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公开(公告)号:US12109074B2
公开(公告)日:2024-10-08
申请号:US18198486
申请日:2023-05-17
申请人: Inscopix, Inc.
发明人: Mark O. Trulson , Alice Stamatakis , Koen Visscher
IPC分类号: A61B90/20 , A61B5/00 , G01N21/64 , G02B21/00 , G02B21/02 , G02B21/06 , G02B21/16 , G02B21/32 , G01Q10/00 , G02B3/14 , G02B21/24
CPC分类号: A61B90/20 , A61B5/0059 , A61B5/0071 , A61B5/4064 , G01N21/6458 , G02B21/0004 , G02B21/0096 , G02B21/025 , G02B21/06 , G02B21/16 , G02B21/32 , A61B5/0035 , G01N2021/6439 , G01N2021/6441 , G01Q10/00 , G02B3/14 , G02B21/242
摘要: Systems and methods configured for simultaneous imaging and stimulation using a microscope system. The microscope system can have a relatively small size compared to an average microscope system. The microscope can comprise in part an imaging light source and a stimulation light source. Light from the imaging light source and the stimulation light source can be spectrally separated to reduce cross talk between the stimulation light and the imaging light.
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公开(公告)号:US11197735B2
公开(公告)日:2021-12-14
申请号:US16851678
申请日:2020-04-17
申请人: INSCOPIX, INC.
发明人: Mark O. Trulson , Alice Stamatakis , Koen Visscher
IPC分类号: A61B90/20 , G01N21/64 , G02B21/16 , G02B21/06 , A61B5/00 , G02B21/02 , G02B21/00 , G02B21/32 , G02B3/14 , A61B5/24 , G01Q10/00 , G02B21/24
摘要: Provided herein are systems and methods for simultaneous imaging and stimulation using a microscope system. The microscope system can have a relatively small size compared to an average microscope system. The microscope can comprise in part an imaging light source and a stimulation light source. Light from the imaging light source and the stimulation light source can be spectrally separated to reduce cross talk between the stimulation light and the imaging light.
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公开(公告)号:US20210059578A1
公开(公告)日:2021-03-04
申请号:US17020978
申请日:2020-09-15
申请人: INSCOPIX, INC.
发明人: Jonathan J. NASSI , David CHENG , Mark TRULSON
IPC分类号: A61B5/1459 , A61B5/1473 , A61B5/145 , A61B5/00 , A61K9/00 , A61K49/00 , A61K35/761 , C12N7/00 , C07K14/435 , C07K14/47 , C12N9/12
摘要: Disclosed herein are implantable devices coated with a reagent, and methods of preparing and utilizing such devices. The implantable device may comprise an implantable light conduit. The present disclosure enables a more precise registration between the reagent and the device implanted in the target tissue of a subject.
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公开(公告)号:US20180296074A1
公开(公告)日:2018-10-18
申请号:US15955887
申请日:2018-04-18
申请人: INSCOPIX, INC.
发明人: Mark O. TRULSON , Sam J. MALANOWSKI
摘要: Provided herein are optical probes to enhance the accessible volume imaged with a microscope, and systems and methods for inserting the optical probes into an object for imaging of the interior of the object. The object can be a tissue of a living organism. The probe can continuously image the space in the vicinity of the probe as the probe is inserted into the object. The probe can image a sample at an angle great than 0° relative to the implantation axis of the probe. The probe can be connected to a surface of the object by a cuff. The cuff can comprise one or more surface features to increase a surface area of the cuff that attaches to the surface of the object. The cuff can be held by a clamp while the probe is inserted into the object for imaging.
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公开(公告)号:US20180220106A1
公开(公告)日:2018-08-02
申请号:US15687166
申请日:2017-08-25
申请人: Inscopix, Inc.
发明人: Kunal GHOSH
CPC分类号: H04N7/183 , G02B21/365
摘要: System and methods are provided for distributed microscopy. A plurality of microscopes may capture images and send them to a media server. The microscopes and the media server may be part of a local area network. The microscopes may each have a distinct network address. The media server may communicate with an operations console, which may be used to view images captured by the microscopes. The operations console may also accept user input which may be used to selectively control the microscopes.
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公开(公告)号:US20180074306A1
公开(公告)日:2018-03-15
申请号:US15697702
申请日:2017-09-07
申请人: Inscopix, Inc.
发明人: Koen Visscher , Shung Chieh , Arash Tajik
IPC分类号: G02B21/18 , A61B5/00 , G01N1/44 , H04N5/232 , G02B21/36 , G06T11/00 , G06T7/38 , G06T7/32 , G06T3/00
CPC分类号: G02B21/18 , A61B1/00186 , A61B5/0064 , A61B5/0068 , A61B5/0071 , A61B5/0084 , G01N1/44 , G02B21/367 , G06T3/0081 , G06T7/32 , G06T7/33 , G06T7/38 , G06T11/003 , G06T2207/10016 , G06T2207/10056 , G06T2207/20024 , G06T2207/20056 , H04N5/23212
摘要: Disclosed herein are adapters configured to be optically coupled to a plurality of microscopes, said adapter comprising: a) a first microscope interface configured to optically couple a first microscope to an optical element in optical communication with an optical probe; b) a second microscope interface configured to optically couple a second microscope to the optical element in optical communication with the optical probe; and c) an optical arrangement configured to direct light collected from a sample with aid of the optical probe to (1) the first microscope and second microscope simultaneously, or (2) the first microscope or second microscope selectively.
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公开(公告)号:US12066618B2
公开(公告)日:2024-08-20
申请号:US18218846
申请日:2023-07-06
申请人: Inscopix, Inc.
发明人: Mark Trulson , Koen Visscher , Kevin Newman
CPC分类号: G02B21/18 , G02B19/0014 , G02B19/0066 , G02B21/02 , G02B21/241 , G02B21/361 , G02B21/367 , G02B27/0037
摘要: Systems and methods for multi-color imaging using a microscope system. The microscope system can have a relatively small size as compared to an average microscope system. The microscope system can include various components configured to reduce or eliminate image artifacts such as chromatic aberrations and/or noise from stray light that can occur during multi-color imaging. The components can be configured to reduce or eliminate the image artifacts, and/or noise without substantially changing the size of the microscope system.
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公开(公告)号:US11960072B2
公开(公告)日:2024-04-16
申请号:US17481123
申请日:2021-09-21
申请人: Inscopix, Inc.
发明人: Koen Visscher , Pei Sabrina Xu , Shay Neufeld
CPC分类号: G02B21/367 , G02B21/18 , G06N3/08 , G06T7/37 , G06T11/60 , G06T2207/10056
摘要: An adapter configured to be optically coupled to a plurality of microscopes. The adapter includes a) a first microscope interface configured to optically couple a first microscope to an optical element in optical communication with an optical probe; b) a second microscope interface configured to optically couple a second microscope to the optical element in optical communication with the optical probe; and c) an optical arrangement configured to direct light collected from a sample with aid of the optical probe to (1) the first microscope and second microscope simultaneously, or (2) the first microscope or second microscope selectively.
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公开(公告)号:US20230359011A1
公开(公告)日:2023-11-09
申请号:US18218846
申请日:2023-07-06
申请人: Inscopix, Inc.
发明人: Mark TRULSON , Koen VISSCHER , Kevin NEWMAN
CPC分类号: G02B21/18 , G02B27/0037 , G02B21/02 , G02B19/0014 , G02B19/0066 , G02B21/241 , G02B21/361 , G02B21/367
摘要: Systems and methods for multi-color imaging using a microscope system. The microscope system can have a relatively small size as compared to an average microscope system. The microscope system can include various components configured to reduce or eliminate image artifacts such as chromatic aberrations and/or noise from stray light that can occur during multi-color imaging. The components can be configured to reduce or eliminate the image artifacts, and/or noise without substantially changing the size of the microscope system.
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公开(公告)号:US20220094881A1
公开(公告)日:2022-03-24
申请号:US17316394
申请日:2021-05-10
申请人: Inscopix, Inc.
发明人: Kunal GHOSH
摘要: System and methods are provided for distributed microscopy. A plurality of microscopes may capture images and send them to a media server. The microscopes and the media server may be part of a local area network. The microscopes may each have a distinct network address. The media server may communicate with an operations console, which may be used to view images captured by the microscopes. The operations console may also accept user input which may be used to selectively control the microscopes.
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