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公开(公告)号：USRE45721E1
公开(公告)日：2015-10-06
申请号：US10400017
申请日：2003-03-25
申请人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
发明人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
CPC分类号： C07K19/00 , C07K14/4702 , C07K14/4705 , C07K2319/00 , C07K2319/09 , C07K2319/30 , C07K2319/81 , C12N15/1037 , C12Q1/68 , C40B40/02
摘要： Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in vivo applications.
摘要翻译： 公开了编码用于显示在颗粒上的锌指结合基序的DNA序列的文库，以及设计用于结合特定靶序列的锌指结合多肽的方法，特别地，使用设计的锌指多肽用于体外或 体内应用。
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公开(公告)号：US20080311092A1
公开(公告)日：2008-12-18
申请号：US11915318
申请日：2006-05-24
IPC分类号： A61K35/12 , A01K67/027 , C12N5/02 , C12N5/10 , C12Q1/68 , A61P35/00 , C12N15/11 , G01N33/574 , C12Q1/02
CPC分类号： C12N5/0695 , C12N2503/00 , G01N33/5073
摘要： The invention relates to animal solid tumour models which comprise a transgenic non-human mammal containing in its genome a DNA construct that comprises a gene created and/or activated by a genetic anomaly associated with human cancer operatively bound to a promoter that directs the expression of the gene in Sca1+ cells. The invention also relates to stem cells capable of specifically expressing in stem cells human genetic anomalies associated with human pathologies. Applications of these models and stem cells, such as diagnostic, therapeutic and prophylactic applications for human diseases, and products and methods are provided.
摘要翻译： 本发明涉及包含转基因非人哺乳动物的动物实体肿瘤模型，所述哺乳动物在其基因组中含有DNA构建体，所述DNA构建体包含通过可操作地结合于引导表达的启动子的与人类癌症相关的遗传异常而产生和/或激活的基因 Sca1 +细胞中的基因。 本发明还涉及能够在干细胞中特异性表达人类病理学相关的人类遗传异常的干细胞。 提供了这些模型和干细胞的应用，例如人类疾病的诊断，治疗和预防应用，以及产品和方法。
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公开(公告)号：USRE45795E1
公开(公告)日：2015-11-10
申请号：US10309578
申请日：2002-12-03
申请人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
发明人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
CPC分类号： C07K19/00 , C07K14/4702 , C07K14/4705 , C07K2319/00 , C07K2319/09 , C07K2319/30 , C07K2319/81 , C12N15/1037 , C12Q1/68 , C40B40/02
摘要： Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in vivo applications.
摘要翻译： 公开了编码用于显示在颗粒上的锌指结合基序的DNA序列的文库，以及设计用于结合特定靶序列的锌指结合多肽的方法，特别地，使用设计的锌指多肽用于体外或 体内应用。
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公开(公告)号：US6007988A
公开(公告)日：1999-12-28
申请号：US793408
申请日：1997-06-02
申请人： Yen Choo , Aaron Klug , Isidro Sanchez Garcia
发明人： Yen Choo , Aaron Klug , Isidro Sanchez Garcia
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P35/00 , C07K14/47 , C12N15/10 , C12N15/12 , C12N15/62 , C12Q1/68 , C40B40/02 , C07H21/04
CPC分类号： C07K19/00 , C07K14/4702 , C07K14/4705 , C12N15/1037 , C12Q1/68 , C40B40/02 , C07K2319/00 , C07K2319/09 , C07K2319/30 , C07K2319/81
摘要： Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in vivo applications.
摘要翻译： PCT No.PCT / GB95 / 01949 Sec。 371日期：1997年6月3日 102（e）日期1997年6月3日PCT提交1995年8月17日PCT公布。 公开号WO96 / 06166 日期1996年2月29日公开是编码用于显示在颗粒上的锌指结合基序的DNA序列文库，以及设计用于结合特定靶序列的锌指结合多肽的方法，特别是使用设计的锌指多肽 各种体外或体内应用。
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公开(公告)号：US20100143330A1
公开(公告)日：2010-06-10
申请号：US12445928
申请日：2007-09-24
IPC分类号： A61K39/395 , A61K38/43 , C12Q1/68 , C12N9/00 , A61K38/16 , A61K31/7088 , C07K14/435 , C07K16/00 , C07H21/04 , G01N33/00 , A61P3/04
CPC分类号： C07K14/4702 , A01K2217/075 , A01K2217/203 , A01K2227/105 , A01K2267/0362 , A61K38/00 , G01N33/5073 , G01N33/5088 , G01N33/92 , G01N2800/044
摘要： The invention relates, in general, to markers of obesity and lipodystrophy. In particular, the expression level of the SLUG gene or its expression products can be used as such a marker. Furthermore, the invention additionally relates to the use of SLUG as a therapeutic and diagnostic target for these pathologies. The invention further relates to a method of treating a disorder associated with increased or decreased fat storage in a mammal comprising modulating the activity or level of the SLUG protein or the SLUG gene in the mammal.
摘要翻译： 本发明一般涉及肥胖和脂肪营养不良的标志物。 特别地，SLUG基因或其表达产物的表达水平可以用作这样的标记物。 此外，本发明还涉及SLUG作为这些病理学的治疗和诊断靶标的用途。 本发明还涉及治疗与哺乳动物中脂肪储存增加或减少相关的病症的方法，包括调节哺乳动物中SLUG蛋白或SLUG基因的活性或水平。
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6.发明申请Use of the slug gene as a genetic marker in functions mediated by SCF (stem cell factor) and applications 审中-公开在SCF介导的功能（干细胞因子）和应用中使用slug基因作为遗传标记公开(公告)号：US20090118209A1
公开(公告)日：2009-05-07
申请号：US11827149
申请日：2007-07-10
IPC分类号： A61K31/7088 , C12N5/06
CPC分类号： A01K67/0275 , A01K2217/05 , A61K38/00 , A61K48/00 , C07K14/47
摘要： The Slug gene mediates the functions of SCF linking and its c-kit receptor which means that the Slug gene, the Slug gene's cDNA, Slug protein and/or drugs or substances that activate the expression of the Slug gene can be used as therapeutic agents in the mobilization of hematopoyetic stem cells for transplants or gene therapy, in the ex vivo expansion of hematopoyetic stem cells and/or in the treatment of masculine sterility problems.
摘要翻译： Slug基因介导SCF连接及其c-kit受体的功能，这意味着Slug基因，Slug基因的cDNA，Slug蛋白和/或激活Slug基因表达的药物或物质可用作治疗剂 造血干细胞移植或基因治疗的动员，造血干细胞的离体扩增和/或治疗阳性不育问题。
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7.发明授权Transgenic non-human mammals as models for human pathologies of stem cell origin 失效转基因非人类哺乳动物作为干细胞来源的人类病理模型公开(公告)号：US07456333B2
公开(公告)日：2008-11-25
申请号：US11344159
申请日：2006-02-01
IPC分类号： A01K67/027 , C12N5/00
CPC分类号： A01K67/0275 , A01K67/0271 , A01K2217/05 , A01K2227/105 , A01K2267/03 , A01K2267/0331 , A01K2267/0381 , A61K49/0008 , C07K14/82 , C12N15/8509 , C12N2830/008 , G01N33/5011
摘要： Transgenic non-human mammals that reproduce human pathologies of stem cell origins, such as chromosomal anomalies associated with chronic myeloid leukemia, B-cell acute lymphoblastic leukemia, T-cell acute or lymphoblastic leukemia, or with the migration of hematopoietic or embryonic stem calls. The transgenic non-human mammals can be produced using as a strategy the expression of genes involved in said pathologies by means of a promoter that directs the expression of a transgene in Sca-1+ cells. Said transgenic animals constitute a model for the study of said diseases and for the evaluation of compounds for the treatment and/or prevention of the diseases. Also disclosed are DNA construct and methods useful for producing the non-human transgenic mammals.
摘要翻译： 复制干细胞起源的人类病理学的转基因非人类哺乳动物，例如与慢性骨髓性白血病，B细胞急性成淋巴细胞白血病，T细胞急性或淋巴细胞白血病相关的染色体异常，或与造血或胚胎干细胞呼吸的迁移。 转基因非人哺乳动物可以通过引导在Sca-1 +细胞中转基因表达的启动子作为策略来参与所述病理学的基因的表达来产生。 所述转基因动物构成用于研究所述疾病和评估用于治疗和/或预防疾病的化合物的模型。 还公开了可用于生产非人转基因哺乳动物的DNA构建体和方法。
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8.发明申请公开(公告)号：US20080108711A1
公开(公告)日：2008-05-08
申请号：US11666358
申请日：2005-10-25
CPC分类号： G01N33/57488 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The invention relates to the Slug gene, the replication, transcription or expression products thereof and products related with the regulation of said Slug gene or with the regulation, elimination or degradation of the expression or translation products of same, which can be used in the identification, prevention or treatment of the spread or development of metastasis in cancer patients, such as a patient suffering from a cancer with cancer cells that express the Slug gene.
摘要翻译： 本发明涉及Slug基因，其复制，转录或表达产物以及与所述Slug基因的调控有关的产物，或与其相同的表达或翻译产物的调节，消除或降解有关，可用于鉴定 预防或治疗癌症患者转移的扩散或发展，例如患有表达Slug基因的癌细胞的癌症患者。
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公开(公告)号：USRE39229E1
公开(公告)日：2006-08-08
申请号：US10033129
申请日：1995-08-17
申请人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
发明人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
CPC分类号： C07K19/00 , C07K14/4702 , C07K14/4705 , C07K2319/00 , C07K2319/09 , C07K2319/30 , C07K2319/81 , C12N15/1037 , C12Q1/68 , C40B40/02
摘要： Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in vivo applications.
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公开(公告)号：US6013453A
公开(公告)日：2000-01-11
申请号：US139762
申请日：1998-08-25
申请人： Yen Choo , Aaron Klug , Isidro Sanchez Garcia
发明人： Yen Choo , Aaron Klug , Isidro Sanchez Garcia
IPC分类号： C12N15/09 , A61K38/00 , A61K48/00 , A61P35/00 , C07K14/47 , C12N15/10 , C12N15/12 , C12N15/62 , C12Q1/68 , C40B40/02 , C07H21/04
CPC分类号： C07K19/00 , C07K14/4702 , C07K14/4705 , C12N15/1037 , C12Q1/68 , C40B40/02 , C07K2319/00 , C07K2319/09 , C07K2319/30 , C07K2319/81
摘要： Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in vivo applications.
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