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公开(公告)号：US08907121B2
公开(公告)日：2014-12-09
申请号：US13140754
申请日：2009-12-11
摘要： A process for purifying methyl methacrylate (MMA) is described. The process involves contacting liquid MMA having impurities therein with a sulphonic acid resin, in the presence of formaldehyde or a suitable source of methylene or ethylene of formula I. R5 and R6 are independently selected from C1-C12 hydrocarbons or H; X is either O or S; n is an integer from, 1 to 100; and m is 1 or 2: The compound of formula I may be suitable source of formaldehyde.
摘要翻译： 描述了甲基丙烯酸甲酯（MMA）的纯化方法。 该方法包括在甲醛或合适的式I的亚甲基或亚乙基的存在下使其中含有杂质的液体MMA与磺酸树脂接触.R 5和R 6独立地选自C 1 -C 12烃或H; X是O或S; n是1至100的整数; 并且m为1或2：式I化合物可以是合适的甲醛源。
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公开(公告)号：US08592624B2
公开(公告)日：2013-11-26
申请号：US12992906
申请日：2009-05-15
CPC分类号： C07C67/343 , C07C51/50 , C07C67/62 , C07C57/04 , C07C69/54
摘要： A production process for the manufacture of ethylenically unsaturated acids or esters thereof is described. The process includes the steps of reaction of an alkanoic acid, or ester of an alkanoic acid, of the formula R3—CH2—COOR4 where R3 and R4 are each independently hydrogen or an alkyl group, in the presence of a catalyst system to produce an ethylenically unsaturated acid or ester product. The process is characterised in that the acid or ester product is subsequently contacted with a dienophile to thereby remove discolouration therefrom. An ethylenically unsaturated acid or ester crude product purification process is also described.
摘要翻译： 描述了用于制备烯属不饱和酸或其酯的制备方法。 该方法包括在催化剂体系的存在下使式R3-CH2-COOR4的链烷酸或链烷酸的酯反应的步骤，其中R 3和R 4各自独立地为氢或烷基，以产生 烯属不饱和酸或酯产物。 该方法的特征在于酸或酯产物随后与亲二烯体接触，从而除去其变色。 还描述了烯属不饱和酸或酯粗产物纯化方法。
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公开(公告)号：US20120059073A1
公开(公告)日：2012-03-08
申请号：US13259951
申请日：2010-03-25
申请人： Trevor Huw Morris
发明人： Trevor Huw Morris
IPC分类号： B01J49/00 , C07C51/47 , C07C51/353 , C07C67/347 , C07C67/56
CPC分类号： B01J49/60 , B01J49/50 , B01J49/53 , C07C67/343 , C07C67/60 , Y02P20/582 , C07C69/54
摘要： A process for the reactivation of an acidic ion exchange resin is described. The invention relates to the treatment of an at least partially deactivated resin which has been deactivated by contact with an impure ethylenically unsaturated acid or ester containing target impurities. The reactivation includes the step of contacting the at least partially deactivated resin with an alcohol to thereby increase the activity thereof. The invention extends to reactivating a resin deactivated by contact with an impure ethylenically unsaturated acid, ester or nitrile containing target impurities by contacting the at least partially deactivated resin with an alcohol and a carboxylic acid to thereby increase the activity thereof. A reactivated resin and a process for preparing and purifying an ethylenically unsaturated acid or ester of the following formula:— R1—C(═(CH2)—COOR2 are also described.
摘要翻译： 描述了酸性离子交换树脂的再活化方法。 本发明涉及至少部分失活的树脂的处理，其通过与不纯的烯属不饱和酸或含有目标杂质的酯接触而失活。 再活化包括使至少部分失活的树脂与醇接触从而增加其活性的步骤。 本发明通过使至少部分失活的树脂与醇和羧酸接触从而增加其活性，延长了通过与不纯的烯键式不饱和酸，含有目标杂质的酯或腈的接触来还原的树脂失活。 还原活化的树脂和用于制备和纯化下式的烯属不饱和酸或酯的方法：-R 1 -C（=（CH 2）-COOR 2）。
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公开(公告)号：US09896729B2
公开(公告)日：2018-02-20
申请号：US14241646
申请日：2012-08-31
申请人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
发明人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
CPC分类号： C12Q1/6883 , A61K38/1709 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/502 , G01N33/5088 , G01N33/6896 , G01N2333/47 , G01N2800/2814 , G01N2800/2835
摘要： The present invention relates to methods of assessing whether a subject has or is likely to develop a neurodegenerative disease comprising determining whether the subject has a mutation in the C9orf72 gene wherein said mutation prevents or disrupts C9orf72 expression relative to expression in a reference from subjects without the mutation.
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公开(公告)号：US20150252421A1
公开(公告)日：2015-09-10
申请号：US14241646
申请日：2012-08-31
申请人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
发明人： Stuart Pickering-Brown , Bryan Traynor , Andrew B. Singleton , Huw Morris , Peter Heutink , John Hardy , Pentti Tienari
CPC分类号： C12Q1/6883 , A61K38/1709 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/502 , G01N33/5088 , G01N33/6896 , G01N2333/47 , G01N2800/2814 , G01N2800/2835
摘要： The present invention relates to methods of assessing whether a subject has or is likely to develop a neurodegenerative disease comprising determining whether the subject has a mutation in the C9orf72 gene wherein said mutation prevents or disrupts C9orf72 expression relative to expression in a reference from subjects without the mutation.
摘要翻译： 本发明涉及评价受试者是否具有或可能发展神经变性疾病的方法，包括确定受试者是否具有C9orf72基因中的突变，其中所述突变阻止或破坏C9orf72表达相对于来自没有 突变。
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公开(公告)号：US20110282023A1
公开(公告)日：2011-11-17
申请号：US13140754
申请日：2009-12-11
IPC分类号： C08F120/18 , C07C69/54 , C07C67/56
摘要： A process for purifying methyl methacrylate (MMA) is described. The process involves contacting liquid MMA having impurities therein with a sulphonic acid resin, in the presence of formaldehyde or a suitable source of methylene or ethylene of formula I. R5 and R6 are independently selected from C1-C12 hydrocarbons or H; X is either O or S; n is an integer from, 1 to 100; and m is 1 or 2: The compound of formula I may be suitable source of formaldehyde.
摘要翻译： 描述了甲基丙烯酸甲酯（MMA）的纯化方法。 该方法包括在甲醛或合适的式I的亚甲基或亚乙基的存在下使其中含有杂质的液体MMA与磺酸树脂接触.R 5和R 6独立地选自C 1 -C 12烃或H; X是O或S; n是1至100的整数; 并且m为1或2：式I化合物可以是合适的甲醛源。
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公开(公告)号：US20110071311A1
公开(公告)日：2011-03-24
申请号：US12992906
申请日：2009-05-15
IPC分类号： C07C51/347 , C07C67/08
CPC分类号： C07C67/343 , C07C51/50 , C07C67/62 , C07C57/04 , C07C69/54
摘要： A production process for the manufacture of ethylenically unsaturated acids or esters thereof is described. The process includes the steps of reaction of an alkanoic acid, or ester of an alkanoic acid, of the formula R3—CH2—COOR4 where R3 and R4 are each independently hydrogen or an alkyl group, in the presence of a catalyst system to produce an ethylenically unsaturated acid or ester product. The process is characterised in that the acid or ester product is subsequently contacted with a dienophile to thereby remove discolouration therefrom. An ethylenically unsaturated acid or ester crude product purification process is also described.
摘要翻译： 描述了用于制备烯属不饱和酸或其酯的制备方法。 该方法包括在催化剂体系的存在下使式R3-CH2-COOR4的链烷酸或链烷酸的酯反应的步骤，其中R 3和R 4各自独立地为氢或烷基，以产生 烯属不饱和酸或酯产物。 该方法的特征在于酸或酯产物随后与亲二烯体接触，从而除去其变色。 还描述了烯属不饱和酸或酯粗产物纯化方法。
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公开(公告)号：US08835518B2
公开(公告)日：2014-09-16
申请号：US13259951
申请日：2010-03-25
申请人： Trevor Huw Morris
发明人： Trevor Huw Morris
IPC分类号： B01J49/00
CPC分类号： B01J49/60 , B01J49/50 , B01J49/53 , C07C67/343 , C07C67/60 , Y02P20/582 , C07C69/54
摘要： A process for the reactivation of an acidic ion exchange resin is described. The invention relates to the treatment of an at least partially deactivated resin which has been deactivated by contact with an impure ethylenically unsaturated acid or ester containing target impurities. The reactivation includes the step of contacting the at least partially deactivated resin with an alcohol to thereby increase the activity thereof. The invention extends to reactivating a resin deactivated by contact with an impure ethylenically unsaturated acid, ester or nitrile containing target impurities by contacting the at least partially deactivated resin with an alcohol and a carboxylic acid to thereby increase the activity thereof. A reactivated resin and a process for preparing and purifying an ethylenically unsaturated acid or ester of the following formula: —R1—C(═(CH2)m)—COOR2 are also described.
摘要翻译： 描述了酸性离子交换树脂的再活化方法。 本发明涉及至少部分失活的树脂的处理，其通过与不纯的烯属不饱和酸或含有目标杂质的酯接触而失活。 再活化包括使至少部分失活的树脂与醇接触从而增加其活性的步骤。 本发明通过使至少部分失活的树脂与醇和羧酸接触从而增加其活性，延长了通过与不纯的烯键式不饱和酸，含有目标杂质的酯或腈的接触来还原的树脂失活。 还描述了再活化的树脂和用于制备和纯化下式的烯属不饱和酸或酯的方法：-R1-C（=（CH2）m）-COOR2。
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