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    Use of lignan compound for anti-wrinkle treatment
    1.
    发明授权
    Use of lignan compound for anti-wrinkle treatment 有权
    使用木酚素化合物进行抗皱治疗

    公开(公告)号：US08435957B2

    公开(公告)日：2013-05-07

    申请号：US12665206

    申请日：2008-06-20

    申请人： Jae-Kwan Hwang ,  Hae Ji Lee ,  Jae Young Lee ,  Jae-Seok Shim ,  Jeong Hwan Kim ,  Do Un Kim ,  Heechul Chung ,  Jae Youn Chung

    发明人： Jae-Kwan Hwang ,  Hae Ji Lee ,  Jae Young Lee ,  Jae-Seok Shim ,  Jeong Hwan Kim ,  Do Un Kim ,  Heechul Chung ,  Jae Youn Chung

    IPC分类号： A61K31/70

    CPC分类号： A61K8/97 ,  A61K8/347 ,  A61K8/498 ,  A61Q19/08

    摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.

    摘要翻译： 本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途 肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。 本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由 光老化 因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。

    USE OF LIGNAN COMPOUNDS FOR TREATING OR PREVENTING INFLAMMATORY DISEASE
    2.
    发明申请
    USE OF LIGNAN COMPOUNDS FOR TREATING OR PREVENTING INFLAMMATORY DISEASE 有权
    使用化合物治疗或预防炎症疾病

    公开(公告)号：US20100285154A1

    公开(公告)日：2010-11-11

    申请号：US12766255

    申请日：2010-04-23

    申请人： Jae-Kwan Hwang ,  Do-Un Kim ,  Jae-Youn Chung ,  Hee-Chul Chung ,  Kyu-Lee Han

    发明人： Jae-Kwan Hwang ,  Do-Un Kim ,  Jae-Youn Chung ,  Hee-Chul Chung ,  Kyu-Lee Han

    IPC分类号： A61K36/185 ,  A61P19/02 ,  A61P29/00 ,  A61P17/00 ,  A61P11/06 ,  A61K31/36

    CPC分类号： A61K31/36 ,  A61K9/0095 ,  A61K9/2054 ,  A61K36/185 ,  Y02A50/401 ,  Y10S514/859 ,  Y10S514/886

    摘要： The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a method for preventing or treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of macelignan represented by Chemical Formula I or a pharmaceutically acceptable salt thereof. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-α and by treating or preventing inflammatory disease in vivo. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.

    摘要翻译： 本发明涉及木素素化合物用于治疗或预防炎性疾病的用途。 更具体地说，本发明涉及一种预防或治疗炎性疾病的方法，其包括向有需要的受试者施用有效量的由化学式I表示的肉豆蔻衣木脂或其药学上可接受的盐。 木酚素化合物具有通过抑制炎症介质NO，iNOS，PGE2，COX-2和TNF-α的产生或表达并通过在体内治疗或预防炎性疾病来抑制炎症反应的作用。 因此，木脂素化合物或肉豆蔻提取物对于治疗或预防炎性疾病是非常有用的。

    METHOD AND COMPOSITION FOR TREATING ACNE USING LIGNAN COMPOUNDS
    3.
    发明申请
    METHOD AND COMPOSITION FOR TREATING ACNE USING LIGNAN COMPOUNDS 有权
    使用LIGNAN化合物治疗ACNE的方法和组合物

    公开(公告)号：US20090192217A1

    公开(公告)日：2009-07-30

    申请号：US10585553

    申请日：2005-01-07

    申请人： Jae-Kwan Hwang ,  Jae-Youn Chung ,  Hee-Chul Chung ,  Kyung-Min Park

    发明人： Jae-Kwan Hwang ,  Jae-Youn Chung ,  Hee-Chul Chung ,  Kyung-Min Park

    IPC分类号： A01N43/30 ,  C07D317/54 ,  A61P31/04

    CPC分类号： A61K31/085 ,  A61K31/05 ,  A61K31/352

    摘要： The present invention relates to a method and composition for treating acne using lignan compounds represented by Formula 1. More particularly, the invention relates to an antibacterial composition against acne-causing bacteria, containing lignan compounds represented by Formula 1, as well as a method for treating acne using the same. The lignan compounds represented by Formula 1 are excellent not only in the antibacterial activity of, inhibiting the growth of acne-causing bacteria, but also in thermal stability. Accordingly, the lignan compounds may be useful as antibacterial agents against the acne-causing bacteria, and acne treatment agents.

    摘要翻译： 本发明涉及使用由式1表示的木酚素化合物治疗痤疮的方法和组合物。更具体地说，本发明涉及含有由式1表示的木酚素化合物的抗痤疮细菌的抗菌组合物，以及用于 使用相同的治疗痤疮。 由式1表示的木酚素化合物不仅具有抑制痤疮细菌生长的抗菌活性以及热稳定性的优异性。 因此，木脂素化合物可用作抗痤疮细菌和痤疮治疗剂的抗菌剂。

    Method and composition for treating acne using lignan compounds
    5.
    发明授权
    Method and composition for treating acne using lignan compounds 有权
    使用木酚素化合物治疗痤疮的方法和组合物

    公开(公告)号：US08642646B2

    公开(公告)日：2014-02-04

    申请号：US10585553

    申请日：2005-01-07

    申请人： Jae-Kwan Hwang ,  Jae-Youn Chung ,  Hee-Chul Chung ,  Kyung-Min Park

    发明人： Jae-Kwan Hwang ,  Jae-Youn Chung ,  Hee-Chul Chung ,  Kyung-Min Park

    IPC分类号： A61K8/97 ,  A61K31/36 ,  A61Q19/00

    CPC分类号： A61K31/085 ,  A61K31/05 ,  A61K31/352

    摘要： The present invention relates to a method and composition for treating acne using lignan compounds represented by Formula 1. More particularly, the invention relates to an antibacterial composition against acne-causing bacteria, containing lignan compounds represented by Formula 1, as well as a method for treating acne using the same. The lignan compounds represented by Formula 1 are excellent not only in the antibacterial activity of inhibiting the growth of acne-causing bacteria, but also in thermal stability. Accordingly, the lignan compounds may be useful as antibacterial agents against the acne-causing bacteria, and acne treatment agents.

    摘要翻译： 本发明涉及使用由式1表示的木酚素化合物治疗痤疮的方法和组合物。更具体地说，本发明涉及含有由式1表示的木酚素化合物的抗痤疮细菌的抗菌组合物，以及用于 使用相同的治疗痤疮。 由式1表示的木酚素化合物不仅具有抑制痤疮细菌生长的抗菌活性，而且在热稳定性方面优异。 因此，木脂素化合物可用作抗痤疮细菌和痤疮治疗剂的抗菌剂。

    NOVEL USE OF PANDURATIN DERIVATIVES OR EXTRACT OF KAEMPFERIA PANDURATA COMPRISING THE SAME
    6.
    发明申请
    NOVEL USE OF PANDURATIN DERIVATIVES OR EXTRACT OF KAEMPFERIA PANDURATA COMPRISING THE SAME 审中-公开
    使用潘多拉汀衍生物或提取其包含其的卡潘普兰

    公开(公告)号：US20120065272A1

    公开(公告)日：2012-03-15

    申请号：US12738591

    申请日：2008-10-17

    申请人： Jae Kwan Hwang ,  Jae-Seok Shim ,  Song Hui Gwon ,  Yi Young Kwon ,  Hyun In Oh ,  Young Sun Han ,  Eun Jung Choi ,  Do Un Kim

    发明人： Jae Kwan Hwang ,  Jae-Seok Shim ,  Song Hui Gwon ,  Yi Young Kwon ,  Hyun In Oh ,  Young Sun Han ,  Eun Jung Choi ,  Do Un Kim

    IPC分类号： A61K8/35 ,  C07C49/573 ,  A61Q19/08 ,  C07C49/577

    CPC分类号： A61K8/35 ,  A61K8/97 ,  A61K2800/91 ,  A61Q19/08

    摘要： The present invention relates to a new use of panduratin derivatives or a Kaempferia pandurata extract comprising the same. More particularly, the present invention relates to a composition for improving wrinkles and/or preventing aging, which comprises a panduratin derivative or a Kaempferia pandurata extract comprising the same. The said the panduratin derivative or the Kaempferia pandurata extract comprising the same induces cell proliferation, inhibits degradation of collagen, and promotes synthesis of collagen, therefore, it shows excellent activity in prevention of aging, particularly preventing, improving or treating wrinkle and it can be used as an effective ingredient in a cosmetic, food or pharmaceutical composition.

    摘要翻译： 本发明涉及潘多汀衍生物的新用途或包含其的白头翁提取物。 更具体地说，本发明涉及一种用于改善皱纹和/或防止衰老的组合物，其包含潘杜林衍生物或包含其的白芍提取物。 所述的潘多汀衍生物或含有它们的山茱萸提取物诱导细胞增殖，抑制胶原蛋白的降解，促进胶原蛋白的合成，因此在防止老化，特别是防止，改善或治疗皱纹方面表现出优异的活性，并且可以 用作化妆品，食品或药物组合物中的有效成分。

    Immunostimulating Polysaccharides Isolated From Curcuma Xanthorrhiza and Manufacturing Method Thereof
    7.
    发明申请
    Immunostimulating Polysaccharides Isolated From Curcuma Xanthorrhiza and Manufacturing Method Thereof 审中-公开
    免疫刺激从姜黄素分离的多糖及其制备方法

    公开(公告)号：US20100048885A1

    公开(公告)日：2010-02-25

    申请号：US11922107

    申请日：2006-06-14

    申请人： Jae-Kwan Hwang ,  Ah-Jin Kim ,  Jong-Hee Sohn ,  Kyu-Lee Han ,  Sun-Hee Lee ,  Jeong-Han Choo

    发明人： Jae-Kwan Hwang ,  Ah-Jin Kim ,  Jong-Hee Sohn ,  Kyu-Lee Han ,  Sun-Hee Lee ,  Jeong-Han Choo

    IPC分类号： C07H1/00 ,  C07H3/00

    CPC分类号： C08B37/006 ,  C12P19/04

    摘要： The present invention provides a method for manufacturing polysaccharides isolated from Curcuma xanthorrhiza, including steps of: (S1) preparing a powder of Curcuma xanthorrhiza Roxb.; (S2) extracting the powder with an organic solvent, and then filtering or centrifuging to obtain a residue; (S3) extracting the residue to prepare a solution containing polysaccharides; (S4) removing starch by adding starch-hydrolyzing enzyme to the polysaccharides-containing solution; (S5) precipitating the polysaccharides after the step (S4); and (S6) purifying the polysaccharides after the step (S5), polysaccharides obtained according to the manufacturing method, and a pharmaceutical composition in eluding the polysaccharides as effective component. The polysaccharides according to the present invention may be very effectively used in drugs and functional foods for stimulating macrophage activity, preventing and treating immunological diseases including cancer, and enhancing immunity after the treatment of the immunological diseases.

    摘要翻译： 本发明提供了从姜黄分离得到的多糖的制造方法，包括以下步骤：（S1）制备姜黄黄酮粉末; （S2）用有机溶剂萃取粉末，然后过滤或离心得到残留物; （S3）提取残渣以制备含有多糖的溶液; （S4）通过向含多糖溶液中加入淀粉水解酶除去淀粉; （S5）在步骤（S4）后沉淀多糖; 和（S6）步骤（S5）后的多糖的纯化，根据制造方法得到的多糖，以及除了多糖作为有效成分的药物组合物。 本发明的多糖可以非常有效地用于药物和功能性食品中，用于刺激巨噬细胞活性，预防和治疗免疫疾病，包括癌症，以及增强免疫疾病治疗后的免疫力。

    Use Of Lignan Compounds For Treating Or Preventing Inflammatory Disease
    9.
    发明申请
    Use Of Lignan Compounds For Treating Or Preventing Inflammatory Disease 审中-公开
    使用木质素化合物治疗或预防炎性疾病

    公开(公告)号：US20080114058A1

    公开(公告)日：2008-05-15

    申请号：US11813590

    申请日：2006-01-06

    申请人： Jae-Kwan Hwang ,  Do-Un Kim ,  Jae-Youn Chung ,  Hee-Chul Chung ,  Kyu-Lee Han

    发明人： Jae-Kwan Hwang ,  Do-Un Kim ,  Jae-Youn Chung ,  Hee-Chul Chung ,  Kyu-Lee Han

    IPC分类号： A61K31/05 ,  A61K31/335

    CPC分类号： A61K31/357 ,  Y02A50/40 ,  Y02A50/401

    摘要： The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a pharmaceutical composition for the treatment or prevention of an inflammatory disease, comprising a lignan compound represented by Formula I, as well as a treating method and the use of an inflammatory disease using the lignan compound. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE2, COX-2 and TNF-α. Accordingly, the lignan compound or a Myristica fragrans extract will be highly useful for the treatment or prevention of an inflammatory disease.

    摘要翻译： 本发明涉及木素素化合物用于治疗或预防炎性疾病的用途。 更具体地说，本发明涉及用于治疗或预防炎性疾病的药物组合物，其包含式I所示的木酚素化合物，以及使用所述木酚素化合物的治疗方法和使用炎性疾病。 木酚素化合物具有通过抑制炎症介质NO，iNOS，PGE 2，COX-2和TNF-α的产生或表达来抑制炎症反应的作用。 因此，木脂素化合物或肉豆蔻提取物对于治疗或预防炎性疾病是非常有用的。

    USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT
    10.
    发明申请
    USE OF LIGNAN COMPOUND FOR ANTI-WRINKLE TREATMENT 有权
    LIGNAN化合物用于抗皱治疗的用途

    公开(公告)号：US20120288579A1

    公开(公告)日：2012-11-15

    申请号：US12665206

    申请日：2009-06-20

    申请人： Jae-Kwan Hwang ,  Hae Ji Lee ,  Jae Young Lee ,  Jae-Seok Shim ,  Jeong Hwan Kim ,  Do Un Kim ,  Heechul Chung ,  Jae Youn Chung

    发明人： Jae-Kwan Hwang ,  Hae Ji Lee ,  Jae Young Lee ,  Jae-Seok Shim ,  Jeong Hwan Kim ,  Do Un Kim ,  Heechul Chung ,  Jae Youn Chung

    IPC分类号： A61K36/575 ,  A61K31/075 ,  A61P17/00 ,  C07D317/46 ,  C07C43/23 ,  A61K31/357 ,  C07D407/10

    CPC分类号： A61Q19/08 ,  A61K8/347 ,  A61K8/498 ,  A61K8/9789

    摘要： The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-1, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.

    摘要翻译： 本发明涉及木糖素化合物的新用途，其从肉豆蔻或肉豆蔻的肠道中分离和纯化用于抗皱，更具体地，本发明涉及用于抗皱的提取物的抗皱纹的新用途 肉豆蔻或肉豆蔻，fragrin A，奥维菌素7，licarin E和肉豆蔻衣木脂的提取物。 本发明的提取物和木脂素化合物具有抑制胶原降解酶-1（MMP-1，基质金属蛋白酶-1）和新型胶原（1型前胶原）的形成的作用，从而具有抑制由 光老化 因此，本发明的提取物和木酚素化合物可用于预防或治疗由光老化引起的皱纹。