公开(公告)号：US08287934B2

公开(公告)日：2012-10-16

申请号：US12300820

申请日：2007-05-07

申请人： Jakob Ley ,  Berthold Weber ,  Gerhard Krammer ,  Ingo Reiss ,  Heinz-Jürgen Bertram ,  Ian Gatfield ,  Petra Hoffmann-Lücke

发明人： Jakob Ley ,  Berthold Weber ,  Gerhard Krammer ,  Ingo Reiss ,  Heinz-Jürgen Bertram ,  Ian Gatfield ,  Petra Hoffmann-Lücke

IPC分类号： A23L1/22 ,  A61K8/02

CPC分类号： A23C9/1307 ,  A21D2/14 ,  A21D13/40 ,  A21D13/80 ,  A23C9/156 ,  A23D7/0056 ,  A23D7/015 ,  A23G3/36 ,  A23G4/06 ,  A23G9/32 ,  A23L19/00 ,  A23L27/206 ,  C12C5/026 ,  C12G1/00 ,  C12G3/06

摘要： The invention relates to the use of 5-acetyl-2,5-dimethyl-2-hydroxy-tetrahydrofuran-3-one (diacetyl dimer of formula (I)) in the form of one of its stereoisomers or in the form of a mixture consisting of or containing two, three or four of its stereoisomers (i) for imparting, intensifying and/or modifying a creamy and/or fatty sensation in the mouth, (ii) for imparting, intensifying and/or modifying a sweet, buttery, cream-like and/or creamy flavor; and/or (iii) as an aromatic and/or flavoring substance. The invention furthermore relates to a process (i) for imparting, intensifying and/or modifying a creamy and/or fatty sensation in the mouth, (ii) for imparting, intensifying and/or modifying a sweet, buttery, cream-like and/or creamy flavor, to corresponding aromatic compositions, to formulations selected from a nutrition formulation (foodstuff), an oral hygiene formulation, a luxury product formulation, a formulation for oral pharmaceutical use or a semi-finished good formulation for the preparation of nutrition formulations or luxury product formulations, as well as preparations comprising one or more of said compositions and/or formulations.

摘要翻译： 本发明涉及其一种立体异构体形式的5-乙酰基-2,5-二甲基-2-羟基 - 四氢呋喃-3-酮（式（I）的二乙酰二聚体）或混合物形式的用途 包含或含有二，三或四种立体异构体（i）用于赋予，增强和/或改变口腔中的乳状和/或脂肪感觉，（ii）用于赋予，增强和/或改变甜味， 奶油状和/或奶油味; 和/或（iii）作为芳香和/或调味物质。 本发明还涉及一种用于赋予，增强和/或改变口腔中的乳状和/或脂肪感觉的方法（i），（ii）用于赋予，加强和/或改变甜味，奶油状和/ 或奶油味，与相应的芳香族组合物相对于选自营养制剂（食品），口腔卫生制剂，豪华产品制剂，用于口服药物用途的制剂或用于制备营养制剂的半成品良好制剂的制剂，或 豪华产品制剂，以及包含一种或多种所述组合物和/或制剂的制剂。

公开(公告)号：US5753473A

公开(公告)日：1998-05-19

申请号：US723707

申请日：1996-09-30

申请人： Ian Gatfield ,  Gunter Kindel

发明人： Ian Gatfield ,  Gunter Kindel

IPC分类号： C12P7/64 ,  C12P7/62

CPC分类号： C12P7/62 ,  Y10S435/921

摘要： Trans-2,cis-4-decadienoic acid ethyl ester can be prepared from Stillingia oil by enzymatic transesterification with lipase from Candida antarctica in the presence of ethanol.

摘要翻译： 反式-2顺式-4-癸烯二酸乙酯可以从Stillingia油中通过在乙醇存在下用来自南极假丝酵母的脂肪酶进行酶酯交换反应制备。

公开(公告)号：US08318711B2

公开(公告)日：2012-11-27

申请号：US11720582

申请日：2005-11-30

申请人： Ian Gatfield ,  Jakob Ley ,  Ingo Reiss ,  Günter Kindel ,  Gerhard Krammer

发明人： Ian Gatfield ,  Jakob Ley ,  Ingo Reiss ,  Günter Kindel ,  Gerhard Krammer

IPC分类号： A01N43/00 ,  A01N35/00 ,  A61K31/33 ,  A61K31/12

CPC分类号： A23L27/88 ,  A23L27/86

摘要： The invention relates to the use of 2,5-diacetyl-3a,5,6,6a-tetrahydro-6a-hydroxy-2,3a,5-trimethylfuro[2,3-d]-1,3-dioxole (diacetyl trimer) of the formula in the form of one of its stereoisomers or in the form of a mixture consisting of or containing two or more of the stereoisomers (i) as an odoriferous or aromatic substance, (ii) for imparting, intensifying and/or modifying a creamy and/or fatty sensation in the mouth, (iii) for imparting, intensifying and/or modifying a sweet, buttery, cream-like and/or creamy flavor, and/or (iv) for masking a bitter flavor. The invention furthermore relates to corresponding aromatic compositions as well as compositions which serve for nutrition, oral hygiene, consumption for pleasure or for oral pharmaceutical use.

摘要翻译： 本发明涉及2,5-二乙酰基-3,3,5,6,6a-四氢-6a-羟基-2,3a，5-三甲基呋喃并[2,3-d] -1,3-二氧杂环戊烯（二乙酰基三聚体 ）式中其一种立体异构体形式或以由两种或多种立体异构体组成的混合物形式的混合物（i）作为有气味或芳族物质，（ii）用于赋予，增强和/或改变 （iii）用于赋予，加强和/或改变甜的，黄油状，奶油状和/或奶油味，和/或（iv）掩蔽苦味的口香糖和/或脂肪感觉。 本发明还涉及相应的芳族组合物以及用于营养，口腔卫生，快乐消费或口服药物使用的组合物。

公开(公告)号：US20090208426A1

公开(公告)日：2009-08-20

申请号：US11720582

申请日：2005-11-30

申请人： Ian Gatfield ,  Jakob Ley ,  Ingo Reiss ,  Günter Kindel ,  Gerhard Krammer

发明人： Ian Gatfield ,  Jakob Ley ,  Ingo Reiss ,  Günter Kindel ,  Gerhard Krammer

IPC分类号： A61K8/49 ,  C07D317/44 ,  A23L1/226 ,  A61K31/357 ,  A61Q11/00

CPC分类号： A23L27/88 ,  A23L27/86

摘要： The invention relates to the use of 2,5-diacetyl-3a,5,6,6a-tetrahydro-6a-hydroxy-2,3a,5-trimethylfuro[2,3-d]-1,3-dioxole (diacetyl trimer) of the formula in the form of one of its stereoisomers or in the form of a mixture consisting of or containing two or more of the stereoisomers (i) as an odoriferous or aromatic substance, (ii) for imparting, intensifying and/or modifying a creamy and/or fatty sensation in the mouth, (iii) for imparting, intensifying and/or modifying a sweet, buttery, cream-like and/or creamy flavour, and/or (iv) for masking a bitter flavour. The invention furthermore relates to corresponding aromatic compositions as well as compositions which serve for nutrition, oral hygiene, consumption for pleasure or for oral pharmaceutical use.

摘要翻译： 本发明涉及2,5-二乙酰基-3,3,5,6,6a-四氢-6a-羟基-2,3a，5-三甲基呋喃并[2,3-d] -1,3-二氧杂环戊烯（二乙酰基三聚体 ）式中其一种立体异构体形式或以由两种或多种立体异构体组成的混合物形式的混合物（i）作为有气味或芳族物质，（ii）用于赋予，增强和/或改变 （iii）用于赋予，加强和/或改变甜的，黄油状，奶油状和/或奶油味，和/或（iv）掩蔽苦味的口香糖和/或脂肪感觉。 本发明还涉及相应的芳族组合物以及用于营养，口腔卫生，快乐消费或口服药物使用的组合物。

公开(公告)号：US5468627A

公开(公告)日：1995-11-21

申请号：US27915

申请日：1993-03-08

申请人： Ian Gatfield ,  Theodor Sand

发明人： Ian Gatfield ,  Theodor Sand

IPC分类号： C12P7/40 ,  C12P7/52 ,  C12N1/20

CPC分类号： C12P7/40 ,  Y10S435/823

摘要： Disclosed is a process for the preparation of aliphatic carboxylic acids by microbial oxidation of alcohols with relatively long, optionally branched C chains by means of atmospheric oxygen, in which the bacteria species Gluconobacter roseus is used as the microorganism. Contemplated is the use of Gluconobacter roseus strain IAM 1841 to oxidize n-butanol, isobutanol, 2-methylbutanol and 3-methylbutanol to the corresponding acids. Also contemplated is the use of Gluconobacter roseus strain IFO 3990 to oxidize isobutanol, 2-methylbutanol and 3-methylbutanol to the corresponding acids.

摘要翻译： 公开了一种通过微生物氧化具有相对长的任选支链的C链的醇的制备脂肪族羧酸的方法，其中使用细菌种类的葡萄糖酸杆菌葡萄球菌作为微生物。 考虑到使用葡萄糖酸杆菌菌株IAM 1841将正丁醇，异丁醇，2-甲基丁醇和3-甲基丁醇氧化成相应的酸。 还考虑使用葡萄糖酸杆菌菌株IFO 3990将异丁醇，2-甲基丁醇和3-甲基丁醇氧化成相应的酸。

公开(公告)号：US06451565B1

公开(公告)日：2002-09-17

申请号：US09830148

申请日：2001-04-20

申请人： Jürgen Rabenhorst ,  Ian Gatfield

发明人： Jürgen Rabenhorst ,  Ian Gatfield

IPC分类号： C12N100

CPC分类号： C12P17/04 ,  C12P7/62 ,  Y10S435/911

摘要： A process is provided for producing &ggr;-decalactone using Yarrowia lipolytica HR 145 (DSM 12397). The process includes preparing the product in a bioreactor by culturing the pure strain of Yarrowia lipolytica in a culture medium containing carbon compounds, nitrogen compounds, inorganic salts, trace elements, vitamins, etc. Other ingredients of the culture medium include glycerol, glucose, mannitol, citric acid, malt extract, yeast extract, casein hydrolysate, castor oil, cotton seed meal or corn steep liquor. Also sulphates, nitrates, chlorides, carbonates or phosphates of metals sodium, potassium magnesium, manganese, calcium, zinc, and mixtures thereof can be used in the culture medium. Further, a pure strain of Yarrowia lipolytica HR 145 (DSM 12397) is provided.

摘要翻译： 提供了使用解脂耶氏酵母HR 145（DSM 12397）产生γ-癸内酯的方法。 该方法包括在生物反应器中通过在含有碳化合物，氮化合物，无机盐，微量元素，维生素等的培养基中培养纯化的解脂耶氏酵母菌株来制备该产物。培养基的其它成分包括甘油，葡萄糖，甘露醇 ，柠檬酸，麦芽提取物，酵母提取物，酪蛋白水解物，蓖麻油，棉籽粉或玉米浆。 也可以在培养基中使用金属钠，钾镁，锰，钙，锌及其混合物的硫酸盐，硝酸盐，氯化物，碳酸盐或磷酸盐。 此外，提供了解脂耶氏酵母属HR 145（DSM 12397）的纯菌株。

公开(公告)号：US4451565A

公开(公告)日：1984-05-29

申请号：US350519

申请日：1982-02-19

申请人： Ian Gatfield ,  Theodor Sand

发明人： Ian Gatfield ,  Theodor Sand

IPC分类号： C12P7/40 ,  C12P7/42 ,  C12P7/62 ,  C12P17/02 ,  C12P17/04 ,  C12P17/00 ,  C12P7/00 ,  C12R1/785

CPC分类号： C12P17/04 ,  C12P7/62 ,  Y10S435/931

摘要： In the enzyme-mediated synthesis of an ester or lactone from at least one carboxylic acid of the formulaR--CH.sub.2 --CH.sub.2 --COOHwhereinR is a hydrogen atom, or a hydrocarbon radical which has 1 to 21 carbon atoms and which can be optionally substituted by hydroxyl groups or alkoxy groups with 1 to 10 carbon atoms,with at least one primary or secondary alcohol having 1 to 15 carbon atoms, the improvement which comprises employing as the enzyme the esterase from Mucor miehei and effecting the synthesis in the absence of water. Advantageously, the synthesis is effected at about room temperature, the mol ratio of carboxylic acid to alcohol is from about 1:1 to 1:1.1, and the enzyme is used in a quantity of about 3 to 20% by weight of the carboxylic acid. The absence of water facilitates recovery, as by distillation.

摘要翻译： 在酶介导的由至少一种式R-CH 2 -CH 2 -COOH的羧酸（其中R是氢原子）或具有1至21个碳原子的烃基的酯或内酯的合成中，其可以是任选的 由具有1-10个碳原子的羟基或烷氧基取代，至少一个具有1至15个碳原子的伯醇或仲醇，其改进包括使用来自Mucor miehei的酯酶并在不存在下进行合成 水。 有利地，合成在约室温下进行，羧酸与醇的摩尔比为约1:1至1:1.1，酶的用量为羧酸的约3-20重量％ 。 没有水有助于回收，如通过蒸馏。