公开(公告)号：US20120149091A1

公开(公告)日：2012-06-14

申请号：US11608527

申请日：2006-12-08

申请人： Brian D. Wilkerson ,  James C. Chen ,  John Pulse ,  Andrei Guschin ,  Michael Weaver

发明人： Brian D. Wilkerson ,  James C. Chen ,  John Pulse ,  Andrei Guschin ,  Michael Weaver

IPC分类号： C12N1/12 ,  C12N1/00 ,  C12M1/02 ,  C12M1/42

CPC分类号： C12P7/649 ,  C12M21/02 ,  C12M31/10 ,  C12M41/06 ,  C12M41/36 ,  C12N1/12 ,  C12N13/00 ,  C12P7/6463 ,  C12P39/00 ,  Y02E50/13 ,  Y02E50/343 ,  Y02P20/134

摘要： Systems, devices, and methods for cultivating biomasses. A bioreactor system is operable for growing photosynthetic organisms. The bioreactor system includes a bioreactor and a lighting system. The lighting system includes one more light-emitting substrates configured to light at least some of a plurality of photosynthetic organisms retained in the bioreactor.

摘要翻译： 用于培育生物质的系统，装置和方法。 生物反应器系统可用于生长光合生物。 生物反应器系统包括生物反应器和照明系统。 照明系统包括一个以上的发光基板，其被配置为点亮保留在生物反应器中的多个光合生物中的至少一些光合生物。

公开(公告)号：US08097028B2

公开(公告)日：2012-01-17

申请号：US11357358

申请日：2006-02-17

申请人： James C. Chen ,  Nicholas Yeo ,  Phillip Burwell ,  Thomas Wenger

发明人： James C. Chen ,  Nicholas Yeo ,  Phillip Burwell ,  Thomas Wenger

IPC分类号： A61N5/06

CPC分类号： A61K41/0071 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0651 ,  A61N2005/0661

摘要： The present invention provides a prophylactic light activated treatment method for subjects at risk of a plaque-mediated thrombotic event, such as acute coronary syndromes. In one embodiment, the subject receives a dose of photosensitizer sufficient to result in a concentration of photosensitizer in the neovascularization associated with atherosclerotic disease to permit effective photodynamic therapy. Light of a wavelength that excites the photosensitizer, but that does not to any significant extent penetrate to an adventitial layer of the blood vessel, is applied to the region of the blood vessel. The therapeutic light dose, which may be applied in sequential stages, is sufficient to cause closure of neovasculature leakage and lead to plaque stabilization and reduced adverse clinical outcomes. The present invention further provides light transmission devices and systems useful in carrying out the methods of the present invention.

摘要翻译： 本发明为患有斑块介导的血栓形成事件风险的受试者，例如急性冠状动脉综合征提供预防性光活化治疗方法。 在一个实施方案中，受试者接受足以导致与动脉粥样硬化疾病相关的新血管形成中的光敏剂浓度以允许有效的光动力疗法的剂量的光敏剂。 激发光敏剂的波长的光被施加到血管的区域，而不是任何显着程度的透射到血管的外膜层。 可以按顺序施用的治疗光剂量足以引起新血管渗漏的闭合并导致斑块稳定化并减少不良临床结果。 本发明还提供了用于实施本发明的方法的光传输装置和系统。

公开(公告)号：US20110009464A1

公开(公告)日：2011-01-13

申请号：US12817068

申请日：2010-06-16

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： A61K31/407 ,  A61P35/00

CPC分类号： A61K41/0057 ,  A61K9/0019 ,  A61K31/407

摘要： The efficacy of light activated therapy treatment is enhanced by stimulating the immune system of the patient substantially above the pre-therapy level. Abnormal tissue that is destroyed by the light activated therapy releases factors that stimulate the immune system, leading to systemic reductions in abnormal tissue (i.e., reduction beyond the area treated using light), so long as the light therapy conditions favor apoptosis over necrosis. The volume of abnormal tissue destroyed is maximized to the extent possible, reducing tumor load, which reduces an amount of immunosuppressive factors in the body, enabling stimulation of the immune system to be successful.

摘要翻译： 通过刺激患者的免疫系统显着高于治疗前水平，提高了光活化治疗的疗效。 被光激活治疗破坏的异常组织释放刺激免疫系统的因素，导致异常组织的系统性减少（即，除了使用光治疗的区域之外减少），只要光疗条件有利于凋亡超过坏死。 破坏的异常组织的体积尽可能地最大化，减少肿瘤负荷，这减少了身体中的免疫抑制因子的量，使得能够刺激免疫系统成功。

公开(公告)号：US20110008372A1

公开(公告)日：2011-01-13

申请号：US12832494

申请日：2010-07-08

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： A61K39/395 ,  A61K31/58 ,  A61K31/395 ,  A61K31/69 ,  A61K31/165 ,  A61K31/704 ,  A61P35/00

CPC分类号： A61K31/165 ,  A61K31/395 ,  A61K31/58 ,  A61K31/69 ,  A61K31/704

摘要： The efficacy of light activated therapy treatment is enhanced by use of additional therapeutic agents. Abnormal tissue is destroyed by light activated therapy, and the associated administration of one or more additional therapeutic agents can synergistically enhance the therapy. For example, the concepts disclosed herein encompass the use of the following agents in combination with light activated drug therapy: (1) agents that selectively inhibit heat shock protein 90 (Hsp90); (2) agents that inhibit the Hedgehog pathway (which is believed to play a central role in allowing the proliferation and survival of certain cancer-causing cells, and which is implicated in many of the most deadly cancers); and, (3) agents for reducing the anti-apoptotic effects of Bcl-2 or Bcl-xL. These agents can be used with light activated drug therapy individually, or in various combinations and permutations.

摘要翻译： 通过使用额外的治疗剂来增强光活化治疗的疗效。 异常组织被光激活治疗破坏，并且相关的一种或多种另外的治疗剂的施用可以协同增强治疗。 例如，本文公开的概念包括以下试剂与光活化药物治疗的组合的用途：（1）选择性抑制热休克蛋白90（Hsp90）的药剂; （2）抑制Hedgehog途径的药物（被认为在允许某些致癌细胞的增殖和存活中发挥核心作用，并且涉及许多致命的癌症）; 和（3）降低Bcl-2或Bcl-xL的抗凋亡作用的药剂。 这些药物可以单独使用轻度活化药物治疗，或以各种组合和排列使用。

公开(公告)号：US06396443B1

公开(公告)日：2002-05-28

申请号：US08665755

申请日：1996-06-18

申请人： Kenneth F. Conklin ,  David B. Giguere ,  James C. Chen

发明人： Kenneth F. Conklin ,  David B. Giguere ,  James C. Chen

IPC分类号： H01Q124

CPC分类号： H01Q1/22 ,  H01Q13/28 ,  H01Q21/061 ,  H01Q23/00

摘要： A point-to-point radio frequency unit/antenna has a flat antenna, preferably a continuous transverse stub antenna, integrated into the housing of the microwave unit. The radio frequency unit/antenna includes a housing having an exterior wall, a microwave radio frequency transceiver electronics package within the housing and having an antenna connection, and a flat antenna affixed to one face of the exterior wall of the housing. A microwave radio frequency feed communicates between the flat antenna and the antenna connection of the microwave transceiver electronics package. There is preferably a bracket structure on another face of the housing to affix the housing to a support.

摘要翻译： 点对点射频单元/天线具有集成到微波单元的壳体中的平坦天线，优选地是连续的横向短截线天线。 射频单元/天线包括具有外壁的外壳，壳体内的微波射频收发器电子封装，并且具有天线连接，以及固定到外壳的外壁的一个面上的平坦天线。 微波射频馈送在平坦天线和微波收发器电子封装的天线连接之间进行通信。 在壳体的另一个表面上优选地具有支架结构，以将壳体固定到支撑件上。

公开(公告)号：US06344050B1

公开(公告)日：2002-02-05

申请号：US09218336

申请日：1998-12-21

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： A61N700

CPC分类号： A61K41/0057 ,  A61K47/60 ,  A61K47/68 ,  A61K47/6927

摘要： A photosensitizer suitable for use in administering photodynamic therapy (PDT), conjugated with antibodies that are targeted to antigens on abnormal tissue and polyethylene glycol (PEG) or other polymer that extends the residence time of the conjugate within a patient's body. The resulting pegylated targeted conjugate is administered to a patient, and after the antibodies have had sufficient time to bind with the antigens, light from an external or internal source having a waveband corresponding to an absorption waveband of the photosensitizer is administered. Use of an external light source that emits relatively long wavelength light enables the light to pass through any intervening dermal layer and normal tissue between the external light source and the treatment site. Since the photosensitizer in the conjugate is bound to the abnormal tissue, the light therapy has minimal effect on the intervening normal tissue. Furthermore, the efficacy of the PDT is enhanced due to the increased concentration of the photosensitizer of the conjugate linked to the abnormal tissue.

摘要翻译： 适用于施用光动力疗法（PDT）的光敏剂，其与针对异常组织上的抗原的抗体和聚乙二醇（PEG）或其它聚合物结合，所述聚合物延长缀合物在患者体内的停留时间。 将所得的聚乙二醇化靶向缀合物施用于患者，并且在抗体具有足够的时间与抗原结合之后，施用来自具有对应于光敏剂的吸收波段的波段的外部或内部源的光。 使用发射相对较长波长的光的外部光源使得光能够通过外部光源和处理部位之间的任何中间真皮层和正常组织。 由于缀合物中的光敏剂与异常组织结合，光疗对中间正常组织的影响最小。 此外，由于与异常组织连接的缀合物的光敏剂的浓度增加，PDT的功效增强。

公开(公告)号：US06331744B1

公开(公告)日：2001-12-18

申请号：US09547700

申请日：2000-04-11

申请人： James C. Chen ,  Darrin Huston ,  Brian D. Wilkerson

发明人： James C. Chen ,  Darrin Huston ,  Brian D. Wilkerson

IPC分类号： H02K3300

CPC分类号： A61N1/08 ,  A47J36/02 ,  A47J36/26 ,  A61F2250/0001 ,  A61N1/3787 ,  H01F38/12 ,  H01F38/14 ,  H01M10/46 ,  H01M10/48 ,  H02K5/1282 ,  H02K7/1807 ,  H02K7/1876 ,  H02K21/12 ,  H02K21/24 ,  H02K35/02 ,  H05B6/1236 ,  Y02B40/123

摘要： A flux generator base unit electromagnetically coupled with a receiving unit to transfer energy into the receiving unit. The base unit includes one or more permanent magnets that produce a magnetic flux, which passes through a receiver coil in the receiving unit. The receiver coil is either disposed in a separate housing that is electrically connected with a portable device, or integrated into the housing of the portable device. Either the permanent magnets or a flux shunt is moved in the base unit to produce the varying magnetic flux that is coupled to the receiver coil. As a result of the varying magnetic field experienced by the receiver coil, an electric current is induced in the receiver coil, which is conditioned (e.g., rectified, filtered, and regulated) by a conditioning circuit to charge a battery or energize electronics contained in the portable device. Various embodiments of both the base unit and receiving unit are disclosed, including “universal” base units suitable for operation with different size receiving units.

公开(公告)号：US06300765B1

公开(公告)日：2001-10-09

申请号：US09246469

申请日：1999-02-09

申请人： James C. Chen

发明人： James C. Chen

IPC分类号： G01R3108

CPC分类号： G01R31/3004 ,  G01R31/2884

摘要： A system, an IC chip, a test structure formed on the IC chip, and a corresponding method for modeling one or more target interconnect capacitances is disclosed. The test structure comprises an interconnect configuration comprising a test interconnect and one or more target interconnects. The interconnect configuration has, for each target interconnect, a corresponding target interconnect capacitance between the test interconnect and the target interconnect. The test structure also comprises a test interconnect charging circuit connected to the test interconnect. The test interconnect charging circuit is configured to place a test charge on the test interconnect. The test structure further comprises one or more target interconnect charging circuits. Each target interconnect charging circuit is connected to a corresponding target interconnect. Each target interconnect charging circuit is configured to draw a target interconnect charging current from the corresponding target interconnect in response to the test charge. This places an opposite charge on the corresponding target interconnect that is induced by the corresponding target interconnect capacitance. As a result, a measurement of the corresponding target interconnect capacitance may be computed by making a measurement of the target interconnect charging current with a current meter of the system.

公开(公告)号：US06273904B1

公开(公告)日：2001-08-14

申请号：US09260923

申请日：1999-03-02

申请人： James C. Chen ,  David J. Brown ,  Brian D. Wilkerson ,  Charles M. McQuade ,  Darrin Huston

发明人： James C. Chen ,  David J. Brown ,  Brian D. Wilkerson ,  Charles M. McQuade ,  Darrin Huston

IPC分类号： A61N506

CPC分类号： A61N5/062 ,  A61N1/3787 ,  A61N5/0601 ,  H01M2/1066 ,  H01M6/181

摘要： Several different embodiments of a flexible polymer battery are disclosed in connection with providing a medical therapy. For example, the electrical current from the polymer battery may be used to energize light sources for administering light therapy. In one embodiment, the polymer battery is formed as a substantially elongate structure having one end attached to an internal receiver coil, and the other end attached to a medical device such as a light probe that is adapted to be implanted within a patient's body. The polymer battery thus provides a conductive link between the internal receiver coil, which is electromagnetically coupled to an external transmitter coil for recharging the battery, and the light probe which is energized with current supplied by the flexible polymer battery. In another embodiment, the polymer battery is used to support a substrate on which a plurality of light sources are mounted in spaced-apart array. Yet other forms of the invention include polymer batteries within capsules or bead to energize light sources contained therein. The beads include receiver coils for recharging the polymer battery. Further, because of their small size, the beads or capsules are readily moved or held at a treatment site with an external magnet while therapy is rendered. Since a polymer battery includes very little metal, it is less likely to cause artifacts when the patient's body is imaged.

摘要翻译： 结合提供医学疗法来公开柔性聚合物电池的若干不同实施方案。 例如，可以使用来自聚合物电池的电流来激发用于施用光疗的光源。 在一个实施例中，聚合物电池形成为具有附接到内部接收器线圈的一端的基本上细长的结构，另一端附接到医疗设备，例如适于植入患者体内的光探针。 因此，聚合物电池在内部接收器线圈之间提供导电连接，内部接收器线圈电磁耦合到用于对电池充电的外部发射器线圈和由柔性聚合物电池供应的电流供电的光探针。 在另一个实施例中，聚合物电池用于支撑其上安装有多个光源的衬底以间隔开的阵列。 本发明的其它形式包括胶囊或珠粒内的聚合物电池，以激励其中所含的光源。 珠子包括用于对聚合物电池充电的接收器线圈。 此外，由于它们的小尺寸，在进行治疗时，珠或胶囊容易地与外部磁体移动或保持在治疗部位。 由于聚合物电池包含非常少的金属，所以当患者的身体成像时不太可能引起伪影。

公开(公告)号：US6138681A

公开(公告)日：2000-10-31

申请号：US949308

申请日：1997-10-13

申请人： James C. Chen ,  Brian D. Wilkerson ,  Darrin Huston

发明人： James C. Chen ,  Brian D. Wilkerson ,  Darrin Huston

IPC分类号： A61B19/00 ,  A61B5/06 ,  A61F2/02 ,  A61N1/378 ,  H02J17/00

CPC分类号： A61B5/06 ,  A61F2250/0001

摘要： The alignment and positioning of an external device relative to an internal device is indicated on a display and/or by an acoustical signal. In the disclosed application, the external device transcutaneously transmits electromagnetic energy to an internal receiver to provide electrical power for an implanted medical device. To ensure optimal coupling between the external transmitter and the internal receiver, two permanent magnets are disposed at spaced-apart positions on the internal receiver. The magnetic field strength of the permanent magnets is sensed by a pair of correspondingly spaced-apart Hall effect sensor on the external transmitter. As the external transmitter is moved about over the internal receiver, the signals produced by the Hall effect sensors drive a display of light emitting diodes (LEDs) that indicates when the maximum magnetic field strength is achieved, i.e., when the Hall effect sensors on the external transmitter are each positioned directly opposite the corresponding permanent magnets on the internal receiver.

摘要翻译： 外部设备相对于内部设备的对准和定位在显示器和/或声学信号上指示。 在所公开的应用中，外部设备经常地将电磁能量传输到内部接收器以为植入的医疗设备提供电力。 为了确保外部发射器和内部接收器之间的最佳耦合，两个永磁体设置在内部接收器上的间隔位置。 永磁体的磁场强度由外部发射器上的一对相应间隔的霍尔效应传感器感测。 当外部发射器在内部接收器上移动时，由霍尔效应传感器产生的信号驱动发光二极管（LED）的显示器，该发光二极管指示何时实现最大磁场强度，即当霍尔效应传感器 外部发射器分别与内部接收器上相应的永久磁铁正好相对。