摘要:
A device for cleaning a surface of a component includes a high voltage source having a cathode configured to be electrically connected with the surface of the component. An ionization electrode includes at least one individual electrode configured to be electrically connected with an anode of the high voltage source. A movable carriage moves the ionization electrode relative to the surface of the component so that an electric field generated between the ionization electrode and the surface of the component is also moved relative to the surface of the component.
摘要:
A part-bearing-ring of a rolling-element bearing includes first and second assembly bores on its end surface, and the second assembly bore has a larger diameter than the first assembly bore so that it can accommodate a securing sleeve. The second assembly bore may include an internal thread for attaching the securing sleeve. Also a bearing ring formed of two part-bearing-rings and a securing sleeve and a method of installing a bearing ring.
摘要:
A method of mounting a rolling-element bearing support module on a machine having a shaft includes providing a rolling-element bearing support module having a support and a first rolling-element bearing for supporting the shaft, bringing the first rolling-element bearing with the rolling-element bearing support module up to the shaft so that the support abuts the end surface of the machine, rolling the shaft on at least a portion of a circumference of the bore, recording movement data of the shaft during the rolling, determining an alignment point based on the movement data, aligning the rolling-element bearing support module to the alignment point, and affixing the rolling-element bearing support module to the end side of the machine in the aligned position.
摘要:
The present invention provides a method for the treatment of neuronal disorders, in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of at least one QC-inhibitor, optionally in combination with at least one agent, selected from the group consisting of PEP-inhibitors, LiCl, inhibitors of DP IV/DP IV-like enzymes, NPY-receptor ligands, NPY agonists, NPY antagonists, ACE-inhibitors, PIMT enhancers, inhibitors of beta secretases, inhibitors of gamma secretases and inhibitors of neutral endopeptidase, to a mammal in need thereof.
摘要翻译:本发明提供在哺乳动物例如人中治疗神经元疾病的方法,该方法包括施用有效的,无毒的和药学上可接受量的至少一种QC抑制剂,任选地与至少一种 选自PEP抑制剂,LiCl,DP IV / DP IV类酶的抑制剂,NPY受体配体,NPY激动剂,NPY拮抗剂,ACE抑制剂,PIMT增强剂,β分泌酶抑制剂,抑制剂 γ-分泌酶和中性肽链内切酶抑制剂。
摘要:
The present invention provides a method for the treatment of neuronal disorders, in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of at least one QC-inhibitor, optionally in combination with at least one agent, selected from the group consisting of PEP-inhibitors, inhibitors of DP IV/DP IV-like enzymes, NPY-receptor ligands, NPY agonists, NPY antagonists, ACE-inhibitors, PIMT enhancers, inhibitors of beta secretases, inhibitors of gamma secretases and inhibitors of neutral endopeptidase, to a mammal in need thereof.
摘要翻译:本发明提供在哺乳动物例如人中治疗神经元疾病的方法,该方法包括施用有效的,无毒的和药学上可接受量的至少一种QC抑制剂,任选地与至少一种 选自PEP抑制剂,DP IV / DP IV类酶抑制剂,NPY受体配体,NPY激动剂,NPY拮抗剂,ACE抑制剂,PIMT增强剂,β分泌酶抑制剂,γ分泌酶抑制剂 和中性肽链内切酶的抑制剂。
摘要:
A bearing having grease lubrication includes a first ring and a second ring. A plurality of screw holes axially extend through the first ring. A first axial end of the first ring is affixed to a housing by a plurality of screws extending from the housing into the respective screw holes. A first bore is defined in the first ring adjacent to a second axial end of the first ring. The first bore intersects and fluidly communicates with one of the screw holes such that grease is dischargeable therethrough.
摘要:
A bearing cage has an annular structure with a plurality of pockets defined therein. At least one first surface area of the annular structure is made from, or is coated with, a first material having lipophobic and/or oleophobic properties. A rolling-element bearing includes this bearing cage, a plurality of roller bodies respectively disposed in the pockets, and a lubricant that forms a contact angle of at least 90° when disposed on the first material.
摘要:
The invention provides compounds of general formula (I) or a pharmaceutically acceptable salt, polymorph or solvate thereof, including all tautomers and stereoisomers thereof, wherein K, W, X; Y and Z are described throughout the description and claims.The compounds of the present invention are useful as inhibitors of prolyl endopeptidase (PEP, EC 3.4.21.26) and/or IL-6.
摘要:
Inhibitors of prolyl endopeptidase of formula 1 W—KCONH—X—CON—Y—CO—Z (1) wherein K, W, X, Y and Z are specified in the description. The compounds are useful for the treatment of diseases such as mild cognitive impairment (MCI), Alzheimer's disease, Down Syndrome, Parkinson disease and Chorea Huntington.
摘要:
The present invention provides a method for the treatment of neuronal disorders, in a mammal such as a human, which method comprises administering an effective, non-toxic and pharmaceutically acceptable amount of at least one QC-inhibitor, optionally in combination with at least one agent, selected from the group consisting of PEP-inhibitors, LiCl, inhibitors of DP IV/DP IV-like enzymes, NPY-receptor ligands, NPY agonists, NPY antagonists, ACE-inhibitors, PIMT enhancers, inhibitors of beta secretases, inhibitors of gamma secretases and inhibitors of neutral endopeptidase, to a mammal in need thereof.
摘要翻译:本发明提供在哺乳动物例如人中治疗神经元疾病的方法,该方法包括施用有效的,无毒的和药学上可接受量的至少一种QC抑制剂,任选地与至少一种 选自PEP抑制剂,LiCl,DP IV / DP IV类酶的抑制剂,NPY受体配体,NPY激动剂,NPY拮抗剂,ACE抑制剂,PIMT增强剂,β分泌酶抑制剂,抑制剂 γ-分泌酶和中性肽链内切酶抑制剂。