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    Mucosal immunization to prevent prion infection
    2.
    发明授权
    Mucosal immunization to prevent prion infection 有权
    粘膜免疫以预防朊病毒感染

    公开(公告)号：US08685718B2

    公开(公告)日：2014-04-01

    申请号：US10558276

    申请日：2004-05-20

    申请人： Thomas Wisniewski ,  Einar M. Sigurdsson ,  Jose Alejandro Chabalgoity ,  Fernando R. Goni ,  Blas Frangione

    发明人： Thomas Wisniewski ,  Einar M. Sigurdsson ,  Jose Alejandro Chabalgoity ,  Fernando R. Goni ,  Blas Frangione

    IPC分类号： G01N33/68

    CPC分类号： C07K14/47 ,  A61K39/0007 ,  A61K2039/523 ,  A61K2039/542 ,  A61K2039/55544

    摘要： Vaccines against prion disease eliciting a humoral immune response when administered mucosally are described. The vaccines comprise a prion protein, a prion protein fragment, or a non-amyloidogenic prion protein homolog and an adjuvant suitable for inducing a humoral immune response after mucosal administration. Suitable adjuvants include cholera toxin subunit B, heat-labile enterotoxin and aluminum hydroxide. Alternatively, the vaccine comprises a vector encoding a prion protein, fragment, or homolog in an attenuated Salmonella host. The vaccines can be used to prevent or treat prion disease in humans and other mammals.

    摘要翻译： 描述了在粘膜给药时引起体液免疫应答的针对朊病毒疾病的疫苗。 疫苗包含朊病毒蛋白，朊病毒蛋白片段或非淀粉样蛋白生成朊蛋白同系物和适于在粘膜给药后诱导体液免疫应答的佐剂。 合适的佐剂包括霍乱毒素亚基B，热不稳定肠毒素和氢氧化铝。 或者，疫苗包含编码减毒沙门氏菌宿主中的朊病毒蛋白，片段或同系物的载体。 疫苗可用于预防或治疗人类和其他哺乳动物中的朊病毒疾病。

    Illumination system for cavities
    3.
    发明授权
    Illumination system for cavities 有权
    空腔照明系统

    公开(公告)号：US08277065B2

    公开(公告)日：2012-10-02

    申请号：US12837782

    申请日：2010-07-16

    申请人： Oscar Tomas Camarillo Fernandez ,  Jose Alejandro Orozco Vazquez ,  Antonio Lopez Juarez

    发明人： Oscar Tomas Camarillo Fernandez ,  Jose Alejandro Orozco Vazquez ,  Antonio Lopez Juarez

    IPC分类号： F21V33/00

    CPC分类号： F24C15/008 ,  A47L15/4246 ,  F24C15/02

    摘要： A system to light a cavity 19 in an appliance. A source or light emitter 27 is mounted on a circuit board 32, so that the light emanating from said source or light emitter 27, is concentrated into a light beam using an optical collimator system 28 or in some cases a Fresnel arrangement; wherein the foregoing elements may be found outside a door 14, which allow access into the cavity; thus the light beam exiting the optical collimator 27 or Fresnel arrangement travels a distance though air between the optical collimator system 27 or Fresnel arrangement and the upper face of the light guide 29 which is placed on the door 14, the light guide 29 transports the luminous flux towards a notch which diverts said luminous flux directing into the cavity's 19 interior.

    摘要翻译： 一种照明器具中的空腔19的系统。 源极或光发射器27安装在电路板32上，使得从所述源极或光发射器27发出的光利用光学准直器系统28集中在光束中，或者在某些情况下集中在菲涅尔布置中; 其中上述元件可以被发现在门14的外部，这允许进入空腔; 因此离开光学准直仪27或菲涅耳排列的光束经过光学准直仪系统27或菲涅耳排列之间的空气和放置在门14上的光导29的上表面之间的距离传播一段距离，光导29传送发光 磁通朝着将所述光通量转向空腔19内部的凹口。

    Energy based devices and methods for treatment of anatomic tissue defects
    4.
    发明授权
    Energy based devices and methods for treatment of anatomic tissue defects 有权
    用于治疗解剖组织缺陷的基于能量的装置和方法

    公开(公告)号：US08133221B2

    公开(公告)日：2012-03-13

    申请号：US11771528

    申请日：2007-06-29

    申请人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

    发明人： William Malecki ,  Dan Francis ,  Kenneth Horne ,  Mark E. Deem ,  Hanson Gifford ,  Jose Alejandro

    IPC分类号： A61B18/14

    CPC分类号： A61B18/1492 ,  A61B2017/00575 ,  A61B2018/00214 ,  A61B2018/00291 ,  A61B2018/00351

    摘要： Methods for treating anatomic tissue defects such as patent foramen ovale (PFO) generally involve positioning a distal end of an elongate catheter device at the site of the anatomic defect, exposing an expandable housing and energy transmission member out of the distal end of the catheter device, engaging the housing with tissues at the site of the anatomic defect, applying suction to the tissues via the housing to bring the tissues together; and applying energy to the tissues with the energy transmission member to substantially close the anatomic defect acutely. Apparatus generally include an elongate catheter body, a housing extending from a distal end of the catheter body for engaging tissues at the site of the anatomic defect, and an energy transmission member adjacent a distal end of the housing, the energy transmission member having at least one substantially planar surface.

    摘要翻译： 用于治疗解剖组织缺陷如卵圆孔（PFO）的方法通常涉及将细长导管装置的远端定位在解剖缺损部位，将可扩张的壳体和能量传递构件暴露于导管装置的远端 将所述壳体与所述解剖缺陷部位的组织接合，通过所述壳体向所述组织施加吸力以将所述组织带在一起; 以及用能量传递构件向组织施加能量以急剧地基本上闭合解剖缺陷。 装置通常包括细长的导管主体，从导管主体的远端延伸的壳体，用于接合解剖缺陷部位的组织，以及邻近壳体的远端的能量传递构件，能量传递构件至少具有 一个基本平坦的表面。

    SYSTEM FOR MONITORING UNSUPERVISED WORKERS AND GENERATING AND DELIVERING A REPORT BASED ON THE MONITORED ACTIVITY
    10.
    发明申请
    SYSTEM FOR MONITORING UNSUPERVISED WORKERS AND GENERATING AND DELIVERING A REPORT BASED ON THE MONITORED ACTIVITY 失效
    监测不合格劳动者的制度和根据监测活动产生和交付报告的制度

    公开(公告)号：US20080284591A1

    公开(公告)日：2008-11-20

    申请号：US11749923

    申请日：2007-05-17

    申请人： Brian Stewart Randall Armstrong ,  Jose Alejandro Gutierrez

    发明人： Brian Stewart Randall Armstrong ,  Jose Alejandro Gutierrez

    IPC分类号： G08B21/18 ,  H04M3/42

    CPC分类号： G08B21/04

    摘要： A system for monitoring an unsupervised worker is provided that includes a plurality of sensors and a base station provided at the monitored location, a service provider server located remotely from the monitored location and operated by a third party service provider, and a computing device associated with a subscriber to the system. At least a portion of the sensed data is sent to and stored by the service provider server so that a report based thereon may, at the request of the system subscriber, be selectively generated and provided to the system subscriber. The computing device is also adapted to generate configuration data for one or more of the sensors and transmit the configuration data to the service provider server. The configuration data is then sent to the base station and used to control the operation of the sensors

    摘要翻译： 提供了一种用于监视无监督的工作者的系统，其包括多个传感器和在被监视位置处提供的基站，远离监控位置并由第三方服务提供商操作的服务提供商服务器，以及与第 系统的订户。 感测数据的至少一部分被发送到服务提供商服务器并由服务提供者服务器存储，使得基于该系统用户的请求可以有选择地生成并提供给系统用户。 计算设备还适于生成一个或多个传感器的配置数据，并将配置数据发送到服务提供商服务器。 然后将配置数据发送到基站并用于控制传感器的操作