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公开(公告)号：US08568970B2
公开(公告)日：2013-10-29
申请号：US12034765
申请日：2008-02-21
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04 , C12N2795/00011 , C12N2795/00032
摘要： Compositions containing bacteriophages and methods of using bacteriophages in microorganism detection assays and microbial growth and plating media are disclosed. The lytic ability of these phages to control the growth of non-target populations provides superior sensitivity and specificity to detection assays and reduces false negative and false positive results. The removal of contaminating bacteria reduces the microbial competition for nutrients in the growth media thereby increasing the efficiency and productivity of the culture. The phage treatment of the sample increases the proportion of target microorganisms in the sample over contaminating bacteria thereby requiring less time for enrichment to obtain a significant signal improving overall signal to noise ratio in assays and providing for higher yield of end product in microbiological production systems.
摘要翻译： 公开了包含噬菌体的组合物和在微生物检测测定和微生物生长和电镀培养基中使用噬菌体的方法。 这些噬菌体控制非目标群体生长的溶解能力为检测测定提供了出色的灵敏度和特异性，并减少了假阴性和假阳性结果。 污染细菌的去除减少了生长培养基中营养物的微生物竞争，从而提高了培养物的效率和生产力。 样品的噬菌体处理增加了样品中目标微生物在污染细菌上的比例，从而需要更少的浓缩时间来获得显着的信号，从而提高了测定中的整体信噪比，并提供了微生物生产系统中最终产品的更高产量。
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公开(公告)号：US06750328B1
公开(公告)日：2004-06-15
申请号：US08506793
申请日：1995-07-25
IPC分类号： C07K2108
CPC分类号： C07K16/44 , G01N33/5308 , Y10S435/975
摘要： The invention provides an antibody having an affinity to water treatment polymers. The antibodies of the invention are used in assays to determine the presence or concentration of a water treatment polymer in a fluid or aqueous system.
摘要翻译： 本发明提供对水处理聚合物具有亲和性的抗体。 本发明的抗体用于测定中以确定水处理聚合物在流体或水系统中的存在或浓度。
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公开(公告)号：US20180128828A1
公开(公告)日：2018-05-10
申请号：US15803420
申请日：2017-11-03
申请人： James W. Stave , Megan Carpenter , Marc Arnone , Tony Joaquim , Martin Raymond Gould , John Leon Miamidian
发明人： James W. Stave , Megan Carpenter , Marc Arnone , Tony Joaquim , Martin Raymond Gould , John Leon Miamidian
IPC分类号： G01N33/569 , C12Q1/40
CPC分类号： G01N33/56911 , C12Q1/04 , C12Q1/40 , C12Y302/01035 , G01N33/56938 , G01N33/56961 , G01N2800/10 , G01N2800/26 , G01N2800/60
摘要： Methods are provided for preparing patient samples for direct detection and identification of microorganisms in the patient samples using multiplex immunoassays. The method includes enzymatic treatment of the patient sample, boiling and centrifugation of the sample to provide a treated sample that may be used in an immunoassay. There are also provided immunoassay compositions and systems for the direct detection and identification of microorganism in patient tissue.
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公开(公告)号：US20080213752A1
公开(公告)日：2008-09-04
申请号：US12034765
申请日：2008-02-21
申请人： James W. Stave , George B. Teaney
发明人： James W. Stave , George B. Teaney
CPC分类号： C12Q1/04 , C12N2795/00011 , C12N2795/00032
摘要： Compositions containing bacteriophages and methods of using bacteriophages in microorganism detection assays and microbial growth and plating media are disclosed. The lytic ability of these phages to control the growth of non-target populations provides superior sensitivity and specificity to detection assays and reduces false negative and false positive results. The removal of contaminating bacteria reduces the microbial competition for nutrients in the growth media thereby increasing the efficiency and productivity of the culture. The phage treatment of the sample increases the proportion of target microorganisms in the sample over contaminating bacteria thereby requiring less time for enrichment to obtain a significant signal improving overall signal to noise ratio in assays and providing for higher yield of end product in microbiological production systems.
摘要翻译： 公开了包含噬菌体的组合物和在微生物检测测定和微生物生长和电镀培养基中使用噬菌体的方法。 这些噬菌体控制非目标群体生长的溶解能力为检测测定提供了出色的灵敏度和特异性，并减少了假阴性和假阳性结果。 污染细菌的去除减少了生长培养基中营养物的微生物竞争，从而提高了培养物的效率和生产力。 样品的噬菌体处理增加了样品中目标微生物在污染细菌上的比例，从而需要更少的浓缩时间来获得显着的信号，从而提高了测定中的整体信噪比，并提供了微生物生产系统中最终产品的更高产量。
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公开(公告)号：US20080062417A1
公开(公告)日：2008-03-13
申请号：US11852825
申请日：2007-09-10
申请人： James W. Stave , Matthew H. Knight
发明人： James W. Stave , Matthew H. Knight
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , C02F1/008 , C02F1/5209 , G01J3/44 , G01N21/658 , G01N33/1826 , G01N2021/653
摘要： Compositions and methods utilizing Raman Spectroscopy to detect and determine, directly or indirectly, the concentration of water treatment polymers in water or methods for measuring or quantifying the amount of water treatment polymer in a sample, such as an industrial, commercial, or municipal water sample, are provided. The compositions contain water treatment polymers that have been modified to include one or more Raman-active functional groups. The methods utilize Raman spectroscopy to detect the presence or amount of water treatment polymer either directly or indirectly. The method provides the ability to detect or measure the amount of active water treatment polymer remaining in the sample.
摘要翻译： 使用拉曼光谱法的组合物和方法直接或间接地检测和测定水中水处理聚合物的浓度或测量或定量样品中的水处理聚合物的量的方法，例如工业，商业或城市水样品 ，提供。 该组合物含有经过改性以包括一个或多个拉曼活性官能团的水处理聚合物。 该方法利用拉曼光谱法直接或间接地检测水处理聚合物的存在或量。 该方法提供检测或测量残留在样品中的活性水处理聚合物的量的能力。
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公开(公告)号：US06663833B1
公开(公告)日：2003-12-16
申请号：US09263183
申请日：1999-03-05
IPC分类号： G01N2100
CPC分类号： G01N33/54366 , G01N33/5302 , G01N33/538 , G01N33/54313 , G01N33/558 , Y10T436/255
摘要： An assay device for the detection of analyte in a sample, methods and immunoassay formats for performing an assay with or without the device, and methods for manufacturing the device are provided. The device is a continuous liquid flow channel having a proximal and a distal end, with a detection membrane in fluid communication with the distal end of the flow channel. Interspersed between the assay buffer and detection membrane, and continuous with the liquid flow channel, are a sample delivery means, one or more reservoirs containing the reagents necessary for conducting the assay, and, optionally, mixing or incubation reservoirs for combining the sample and reagents. The geometry of the liquid flow channel regulates the flow rate of the liquids through the channel, thereby controlling incubation, mixing and reaction time. The preferred detection membrane is an immunochromatographic test strip containing immobilized reagents. The detection of labeled reagent in a particular area of the detection membrane reflects the presence or relative amount of analyte in the sample. Detection may be achieved visually. One or more liquid flow channels may be contained within a single housing for simultaneous, consecutive, or comparative sample analysis.
摘要翻译： 提供了用于检测样品中分析物的测定装置，用于进行具有或不具有该装置的测定的方法和免疫测定形式以及用于制造该装置的方法。 该装置是具有近端和远端的连续液体流动通道，其中检测膜与流动通道的远端流体连通。 分散在测定缓冲液和检测膜之间并且与液体流动通道连续的是样品递送装置，一个或多个含有进行测定所必需的试剂的储存器，以及任选地混合或孵育用于组合样品和试剂的储存器 。 液体流动通道的几何形状调节通过通道的液体的流速，从而控制孵育，混合和反应时间。 优选的检测膜是含有固定化试剂的免疫色谱试纸。 在检测膜的特定区域中的标记试剂的检测反映了样品中分析物的存在或相对量。 可以在视觉上实现检测。 一个或多个液体流动通道可以包含在单个壳体内用于同时，连续或对比的样品分析。
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公开(公告)号：US20180045737A1
公开(公告)日：2018-02-15
申请号：US15664402
申请日：2017-07-31
CPC分类号： G01N33/6893 , C12Q1/6883 , C12Q2600/106 , C12Q2600/158 , G01N2800/52 , G01N2800/60 , G01N2800/7095
摘要： This invention relates to field of screening and diagnosing adverse local tissue reaction (ALTR) in a subject who has received a joint replacement by measuring the level of a nucleic acid or protein biomarker that are elevated in patients suffering from ALTR, even those with no symptoms. The early diagnosis of the ALTR can lead to its treatment and thus, the prevention of implant failure caused by the ALTR. The elevated proteins and genes are also the basis for treatment for ALTR and provide targets for drug development and basic research.
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公开(公告)号：US07532321B2
公开(公告)日：2009-05-12
申请号：US11852825
申请日：2007-09-10
申请人： James W. Stave , Matthew H. Knight
发明人： James W. Stave , Matthew H. Knight
CPC分类号： G01N21/65 , C02F1/008 , C02F1/5209 , G01J3/44 , G01N21/658 , G01N33/1826 , G01N2021/653
摘要： Compositions and methods utilizing Raman Spectroscopy to detect and determine, directly or indirectly, the concentration of water treatment polymers in water or methods for measuring or quantifying the amount of water treatment polymer in a sample, such as an industrial, commercial, or municipal water sample, are provided. The compositions contain water treatment polymers that have been modified to include one or more Raman-active functional groups. The methods utilize Raman spectroscopy to detect the presence or amount of water treatment polymer either directly or indirectly. The method provides the ability to detect or measure the amount of active water treatment polymer remaining in the sample.
摘要翻译： 使用拉曼光谱法的组合物和方法直接或间接地检测和测定水中水处理聚合物的浓度或测量或定量样品中的水处理聚合物的量的方法，例如工业，商业或城市水样品 ，提供。 该组合物含有经过改性以包括一个或多个拉曼活性官能团的水处理聚合物。 该方法利用拉曼光谱法直接或间接地检测水处理聚合物的存在或量。 该方法提供检测或测量残留在样品中的活性水处理聚合物的量的能力。
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公开(公告)号：US07521201B2
公开(公告)日：2009-04-21
申请号：US11262859
申请日：2005-10-31
IPC分类号： C12Q1/04
CPC分类号： C12Q1/04 , C12N7/00 , C12N2795/00011 , C12N2795/10045 , C12Q1/10 , G01N2333/005 , G01N2333/255
摘要： Compositions containing bacteriophages and methods of using bacteriophages in microorganism detection assays and microbial growth and plating media are disclosed. The lytic ability of these phages to control the growth of non-target populations provides superior sensitivity and specificity to detection assays and reduces false negative and false positive results. The removal of contaminating bacteria reduces the microbial competition for nutrients in the growth media thereby increasing the efficiency and productivity of the culture. The phage treatment of the sample increases the proportion of target microorganisms in the sample over contaminating bacteria thereby requiring less time for enrichment to obtain a significant signal improving overall signal to noise ratio in assays and providing for higher yield of end product in microbiological production systems.
摘要翻译： 公开了包含噬菌体的组合物和在微生物检测测定和微生物生长和电镀培养基中使用噬菌体的方法。 这些噬菌体控制非目标群体生长的溶解能力为检测测定提供了出色的灵敏度和特异性，并减少了假阴性和假阳性结果。 污染细菌的去除减少了生长培养基中营养物的微生物竞争，从而提高了培养物的效率和生产力。 样品的噬菌体处理增加了样品中目标微生物在污染细菌上的比例，从而需要更少的浓缩时间来获得显着的信号，从而提高了测定中的整体信噪比，并提供了微生物生产系统中最终产品的更高产量。
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公开(公告)号：US07189520B2
公开(公告)日：2007-03-13
申请号：US10734654
申请日：2003-12-12
IPC分类号： G01N33/53
CPC分类号： G01N33/6887 , C07K16/18 , G01N33/02
摘要： Analytes and ligands for detecting animal byproduct in agricultural samples such as animal feed to minimize the transmission of prion pathogens into food products consumed by humans. The analyte is a component of rendered animal byproduct such as meat and bone meal (MBM). An antibody specific for the analyte is produced by immunizing an animal with MBM or an immunogenic component of MBM that is found in rendered animal product.
摘要翻译： 用于检测农业样品如动物饲料中的动物副产物的分析物和配体，以最小化朊病毒病原体向食物消费的食物的传播。 分析物是呈现的动物副产物如肉和骨粉（MBM）的组分。 对分析物特异性的抗体是通过用生物动物产品中发现的MBM或MBM的免疫原性成分免疫动物产生的。
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