公开(公告)号：US07252677B2

公开(公告)日：2007-08-07

申请号：US10799357

申请日：2004-03-12

申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Kristine Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Kristine Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61N5/06

CPC分类号： A61N5/0601 ,  A61B2018/2261 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0652 ,  A61N2005/1003

摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

摘要翻译： 用于照射血管组织部分的光产生装置，以进行光动力疗法。 在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。 可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。 光纤可选地将来自光源的光引导到漫射元件。 光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。 线性光源元件特别适用于处理容器中组织的细长部分。 旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

公开(公告)号：US20190090666A1

公开(公告)日：2019-03-28

申请号：US15714641

申请日：2017-09-25

申请人： Jean Bishop

发明人： Jean Bishop

IPC分类号： A47G9/02 ,  D05B11/00

摘要： Improved batting insert materials for quilting are provided herein. The improved batting materials are adapted to be positioned between a quilt top and quilt bottom, and the materials advantageously prevent slippage of quilt layers during stitching without the need for pinning or basting. The insert materials generally comprise a batting layer and a flannel layer secured to the batting layer. The flannel layer is adapted to be positioned abutting the quilt bottom, and it has been discovered that the interaction between the surfaces of these fabrics prevents the layers from slipping. Quilts and methods utilizing the improved batting insert materials are also provided herein.

公开(公告)号：US20080033519A1

公开(公告)日：2008-02-07

申请号：US11834572

申请日：2007-08-06

申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61N1/05 ,  A61M29/02 ,  F21S2/00

CPC分类号： A61N5/062 ,  A61B2018/2261 ,  A61N5/0601 ,  A61N2005/0602 ,  A61N2005/063 ,  A61N2005/0652

摘要： Light sources are incorporated into a guidewire for enabling the ability to render light therapy be added to catheters that do not have that capability. In one exemplary embodiment, a solid guidewire includes a conductive core, and light sources are added to compartments formed in a distal end of the guidewire. In another exemplary embodiment, a light source array is included in a distal end of a hollow guidewire. A plurality of openings are formed into the walls of the hollow guidewire surrounding the array, enabling light to pass through the openings. Conductors extend from the array though the hollow center of the guidewire, to a proximal end of the hollow guidewire. The hollow guidewire can be coated with a conductive material, so that the coating on the guidewire serves as a conductor.

摘要翻译： 光源被结合到导丝中，以使能够将光疗法添加到不具有该能力的导管的能力。 在一个示例性实施例中，实心导线包括导电芯，并且将光源添加到形成在导丝的远端中的隔室。 在另一示例性实施例中，光源阵列包括在中空导丝的远端中。 多个开口形成在围绕阵列的中空导丝的壁中，使得光能够穿过开口。 导体通过导丝的中空中心从阵列延伸到中空导丝的近端。 中空导丝可以用导电材料涂覆，使得导丝上的涂层用作导体。

公开(公告)号：US20050228260A1

公开(公告)日：2005-10-13

申请号：US10799357

申请日：2004-03-12

申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61B18/22 ,  A61M20060101 ,  A61N1/00 ,  A61N5/00 ,  A61N5/06 ,  A61N5/10

CPC分类号： A61N5/0601 ,  A61B2018/2261 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0652 ,  A61N2005/1003

摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

摘要翻译： 用于照射血管组织部分的光产生装置，以进行光动力疗法。 在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。 可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。 光纤可选地将来自光源的光引导到漫射元件。 光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。 线性光源元件特别适用于处理容器中组织的细长部分。 旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

公开(公告)号：US20070002582A1

公开(公告)日：2007-01-04

申请号：US11323319

申请日：2005-12-30

申请人： Phillip Burwell ,  James Chen ,  Zihong Guo ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jennifer Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  James Chen ,  Zihong Guo ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jennifer Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61B1/06

CPC分类号： A61N5/062 ,  A61N2005/0652

摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

公开(公告)号：US5550029A

公开(公告)日：1996-08-27

申请号：US303056

申请日：1994-09-08

申请人： James W. Simpkins ,  Jean Bishop

发明人： James W. Simpkins ,  Jean Bishop

IPC分类号： G01N33/49 ,  G01N33/493 ,  G01N33/50 ,  G01N33/60 ,  G01N33/66 ,  G01N33/74 ,  G01N33/76 ,  C12Q1/54

CPC分类号： G01N33/743 ,  G01N33/60 ,  Y10S436/817

摘要： A method and diagnostic kit is provided for diagnosing responsiveness to a hormone in a human subject that includes determining the amount of glucose utilized by a sample taken from the subject in the presence of the hormone. The sample taken from the subject may include body fluid or body tissue such as blood or skin. The glucose utilized in the test may be labelled for example, with a radioactive label. The diagnostic test may be used to determine responsiveness to estrogen in a human subject prior to treatment with hormone replacement therapy.

摘要翻译： 提供了一种用于诊断人类受试者对激素的反应性的方法和诊断试剂盒，其包括在激素存在下测定取自受试者的样品所用的葡萄糖的量。 从受试者取出的样品可以包括体液或身体组织，例如血液或皮肤。 在测试中使用的葡萄糖可以例如用放射性标记标记。 在用激素替代疗法治疗之前，可以使用诊断测试来确定人类受试者对雌激素的反应性。

公开(公告)号：US08685071B2

公开(公告)日：2014-04-01

申请号：US13401747

申请日：2012-02-21

申请人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  James C. Chen ,  Zihong Guo ,  Steven R. Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jennifer K. Matson ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61N2005/0652

摘要： A method of manufacture and medical apparatus that provides an apparatus useful in illuminating at least a portion of a lumen of a body. The apparatus includes an elongated flexible member and a polymer encasement portion encasing a plurality of light emitters. The light emitters may be electrically coupled to one another without the use of wire bonds, and in some embodiments may be coupled without intervening electrical paths or traces. A maximum cross-sectional dimension of the polymer encasement portion may be less than twice a dimension of one of the light emitters. In some embodiments the maximum cross-sectional dimension is less than or equal to the sum of the dimension of one of the light emitters and a marginal dimension by which an outer portion of the polymer encasement portion extends beyond the light emitter. Light emitters may be arranged linearly, helically or in partially overlapping back-to-back relation.

摘要翻译： 一种制造方法和医疗装置，其提供用于照亮身体的内腔的至少一部分的装置。 该装置包括细长的柔性构件和封装多个发光体的聚合物封装部分。 光发射器可以在不使用引线键的情况下彼此电耦合，并且在一些实施例中可以耦合而没有中间的电路径或迹线。 聚合物封装部分的最大横截面尺寸可以小于一个发光体的尺寸的两倍。 在一些实施例中，最大横截面尺寸小于或等于光发射器之一的尺寸之和和聚合物封装部分的外部部分延伸超过光发射器的边缘尺寸之和。 光发射器可以线性地，螺旋状地或以部分重叠的背靠背关系布置。

公开(公告)号：US07730894B2

公开(公告)日：2010-06-08

申请号：US11773555

申请日：2007-07-05

申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Kristine Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Kristine Matson ,  Steven Ross Daly ,  David B. Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61B19/00

CPC分类号： A61N5/0601 ,  A61B2018/2261 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0652 ,  A61N2005/1003

摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

摘要翻译： 用于照射血管组织部分的光产生装置，以进行光动力疗法。 在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。 可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。 光纤可选地将来自光源的光引导到漫射元件。 光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。 线性光源元件特别适用于处理容器中组织的细长部分。 旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

公开(公告)号：US20080027517A1

公开(公告)日：2008-01-31

申请号：US11773555

申请日：2007-07-05

申请人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

发明人： Phillip Burwell ,  Zihong Guo ,  Jennifer Matson ,  Steven Daly ,  David Shine ,  Gary Lichttenegger ,  Jean Bishop ,  Nick Yeo ,  Hugh Narciso

IPC分类号： A61N5/06

CPC分类号： A61N5/0601 ,  A61B2018/2261 ,  A61N5/062 ,  A61N2005/0602 ,  A61N2005/0652 ,  A61N2005/1003

摘要： Light generating devices for illuminating portions of vascular tissue, to render photodynamic therapy. In one embodiment, a light source array preferably including a plurality of light emitting diodes, a focusing lens, and a light diffusing element are included in a distal end of a catheter. A balloon is optionally provided to interrupt blood flow that can block the transmission of light, and to center the apparatus in a blood vessel. Optical fibers optionally direct light from the light source to the diffusing element. The light source array can have a radial or linear configuration and can produce more than one wavelength of light for activating different photoreactive agents. Linear light source elements are particularly useful to treat elongate portions of tissue in a vessel. One embodiment intended for use with a conventional balloon catheter integrates light sources into a guidewire.

摘要翻译： 用于照射血管组织部分的光产生装置，以进行光动力疗法。 在一个实施例中，优选地包括多个发光二极管的光源阵列，聚焦透镜和光漫射元件被包括在导管的远端中。 可选地提供气囊以中断可阻挡光的传播的血流，并使装置居中在血管中。 光纤可选地将来自光源的光引导到漫射元件。 光源阵列可以具有径向或线性配置并且可以产生多于一个波长的光以激活不同的光反应剂。 线性光源元件特别适用于处理容器中组织的细长部分。 旨在用于常规气囊导管的一个实施例将光源集成到导丝中。

公开(公告)号：US5554601A

公开(公告)日：1996-09-10

申请号：US318042

申请日：1994-10-04

申请人： James W. Simpkins ,  Meharvan Singh ,  Jean Bishop

发明人： James W. Simpkins ,  Meharvan Singh ,  Jean Bishop

IPC分类号： A61K31/56 ,  A61K31/00 ,  A61K31/565 ,  A61K31/566 ,  A61P3/08 ,  A61P25/00 ,  A61P25/02 ,  A61P25/08 ,  A61P25/14 ,  A61P25/16 ,  A61P25/18 ,  A61P25/28 ,  C07J1/00

CPC分类号： B82Y5/00 ,  A61K31/565

摘要： A method is provided for conferring neuroprotection on a population of cells using estrogen compounds that have insubstantial sex activity and furthermore, a method is provided that utilizes estrogen compounds in the absence of testosterone for treating neurodegenerative diseases including Alzheimer's disease so as to retard the adverse effects of these disorders, Examples of estrogen compounds that have insubstantial sex activity includes alpha isomers of estrogen compounds such as 17.alpha. estradiol.

摘要翻译： 提供了一种使用具有非实质性活动的雌激素化合物对细胞群赋予神经保护作用的方法，此外，提供了在不存在睾丸激素的情况下利用雌激素化合物治疗包括阿尔茨海默氏病在内的神经变性疾病以延缓不良反应的方法 具有非实质性活动的雌激素化合物的实例包括雌激素化合物如17α雌二醇的α异构体。