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    Lateral flow assay systems and methods
    3.
    发明授权
    Lateral flow assay systems and methods 有权
    侧流测定系统和方法

    公开(公告)号：US09091631B2

    公开(公告)日：2015-07-28

    申请号：US13360081

    申请日：2012-01-27

    申请人： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

    发明人： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

    IPC分类号： G01N21/17 ,  G01N21/84 ,  G01N33/558

    CPC分类号： G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

    摘要： In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of the localized regions is characterized by at least one surface dimension smaller than the first dimension. The data analyzer identifies ones of the light intensity measurements obtained from the at least one test region and computes at least one parameter from the identified ones of the light intensity measurements. In another aspect, the reader obtains a respective set of light intensity measurements from each of multiple corresponding regions of the exposed surface area of the detection zone, and the data analyzer computes at least one parameter from at least one of the sets of light intensity measurements.

    摘要翻译： 一方面，诊断测试系统包括壳体，读取器和数据分析器。 壳体包括用于接收测试条的端口。 读取器从暴露于光学检查的检测区域的区域的局部区域获得可分离的光强度测量值，其中每个局部区域的特征在于至少一个小于第一维度的表面尺寸。 数据分析器识别从至少一个测试区域获得的光强度测量结果中的一个，并从所识别的光强测量中计算至少一个参数。 在另一方面，读取器从检测区域的暴露表面区域的多个对应区域中的每一个获得相应的一组光强度测量值，并且数据分析器从至少一个光强度测量集合中计算至少一个参数 。

    LATERAL FLOW ASSAY SYSTEMS AND METHODS
    4.
    发明申请
    LATERAL FLOW ASSAY SYSTEMS AND METHODS 有权
    侧流测量系统和方法

    公开(公告)号：US20140004624A1

    公开(公告)日：2014-01-02

    申请号：US14019166

    申请日：2013-09-05

    申请人： Alverix, Inc.

    发明人： Patrick T. Petruno ,  John F. Petrilla ,  Michael J. Brosnan ,  Rong Zhou ,  Daniel B. Roitman

    IPC分类号： G01N21/17

    CPC分类号： G01N33/54386 ,  G01N21/17 ,  G01N21/274 ,  G01N21/6428 ,  G01N21/8483 ,  G01N33/558 ,  G01N2021/6439 ,  G01N2201/062 ,  G01N2201/067 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/809 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

    摘要： In one aspect, a diagnostic test system includes a housing, a reader, and a data analyzer. The housing includes a port for receiving a test strip. The reader obtains separable light intensity measurements from localized regions of an area of the detection zone exposed for optical inspection, wherein each of the localized regions is characterized by at least one surface dimension smaller than the first dimension. The data analyzer identifies ones of the light intensity measurements obtained from the at least one test region and computes at least one parameter from the identified ones of the light intensity measurements. In another aspect, the reader obtains a respective set of light intensity measurements from each of multiple corresponding regions of the exposed surface area of the detection zone, and the data analyzer computes at least one parameter from at least one of the sets of light intensity measurements.

    摘要翻译： 一方面，诊断测试系统包括壳体，读取器和数据分析器。 壳体包括用于接收测试条的端口。 读取器从暴露于光学检查的检测区域的区域的局部区域获得可分离的光强度测量值，其中每个局部区域的特征在于至少一个小于第一维度的表面尺寸。 数据分析器识别从至少一个测试区域获得的光强度测量结果中的一个，并从所识别的光强测量中计算至少一个参数。 在另一方面，读取器从检测区域的暴露表面区域的多个对应区域中的每一个获得相应的一组光强度测量值，并且数据分析器从至少一个光强度测量集合中计算至少一个参数 。

    Method for adding an apparent non-signal line to a rapid diagnostic assay
    5.
    发明授权
    Method for adding an apparent non-signal line to a rapid diagnostic assay 有权
    将明显的非信号线添加到快速诊断测定中的方法

    公开(公告)号：US08030091B2

    公开(公告)日：2011-10-04

    申请号：US12423697

    申请日：2009-04-14

    申请人： Jeremy Jerome ,  Mark Daquipa ,  Bruce Jacono ,  Hans Boehringer ,  Paul Lambotte ,  Paul J. Lawrence

    发明人： Jeremy Jerome ,  Mark Daquipa ,  Bruce Jacono ,  Hans Boehringer ,  Paul Lambotte ,  Paul J. Lawrence

    IPC分类号： G01N33/543

    CPC分类号： G01N21/8483 ,  B01L3/5023 ,  G01N33/54386 ,  G01N33/558 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

    摘要： A test device and method for determining the presence or absence of one or more analytes in a fluid sample, the test device including a support or member bearing a mark thereon, and a matrix or member containing a capture zone. In operation, an observation area in the test device becomes transparent, thereby allowing the user to view a mark that is present on a support that is disposed beneath the observation area. Typically, the mark on the underlying support is configured as a minus (−) sign. In the absence of analyte in the sample, the test device presents a negative result as a minus (−) signal. In the presence of analyte in the sample, however, the mark operates in concert with a perpendicular test line on the observation area to present a positive result as a plus (+) signal that is visible to the user.

    摘要翻译： 一种用于确定流体样品中一种或多种分析物的存在或不存在的测试装置和方法，所述测试装置包括在其上具有标记的支撑件或构件，以及包含捕获区的基质或构件。 在操作中，测试装置中的观察区域变得透明，从而允许用户观看存在于设置在观察区域下方的支撑体上的标记。 通常，底层支持上的标记被配置为减号（ - ）。 在样品中没有分析物的情况下，测试装置呈负值（-1）信号。 然而，在样品中存在分析物的情况下，标记与观察区域上的垂直测试线一致，以将正的结果呈现为使用者可见的加号（+）信号。

    Method for Adding an Apparent Non-Signal Line to a Rapid Diagnostic Assay
    6.
    发明申请
    Method for Adding an Apparent Non-Signal Line to a Rapid Diagnostic Assay 失效
    将快速诊断测试中添加视觉非信号线的方法

    公开(公告)号：US20070111323A1

    公开(公告)日：2007-05-17

    申请号：US11622201

    申请日：2007-01-11

    申请人： Jeremy Jerome ,  Mark Daquipa ,  Bruce Jacono ,  Hans Boehringer ,  Paul Lambotte ,  Paul Lawrence

    发明人： Jeremy Jerome ,  Mark Daquipa ,  Bruce Jacono ,  Hans Boehringer ,  Paul Lambotte ,  Paul Lawrence

    IPC分类号： G01N33/558

    CPC分类号： G01N21/8483 ,  B01L3/5023 ,  G01N33/54386 ,  G01N33/558 ,  Y10S435/805 ,  Y10S435/823 ,  Y10S436/807 ,  Y10S436/81 ,  Y10S436/823 ,  Y10T436/25125

    摘要： A test device and method for determining the presence or absence of one or more analytes in a fluid sample, the test device including a support or member bearing a mark thereon, and a matrix or member containing a capture zone. In operation, an observation area in the test device becomes transparent, thereby allowing the user to view a mark that is present on a support that is disposed beneath the observation area. Typically, the mark on the underlying support is configured as a minus (−) sign. In the absence of analyte in the sample, the test device presents a negative result as a minus (−) signal. In the presence of analyte in the sample, however, the mark operates in concert with a perpendicular test line on the observation area to present a positive result as a plus (+) signal that is visible to the user.

    摘要翻译： 一种用于确定流体样品中一种或多种分析物的存在或不存在的测试装置和方法，所述测试装置包括在其上具有标记的支撑件或构件，以及包含捕获区的基质或构件。 在操作中，测试装置中的观察区域变得透明，从而允许用户观看存在于设置在观察区域下方的支撑体上的标记。 通常，底层支持上的标记被配置为减号（ - ）。 在样品中没有分析物的情况下，测试装置呈负值（-1）信号。 然而，在样品中存在分析物的情况下，标记与观察区域上的垂直测试线一致，以将正的结果呈现为使用者可见的加号（+）信号。

    Systemic non-nodular endosymbiotic nitrogen fixation in plants
    7.
    发明申请
    Systemic non-nodular endosymbiotic nitrogen fixation in plants 有权
    系统性非结节性内共生植物固氮植物

    公开(公告)号：US20040235663A1

    公开(公告)日：2004-11-25

    申请号：US10488422

    申请日：2004-06-14

    发明人： Edward Charles Daniel Cocking

    IPC分类号： A01N063/00 ,  A01H005/00

    CPC分类号： A01H17/00 ,  Y10S435/822 ,  Y10S435/823

    摘要： Non-leguminous crops, e.g. wheat, maize and rice, do not form nodules and are dependant for their nutrition on fixed nitrogen from the soil, or from chemical/nitrogenous fertilizers. The present invention provides non-leguminous plants and leguminous plants, including legumes that fail to nodulate with Rhizobia, with bacteria that enable them to fix nitrogen endophytically. Therefore, the plants contain nitrogen fixing bacteria the bacteria being located intacellularly in living plant cells.

    摘要翻译： 非豆科作物，例如 小麦，玉米和大米不会形成结节，并且依赖于在土壤或化学/氮肥肥料固定氮素上的营养。 本发明提供非豆科植物和豆科植物，包括不能根瘤菌结瘤的豆类，以及能够内生固氮的细菌。 因此，植物含有细菌在生物植物细胞中位于细胞内的固氮细菌。

    Process for the production of bacterial cellulose
    8.
    发明授权
    Process for the production of bacterial cellulose 失效
    生产细菌纤维素的方法

    公开(公告)号：US6017740A

    公开(公告)日：2000-01-25

    申请号：US836986

    申请日：1997-08-07

    申请人： Tohru Kouda ,  Takaaki Naritomi ,  Hisato Yano ,  Fumihiro Yoshinaga

    发明人： Tohru Kouda ,  Takaaki Naritomi ,  Hisato Yano ,  Fumihiro Yoshinaga

    IPC分类号： C12P19/04 ,  C08B1/00 ,  C12N1/20

    CPC分类号： C12P19/04 ,  Y10S435/822 ,  Y10S435/823

    摘要： The present invention relates to a process for the production of cellulosic material which comprises culturing a cellulose-producing bacterium while maintaining the internal pressure within the fermentation tank at about 1.1 kg/cm.sup.2 A or more, preferably at about 1.2 kg/cm.sup.2 A or more, more preferably at about 1.5 kg/cm.sup.2 A or more, generally in the later stage of the cultivation (the growth decline phase and stationary phase), namely, at the stage where a concentration of the cellulosic material in a culture medium reaches about 10 g/L or more, preferably about 12 g/L or more; at the culturing stage where an apparent density of the culture medium at 10 rad/s or 1 l/s reaches about 10 Pa.s or more; at the culturing stage where the K value (consistency index) reaches about 10 Pa.s.sup.n or more considering that rheology follows the Power law model; or at the stage where the oxygen-demand of the culture medium reaches about 35 mmol/L.hr or more.

    摘要翻译： PCT No.PCT / JP96 / 02454 Sec。 371日期1997年8月7日 102（e）日期1997年8月7日PCT 1996年8月30日PCT公布。 公开号WO97 / 12987 日期1997年04月10日本发明涉及一种生产纤维素材料的方法，该方法包括培养产生纤维素的细菌，同时将发酵罐内的内部压力保持在约1.1kg / cm2A或更高，优选约1.2kg / cm 2 A以上，更优选为约1.5kg / cm 2 A以上，通常在培养的后期（生长下降阶段和固定相），即在纤维素材料的浓度为 培养基达到约10g / L以上，优选为约12g / L以上; 在10rad / s或1l / s的培养基的表观密度达到约10Pa.s或更高的培养阶段; 考虑到流变学遵循幂律模型，在K值（一致性指数）达到约10Pa.s以上的培养阶段; 或培养基的需氧量达到约35mmol / L或更高的阶段。

    Cellulose-producing bacteria
    9.
    发明授权
    Cellulose-producing bacteria 失效
    纤维素生产菌

    公开(公告)号：US5962278A

    公开(公告)日：1999-10-05

    申请号：US973757

    申请日：1998-02-03

    申请人： Takayasu Tsuchida ,  Naoto Tonouchi ,  Akira Seto ,  Yukiko Kojima ,  Masanobu Matsuoka ,  Fumihiro Yoshinaga

    发明人： Takayasu Tsuchida ,  Naoto Tonouchi ,  Akira Seto ,  Yukiko Kojima ,  Masanobu Matsuoka ,  Fumihiro Yoshinaga

    IPC分类号： C12P19/04 ,  C12R1/02 ,  C12N1/20

    CPC分类号： C12R1/02 ,  C12P19/04 ,  Y10S435/823

    摘要： This invention relates to a microorganism that is capable of producing a cellulosic product (referred to hereinafter as a "cellulose-producing bacterium") and belongs to a novel subspecies which is substantialy negative or very slightly positive in oxidation of acetates and lactates. This invention also relates to novel saccharide analog-resistant strains, amino acid analog-resistant strains and levan sucrase-defective strains.Further, this invention relates to a method for the production of cellulosic material (bacterial cellulose: "BC"), which comprises culturing these novel bactria and to bacterial cellulose which may be thus obtained.A larger amount of bacterial cellulose may be produced by culturing Acetobacter xylinum subsp. nonacetoxidans, the present resistant strains and the levan sucrase-defective strains, which have been derived and bred from the cellulose-producing bacteria, than by culturing the BPR 2001 strain in the medium containing especially sucrose or glucose as carbon sources.

    摘要翻译： PCT No.PCT / JP97 / 00514 Sec。 371日期1998年2月3日 102（e）日期1998年2月3日PCT 1997年2月24日提交PCT公布。 出版物WO97 / 40135 日期1997年10月30日本发明涉及一种能够生产纤维素产品（以下称为“纤维素生产菌”）的微生物，属于新陈代谢，其在乙酸酯的氧化中具有显着的负性或非常微量的阳性 和乳酸盐。 本发明还涉及新型糖类似物抗性菌株，氨基酸类似物抗性菌株和levan蔗糖酶缺陷菌株。 此外，本发明涉及一种生产纤维素材料（细菌纤维素“BC”）的方法，该方法包括培养这些新型细菌和可得到的细菌纤维素。 可以通过培养木醋杆菌（Subst。）来生产更多的细菌纤维素。 通过在特别是蔗糖或葡萄糖作为碳源的培养基中培养BPR 2001菌株，从纤维素生产细菌中衍生和繁殖的本发明的耐药菌株，本发明的抗性菌株和levan蔗糖酶缺陷菌株。