-
公开(公告)号：US09060844B2
公开(公告)日：2015-06-23
申请号：US10698148
申请日：2003-10-31
Applicant: Jonathan Kagan , James Balliro , David Carr-Locke , Mitchell Dann , Lee Guterman , Sayeed Ikramuddin , James Leary , Richard Thomas
Inventor： Jonathan Kagan , James Balliro , David Carr-Locke , Mitchell Dann , Lee Guterman , Sayeed Ikramuddin , James Leary , Richard Thomas
CPC classification number: A61F5/0079 , A61F2/04 , A61F5/0083 , A61F5/0086 , A61F2220/0008
Abstract: Apparatus and methods are described for treatment of morbid obesity using minimally invasive techniques. The apparatus includes a system of components that may be used separately or in combination for effectively reducing stomach volume, bypassing a portion of the stomach and/or small intestines, reducing nutrient absorption in the stomach and/or small intestines and/or depositing minimally or undigested food farther than normal into the intestines, thereby stimulating intestinal responses. The components described include an artificial stoma device, a gastric sleeve device, an intestinal sleeve device, a combined gastrointestinal sleeve device and permanent and detachable attachment systems. Also described are devices for delivering and deploying the components of the system.
Abstract translation: 描述了使用微创技术治疗病态肥胖症的装置和方法。 该装置包括可以单独使用或组合使用以有效地减少胃体积，绕过胃和/或小肠的一部分的组件系统，减少胃和/或小肠中的营养吸收和/或最小化或 未消化的食物比正常进食更远，从而刺激肠道反应。 所描述的组件包括人工造口装置，胃套筒装置，肠套管装置，组合的胃肠套管装置和永久和可拆卸的附接系统。 还描述了用于递送和部署系统的部件的装置。
-
公开(公告)号：US20050096750A1
公开(公告)日：2005-05-05
申请号：US10998424
申请日：2004-11-29
Applicant: Jonathan Kagan , James Balliro , David Carr-Locke , Mitchell Dann , Lee Guterman , Sayeed Ikramuddin , James Leary , Richard Thomas
Inventor： Jonathan Kagan , James Balliro , David Carr-Locke , Mitchell Dann , Lee Guterman , Sayeed Ikramuddin , James Leary , Richard Thomas
CPC classification number: A61F5/0079 , A61F2/04 , A61F5/0083 , A61F5/0086 , A61F2220/0008
Abstract: Apparatus and methods are described for treatment of morbid obesity using minimally invasive techniques. The apparatus includes a system of components that may be used separately or in combination for effectively reducing stomach volume, bypassing a portion of the stomach and/or small intestines, reducing nutrient absorption in the stomach and/or small intestines and/or depositing minimally or undigested food farther than normal into the intestines, thereby stimulating intestinal responses. The components described include an artificial stoma device, a gastric sleeve device, an intestinal sleeve device, a combined gastrointestinal sleeve device and permanent and detachable attachment systems. Also described are devices for delivering and deploying the components of the system.
Abstract translation: 描述了使用微创技术治疗病态肥胖症的装置和方法。 该装置包括可以单独使用或组合使用以有效地减少胃体积，绕过胃和/或小肠的一部分的组件系统，减少胃和/或小肠中的营养吸收和/或最小程度地沉积或 未消化的食物比正常进食更远，从而刺激肠道反应。 所描述的组件包括人工造口装置，胃套筒装置，肠套管装置，组合的胃肠套管装置和永久和可拆卸的附接系统。 还描述了用于递送和部署系统的部件的装置。
-
公开(公告)号：US20240187739A1
公开(公告)日：2024-06-06
申请号：US18428191
申请日：2024-01-31
Applicant: Matthew James Leary
Inventor： Matthew James Leary
IPC: H04N23/73 , A63B69/36 , H04N23/695
CPC classification number: H04N23/73 , A63B69/3658 , H04N23/695
Abstract: A method may include using a camera to capture a group of image exposures of an object, where each exposure is illuminated by a respective illumination pulse from a sequence of pulses. The method may further include determining pulse ratios of pairs of the time intervals that exist between the pulses, as well as a distance ratio of two of the distances between two pairs of the exposures. Additionally, the method may include comparing the distance ratio to the pulse ratios to determine a correlation between the illumination pulses and the exposures. The method may also further include using the correlation to determine characteristics of the object's motion, such as the object's velocity, position, speed, trajectory, orientation or spin rates.
-
4.发明申请STRUCTURE BASED AND COMBINATORIALLY SELECTED OLIGONUCLEOSIDE PHOSPHOROTHIOATE AND PHOSPHORODITHIOATE APTAMER TARGETING AP-1 TRANSCRIPTION FACTORS 有权基于结构和组合选择的寡核苷酸磷酸酯和磷酸化APTAMER靶向AP-1转录因子公开(公告)号：US20110212843A1
公开(公告)日：2011-09-01
申请号：US13014597
申请日：2011-01-26
Applicant: David G. Gorenstein , Bruce A. Luxon , James Leary
Inventor： David G. Gorenstein , Bruce A. Luxon , James Leary
CPC classification number: C12N15/1048 , C12N15/1034 , G01N33/6818 , G01N33/6848 , G01N33/6851
Abstract: The present invention includes composition and methods for making and using a combinatorial library to identify modified thioaptamers that bind to, and affect the immune response of a host animal, transcription factors such as IL-6, NF-κB, AP-1 and the like. Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.
Abstract translation: 本发明包括用于制备和使用组合文库以鉴定与宿主动物结合并影响宿主动物的免疫应答的转录因子如IL-6，NF-κB，AP-1和 类似。 还提供组合物和方法用于治疗病毒感染，以及疫苗和提供修饰宿主免疫应答的疫苗佐剂。
-
公开(公告)号：US20050218032A1
公开(公告)日：2005-10-06
申请号：US10818424
申请日：2004-04-02
Applicant: Todd Maddock , Timothy Giddens , Jerry Newman , Herbert Kaiser , James Leary
Inventor： Todd Maddock , Timothy Giddens , Jerry Newman , Herbert Kaiser , James Leary
CPC classification number: B65D23/12 , B65D77/003 , B65D81/32
Abstract: A kit for forming a sterile cleaning solution. The kit is comprised of a container, a packet, a first flexible package and a second flexible package. The container contains a liquid and has an opening and a removable cap sealing the opening. The packet contains a pre-measured amount of an active agent. The first flexible package is dimensioned to enclose the container and the packet. The second flexible package is dimensioned to enclose the first flexible package, the container and the packet.
Abstract translation: 用于形成无菌清洁溶液的试剂盒。 该套件包括容器，包装盒，第一柔性包装盒和第二柔性包装盒。 容器包含液体并具有开口和密封开口的可拆卸盖。 分组包含预先测量的活性剂量。 第一个灵活包装的尺寸用于封闭容器和包装。 第二灵活包装的尺寸设计成包围第一柔性包装，容器和包装。
-
Patent Agency Ranking
公开(公告)号：US20050085845A1
公开(公告)日：2005-04-21
申请号：US10833494
申请日：2004-04-27
Applicant: Pierre Hilaire , James Leary , Machiel Van Der Leest
Inventor： Pierre Hilaire , James Leary , Machiel Van Der Leest
CPC classification number: A61F2/954 , A61F2/856 , A61F2/958 , A61F2/97 , A61F2002/065 , A61F2002/067 , A61F2250/006
Abstract: A catheter system and method are described for stenting a vessel at a bifurcation or sidebranch of the vessel. The catheter system includes a first balloon catheter, a second balloon catheter and a releasable linking device for holding the first and second balloon catheters arranged in a side-by-side configuration and aligned with one another along a longitudinal axis. The linking device allows the catheter system to be advanced as a unit and helps prevent premature or inadvertent dislodgement of the stent from the catheters, yet is releasable so that one or both of the balloon catheters can be released from the linking device and maneuvered separately from the rest of the catheter system when desired. The method utilizes the described catheter system for stenting bifurcated vessels using a modified “kissing balloons” technique.
Abstract translation: 描述了用于在血管的分叉或侧分支处支架血管的导管系统和方法。 导管系统包括第一气囊导管，第二球囊导管和可释放连接装置，用于保持以并排构造布置并沿着纵向轴线彼此对准的第一和第二气囊导管。 连接装置允许导管系统作为一个单元前进，并且有助于防止支架从导管中过早或无意地移出，但是可释放，使得气囊导管中的一个或两个可以从连接装置释放并与 导管系统的其余部分。 该方法利用所描述的导管系统用于使用改进的“接吻气球”技术支架分叉血管。
-
7.发明授权Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting AP-1 transcription factors 有权基于结构和组合选择的寡核苷酸硫代磷酸酯和二硫代磷酸酯适体靶向AP-1转录因子公开(公告)号：US09567579B2
公开(公告)日：2017-02-14
申请号：US13014597
申请日：2011-01-26
Applicant: David G. Gorenstein , Bruce A. Luxon , James Leary , Xianbin Yang
Inventor： David G. Gorenstein , Bruce A. Luxon , James Leary , Xianbin Yang
CPC classification number: C12N15/1048 , C12N15/1034 , G01N33/6818 , G01N33/6848 , G01N33/6851
Abstract: The present invention includes composition and methods for making and using a combinatorial library to identify modified thioaptamers that bind to, and affect the immune response of a host animal, transcription factors such as IL-6, NF-κB, AP-1 and the like. Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.
Abstract translation: 本发明包括用于制备和使用组合文库以鉴定与宿主动物结合并影响宿主动物的转录因子如IL-6，NF-κB，AP-1等的修饰硫胺素的组合物和方法 。 还提供组合物和方法用于治疗病毒感染，以及疫苗和提供修饰宿主免疫应答的疫苗佐剂。
-
8.发明授权Structure based and combinatorially selected oligonucleoside phosphorothioate and phosphorodithioate aptamer targeting AP-1 transcription factors 有权基于结构和组合选择的寡核苷酸硫代磷酸酯和二硫代磷酸酯适体靶向AP-1转录因子公开(公告)号：US07910523B2
公开(公告)日：2011-03-22
申请号：US10851864
申请日：2004-05-20
Applicant: David G. Gorenstein , Bruce A. Luxon , James Leary
Inventor： David G. Gorenstein , Bruce A. Luxon , James Leary
IPC: C40B50/16
CPC classification number: C12N15/1048 , C12N15/1034 , G01N33/6818 , G01N33/6848 , G01N33/6851
Abstract: The present invention includes composition and methods for making and using a combinatorial library to identify modified thioaptamers that bind to, and affect the immune response of a host animal, transcription factors such as IL-6, NF-κB, AP-1 and the like. Composition and methods are also provided for the treatment of viral infections, as well as, vaccines and vaccine adjuvants are provided that modify host immune responses.
Abstract translation: 本发明包括用于制备和使用组合文库以鉴定与宿主动物结合并影响宿主动物的免疫应答的转录因子如IL-6，NF-κB，AP-1和 类似。 还提供组合物和方法用于治疗病毒感染，以及疫苗和提供修饰宿主免疫应答的疫苗佐剂。
-
9.发明申请公开(公告)号：US20090157160A1
公开(公告)日：2009-06-18
申请号：US12067142
申请日：2006-09-19
Applicant: Machiel Van Der Leest , Pierre Hilaire , Philippe Moulin , James Leary
Inventor： Machiel Van Der Leest , Pierre Hilaire , Philippe Moulin , James Leary
IPC: A61F2/84
CPC classification number: A61F2/95 , A61F2/958 , A61M25/104 , A61M2025/0183
Abstract: Apparatus and methods are described for performing protected angioplasty and stenting of a patient's carotid bifurcation. An integrated catheter system can be configured in a rapid-exchange version or in an over-the-wire version. The catheter system includes a self-expanding stent, a stent delivery sheath, a combination angioplasty balloon catheter and stent pusher catheter, an embolic protection device and, in the rapid-exchange version, an auto-releasing sheath. The method includes: inserting a guiding catheter to the carotid bifurcation; inserting the catheter system through the guiding catheter; advancing the embolic protection device beyond the lesion; positioning the stent and balloon segment of the catheter system at the lesion; releasing the self-expanding stent; pulling the stent delivery sheath back into the guiding catheter; positioning and deploying the protection member; advancing the combination angioplasty balloon catheter and stent pusher catheter and inflating the angioplasty balloon within the lesion; deflating the angioplasty balloon and withdrawing the combination angioplasty balloon catheter and stent pusher catheter and stent delivery sheath together; and aspirating potential emboli through the guiding catheter.
Abstract translation: 描述了用于执行患者颈动脉分叉的保护性血管成形术和支架置入的装置和方法。 集成导管系统可以以快速交换版本或线上版本配置。 导管系统包括自扩张支架，支架输送护套，组合血管成形术球囊导管和支架推进导管，栓塞保护装置，并且在快速更换版本中具有自动释放护套。 该方法包括：将引导导管插入颈动脉分叉; 通过引导导管插入导管系统; 推进栓塞保护装置超过病变; 将导管系统的支架和气囊段定位在病变处; 释放自扩张支架; 将支架输送护套拉回导引导管; 定位和部署保护构件; 推进组合血管成形术球囊导管和支架推动导管，并使病变内的血管成形术气囊膨胀; 将血管成形术气囊放气并将组合血管成形术球囊导管和支架推进导管和支架输送护套并入; 并通过引导导管抽吸潜在的栓塞。
-
10.发明申请Molecular programming of nanoparticle systems for an ordered and controlled sequence of events for gene-drug delivery 审中-公开用于基因药物递送的有序和受控序列的纳米颗粒系统的分子编程公开(公告)号：US20070190155A1
公开(公告)日：2007-08-16
申请号：US10591213
申请日：2005-03-04
Applicant: James Leary , Tarl Prow
Inventor： James Leary , Tarl Prow
CPC classification number: C12N15/88 , A61K47/6923 , A61K47/6929 , A61K48/0008 , A61K48/0058 , B82Y5/00
Abstract: The disclosure provides a nanodelivery system and related process having complex, multilayered nanoparticles for sophisticated drug/gene delivery systems to intracellular portions of a cell. Outermost layers can include cell targeting and cell-entry facilitating molecules. The next layer can include intracellular targeting molecules for precise delivery of the nanoparticle complex inside the cell of interest. Molecular biosensors can be used to confirm the presence of expected molecules as a surrogate molecule for signs of infection, for activation in radiation damage, or other criteria, prior to delivery of counter-measure molecules such as drugs or gene therapy. The biosensors can also be used as a feedback control mechanism to control the proper amount of drug/gene delivery for each cell. Further, the nanodelivery system can be used to restrict any cells from encountering the drug unless that cell is specifically targeted. Successful targeting can be verified by 3D multispectral confocal microscopy.
Abstract translation: 本公开提供了纳米递送系统和相关方法，其具有复杂的多层纳米颗粒，用于细胞的细胞内部分的复杂药物/基因递送系统。 最外层可以包括细胞靶向和促进分子的细胞进入。 下一层可以包括细胞内靶向分子，用于在感兴趣的细胞内精确递送纳米颗粒复合物。 可以使用分子生物传感器来确认在递送对抗分子如药物或基因治疗之前预期分子作为感染迹象的替代分子的存在，辐射损伤中的激活或其他标准。 生物传感器也可用作反馈控制机制，以控制每个细胞的药物/基因递送的适量。 此外，纳米递送系统可以用于限制任何细胞遇到药物，除非该细胞是特异性靶向的。 成功的定位可以通过3D多光谱共聚焦显微镜来验证。
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.02 seconds)
