08L2314/06 ,  Y10T428/1352 ,  Y10T428/1386 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/31746 ,  Y10T428/31913 ,  Y10T428/31924 ,  Y10T428/31931 ,  C08L2666/24 ,  C08L2666/04 ,  B29C65/00 ,  B29K2079/08 ,  B29K2077/00 ,  B29K2075/02 ,  B29K2075/00 ,  B29K2067/00 ,  B29K2033/12 ,  B29K2033/08 ,  B29K2023/18 ,  B29K2023/14 ,  B29K2023/12 ,  B29K2023/086 ,  B29K2023/083 ,  B29K2023/08 ,  B29K2021/003 ,  B29K2009/00

摘要： The present invention provides a flowable material container assembly having a membrane tube disposed coaxially within a port tube. The membrane tube has an outer layer, a core layer, and an inner layer. The outer layer is a blend of a polyolefin and a thermoplastic elastomer. The core layer is a blend of a polyolefin and a thermoplastic elastomer. The inner layer is a blend of a polyolefin, a radio frequency susceptible polymer, and a thermoplastic elastomer.

摘要翻译： 本发明提供了一种可流动的材料容器组件，其具有同轴地设置在端口管内的膜管。 膜管具有外层，芯层和内层。 外层是聚烯烃和热塑性弹性体的共混物。 芯层是聚烯烃和热塑性弹性体的共混物。 内层是聚烯烃，射频敏感聚合物和热塑性弹性体的混合物。

公开(公告)号：US20090223899A1

公开(公告)日：2009-09-10

申请号：US12465005

申请日：2009-05-13

申请人： Mitchell J. Poss ,  Henk Blom ,  Alex Odufu ,  Robert Smakman

发明人： Mitchell J. Poss ,  Henk Blom ,  Alex Odufu ,  Robert Smakman

IPC分类号： B01D61/00 ,  C08F16/36

CPC分类号： B01J20/265 ,  A61M1/1696 ,  B01J20/26 ,  B01J39/20 ,  B01J41/14 ,  C08F8/06 ,  C08F8/10 ,  C08F212/08

摘要： Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.

摘要翻译： 提供生产大分子组合物并使用其的方法。 该方法包括制备树脂材料; 在树脂材料上形成乙酰基; 并通过一步反应氧化乙酰基，包括使亚砜与酸与乙酰基反应形成酮醛基。 大分子组合物能够在透析治疗期间从生理溶液例如尿素中除去有效量的一种或多种成分。

公开(公告)号：US20050131141A1

公开(公告)日：2005-06-16

申请号：US10987331

申请日：2004-11-12

申请人： Mitchell Poss ,  Henk Blom ,  Alex Odufu ,  Robert Smakman

发明人： Mitchell Poss ,  Henk Blom ,  Alex Odufu ,  Robert Smakman

IPC分类号： A61M1/16 ,  B01J20/26 ,  B01J39/20 ,  B01J41/14 ,  C08F8/06 ,  C08G63/48

CPC分类号： B01J20/265 ,  A61M1/1696 ,  B01J20/26 ,  B01J39/20 ,  B01J41/14 ,  C08F8/06 ,  C08F8/10 ,  C08F212/08

摘要： Methods of producing macromolecular compositions and using same are provided. The method includes preparing a resin material; forming an acetyl group on the resin material; and oxidizing the acetyl group via a one-step reaction including reacting a sulfoxide and an acid with the acetyl group to form a ketoaldehyde group. The macromolecular compositions are capable of removing an effective amount of one or more constituents from a physiological solution, such as urea during dialysis therapy.

公开(公告)号：US20050158499A1

公开(公告)日：2005-07-21

申请号：US11079767

申请日：2005-03-14

申请人： Michael Ling ,  William Hurst ,  Lecon Woo ,  Algirdas Bindokas ,  Patrick Ryan ,  Scott Edwards ,  Henk Blom ,  Atul Khare

发明人： Michael Ling ,  William Hurst ,  Lecon Woo ,  Algirdas Bindokas ,  Patrick Ryan ,  Scott Edwards ,  Henk Blom ,  Atul Khare

IPC分类号： F16L11/04 ,  A61J1/10 ,  A61J1/14 ,  A61L29/12 ,  A61L31/00 ,  B29C35/08 ,  B29C65/04 ,  B32B1/08 ,  B32B25/08 ,  B32B27/08 ,  B32B27/32 ,  C08L23/08 ,  C08L23/12 ,  C08L23/14 ,  C08L51/00 ,  C08L53/02 ,  C08L75/04 ,  C08L77/00 ,  C08L101/00

CPC分类号： C08L23/12 ,  A61L29/126 ,  B29C65/04 ,  B29C66/1122 ,  B29C66/53262 ,  B29C66/71 ,  B29C66/7234 ,  B29C2035/0861 ,  B32B1/08 ,  B32B27/08 ,  B32B27/32 ,  C08L23/0815 ,  C08L23/0869 ,  C08L23/142 ,  C08L51/00 ,  C08L53/02 ,  C08L75/04 ,  C08L77/00 ,  C08L101/00 ,  C08L2314/06 ,  Y10T428/1352 ,  Y10T428/1386 ,  Y10T428/139 ,  Y10T428/1393 ,  Y10T428/31746 ,  Y10T428/31913 ,  Y10T428/31924 ,  Y10T428/31931 ,  C08L2666/24 ,  C08L2666/04 ,  B29C65/00 ,  B29K2079/08 ,  B29K2077/00 ,  B29K2075/02 ,  B29K2075/00 ,  B29K2067/00 ,  B29K2033/12 ,  B29K2033/08 ,  B29K2023/18 ,  B29K2023/14 ,  B29K2023/12 ,  B29K2023/086 ,  B29K2023/083 ,  B29K2023/08 ,  B29K2021/003 ,  B29K2009/00

摘要： The present invention provides a flowable material container closure assembly having a port tube and a membrane tube. The port tube (I) has a first layer and a second layer, (A) the first layer is a polymer blend of: (1) from about 25% to about 50% by weight of the first layer a first polyolefin selected from the group consisting of polypropylene and polypropylene copolymers, (2) from about 0 to about 50% by weight of the first layer a second polyolefin selected from the group consisting of ethylene copolymers, ultra-low density polyethylene, polybutene, and butene ethylene copolymers; (3) from about 0% to about 40% by weight of the first layer a radio frequency susceptible polymer selected from the group consisting of polyamides, ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, polyureas, ethylene vinyl acetate copolymers with a vinyl acetate comonomer content from 12%-50% by weight of the copolymer, ethylene methyl acrylate copolymers with methyl acrylate comonomer content from 12%-40% by weight of the copolymer, ethylene vinyl alcohol with vinyl alcohol comonomer content from 12%-70% by mole percent of the copolymer; (4) from about 0% to about 40% of a first thermoplastic elastomer; and (B) the second layer is disposed coaxially within the first layer and is a second thermoplastic elastomer; and the (II) membrane tube is disposed coaxially within the port tube, the membrane tube has an outer layer, a core layer and an inner layer, the outer layer (A) is a polymer blend of: (1) from about 0% to about 60% by weight of the outer layer of a third polyolefin and (2) from about 40% to about 100% by weight of the outer layer of a second component of a third thermoplastic elastomer, the core layer (B) is attached to the outer layer, the core layer is a polymer blend of: (1) from about 35% to about 100% by weight of the core layer of a fourth thermoplastic elastomer and (2) from about 0% to about 65% by weight of the core layer of a fourth polyolefin; and (C) the inner layer is attached to the core layer on a side opposite of the outer layer, the inner layer is a polymer blend of: (1) from about 25% to about 55% by weight of the inner layer a fifth polyolefin, (2) from about 0 to about 50% by weight of the inner layer a sixth polyolefin selected from the group consisting of ethylene copolymers, ultra-low density polyethylene, polybutene, polybutadiene and butene ethylene copolymers; (3) from about 0% to about 60% by weight of the inner layer a radio frequency susceptible polymer selected from the group consisting of polyamides, ethylene acrylic acid copolymers, ethylene methacrylic acid copolymers, polyimides, polyurethanes, polyesters, polyureas, ethylene vinyl acetate copolymers with a vinyl acetate comonomer content from 12%-50% by weight of the copolymer, ethylene methyl acrylate copolymers with methyl acrylate comonomer content from 12%-40% by weight of the copolymer, ethylene vinyl alcohol with vinyl alcohol comonomer content from 12%-70% by mole percent of the copolymer; (4) from about 0% to about 40% by weight of the inner layer of a fifth thermoplastic elastomer.