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    Pyrimidine derivatives as endothelin antagonists
    7.
    发明授权
    Pyrimidine derivatives as endothelin antagonists 失效
    嘧啶衍生物作为内皮素拮抗剂

    公开(公告)号：US5883092A

    公开(公告)日：1999-03-16

    申请号：US29244

    申请日：1998-03-04

    申请人： Mitsuteru Hirata ,  Takeo Deushi ,  Yoshio Takahashi ,  Masahiro Tamura ,  Takeshi Ohshima ,  Toshiaki Oda ,  Tetsuya Ishikawa ,  Hiroyuki Sonoki ,  Masami Shiratsuchi

    发明人： Mitsuteru Hirata ,  Takeo Deushi ,  Yoshio Takahashi ,  Masahiro Tamura ,  Takeshi Ohshima ,  Toshiaki Oda ,  Tetsuya Ishikawa ,  Hiroyuki Sonoki ,  Masami Shiratsuchi

    IPC分类号： C07D403/04 ,  A61K31/506 ,  A61P9/00 ,  A61P9/12 ,  C07D213/00 ,  C07D239/52 ,  C07D239/545 ,  C07D295/00 ,  C07D401/14 ,  C07D413/04 ,  A61K31/505 ,  A61K31/535

    CPC分类号： C07D239/52

    摘要： The present invention is directed to a pyrimidine derivative of the following formula (1) or a salt of the derivative: ##STR1## �wherein R.sup.1 represents a hydroxyl group, a lower alkoxy group, a phenyloxy group which may have a substituent, an aralkyloxy group which may have a substituent, or --NR.sup.2 R.sup.3 ; X represents an oxygen atom or N--R.sup.4 ; m is 2 or 3; and n is 1 or 2 (wherein each of R.sup.2 and R.sup.3, which are identical to or different from each other, represents a hydrogen atom, a hydroxyl group, a lower alkyl group which may have a substituent, a phenyl group which may have a substituent, an aralkyl group which may have a substituent, or a heterocyclic group which may have a substituent; R.sup.4 represents a lower alkyl group, a phenyl group, a formyl group, or a lower alkoxycarbonyl group)!, as well as to a medicine containing the derivative or salt as the active ingredient. The compounds exhibit strong binding inhibitory activity against endothelin having potent vasoconstrictive effect. Therefore, the compounds are effective as remedies for various diseases including circulatory diseases.

    摘要翻译： PCT No.PCT / JP96 / 02494 Sec。 371日期：1998年3月4日 102（e）1998年3月4日PCT PCT 1996年9月4日PCT公布。 公开号WO97 / 09318 日期1997年3月13日本发明涉及下式（1）的嘧啶衍生物或衍生物的盐：其中R1表示羟基，低级烷氧基，苯氧基 其可以具有取代基，可以具有取代基的芳烷氧基或-NR2R3; X表示氧原子或N-R4; m为2或3; n为1或2（式中，R2，R3各自相同或不同，表示氢原子，羟基，可具有取代基的低级烷基，可具有取代基的苯基， 取代基，可以具有取代基的芳烷基或可以具有取代基的杂环基; R4表示低级烷基，苯基，甲酰基或低级烷氧基羰基）]以及药物 含有衍生物或盐作为活性成分。 该化合物对具有强烈血管收缩作用的内皮素表现出强烈的结合抑制活性。 因此，该化合物作为包括循环系统疾病在内的各种疾病的治疗方法是有效的。

    Vehicle seat
    8.
    发明授权
    Vehicle seat 有权
    车座

    公开(公告)号：US09272642B2

    公开(公告)日：2016-03-01

    申请号：US14477272

    申请日：2014-09-04

    申请人： Hideki Kobayashi ,  Tetsuya Ishikawa ,  Kazuhisa Nishimura

    发明人： Hideki Kobayashi ,  Tetsuya Ishikawa ,  Kazuhisa Nishimura

    IPC分类号： B60N2/30 ,  B60N2/36 ,  B60N2/48

    CPC分类号： B60N2/3065 ,  B60N2/3013 ,  B60N2/3088 ,  B60N2/36 ,  B60N2/859 ,  B60N2/874 ,  B60N2205/40

    摘要： In a vehicle seat (car seat 1) including a first seat portion (seat cushion 10) movable between a use position and a retracted position, and a second seat portion (seat back 20) movable between a use position and a retracted position, an actuator mechanism is configured to cause the second seat portion to start moving toward its retracted position at a time when the first seat portion passes a predetermined intermediate position that is on a way from the use position toward the retracted position. In one embodiment, the actuator mechanism includes a biasing member (torsion spring 13, 23) configured to bias each of the seat cushion 10 and the seat back 20 from the use position toward the retracted position, a lock member (lock arm 42) configured to lock the seat back 20 in the use position, and an unlock device (cable 44, 42A) configured to release the lock member to cause the seat back 20 to start moving toward the retracted position, at a time when the seat cushion 10 passes the predetermined intermediate position that is on the way from a posture in which the seat cushion is ready for use toward a posture in which the seat cushion 10 is tipped up.

    摘要翻译： 在包括在使用位置和缩回位置之间可移动的第一座椅部分（座垫10）和可在使用位置和缩回位置之间移动的第二座椅部分（座椅靠背20）的车辆座椅（汽车座椅1）中， 致动器机构构造成使得第二座椅部分在第一座椅部分经过从使用位置朝向缩回位置的途中经过的预定中间位置时开始向其缩回位置移动。 在一个实施例中，致动器机构包括构造成将座垫10和座椅靠背20中的每一个从使用位置朝向缩回位置偏置的偏置构件（扭转弹簧13,23），配置在锁定构件 将座椅靠背20锁定在使用位置，以及解锁装置（电缆44,42A），其构造成在座垫10通过时释放锁定构件以使座椅靠背20开始向缩回位置移动 在从座垫准备好使用的姿势朝向座垫10倾斜的姿势的途中的预定中间位置。

    Inkjet printing apparatus
    9.
    发明授权
    Inkjet printing apparatus 有权
    喷墨打印设备

    公开(公告)号：US08651638B2

    公开(公告)日：2014-02-18

    申请号：US13218626

    申请日：2011-08-26

    申请人： Tetsuya Ishikawa

    发明人： Tetsuya Ishikawa

    IPC分类号： B41J2/175

    CPC分类号： B41J2/17509 ,  B41J2/175 ,  B41J2/17513 ,  B41J2/1752 ,  B41J2/17523 ,  B41J2/17553 ,  B41J2/17596

    摘要： An inkjet printing apparatus comprises an ink tank including an ink accommodating unit, an ink leading-out mechanism for leading out the ink in the ink accommodating unit to an outside, and a housing, and an ink tank holder for removably retaining the ink tank, wherein a space is formed between the ink leading-out mechanism and the housing, and when the ink tank is mounted to the ink tank holder, an ink flow passage is formed by contact of an outer periphery of an ink leading-out needle in the ink tank holder with a sealing member in the ink leading-out mechanism, further comprising restriction means for restricting a position of the ink tank to the ink tank holder such that when removing the ink tank from the ink tank holder, the ink tank stops in a state where a tip end of the ink leading-out needle is in the space.

    摘要翻译： 一种喷墨打印设备包括一个墨盒，包括墨水容纳单元，用于将墨水容纳单元中的墨水引导到外部的墨水引出机构和外壳以及用于可拆卸地保持墨水盒的墨水盒保持器， 其中在所述墨水引出机构和所述壳体之间形成空间，并且当所述墨水罐安装到所述墨水盒保持器时，墨水流动通道通过所述墨水引出针的外周部 在墨水引出机构中具有密封构件的墨水盒保持器还包括限制装置，用于将墨水罐的位置限制到墨水盒保持器，使得当从墨水盒保持器移除墨水盒时，墨水罐停止 墨水引出针的前端位于空间中的状态。