-
1.发明授权公开(公告)号：US08552030B2
公开(公告)日：2013-10-08
申请号：US13055472
申请日：2009-07-03
Applicant: Tangirala Prakasam , Borkatte Narasimha Hitesh Kumar , Sangu Perumal , Kothandapani Loganathan
Inventor： Tangirala Prakasam , Borkatte Narasimha Hitesh Kumar , Sangu Perumal , Kothandapani Loganathan
IPC: A61K31/445
CPC classification number: C07B57/00 , C07D211/34
Abstract: The invention disclosed in this application relates to an improved process for the manufacture of d-threo-ritalinic acid hydrochloride and l-threo-ritalinic acid hydrochloride in an optically pure form by the resolution of dl-threo-ritalinic acid using a chiral carboxylic acid The d-threo-ritalinic acid hydrochloride prepared by the process of the present invention on esterification gives d-threo-methylphenidate, a very well known CNS stimulant.
Abstract translation: 在本申请中公开的本发明涉及通过使用手性羧酸分解dl-苏氨酸的方法，以光学纯的形式制备d-苏氨酸 - 盐酸盐酸盐和1-苏雷酸 - 盐酸盐的改进方法 通过本发明方法制备的用于酯化的d-苏氨酸盐酸盐，得到了一种非常众所周知的CNS兴奋剂的d-苏 - 哌甲酯。
-
2.发明申请Method of Cloning Stable Stress Tolerant Superoxide Dismutase Using Universal Primers 有权使用通用引物克隆稳定胁迫耐受性超氧化物歧化酶的方法公开(公告)号：US20120070835A1
公开(公告)日：2012-03-22
申请号：US12935881
申请日：2009-03-31
Applicant: Pardeep Kumar Bhardwaj , Arun Kumar , Amit Kishore , Sanjay Ghawana , Arti Rani , Kashmir Singh , Harsharan Singh , Ravi Shankar Singh , Hitesh Kumar , Payal Sood , Som Dutt , Sanjay Kumar , Paramvir Singh Ahuja
Inventor： Pardeep Kumar Bhardwaj , Arun Kumar , Amit Kishore , Sanjay Ghawana , Arti Rani , Kashmir Singh , Harsharan Singh , Ravi Shankar Singh , Hitesh Kumar , Payal Sood , Som Dutt , Sanjay Kumar , Paramvir Singh Ahuja
CPC classification number: C12N9/0089 , C12N15/8271 , C12Q1/6895
Abstract: The present invention relates to a method of cloning stable stress tolerant superoxide dismutase from diverse plant species using universal primers.
Abstract translation: 本发明涉及使用通用引物克隆来自不同植物物种的稳定胁迫耐受性超氧化物歧化酶的方法。
-
Patent Agency Ranking
3.发明申请SUBSTITUTED NUCLEOSIDE DERIVATIVES WITH ANTIVIRAL AND ANTIMICROBIAL PROPERTIES 有权取代的具有抗病毒和抗微生物特性的核苷酸衍生物公开(公告)号：US20110039798A1
公开(公告)日：2011-02-17
申请号：US12668262
申请日：2008-07-09
Applicant: Gustavo F. Doncel , Keykavous Parang , Hitesh Kumar Agarwal
Inventor： Gustavo F. Doncel , Keykavous Parang , Hitesh Kumar Agarwal
IPC: A61K31/7076 , C07H19/06 , C07H19/16 , C07D473/34 , C07D411/04 , A61K31/7072 , A61K31/7068 , A61K31/522 , A61K31/513 , A61P31/18 , A61P31/22 , A61P31/04 , A61P31/20 , A61P31/00 , A61P15/18
CPC classification number: C07H19/06 , C07D411/04 , C07H19/10 , C07H19/16 , C07H19/20
Abstract: The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.
Abstract translation: 本发明涉及脂肪酸和脂肪醇取代的核苷衍生物以及在多价支架（例如，聚合物，肽，多羧酸取代的化合物，含有多环维生素基团的化合物）上取代的核苷和核苷衍生物，其显示有效的抗HIV活性。 此外，它们显示增强的抗多药耐药性，R5和细胞相关病毒的活性。 其中一些还显示针对其他性传播病原体和精子的活动。 本发明提供了它们的合成方法，物质组成和使用方法。 强调其作为局部杀微生物剂的应用，以治疗或预防疾病，特别是艾滋病毒/艾滋病的性传播。
-
4.发明授权Substituted nucleoside derivatives with antiviral and antimicrobial properties 有权取代的具有抗病毒和抗微生物特性的核苷衍生物公开(公告)号：US09296776B2
公开(公告)日：2016-03-29
申请号：US12668262
申请日：2008-07-09
Applicant: Gustavo F. Doncel , Keykavous Parang , Hitesh Kumar Agarwal
Inventor： Gustavo F. Doncel , Keykavous Parang , Hitesh Kumar Agarwal
CPC classification number: C07H19/06 , C07D411/04 , C07H19/10 , C07H19/16 , C07H19/20
Abstract: The present invention relates to fatty acid and fatty alcohol substituted nucleoside derivatives and nucleoside and nucleoside derivatives substituted on multivalent scaffolds (e.g., polymers, peptides, polycarboxylic acid substituted compounds, compounds containing polycycloSaligenyl groups) that display potent anti-HIV activity. Furthermore, they show enhanced activity against multi-drug resistant, R5, and cell-associated virus. Some of them also display activity against other sexually transmitted pathogens and sperm. The present invention provides their methods of synthesis, composition of matter, and methods of use. Emphasis is placed on their application as topical microbicides to treat or prevent sexual transmission of disease, especially HIV/AIDS.
Abstract translation: 本发明涉及脂肪酸和脂肪醇取代的核苷衍生物以及在多价支架（例如，聚合物，肽，多羧酸取代的化合物，含有多环维生素基团的化合物）上取代的核苷和核苷衍生物，其显示有效的抗HIV活性。 此外，它们显示增强的抗多药耐药性，R5和细胞相关病毒的活性。 其中一些还显示针对其他性传播病原体和精子的活动。 本发明提供了它们的合成方法，物质组成和使用方法。 强调其作为局部杀微生物剂的应用，以治疗或预防疾病，特别是艾滋病毒/艾滋病的性传播。
-
5.发明授权Method of cloning stable stress tolerant superoxide dismutase using universal primers 有权使用通用引物克隆稳定的胁迫耐受性超氧化物歧化酶的方法公开(公告)号：US09212350B2
公开(公告)日：2015-12-15
申请号：US12935881
申请日：2009-03-31
Applicant: Pardeep Kumar Bhardwaj , Arun Kumar , Amit Kishore , Sanjay Ghawana , Arti Rani , Kashmir Singh , Harsharan Singh , Ravi Shankar Singh , Hitesh Kumar , Payal Sood , Som Dutt , Sanjay Kumar , Paramvir Singh Ahuja
Inventor： Pardeep Kumar Bhardwaj , Arun Kumar , Amit Kishore , Sanjay Ghawana , Arti Rani , Kashmir Singh , Harsharan Singh , Ravi Shankar Singh , Hitesh Kumar , Payal Sood , Som Dutt , Sanjay Kumar , Paramvir Singh Ahuja
CPC classification number: C12N9/0089 , C12N15/8271 , C12Q1/6895
Abstract: The present invention relates to a method of cloning stable stress tolerant superoxide dismutase from diverse plant species using universal primers.
Abstract translation: 本发明涉及使用通用引物克隆来自不同植物物种的稳定胁迫耐受性超氧化物歧化酶的方法。
-
6.发明申请Process for the Preparation of d-threo-Ritalinic Acid Hydrochloride by Resolution of dl-threo-Ritalinic Acid Using Chiral Carboxylic Acid 失效通过使用手性羧酸分解dl-赖氨酸 - 赖氨酸的方法制备二 - 赖氨酸赖氨酸公开(公告)号：US20110130569A1
公开(公告)日：2011-06-02
申请号：US13055472
申请日：2009-07-03
Applicant: Tangirala Prakasam , Borkatte Narasimha Hitesh Kumar , Sangu Perumal , Kothandapani Loganathan
Inventor： Tangirala Prakasam , Borkatte Narasimha Hitesh Kumar , Sangu Perumal , Kothandapani Loganathan
IPC: C07D211/32
CPC classification number: C07B57/00 , C07D211/34
Abstract: The invention disclosed in this application relates to an improved process for the manufacture of d-threo-ritalinic acid hydrochloride and l-threo-ritalinic acid hydrochloride in an optically pure form by the resolution of dl-threo-ritalinic acid using a chiral carboxylic acid The d-threo-ritalinic acid hydrochloride prepared by the process of the present invention on esterification gives d-threo-methylphenidate, a very well known CNS stimulant.
Abstract translation: 在本申请中公开的本发明涉及通过使用手性羧酸分解dl-苏氨酸的方法，以光学纯的形式制备d-苏氨酸 - 盐酸盐酸盐和1-苏雷酸 - 盐酸盐的改进方法 通过本发明方法制备的用于酯化的d-苏氨酸盐酸盐，得到了一种非常众所周知的CNS兴奋剂的d-苏 - 哌甲酯。
-
公开(公告)号：US20080318289A1
公开(公告)日：2008-12-25
申请号：US12089279
申请日：2006-05-10
Applicant: Parveen Kumar , Hitesh Kumar Malviya , Raj Kumar Maurya , Aniruddha Shukla
Inventor： Parveen Kumar , Hitesh Kumar Malviya , Raj Kumar Maurya , Aniruddha Shukla
IPC: C12P17/16
CPC classification number: C07D498/18 , C12P17/188
Abstract: The present invention relates to improved fermentation processes for the preparation of tacrolimus or a salt or derivative thereof by culturing a microorganism capable of producing tacrolimus or a salt or derivative thereof under submerged aerobic conditions with fed-batch processing at a high aeration rate.
Abstract translation: 本发明涉及通过在高曝气速率下进行补料分批处理，在浸没需氧条件下培养能够产生他克莫司或其盐或衍生物的微生物来制备他克莫司或其盐或衍生物的改进的发酵方法。
-
-
-
-
-
-
Search Results
7
records
(took 0.011 seconds)
