公开(公告)号：US20240197821A1

公开(公告)日：2024-06-20

申请号：US18495355

申请日：2023-10-26

申请人： INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) ,  Université Paris-Sud

发明人： Joël DORE ,  Jamila FAIVRE ,  Nicolas MONIAUX ,  Christian BRECHOT ,  Marion DARNAUD

IPC分类号： A61K38/17 ,  A23L33/19

CPC分类号： A61K38/1709 ,  A23L33/19

摘要： The present disclosure concerns a Reg3α polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for protecting oxygen sensitive gram-positive bacteria, compositions including the polypeptide, and their use. The disclosure shows that increasing concentration of the hReg3α lectin into the gastrointestinal tract (GIT) lumen of hReg3α-transgenic mice induced significant changes in composition of gut microbiota, and dramatically improved host resistance to intestinal inflammation. The Reg3α polypeptide may be used for preventing or treating microbiota-related diseases and/or disorders, including inflammatory bowel disease (IBD), colitis, gastrointestinal infections, irritable bowel syndrome and other gastrointestinal functional diseases, gastrointestinal tract cancer, metabolic syndrome and obesity, diabetes, liver diseases, allergic diseases, neurodegenerative diseases and psychological disorders, and the prevention and treatment methods may also include transferring to said patient fecal microbiota from a human or animal expressing the Reg3α polypeptide.

公开(公告)号：US20230256009A1

公开(公告)日：2023-08-17

申请号：US18303694

申请日：2023-04-20

申请人： TERALI INNOV SAS ,  INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) ,  INRA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE ,  CNRS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE STRASBOURG

发明人： Sébastien ROUX ,  Thierry PLOUVIER ,  Julie LE MERRER ,  Jérôme BECKER

IPC分类号： A61K33/00 ,  A61P25/00 ,  A61K31/522

CPC分类号： A61K33/00 ,  A61P25/00 ,  A61K31/522

摘要： The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).

公开(公告)号：US11666599B2

公开(公告)日：2023-06-06

申请号：US16464403

申请日：2017-11-28

申请人： INSERM, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  INRA, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE ,  CNRS, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE STRASBOURG

发明人： Sébastien Roux ,  Thierry Plouvier ,  Julie Le Merrer ,  Jérôme Becker

IPC分类号： A61K33/00 ,  A61P25/00 ,  A61K31/522

CPC分类号： A61K33/00 ,  A61K31/522 ,  A61P25/00

摘要： The present invention relates to a novel pharmaceutical use of bromide, i.e. the treatment of autism spectral disorder (ASD).

公开(公告)号：US11635372B2

公开(公告)日：2023-04-25

申请号：US16618605

申请日：2018-06-01

申请人： Universite De Lille ,  Centre National De La Recherche Scientifique ,  Institut National De La Recherche Agronomique ,  Institut National Des Sciences Appliquees De Toulouse

发明人： Vincent Senez ,  Alexis Vlandas ,  Sebastien Lamant ,  Bernard Cathala ,  Celine Moreau ,  Gabrielle Veronese ,  Sophie Bozonnet ,  Elisabeth Laville ,  Megane Cleret

IPC分类号： G01N21/45 ,  G01N21/77 ,  G01N21/17

摘要： A process for detecting the sensitivity of one or more polymers and/or of one or more mixtures of polymers to a compound, including the steps of exposing a plurality of individualized micro-deposits including the polymer(s) and/or the mixture(s) of polymers to the compound, and detecting, by interferometry, a variation in appearance of an assembly of micro-deposits exposed to the compound and/or a variation in the dimensions and/or refractive index of at least one of the micro-deposits exposed to the compound, linked to an interaction between the polymer(s) and/or the mixture(s) of polymers and the compound.

公开(公告)号：US20230046953A1

公开(公告)日：2023-02-16

申请号：US17938865

申请日：2022-10-07

申请人： INSTITUT PASTEUR ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (NRA) ,  THE UNITED STATES OF AMERICA , AS REPRESENTED BY THE SECRETARY OF AGRICULTURE

发明人： John P. BANNANTINE ,  Gilles ETIENNE ,  Sylvie BAY ,  Franck BIET

IPC分类号： C07K5/087 ,  A61K47/54 ,  A61K47/60 ,  A61K39/04 ,  C07K7/06 ,  C12Q1/689 ,  G01N33/569

摘要： The present invention is directed to an isolated synthetic tripeptide of formula H-D-Phe-N-Methyl-L-Val-L-Ala-OMe (SEQ ID NO:1), or a derivative thereof, and to the corresponding lipotripeptides, which are specific to Mycobacterium avium subsp. paratuberculosis (Map)S-type strain, as well as derivatives and conjugates thereof. The invention also concerns the use of these antigens in different methods and tests for detecting Map infection, especially by detecting humoral response and cell mediated response of infected animals. The invention is also directed to a genetic signature of Map and a mass spectrometry and NMR spectroscopy signature of Map presence or infection.

公开(公告)号：US11457643B2

公开(公告)日：2022-10-04

申请号：US15541255

申请日：2015-12-28

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE—INRA ,  INSTITUT SUPERIEUR DES SCIENCES AGRONOMIQUES, AGROALIMENTAIRES, HORTICOLES ET DU PAYSAGE

发明人： Gilles Garric ,  Joelle Leonil ,  Romain Jeantet ,  Frederic Gaucheron ,  Pierre Schuck ,  Sylvie Lortal

IPC分类号： A23C19/05 ,  A23L27/20 ,  A23C19/028 ,  A23C20/02

摘要： Disclosed is a method for manufacturing a cheese-based food product, advantageously a cheese, cheese specialty, or cheese substitute, the method including: a) a step A) of providing at least one flavoring matrix, the consistency of which ranges from liquid to pasty, the flavoring matrix resulting from a step of cultivating at least one flavor producing microorganism in a culture medium, the step A) also providing a texture matrix, the consistency of which ranges from liquid to pasty, the texture matrix being suitable for providing the texture of the food product; then b) a step B) of mixing the at least one flavoring matrix with the at least one texture matrix; then c) a texturing step C), during which the mixture from mixing step B is subjected to physiochemical texturing conditions that are adjusted according to the final texture sought for the cheese-based food product.

公开(公告)号：US11453886B2

公开(公告)日：2022-09-27

申请号：US16492619

申请日：2018-03-13

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  UNIVERSITE DE STRASBOURG ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE ,  INSTITUT FRANCAIS DE LA VIGNE ET DU VIN ,  VRIJE UNIVERSITEIT BRUSSEL

发明人： Serge Muyldermans ,  Gérard Demangeat ,  Ahmed Ghannam ,  Léa Ackerer ,  Caroline Hemmer ,  Christophe Ritzenthaler ,  Vianney Poignavent

IPC分类号： C12N7/00 ,  C12N15/82 ,  C07K16/10

摘要： The present invention relates to GFLV virus-like particles and the uses thereof in various fields, such as the pharmaceutical, agro, or veterinary areas.

公开(公告)号：US11445671B2

公开(公告)日：2022-09-20

申请号：US15572110

申请日：2016-05-06

申请人： INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA) ,  LIMAGRAIN EUROPE ,  Centre national de la recherche scientifique

发明人： Jean-Pierre Martinant ,  Jordi Comadran ,  Jean-Baptiste Laffaire ,  Peter Rogowsky ,  Thomas Widiez

IPC分类号： A01H1/08 ,  A01H1/04 ,  C07K14/415 ,  C12Q1/6895 ,  C12N15/82

摘要： The present invention concerns an isolated polynucleotide responsible of haploid induction in maize plants and related processes. Additionally, the invention relates to plants that have been genetically transformed with the polynucleotide of the invention. The invention also relates to a process for screening a mutant plant population for enhanced haploid induction by using said isolated polynucleotide. The invention further relates to molecular markers associated with haploid induction in maize plants and their use in quality control for inducer lines.

公开(公告)号：US11365374B2

公开(公告)日：2022-06-21

申请号：US16044309

申请日：2018-07-24

申请人： S.A. REALCO ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

发明人： Gauthier Boels ,  Gordon Blackman ,  Christine Faille ,  Yannick Lequette ,  Martine Clarisse

IPC分类号： C11D3/386 ,  C11D3/48 ,  A61L2/18 ,  C11D3/00 ,  C11D11/00

摘要： Composition for the removal of biofilms present on a substrate, characterized in that it comprises at least one detergent component comprising a sequestrant and also a wetting agent and a dispersant and at least one enzymatic component containing at least one protease, at least one laccase and at least one polysaccharidase, method of implementation thereof and uses thereof.

公开(公告)号：US20220079956A1

公开(公告)日：2022-03-17

申请号：US17534373

申请日：2021-11-23

申请人： BIOPHYTIS SA ,  UNIVERSITÉ PARIS 6 PIERRE ET MARIE CURIE ,  INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE

发明人： STANISLAS VEILLET ,  RENÉ LAFONT ,  ANNE-SOPHIE FOUCAULT ,  WALY DIOH ,  ANNIE QUIGNARD-BOULANGE

IPC分类号： A61K31/575 ,  A61K36/21 ,  A61K9/00

摘要： A method of improving or maintaining muscle strength of aging muscle tissue. The muscle triglyceride content is decreased to improve or maintain muscle strength of a sarcopenic mammal by administering 20-hydroxyecdysone to said mammal.