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公开(公告)号：US08129376B2
公开(公告)日：2012-03-06
申请号：US12408486
申请日：2009-03-20
Applicant: Kumar Sundaresan , P. Bala Koteswara Rao , Bharathiraja Ainan , Hariharasubramanian Ayyamperumal , Girish A R , Srinivas Tatiparthy , Ganesh Prabhu , Hosahalli Subramanya , Alexander Bischoff
Inventor： Kumar Sundaresan , P. Bala Koteswara Rao , Bharathiraja Ainan , Hariharasubramanian Ayyamperumal , Girish A R , Srinivas Tatiparthy , Ganesh Prabhu , Hosahalli Subramanya , Alexander Bischoff
IPC: A61K31/5375 , A61K31/445 , C07D413/02 , C07D211/00
CPC classification number: C07D211/46 , C07D211/58 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
Abstract translation: 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌啶衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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2.发明申请公开(公告)号：US20090221583A1
公开(公告)日：2009-09-03
申请号：US12144604
申请日：2008-06-23
Applicant: Alexander BISCHOFF , Hosahalli SUBRAMANYA , Kumar SUNDARESAN , Srinivasa Raju SAMMETA , Anil Kumar VAKA
Inventor： Alexander BISCHOFF , Hosahalli SUBRAMANYA , Kumar SUNDARESAN , Srinivasa Raju SAMMETA , Anil Kumar VAKA
IPC: A61K31/5377 , C07D241/04 , C07D401/12 , C07D401/06 , A61P3/04 , A61P3/10 , C07D413/12 , A61K31/495 , A61K31/496
CPC classification number: C07D333/18 , C07D207/416 , C07D211/62 , C07D231/12 , C07D231/14 , C07D261/08 , C07D295/192 , C07D307/68
Abstract: The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
Abstract translation: 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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公开(公告)号：US07842696B2
公开(公告)日：2010-11-30
申请号：US12144604
申请日：2008-06-23
Applicant: Alexander Bischoff , Hosahalli Subramanya , Kumar Sundaresan , Srinivasa Raju Sammeta , Anil Kumar Vaka
Inventor： Alexander Bischoff , Hosahalli Subramanya , Kumar Sundaresan , Srinivasa Raju Sammeta , Anil Kumar Vaka
IPC: A61K31/4965 , C07D295/00
CPC classification number: C07D333/18 , C07D207/416 , C07D211/62 , C07D231/12 , C07D231/14 , C07D261/08 , C07D295/192 , C07D307/68
Abstract: The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
Abstract translation: 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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公开(公告)号：US20120028959A1
公开(公告)日：2012-02-02
申请号：US13262640
申请日：2010-03-26
Applicant: Siva Sanjeeva Rao Thunuguntla , Hosahalli Subramanya , Satish Reddy Kunnam , Sekhar Reddy Sanivaru Vijay , Chakrapani Bingi , Raviraj Kusanur , Matthias Schwarz , Michael Arlt
Inventor： Siva Sanjeeva Rao Thunuguntla , Hosahalli Subramanya , Satish Reddy Kunnam , Sekhar Reddy Sanivaru Vijay , Chakrapani Bingi , Raviraj Kusanur , Matthias Schwarz , Michael Arlt
IPC: A61K31/55 , A61K31/4184 , C07D263/57 , A61K31/423 , C07D409/10 , C07D403/10 , C07D417/10 , A61K31/428 , C07D401/04 , A61K31/4439 , C07D413/10 , A61K31/5377 , A61P25/00 , A61P29/00 , A61P35/00 , A61P1/00 , C07D235/18
CPC classification number: C07D209/08 , C07D235/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04
Abstract: The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.
Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 2，X 1，X 2，Y，R a，R b，Q具有权利要求1中给出的含义。 在治疗自身免疫性疾病如多发性硬化以及治疗癌症中。
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5.发明申请公开(公告)号：US20100160323A1
公开(公告)日：2010-06-24
申请号：US12644162
申请日：2009-12-22
Applicant: Alexander Bischoff , Hosahalli Subramanya , Kumar Sundaresan , Srinivasa Raju Sammeta , Anil Kumar Vaka
Inventor： Alexander Bischoff , Hosahalli Subramanya , Kumar Sundaresan , Srinivasa Raju Sammeta , Anil Kumar Vaka
IPC: A61K31/496 , C07D401/12 , C07D413/12 , C07D403/12 , C07D401/14 , C07D405/12 , C07D241/04 , C07D487/08 , C07D471/04 , C07D413/14 , A61K31/495 , A61K31/4155 , A61K31/5377 , A61P3/04 , A61P3/10
CPC classification number: C07D295/185 , C07D209/88 , C07D213/56 , C07D231/14 , C07D249/06 , C07D261/18 , C07D295/112 , C07D295/192 , C07D333/10 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D487/08
Abstract: The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
Abstract translation: 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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Patent Agency Ranking
6.发明申请公开(公告)号：US20090239810A1
公开(公告)日：2009-09-24
申请号：US12408486
申请日：2009-03-20
Applicant: Kumar Sundaresan , P.Bala Koteswara Rao , Bharathiraja Ainan , Hariharasubramanian Ayyamperumal , Girish A R , Srinivas Tatiparthy , Ganesh Prabhu , Hosahalli Subramanya , Alexander Bischoff
Inventor： Kumar Sundaresan , P.Bala Koteswara Rao , Bharathiraja Ainan , Hariharasubramanian Ayyamperumal , Girish A R , Srinivas Tatiparthy , Ganesh Prabhu , Hosahalli Subramanya , Alexander Bischoff
IPC: A61K38/05 , C07D211/44 , C07D211/58 , C07D413/12 , C07D401/12 , A61K31/445 , A61P3/04
CPC classification number: C07D211/46 , C07D211/58 , C07D401/12 , C07D401/14 , C07D409/14 , C07D413/12 , C07D417/12
Abstract: The present invention relates to piperidine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
Abstract translation: 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌啶衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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7.发明申请公开(公告)号：US20110046134A1
公开(公告)日：2011-02-24
申请号：US12915979
申请日：2010-10-29
Applicant: Alexander Bischoff , Hosahalli Subramanya , Kumar Sundaresan , Srinivasa Raju Sammeta , Anil Kumar Vaka
Inventor： Alexander Bischoff , Hosahalli Subramanya , Kumar Sundaresan , Srinivasa Raju Sammeta , Anil Kumar Vaka
IPC: A61K31/5377 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/501 , A61P3/10 , A61P3/04
CPC classification number: C07D333/18 , C07D207/416 , C07D211/62 , C07D231/12 , C07D231/14 , C07D261/08 , C07D295/192 , C07D307/68
Abstract: The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
Abstract translation: 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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公开(公告)号：US09006454B2
公开(公告)日：2015-04-14
申请号：US13262640
申请日：2010-03-26
Applicant: Siva Sanjeeva Rao Thunuguntla , Hosahalli Subramanya , Satish Reddy Kunnam , Sekhar Reddy Sanivaru Vijay , Chakrapani Bingi , Raviraj Kusanur , Matthias Schwarz , Michael Arlt
Inventor： Siva Sanjeeva Rao Thunuguntla , Hosahalli Subramanya , Satish Reddy Kunnam , Sekhar Reddy Sanivaru Vijay , Chakrapani Bingi , Raviraj Kusanur , Matthias Schwarz , Michael Arlt
IPC: C07D235/18 , C07D403/10 , C07D403/12 , C07D401/10 , C07D401/12 , A61K31/4184 , C07D209/08 , C07D401/04 , C07D403/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04
CPC classification number: C07D209/08 , C07D235/18 , C07D401/04 , C07D401/10 , C07D403/04 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04
Abstract: The invention relates to compounds of formula (I) wherein R1, R2, X1, X2, Y, Ra, Rb, Q have the meanings given in claim 1. The compounds are useful e.g. in the treatment of autoimmune disorders, such as multiple sclerosis and also in the treatment of cancer disorders.
Abstract translation: 本发明涉及式（I）化合物，其中R 1，R 2，X 1，X 2，Y，R a，R b，Q具有权利要求1中给出的含义。 在治疗自身免疫性疾病如多发性硬化以及治疗癌症中。
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9.发明申请公开(公告)号：US20120004213A1
公开(公告)日：2012-01-05
申请号：US13233555
申请日：2011-09-15
Applicant: Kumar SUNDARESAN , Sandeep N. RAIKAR , Srinivasa Raju SAMMETA , Ganesh PRABHU , Hosahalli SUBRAMANYA , Alexander BISCHOFF
Inventor： Kumar SUNDARESAN , Sandeep N. RAIKAR , Srinivasa Raju SAMMETA , Ganesh PRABHU , Hosahalli SUBRAMANYA , Alexander BISCHOFF
IPC: A61K31/495 , C07D295/26 , C07D401/12 , C07D413/12 , A61P3/04 , C07D243/08 , A61K31/496 , A61K31/5377 , A61K31/55 , C07D295/192 , C07D417/12
CPC classification number: C07D295/108 , C07D213/74 , C07D231/40 , C07D263/54 , C07D271/06 , C07D271/107 , C07D277/44 , C07D295/185 , C07D295/192 , C07D295/26 , C07D333/20
Abstract: The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
Abstract translation: 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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公开(公告)号：US08039463B2
公开(公告)日：2011-10-18
申请号：US12408367
申请日：2009-03-20
Applicant: Kumar Sundaresan , Sandeep N. Raikar , Srinivasa Raju Sammeta , Ganesh Prabhu , Hosahalli Subramanya , Alexander Bischoff
Inventor： Kumar Sundaresan , Sandeep N. Raikar , Srinivasa Raju Sammeta , Ganesh Prabhu , Hosahalli Subramanya , Alexander Bischoff
IPC: A61K31/551 , A61K31/495 , A61K31/496 , C07D295/192 , C07D213/75 , C07D231/40 , C07D261/14 , C07D263/58 , C07D271/106 , C07D271/10 , C07D277/46 , C07D333/24
CPC classification number: C07D295/108 , C07D213/74 , C07D231/40 , C07D263/54 , C07D271/06 , C07D271/107 , C07D277/44 , C07D295/185 , C07D295/192 , C07D295/26 , C07D333/20
Abstract: The present invention relates to piperazine derivatives that act as inhibitors of stearoyl-CoA desaturase. The invention also relates to methods of preparing the compounds, compositions containing the compounds, and to methods of treatment using the compounds.
Abstract translation: 本发明涉及作为硬脂酰辅酶A去饱和酶抑制剂的哌嗪衍生物。 本发明还涉及制备化合物的方法，含有该化合物的组合物以及使用该化合物的治疗方法。
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