利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

4 条记录 (耗时 0.012 秒)

    GRAPHICAL MODELS FOR THE ANALYSIS OF GENOME-WIDE ASSOCIATIONS
    1.
    发明申请
    GRAPHICAL MODELS FOR THE ANALYSIS OF GENOME-WIDE ASSOCIATIONS 审中-公开
    用于分析基因组协会的图形模型

    公开(公告)号：US20090326832A1

    公开(公告)日：2009-12-31

    申请号：US12163774

    申请日：2008-06-27

    申请人： David E. Heckerman ,  Carl M. Kadie ,  Hyunmin Kang

    发明人： David E. Heckerman ,  Carl M. Kadie ,  Hyunmin Kang

    IPC分类号： G06F19/00 ,  G06G7/48

    CPC分类号： G16B20/00

    摘要： Systems and methods are provided for the identification of genotype-phenotype associations in genome-wide association (GWA) studies. In an illustrative implementation, a data correlation environment comprises a population structure engine and at least one instruction set to instruct the population structure engine to process pedigree or population genetic data to generate a population structure sub-model according to a selected graphical model-based data correlation paradigm. Illustratively, the parameter of the resulting generalized linear mixed model can be learned using a variational approximation.

    摘要翻译： 提供系统和方法用于鉴定全基因组关联（GWA）研究中的基因型 - 表型关联。 在说明性实现中，数据相关环境包括总体结构引擎和至少一个指令集，以指示人口结构引擎处理血统或群体遗传数据，以根据所选择的基于图形模型的数据生成群体结构子模型 相关范式 说明性地，可以使用变分近似来学习所得到的广义线性混合模型的参数。

    Reactive anthraquinone derivatives and conjugates thereof
    2.
    发明授权
    Reactive anthraquinone derivatives and conjugates thereof 失效
    活性蒽醌衍生物及其偶联物

    公开(公告)号：US5650399A

    公开(公告)日：1997-07-22

    申请号：US420326

    申请日：1995-04-11

    申请人： Steven E. Rokita ,  Hyunmin Kang

    发明人： Steven E. Rokita ,  Hyunmin Kang

    IPC分类号： C07H21/00 ,  C07H21/02 ,  C07H21/04

    CPC分类号： C07H21/00

    摘要： Anthraquinone derivatives are constructed for alkylation of target molecules. The anthraquinone derivative includes an anthraquinone ring system which has been modified by the addition of inducibly reactive substituents at positions on the ring system. The anthraquinone ring system can be selectively activated for alkylation of a target molecule. The substituents may be from 1 to 4 methyl groups, whereupon activation is achieved by a photochemical signal. In an additional alternative embodiment, the inducible reactive substituents may include both methyl groups and substituted methylene groups. In this embodiment, the activation of the anthraquinone derivative is achieved by photochemical and/or reductive signals. Alternatively, the substituents may be from 1 to 8 methyl groups modified to include a reactive group, whereupon activation is achieved by a chemical or enzymatic reductive signal. The anthraquinone derivatives of the invention may be used for non-specific modification of target molecules. Alternatively, the anthraquinone derivative may be further derivatized to permit specific modification of target molecules. The further derivatization of the anthraquinone includes attaching a probe to the anthraquinone ring system by way of a linking group. The probe is chosen to selectively localize to a target molecule, whereupon the anthraquinone derivative may be activated to react with and aklylate the target molecule. Also the process of employing such anthraquinone derivatives for use in vitro or in vivo for alkylating, specifically or non-specifically alkylating, target molecules.

    摘要翻译： 构建蒽醌衍生物用于靶分子的烷基化。 蒽醌衍生物包括通过在环系上的位置添加可诱导的反应性取代基而被修饰的蒽醌环体系。 可以选择性地活化蒽醌环体系用于靶分子的烷基化。 取代基可以是1至4个甲基，因此通过光化学信号实现活化。 在另外的替代实施方案中，可诱导的反应性取代基可以包括甲基和取代的亚甲基。 在该实施方案中，通过光化学和/或还原信号实现蒽醌衍生物的活化。 或者，取代基可以是经修饰以包括反应性基团的1至8个甲基，因此通过化学或酶还原信号实现活化。 本发明的蒽醌衍生物可用于靶分子的非特异性修饰。 或者，可以将蒽醌衍生物进一步衍生化，以允许目标分子的特异性修饰。 蒽醌的进一步衍生化包括通过连接基团将探针附着到蒽醌环体系上。 选择该探针以选择性地定位于靶分子，于是该蒽醌衍生物可以被活化以与靶分子反应并使其成为碱基。 也是使用这种蒽醌衍生物在体外或体内用于烷基化，特异性或非特异性烷基化靶分子的方法。