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    Method of treating a subject suffering from end stage renal disease against cardiovascular disease
    1.
    发明授权
    Method of treating a subject suffering from end stage renal disease against cardiovascular disease 有权
    治疗终末期肾病患者抗心血管疾病的方法

    公开(公告)号：US08657775B2

    公开(公告)日：2014-02-25

    申请号：US12585054

    申请日：2009-09-01

    申请人： Colin Hutchison ,  Paul Cockwell ,  Hermann Göhl ,  Bernd Krause ,  Markus Storr

    发明人： Colin Hutchison ,  Paul Cockwell ,  Hermann Göhl ,  Bernd Krause ,  Markus Storr

    IPC分类号： A61M1/14 ,  A61M1/18 ,  A61M1/34 ,  B01D61/24 ,  B01D61/28 ,  B01D69/08 ,  B01D63/02

    CPC分类号： B01D61/243 ,  A61M1/16 ,  B01D67/0013 ,  B01D69/08 ,  B01D69/12 ,  B01D2325/022 ,  B01D2325/20

    摘要： The present invention relates to high cut-off hemodialysis membranes for the treatment of chronic hemodialysis (CHD) patients, with the potential to improve long-term survival of these patients by reducing the risk of cardiovascular disease, through down-regulation of monocyte activation in the blood. Monocytes are the major circulating blood cells involved in the progression of cardiovascular disease. High cut-off hemodialysis in chronic dialysis patients results in a sustained decrease in expression of monocyte cell-surface proteins that direct the movement of these cells from the blood to the walls of blood vessels, where they promote the progression of arterial disease (atherosclerosis) that leads to cardiovascular disease (CVD); heart disease, strokes and peripheral vascular disease.

    摘要翻译： 本发明涉及用于治疗慢性血液透析（CHD）患者的高截止血液透析膜，可通过降低心血管疾病的风险来改善这些患者的长期存活，通过下调单核细胞活化 血液。 单核细胞是涉及心血管疾病进展的主要循环血细胞。 慢性透析患者的高截止血液透析导致单核细胞表面蛋白质的表达持续下降，从而将这些细胞从血液移动到血管壁，在那里它们促进动脉疾病（动脉粥样硬化）的进展， 导致心血管疾病（CVD）; 心脏病，中风和外周血管疾病。

    Membrane and use thereof
    2.
    发明授权
    Membrane and use thereof 失效
    膜及其用途

    公开(公告)号：US07644825B2

    公开(公告)日：2010-01-12

    申请号：US10532131

    申请日：2003-10-17

    申请人： Bernd Krause ,  Matthias Wessling ,  Hermann Göhl ,  Markus Storr

    发明人： Bernd Krause ,  Matthias Wessling ,  Hermann Göhl ,  Markus Storr

    IPC分类号： B01D71/06 ,  B01D71/68 ,  B01D71/28 ,  B01D71/00

    CPC分类号： B01D67/002 ,  B01D67/0083 ,  B01D69/02 ,  B01D71/68 ,  B01D71/80 ,  B01D2325/36 ,  B29C44/3403

    摘要： The membrane producible by shaping a polymer blend or a block copolymer comprising blocks of monomer units, loading the polymer blend or block copolymer with a blowing gas concentration within the polymer blend or block polymer above a critical concentration at a temperature below a critical temperature, but above the glass transition temperature of the polymer blend/gas or block copolymer/gas mixture and finally stabilizing the foam structure is characterized in that as polymer blend a homogeneous polymer blend comprising at least one hydrophilic and at least one hydrophobic polymer and/or a block copolymer of alternating blocks of hydrophilic and hydrophobic monomer units is used, both the polymer blend and the block copolymer having a solubility relating to the used foaming gas above the critical concentration. The said membrane is used for medical purposes, especially for the haemodialysis, haemofiltration, haemodiafiltration, plasmapherese, immunotherapy, micro- or ultrafiltration or gas separation.

    摘要翻译： 该膜可以通过将包含单体单元的嵌段的聚合物共混物或嵌段共聚物成型，将聚合物共混物或嵌段共聚物以高于临界温度的临界浓度的聚合物共混物或嵌段聚合物内的吹入气体浓度加载， 高于聚合物共混物/气体或嵌段共聚物/气体混合物的玻璃化转变温度，并且最终稳定泡沫结构的特征在于，作为聚合物共混物，包含至少一种亲水和至少一种疏水性聚合物和/或嵌段的均匀聚合物共混物 使用亲水和疏水单体单元的交替嵌段的共聚物，聚合物共混物和嵌段共聚物具有高于临界浓度的所用发泡气体的溶解度。 所述膜用于医疗目的，特别用于血液透析，血液透析，血液透析，血浆置换，免疫治疗，微量或超滤或气体分离。

    Biocompatible polymer film
    3.
    发明授权
    Biocompatible polymer film 有权
    生物相容性聚合物膜

    公开(公告)号：US06841255B2

    公开(公告)日：2005-01-11

    申请号：US10245115

    申请日：2002-09-17

    申请人： Reinhold Deppisch ,  Ulrich Bauer ,  Werner Beck ,  Ruth Dietrich ,  Hermann Göhl ,  Katja Krämer

    发明人： Reinhold Deppisch ,  Ulrich Bauer ,  Werner Beck ,  Ruth Dietrich ,  Hermann Göhl ,  Katja Krämer

    IPC分类号： A61L33/00 ,  A61L27/34 ,  A61L29/08 ,  A61L31/10 ,  A61L33/06 ,  B32B27/06 ,  C08G81/00 ,  C08J5/18 ,  B32B25/20

    CPC分类号： C08J5/18 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L33/068 ,  C08G81/00 ,  Y10T428/31504 ,  Y10T428/31598 ,  C08L83/10

    摘要： The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional —OH end groups and reacting the —OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with —OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The —OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure. The film can be applied to the surface of an article by any convenient means of coating the article with the reaction mixture in solvent, and allowing the solvent to evaporate.

    摘要翻译： 本发明包括可以施加在制品的表面上以形成比未处理制品更具生物相容性并且具有更光滑的表面形态的连续表面的共聚物膜。 通常，本发明的共聚物膜可以通过提供具有官能-OH端基的疏水性聚合物嵌段例如聚二甲基硅氧烷（PDMS）并使-OH端与常规的成膜聚合物的单体或预聚物 能够与-OH基团反应。 举例来说，使用聚内酯 - 聚硅氧烷 - 聚内酯（PL-PDMS-PL）型的三嵌段共聚物或硅氧烷聚酯作为反应性PDMS。 聚内酯嵌段的-OH基团可以在合适的溶剂中与各种异氰酸酯中的任何一种反应，以形成具有结合其PDMS的聚合物。 可以通过用反应混合物在溶剂中涂覆制品的任何便利的方法将膜施加到制品的表面，并使溶剂蒸发。

    Biocompatible polymer film
    4.
    发明授权
    Biocompatible polymer film 有权
    生物相容性聚合物膜

    公开(公告)号：US06500549B1

    公开(公告)日：2002-12-31

    申请号：US09415943

    申请日：1999-10-08

    申请人： Reinhold Deppisch ,  Ulrich Bauer ,  Werner Beck ,  Ruth Dietrich ,  Hermann Göhl ,  Katja Krämer

    发明人： Reinhold Deppisch ,  Ulrich Bauer ,  Werner Beck ,  Ruth Dietrich ,  Hermann Göhl ,  Katja Krämer

    IPC分类号： B32B2520

    CPC分类号： C08J5/18 ,  A61L27/34 ,  A61L29/085 ,  A61L31/10 ,  A61L33/068 ,  C08G81/00 ,  Y10T428/31504 ,  Y10T428/31598 ,  C08L83/10

    摘要： The present invention includes a co-polymer film which can be applied over a surface of an article to form a continuous surface that is more biocompatible and has a smoother surface morphology than an untreated article. In general the co-polymer film of the invention can be formed by providing a hydrophobic polymer block, such as polydimethylsiloxane (PDMS) with functional —OH end groups and reacting the —OH ends with a conventional monomer or prepolymer of a film-forming polymer capable of reacting with —OH groups. Such reactions are exemplified, using as reactive PDMS a triblock copolymer of the polylactone-polysiloxane-polylactone (PL-PDMS-PL) type, or silicone polyesters. The —OH groups of the polylactone blocks can react with any of a variety of isocyanates in a suitable solvent to form a polymer having PDMS incorporated with its structure. The film can be applied to the surface of an article by any convenient means of coating the article with the reaction mixture in solvent, and allowing the solvent to evaporate.

    摘要翻译： 本发明包括可以施加在制品的表面上以形成比未处理制品更具生物相容性并且具有更光滑的表面形态的连续表面的共聚物膜。 通常，本发明的共聚物膜可以通过提供具有官能-OH端基的疏水性聚合物嵌段例如聚二甲基硅氧烷（PDMS）并使-OH端与常规的成膜聚合物的单体或预聚物 能够与-OH基团反应。 举例来说，使用聚内酯 - 聚硅氧烷 - 聚内酯（PL-PDMS-PL）型的三嵌段共聚物或硅氧烷聚酯作为反应性PDMS。 聚内酯嵌段的-OH基团可以在合适的溶剂中与各种异氰酸酯中的任何一种反应，以形成具有结合其PDMS的聚合物。 可以通过用反应混合物在溶剂中涂覆制品的任何便利的方法将膜施加到制品的表面，并使溶剂蒸发。

    High cut-off hemodialysis membranes for the treatment of chronic hemodialysis patients
    7.
    发明申请
    High cut-off hemodialysis membranes for the treatment of chronic hemodialysis patients 有权
    高截止血液透析膜用于治疗慢性血液透析患者

    公开(公告)号：US20100084339A1

    公开(公告)日：2010-04-08

    申请号：US12585054

    申请日：2009-09-01

    申请人： Colin Hutchison ,  Paul Cockwell ,  Hermann Göhl ,  Bernd Krause ,  Markus Storr

    发明人： Colin Hutchison ,  Paul Cockwell ,  Hermann Göhl ,  Bernd Krause ,  Markus Storr

    IPC分类号： B01D61/32

    CPC分类号： B01D61/243 ,  A61M1/16 ,  B01D67/0013 ,  B01D69/08 ,  B01D69/12 ,  B01D2325/022 ,  B01D2325/20

    摘要： The present invention relates to high cut-off hemodialysis membranes for the treatment of chronic hemodialysis (CHD) patients, with the potential to improve long-term survival of these patients by reducing the risk of cardiovascular disease, through down-regulation of monocyte activation in the blood. Monocytes are the major circulating blood cells involved in the progression of cardiovascular disease. High cut-off hemodialysis in chronic dialysis patients results in a sustained decrease in expression of monocyte cell-surface proteins that direct the movement of these cells from the blood to the walls of blood vessels, where they promote the progression of arterial disease (atherosclerosis) that leads to cardiovascular disease (CVD); heart disease, strokes and peripheral vascular disease.

    摘要翻译： 本发明涉及用于治疗慢性血液透析（CHD）患者的高截止血液透析膜，可通过降低心血管疾病的风险来改善这些患者的长期存活，通过下调单核细胞活化 血液。 单核细胞是涉及心血管疾病进展的主要循环血细胞。 慢性透析患者的高截止血液透析导致单核细胞表面蛋白质的表达持续下降，从而将这些细胞从血液移动到血管壁，在那里它们促进动脉疾病（动脉粥样硬化）的进展， 导致心血管疾病（CVD）; 心脏病，中风和外周血管疾病。