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公开(公告)号：USRE45795E1
公开(公告)日：2015-11-10
申请号：US10309578
申请日：2002-12-03
申请人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
发明人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
CPC分类号： C07K19/00 , C07K14/4702 , C07K14/4705 , C07K2319/00 , C07K2319/09 , C07K2319/30 , C07K2319/81 , C12N15/1037 , C12Q1/68 , C40B40/02
摘要： Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in vivo applications.
摘要翻译： 公开了编码用于显示在颗粒上的锌指结合基序的DNA序列的文库，以及设计用于结合特定靶序列的锌指结合多肽的方法，特别地，使用设计的锌指多肽用于体外或 体内应用。
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公开(公告)号：USRE45721E1
公开(公告)日：2015-10-06
申请号：US10400017
申请日：2003-03-25
申请人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
发明人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
CPC分类号： C07K19/00 , C07K14/4702 , C07K14/4705 , C07K2319/00 , C07K2319/09 , C07K2319/30 , C07K2319/81 , C12N15/1037 , C12Q1/68 , C40B40/02
摘要： Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in vivo applications.
摘要翻译： 公开了编码用于显示在颗粒上的锌指结合基序的DNA序列的文库，以及设计用于结合特定靶序列的锌指结合多肽的方法，特别地，使用设计的锌指多肽用于体外或 体内应用。
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公开(公告)号：USRE39229E1
公开(公告)日：2006-08-08
申请号：US10033129
申请日：1995-08-17
申请人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
发明人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
CPC分类号： C07K19/00 , C07K14/4702 , C07K14/4705 , C07K2319/00 , C07K2319/09 , C07K2319/30 , C07K2319/81 , C12N15/1037 , C12Q1/68 , C40B40/02
摘要： Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in vivo applications.
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公开(公告)号：USRE42211E1
公开(公告)日：2011-03-08
申请号：US10397930
申请日：2003-03-25
申请人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
发明人： Yen Choo , Aaron Klug , Isidro Sanchez-Garcia
CPC分类号： C07K19/00 , C07K14/4702 , C07K14/4705 , C07K2319/00 , C07K2319/09 , C07K2319/30 , C07K2319/81 , C12N15/1037 , C12Q1/68 , C40B40/02
摘要： Disclosed are libraries of DNA sequences encoding zinc finger binding motifs for display on a particle, together with methods of designing zinc finger binding polypeptides for binding to a particular target sequence and, inter alia, use of designed zinc finger polypeptides for various in vitro or in vivo applications.
摘要翻译： 公开了编码用于显示在颗粒上的锌指结合基序的DNA序列的文库，以及设计用于结合特定靶序列的锌指结合多肽的方法，特别地，使用设计的锌指多肽用于体外或 体内应用。
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公开(公告)号：US20080311092A1
公开(公告)日：2008-12-18
申请号：US11915318
申请日：2006-05-24
IPC分类号： A61K35/12 , A01K67/027 , C12N5/02 , C12N5/10 , C12Q1/68 , A61P35/00 , C12N15/11 , G01N33/574 , C12Q1/02
CPC分类号： C12N5/0695 , C12N2503/00 , G01N33/5073
摘要： The invention relates to animal solid tumour models which comprise a transgenic non-human mammal containing in its genome a DNA construct that comprises a gene created and/or activated by a genetic anomaly associated with human cancer operatively bound to a promoter that directs the expression of the gene in Sca1+ cells. The invention also relates to stem cells capable of specifically expressing in stem cells human genetic anomalies associated with human pathologies. Applications of these models and stem cells, such as diagnostic, therapeutic and prophylactic applications for human diseases, and products and methods are provided.
摘要翻译： 本发明涉及包含转基因非人哺乳动物的动物实体肿瘤模型，所述哺乳动物在其基因组中含有DNA构建体，所述DNA构建体包含通过可操作地结合于引导表达的启动子的与人类癌症相关的遗传异常而产生和/或激活的基因 Sca1 +细胞中的基因。 本发明还涉及能够在干细胞中特异性表达人类病理学相关的人类遗传异常的干细胞。 提供了这些模型和干细胞的应用，例如人类疾病的诊断，治疗和预防应用，以及产品和方法。
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公开(公告)号：US20100143330A1
公开(公告)日：2010-06-10
申请号：US12445928
申请日：2007-09-24
IPC分类号： A61K39/395 , A61K38/43 , C12Q1/68 , C12N9/00 , A61K38/16 , A61K31/7088 , C07K14/435 , C07K16/00 , C07H21/04 , G01N33/00 , A61P3/04
CPC分类号： C07K14/4702 , A01K2217/075 , A01K2217/203 , A01K2227/105 , A01K2267/0362 , A61K38/00 , G01N33/5073 , G01N33/5088 , G01N33/92 , G01N2800/044
摘要： The invention relates, in general, to markers of obesity and lipodystrophy. In particular, the expression level of the SLUG gene or its expression products can be used as such a marker. Furthermore, the invention additionally relates to the use of SLUG as a therapeutic and diagnostic target for these pathologies. The invention further relates to a method of treating a disorder associated with increased or decreased fat storage in a mammal comprising modulating the activity or level of the SLUG protein or the SLUG gene in the mammal.
摘要翻译： 本发明一般涉及肥胖和脂肪营养不良的标志物。 特别地，SLUG基因或其表达产物的表达水平可以用作这样的标记物。 此外，本发明还涉及SLUG作为这些病理学的治疗和诊断靶标的用途。 本发明还涉及治疗与哺乳动物中脂肪储存增加或减少相关的病症的方法，包括调节哺乳动物中SLUG蛋白或SLUG基因的活性或水平。
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7.发明申请公开(公告)号：US20080108711A1
公开(公告)日：2008-05-08
申请号：US11666358
申请日：2005-10-25
CPC分类号： G01N33/57488 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The invention relates to the Slug gene, the replication, transcription or expression products thereof and products related with the regulation of said Slug gene or with the regulation, elimination or degradation of the expression or translation products of same, which can be used in the identification, prevention or treatment of the spread or development of metastasis in cancer patients, such as a patient suffering from a cancer with cancer cells that express the Slug gene.
摘要翻译： 本发明涉及Slug基因，其复制，转录或表达产物以及与所述Slug基因的调控有关的产物，或与其相同的表达或翻译产物的调节，消除或降解有关，可用于鉴定 预防或治疗癌症患者转移的扩散或发展，例如患有表达Slug基因的癌细胞的癌症患者。
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8.发明授权Use of the transcription of the slug gene in evaluating the redisposition of a subject with cancer to develop metastatis 失效使用slug基因的转录来评估患有癌症的受试者的重新定位以产生转移公开(公告)号：US07790382B2
公开(公告)日：2010-09-07
申请号：US11666358
申请日：2005-10-25
CPC分类号： G01N33/57488 , C12Q1/6886 , C12Q2600/112 , C12Q2600/118 , C12Q2600/158
摘要： The invention relates to the Slug gene, the replication, transcription or expression products thereof and products related with the regulation of said Slug gene or with the regulation, elimination or degradation of the expression or translation products of same, which can be used in the identification, prevention or treatment of the spread or development of metastasis in cancer patients, such as a patient suffering from a cancer with cancer cells that express the Slug gene.
摘要翻译： 本发明涉及Slug基因，其复制，转录或表达产物以及与所述Slug基因的调控有关的产物，或与其相同的表达或翻译产物的调节，消除或降解，其可用于鉴定 预防或治疗癌症患者转移的扩散或发展，例如患有表达Slug基因的癌细胞的癌症患者。
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9.发明申请Graded Expression of Snail as Marker of Cancer Development and DNA Damage-Based Diseases 审中-公开蜗牛分级表达作为癌症发展和DNA损伤基因疾病的标记公开(公告)号：US20100061973A1
公开(公告)日：2010-03-11
申请号：US11989382
申请日：2006-07-28
IPC分类号： A61K39/395 , A01K67/027 , G01N33/574 , G01N33/50 , C12N5/10 , C12Q1/02 , C07H21/02 , C07K16/00 , C07K14/00 , C12N9/00 , A61K31/7088 , A61K38/43 , A61K38/00
CPC分类号： G01N33/5011 , G01N33/57496 , G01N2333/705 , G01N2500/00
摘要： The invention relates to the graded expression level of SNAIL gene or its expression products, as a marker of the capacity of epithelial and mesenchymal tumours and/or cancers for disseminating to other tissues or organs. The invention further relates to a transgenic non-human mammal comprising in its genome a transgene that comprises a nucleic acid sequence encoding the SNAIL protein, and the use of SNAIL as a marker of epithelial and mesenchymal tumours and/or cancers as well as in DNA damage-based diseases In addition, the invention relates to the use of SNAIL as a therapeutic and diagnostic target for said pathologies.
摘要翻译： 本发明涉及SNAIL基因或其表达产物的分级表达水平，作为上皮和间质肿瘤和/或癌症扩散至其他组织或器官的能力的标志物。 本发明进一步涉及在其基因组中包含编码SNAIL蛋白的核酸序列的转基因和使用SNAIL作为上皮和间充质肿瘤和/或癌症的标志物以及DNA的转基因非人哺乳动物 基于损伤的疾病另外，本发明涉及SNAIL作为所述病理学的治疗和诊断靶标的用途。
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公开(公告)号：US20100034736A1
公开(公告)日：2010-02-11
申请号：US12440369
申请日：2007-09-07
IPC分类号： A61K51/10 , C12Q1/68 , C12N5/00 , C12Q1/02 , G01N33/53 , C07H21/00 , A01K67/027 , A61K39/395 , A61K31/7052 , A61K38/02 , A61P35/00
CPC分类号： C12Q1/6886 , C12Q1/6881 , C12Q2600/106 , C12Q2600/118 , C12Q2600/136
摘要： The invention relates to the identification of markers for cancer stem cells. These markers can be used in a number of different ways, including diagnosis and therapy. In particular, the invention relates to a method of detecting, identifying and/or quantifying cancer stem cells, the method comprising the step of assessing the level of expression; the activity; or the sequence of the SLUG, OVOL1 and/or OVOL2 gene, promoter and/or expression product in a cell.
摘要翻译： 本发明涉及癌症干细胞标志物的鉴定。 这些标记可以以多种不同的方式使用，包括诊断和治疗。 特别地，本发明涉及检测，鉴定和/或定量癌症干细胞的方法，所述方法包括评价表达水平的步骤; 活动; 或SLUG，OVOL1和/或OVOL2基因，启动子和/或表达产物在细胞中的序列。
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