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1.发明授权公开(公告)号：US08895747B2
公开(公告)日：2014-11-25
申请号：US13359667
申请日：2012-01-27
申请人： Dieter Heindl , Heribert Maerz , Axel Schmidt
发明人： Dieter Heindl , Heribert Maerz , Axel Schmidt
IPC分类号： C07D213/78 , C07D213/79 , C07D213/82 , C07D213/83 , C07D401/04 , C07D473/04 , C07D473/16
CPC分类号： C07D401/04 , C07D213/82 , C07D473/16
摘要： Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.
摘要翻译： 提供了通过使用N-杂芳基取代的吡啶盐（Zincke盐）合成N-取代的吡啶鎓化合物并使其与亲核胺反应的方法。 还公开了可能在上述反应中有用的试剂的新型嘌呤取代的吡啶基化合物。
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公开(公告)号：US07695980B2
公开(公告)日：2010-04-13
申请号：US11339454
申请日：2006-01-25
申请人： Dieter Heindl , Rupert Herrmann , Wolfgang Jenni , Heribert Maerz
发明人： Dieter Heindl , Rupert Herrmann , Wolfgang Jenni , Heribert Maerz
IPC分类号： G01N33/533 , C07K1/13 , C07D333/50 , C07D307/92
CPC分类号： C07D491/04 , A61K49/0021 , A61K49/0058 , C07D495/04 , G01N33/582 , Y10S436/80 , Y10T436/13 , Y10T436/200833 , Y10T436/201666
摘要： The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especially in immunoassays.
摘要翻译： 本发明涉及新颖的化学发光化合物，涉及将这些化合物合成的方法，包含这些化合物的衍生物和缀合物，以使用这些化合物或其缀合物在基于化学发光的测定中，特别是在免疫测定中。
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公开(公告)号：US20060216736A1
公开(公告)日：2006-09-28
申请号：US11370527
申请日：2006-03-08
申请人： Dieter Heindl , Thomas Froehlich , Heribert Maerz , Monika Seller
发明人： Dieter Heindl , Thomas Froehlich , Heribert Maerz , Monika Seller
摘要： The current invention restates substituted nitroindole nucleosides as both terminal as well as internal building blocks of labeled oligonucleotide probes for the detection, analysis and quantitation of nucleic acids. The substituent comprises a linker and a detectable group or a linker and a reactive group for post synthesis coupling. These modified nucleosides grant access to a wide application area. These new substituted nitroindole nucleosides can be used as labeling reagents for the facile preparation of, e.g., optimized hybridization probes, simple probes, TAQMAN-probes or molecular beacon probes.
摘要翻译： 本发明将取代的硝基吲哚核苷作为两个末端以及用于核酸检测，分析和定量的标记的寡核苷酸探针的内部构建块。 取代基包括接头和可检测的基团或接头以及用于后合成偶联的反应性基团。 这些修饰的核苷允许进入广泛的应用领域。 这些新的取代的硝基吲哚核苷可以用作易于制备例如优化的杂交探针，简单探针，TAQMAN探针或分子信标探针的标记试剂。
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4.发明申请公开(公告)号：US20120171730A1
公开(公告)日：2012-07-05
申请号：US13359667
申请日：2012-01-27
申请人： Dieter Heindl , Heribert Maerz , Axel Schmidt
发明人： Dieter Heindl , Heribert Maerz , Axel Schmidt
IPC分类号： C12P19/32 , C07D213/59 , C07D401/04 , C07D473/16 , C07D213/56
CPC分类号： C07D401/04 , C07D213/82 , C07D473/16
摘要： Methods for the synthesis of N-substituted pyridinium compounds by using an N-heteroaryl substituted pyridinium salt (Zincke salt) and reacting it with a nucleophilic amine are provided. Novel purine-substituted pyridyl compounds, which may be useful reagents in the above reaction, are also disclosed.
摘要翻译： 提供了通过使用N-杂芳基取代的吡啶盐（Zincke盐）合成N-取代的吡啶鎓化合物并使其与亲核胺反应的方法。 还公开了可能在上述反应中有用的试剂的新型嘌呤取代的吡啶基化合物。
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公开(公告)号：US07759469B2
公开(公告)日：2010-07-20
申请号：US11370527
申请日：2006-03-08
申请人： Dieter Heindl , Thomas Froehlich , Heribert Maerz , Monika Seller
发明人： Dieter Heindl , Thomas Froehlich , Heribert Maerz , Monika Seller
摘要： The current invention restates substituted nitroindole nucleosides as both terminal as well as internal building blocks of labeled oligonucleotide probes for the detection, analysis and quantitation of nucleic acids. The substituent comprises a linker and a detectable group or a linker and a reactive group for post synthesis coupling. These modified nucleosides grant access to a wide application area. These new substituted nitroindole nucleosides can be used as labeling reagents for the facile preparation of, e.g., optimized hybridization probes, simple probes, TAQMAN-probes or molecular beacon probes.
摘要翻译： 本发明将取代的硝基吲哚核苷作为两个末端以及用于核酸检测，分析和定量的标记的寡核苷酸探针的内部构建块。 取代基包括接头和可检测的基团或接头以及用于后合成偶联的反应性基团。 这些修饰的核苷允许进入广泛的应用领域。 这些新的取代的硝基吲哚核苷可以用作易于制备例如优化的杂交探针，简单探针，TAQMAN探针或分子信标探针的标记试剂。
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公开(公告)号：US20060199833A1
公开(公告)日：2006-09-07
申请号：US11339454
申请日：2006-01-25
申请人： Dieter Heindl , Rupert Herrmann , Wolfgang Jenni , Heribert Maerz
发明人： Dieter Heindl , Rupert Herrmann , Wolfgang Jenni , Heribert Maerz
IPC分类号： C07D471/02 , C07D491/02 , C07D498/02 , A61K31/4745 , A61K31/4743 , A61K31/4741
CPC分类号： C07D491/04 , A61K49/0021 , A61K49/0058 , C07D495/04 , G01N33/582 , Y10S436/80 , Y10T436/13 , Y10T436/200833 , Y10T436/201666
摘要： The present invention relates to novel chemiluminescent compounds, to a method for synthesizing these compounds, to derivatives and conjugates comprising these compounds, to the use of these compounds or conjugates thereof in chemiluminescence based assays, especially in immunoassays.
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公开(公告)号：US06875850B2
公开(公告)日：2005-04-05
申请号：US09943411
申请日：2001-08-30
IPC分类号： G01N33/58 , C07B61/00 , C07C217/10 , C07C233/18 , C07H21/00 , C07H21/04 , C08G69/08 , C09B11/28 , C09B69/10 , C12N15/09 , C07H19/00 , C12Q1/68
CPC分类号： C07H21/00 , C07B2200/11 , C40B40/00 , Y02P20/55 , Y10T428/2996
摘要： The present invention concerns a labelling reagent in which the label is bound via an amide bond and a linker to a residue of the molecule which is essentially characterized in that the N atom of the amide bond and the label are linked together directly by a covalent bond. In particular these are phosphoramidites or reactive supports suitable for nucleic acid synthesis. The invention also concerns processes for the production of such supports from suitable precursors.
摘要翻译： 本发明涉及一种标记试剂，其中标记通过酰胺键和接头连接至分子的残基，其基本特征在于酰胺键的N原子和标记直接通过共价键连接在一起 。 特别地，这些是适合于核酸合成的亚磷酰胺或反应性载体。 本发明还涉及从合适的前体制备这种载体的方法。
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